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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism
Journal Article
Metabolism, ISSN 0026-0495, 2014, Volume 63, Issue 6, pp. 735 - 745
Abstract New-onset diabetes has been observed in clinical trials and meta-analyses involving statin therapy. To explain this association, three major... 
Endocrinology & Metabolism | Ca2 + channels | HMG-CoA inhibitors | Diabetes mellitus | Adipocytes | GLUT4 | Lipophilicity | Cholesterol | Adiponectin | Isoprenoids | COA REDUCTASE INHIBITORS | CHOLESTEROL ACCUMULATION | DRUG-INTERACTIONS | INSULIN-SECRETION | BETA-CELL FUNCTION | MEVALONIC ACID | Ca2+ channels | ENDOCRINOLOGY & METABOLISM | PPAR-GAMMA | PRAVASTATIN | GLUCOSE-UPTAKE | CORONARY-ARTERY-DISEASE | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Calcium Channels - metabolism | Glucose Transporter Type 4 - metabolism | Humans | Leptin - metabolism | MicroRNAs - metabolism | Caveolins - metabolism | Adipocytes - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Terpenes - antagonists & inhibitors | Mitochondrial Proteins - metabolism | Adiponectin - metabolism | Insulin Secretion | Calcium Channels - drug effects | Hyperinsulinism - metabolism | Ubiquinone - analogs & derivatives | Insulin Resistance | Diabetes Mellitus - metabolism | Ubiquinone - antagonists & inhibitors | Hyperglycemia - metabolism | Hyperinsulinism - chemically induced | Insulin - metabolism | Animals | Dolichol - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Insulin-Secreting Cells - drug effects | Ion Channels - metabolism | Cell Differentiation - drug effects | Diabetes Mellitus - chemically induced | Uncoupling Protein 3 | Phosphates | Enzymes | Pancreatic beta cells | Development and progression | Glucose | Dextrose | Cardiovascular agents | Glucose metabolism | Analysis | Leptin | Cellular signal transduction | Diabetes | Statins | Protein binding | Diabetes therapy
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2566 - 2575
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2007, Volume 35, Issue 5, pp. 779 - 786
Macrolides may cause severe drug interactions due to the inhibition of metabolizing enzymes. Transporter-mediated uptake of drugs into cells [e.g., by members... 
IN-VITRO | PHARMACOKINETICS | SLCO1B1 POLYMORPHISM | PHARMACOLOGY & PHARMACY | HUMAN LIVER | PRAVASTATIN | HEPATIC-UPTAKE | TRANSPORTING POLYPEPTIDE 1B1 | ROSUVASTATIN | P-GLYCOPROTEIN | PREDICTION | Organic Anion Transporters, Sodium-Independent - genetics | Organic Anion Transport Protein 1 - metabolism | Ketolides - pharmacology | Humans | Organic Chemicals - metabolism | Anions - pharmacokinetics | Immunoblotting | Anions - chemistry | Chromatography, High Pressure Liquid | Dose-Response Relationship, Drug | Organic Anion Transport Protein 1 - physiology | Tandem Mass Spectrometry | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Transfection | Macrolides - chemistry | Sulfobromophthalein - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Anti-Bacterial Agents - chemistry | Macrolides - pharmacology | Ketolides - metabolism | Transcription, Genetic | Biological Transport - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters, Sodium-Independent - physiology | Pravastatin - pharmacology | Cell Line | Pravastatin - metabolism | Organic Chemicals - chemistry | Anti-Bacterial Agents - metabolism | Organic Anion Transport Protein 1 - genetics | Macrolides - metabolism | Anions - metabolism | Pharmaceutical Preparations - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Organic Chemicals - pharmacokinetics | Pharmaceutical Preparations - chemistry | Anti-Bacterial Agents - pharmacology
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2010, Volume 6, Issue 3, pp. 202 - 204
The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we... 
HEXOSE-6-PHOSPHATE DEHYDROGENASE | STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | Nutrients | Biochemistry | Cellular biology | Metabolism | Ribonucleic acid--RNA | trichostatin A (TSA) | taurodeoxycholic acid (TUDCA) | fluvastatin | glycochenodeoxycholic acid | pravastatin | 3-phosphoglycerate | phosphoenol pyruvate (PEP) | atorvastatin | cyclosporin A (CsA)
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2006, Volume 34, Issue 7, pp. 1247 - 1254
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0142902
Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining... 
CYCLIC-AMP | ACID | GLUCAGON-LIKE PEPTIDE-1 | CA2+-INDUCED CA2+ RELEASE | ACETYLCHOLINE | MULTIDISCIPLINARY SCIENCES | LINE | PROTEIN-COUPLED RECEPTORS | PANCREATIC BETA-CELL | GPR40 | CAMP | Simvastatin - adverse effects | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Humans | Middle Aged | Male | Receptors, G-Protein-Coupled - agonists | Simvastatin - pharmacology | Metabolic Syndrome - blood | Glucagon-Like Peptide-1 Receptor - metabolism | Colforsin - metabolism | Cyclic AMP - metabolism | Fatty Acids - metabolism | Insulin Secretion | Pravastatin - pharmacology | Cell Line | Signal Transduction | Risk Factors | Erythrocyte Membrane - metabolism | Diabetes Mellitus - metabolism | Pancreas - drug effects | Insulin - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Glucose - metabolism | Mice | Adenosine Triphosphate - chemistry | Complications and side effects | Simvastatin | Disease susceptibility | Diabetes | Research | Insulin | Health aspects | Risk factors | Acetylcholine receptors (muscarinic) | Calcium | Glucose | Pravastatin | Kinases | Channels | Hyperglycemia | Rodents | Potassium channels (voltage-gated) | Pancreas | Statins | Calcium channels | Secretion | Diabetes mellitus | Calcium channels (voltage-gated) | Health risks | Potassium channels | Molecular modelling | Hypercholesterolemia | Forskolin | Cardiovascular diseases | Endoplasmic reticulum | Potassium | Calcium (reticular)
Journal Article