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1. Full Text Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes
by Ménochet, Karelle and Kenworthy, Kathryn E and Houston, J. Brian and Galetin, Aleksandra
Drug metabolism and disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects | Index Medicus
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2. Full Text Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP) Substrates on OATP1B1, OATP2B1, and OATP1B3
by Johannes Noà and Renée Portmann and Marie-Elise Brun and Christoph Funk
Drug metabolism and disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism | Index Medicus
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3. Full Text Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco‐2 cell monolayers
by Kimura, Osamu and Fujii, Yukiko and Haraguchi, Koichi and Ohta, Chiho and Koga, Nobuyuki and Kato, Yoshihisa and Endo, Tetsuya
Journal of pharmacy and pharmacology, ISSN 0022-3573, 07/2016, Volume 68, Issue 7, pp. 883 - 889
Aristolochic acid I | Caco‐2 cell | monocarboxylic acid transporters | quercetin | breast cancer resistance protein | Monocarboxylic acid transporters | Breast cancer resistance protein | Caco-2 cell | Quercetin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Caco-2 Cells | Pravastatin - pharmacology | Propionates - pharmacology | Cyclosporine - pharmacology | Benzoic Acid - pharmacology | Humans | Cells, Cultured | Intestinal Absorption - drug effects | Acetic Acid - pharmacology | Quinidine - pharmacology | Diketopiperazines - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacology | Indomethacin - pharmacology | Quinolines - pharmacology | Aristolochic Acids - pharmacokinetics | Quercetin - pharmacology | Biological Transport - drug effects | Mitoxantrone - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hydrogen-Ion Concentration | Benzoic acid | Organic acids | Monomolecular films | Acids | Ions | Index Medicus
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4. Full Text Differential metabolic effects of distinct statins
by Koh, Kwang Kon and Sakuma, Ichiro and Quon, Michael J
Atherosclerosis, ISSN 0021-9150, 2010, Volume 215, Issue 1, pp. 1 - 8
Cardiovascular | Insulin resistance | Statins | Diabetes | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiovascular system | Cardiology. Vascular system | Atherosclerosis (general aspects, experimental research) | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Vasodilator agents. Cerebral vasodilators | Blood and lymphatic vessels | Pravastatin - pharmacology | Adiponectin - biosynthesis | Humans | Diabetes Mellitus, Type 2 - prevention & control | Rosuvastatin Calcium | Clinical Trials as Topic | Pyrimidines - pharmacology | Simvastatin - pharmacology | Sulfonamides - pharmacology | Adiponectin - blood | Fluorobenzenes - pharmacology | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl CoA Reductases - metabolism | Insulin Resistance - physiology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Mice | Diabetes Mellitus, Type 2 - chemically induced | Homeostasis - drug effects | Heptanoic Acids - pharmacology | Glucose metabolism | RNA | Analysis | Simvastatin | Alternative medicine | Atherosclerosis | Glucose | Pravastatin | Dextrose | Antilipemic agents | Index Medicus
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5. Full Text Comparative evaluation of HMG CoA reductase inhibitors in experimentally-induced myocardial necrosis: Biochemical, morphological and histological studies
by Variya, Bhavesh C and Patel, Snehal S and Trivedi, Jinal I and Gandhi, Hardik P and Rathod, S.P
European journal of pharmacology, ISSN 0014-2999, 10/2015, Volume 764, pp. 283 - 291
Fluvastatin | Simvastatin | Atorvastatin | Rosuvastatin | Myocardial necrosis | Isoproterenol | Pravastatin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Necrosis - drug therapy | Myocardial Infarction - chemically induced | Simvastatin - therapeutic use | Fatty Acids, Monounsaturated - pharmacology | Rosuvastatin Calcium - therapeutic use | Rats, Wistar | Atorvastatin Calcium - pharmacology | Glutathione - metabolism | Cholesterol - blood | Male | Simvastatin - pharmacology | Necrosis - pathology | Cardiotonic Agents - therapeutic use | Fatty Acids, Monounsaturated - therapeutic use | Myocardial Infarction - pathology | Myocardium - metabolism | Indoles - pharmacology | Pravastatin - therapeutic use | Atorvastatin Calcium - therapeutic use | Superoxide Dismutase - metabolism | Pravastatin - pharmacology | Blood Glucose - analysis | Rosuvastatin Calcium - pharmacology | Adenosine Triphosphatases - metabolism | Myocardium - pathology | Necrosis - metabolism | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Necrosis - chemically induced | Catalase - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Myocardial Infarction - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Isoproterenol - pharmacology | Triglycerides - blood | Indoles - therapeutic use | Isoproterenol - therapeutic use | Antioxidants | Pharmacy | Drugstores | Glucose | Comparative analysis | Statins | Dextrose | Necrosis | Cardiotonic agents | Histochemistry | Cardiac glycosides | Index Medicus
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6. Full Text Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis
by Lu, Yongbin and Cheng, Zhiyuan and Zhao, Yaxue and Chang, Xiaoyu and Chan, Cynthia and Bai, Yana and Cheng, Ning
Atherosclerosis, ISSN 0021-9150, 2016, Volume 254, pp. 215 - 227
Cardiovascular | Efficacy | Statin | Safety | Mortality | CHD | Blood-lipid | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Pravastatin - pharmacology | Fatty Acids, Monounsaturated - pharmacology | Lovastatin - pharmacology | Atorvastatin Calcium - pharmacology | Humans | Kidney Diseases - drug therapy | Treatment Outcome | Lovastatin - analogs & derivatives | Simvastatin - pharmacology | Quinolines - pharmacology | Randomized Controlled Trials as Topic | Coronary Disease - pathology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Lipids - blood | Muscles - drug effects | Bayes Theorem | Patient Safety | Coronary Disease - drug therapy | Indoles - pharmacology | Network Meta-Analysis | Anticholesteremic Agents - pharmacology | Epidemiology | Coronary heart disease | Analysis | Statins | Cardiovascular agents | Blood lipids | Index Medicus
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7. Full Text Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke
by Ferreira, Thiago Santos and Lanzetti, Manuella and Barroso, Marina Valente and Rueff-Barroso, Carlos Romualdo and Benjamim, Cláudia Farias and de Brito-Gitirana, Lycia and Porto, Luís Cristóvão and Valença, Samuel Santos
Inflammation, ISSN 0360-3997, 10/2014, Volume 37, Issue 5, pp. 1355 - 1365
lung | Pathology | Medicine & Public Health | inflammation | statins | Rheumatology | Internal Medicine | Pharmacology/Toxicology | cigarette smoke | mice | oxidative stress | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Simvastatin - therapeutic use | Heptanoic Acids - therapeutic use | Oxidative Stress - physiology | Male | Simvastatin - pharmacology | Fluorobenzenes - pharmacology | Inflammation Mediators - metabolism | Anti-Inflammatory Agents - therapeutic use | Inhalation Exposure - adverse effects | Inflammation Mediators - antagonists & inhibitors | Lung - metabolism | Pyrroles - therapeutic use | Pravastatin - therapeutic use | Heptanoic Acids - pharmacology | Pravastatin - pharmacology | Lung - pathology | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Smoking - drug therapy | Rosuvastatin Calcium | Antioxidants - pharmacology | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Atorvastatin Calcium | Smoking - metabolism | Antioxidants - therapeutic use | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Lung - drug effects | Smoking - pathology | Mice | Oxidative Stress - drug effects | Fluorobenzenes - therapeutic use | Oxidative stress | Complications and side effects | Inflammation | Research | Cigarette smoke | Risk factors | Index Medicus
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