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BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 07/2018, Volume 26, Issue 12, pp. 3502 - 3513
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2017, Volume 45, Issue 11, pp. 1166 - 1177
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2012, Volume 84, Issue 6, pp. 766 - 774
OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors.... 
ABC transporters | OSI-930 | Multidrug resistance | ABCG2 | CANCER-CELLS | DRUG-RESISTANCE | SUBFAMILY-B MEMBER-1 | P-GLYCOPROTEIN | ABC TRANSPORTER SUPERFAMILY | IN-VITRO | KIT | PHARMACOLOGY & PHARMACY | INHIBITOR | BINDING | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Benzene Derivatives - chemical synthesis | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Drug Resistance, Multiple - drug effects | Humans | Nitro Compounds - chemistry | Neoplasm Proteins - antagonists & inhibitors | Prazosin - analogs & derivatives | Structure-Activity Relationship | Neoplasm Proteins - metabolism | Quinolines - pharmacology | Transfection | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP-Binding Cassette Transporters - metabolism | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Benzene Derivatives - pharmacology | Photoaffinity Labels | Mitoxantrone - metabolism | Quinolines - chemistry | Cells, Cultured | Pyridines - chemical synthesis | Adenosine Triphosphatases - metabolism | Thiophenes - pharmacology | Nitro Compounds - chemical synthesis | Antineoplastic Agents - chemistry | Quinolines - chemical synthesis | Adenosine Triphosphatases - antagonists & inhibitors | Azides | Thiophenes - chemical synthesis | Pyridines - pharmacology | Benzene Derivatives - chemistry | Thiophenes - chemistry | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Tyrosine | Drug resistance in microorganisms | Heterocyclic compounds | Oncology, Experimental | Research | Thiophene | Phosphotransferases | Cancer | multidrug resistance
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2013, Volume 23, Issue 13, pp. 3959 - 3966
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2013, Volume 23, Issue 13, pp. 3959 - 3966
Multiple-targeted ligands can have certain advantages for the management of hypertension which has multiple controls. Molecules with dual bioactivities are... 
Hypertension | Prazosin | MULTIPLE LIGANDS | ANGIOTENSIN-II RECEPTOR | CHEMISTRY, MEDICINAL | Losartan | CHEMISTRY, ORGANIC | AGENTS | Multiple-targeted ligands | Quinazoline | Dual inhibition | BLOOD-PRESSURE
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2003, Volume 46, Issue 2, pp. 265 - 283
Journal Article
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2006, Volume 26, Issue 2, pp. 467 - 478
In Alzheimer's disease ( AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons. However, functional and anatomical evidence indicates... 
Norepinephrine | In situ hybridization | Alzheimer's disease | Hippocampus | Adrenoreceptors | Locus ceruleus | norepinephrine | SENILE DEMENTIA | HUMAN ALPHA-2-ADRENERGIC RECEPTOR | locus ceruleus | hippocampus | adrenoreceptors | TYROSINE-HYDROXYLASE | CEREBROSPINAL-FLUID | NEURONAL LOSS | NEUROSCIENCES | DUAL-PROBE MICRODIALYSIS | ADRENERGIC PROJECTION | TRANSPORTER MESSENGER-RNA | HUMAN-BRAIN | RAT-BRAIN | in situ hybridization | Receptors, Adrenergic, alpha-1 - metabolism | Receptors, Adrenergic, alpha-2 - genetics | Locus Coeruleus - chemistry | Hippocampus - chemistry | Norepinephrine - physiology | Humans | Middle Aged | Nerve Tissue Proteins - analysis | Receptors, Adrenergic, alpha-2 - metabolism | Prazosin - metabolism | RNA, Messenger - analysis | Male | Dendrites - ultrastructure | Alzheimer Disease - pathology | RNA, Messenger - biosynthesis | Receptors, Adrenergic, alpha-1 - analysis | In Situ Hybridization | Fluoxetine - analogs & derivatives | Aged, 80 and over | Adult | Female | Idazoxan - analogs & derivatives | Locus Coeruleus - pathology | Lewy Body Disease - pathology | Hippocampus - pathology | Tyrosine 3-Monooxygenase - analysis | Receptors, Adrenergic, alpha-2 - analysis | Nerve Tissue Proteins - genetics | Adrenergic alpha-Antagonists - metabolism | Lewy Body Disease - metabolism | Nerve Tissue Proteins - metabolism | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Idazoxan - metabolism | Norepinephrine - chemistry | Receptors, Adrenergic, alpha-1 - genetics | Alzheimer Disease - metabolism | Fluoxetine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - analysis | Aged | Tetralones - metabolism | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Neurobiology of Disease
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 43, Issue 4, pp. 297 - 307
While the utility of cryopreserved human hepatocyte suspensions (CHHS) for drug metabolism assays has been established, less is known about the effects of... 
Drug transport | Cryopreserved human hepatocytes | Drug interaction | OATP | Hepatic drug uptake | NTCP | COLLAGEN-SANDWICH CONFIGURATION | CHOLYL-GLYCYLAMIDO-FLUORESCEIN | METABOLIC-CLEARANCE | HEPATIC-UPTAKE | HEPATOBILIARY DISPOSITION | PROTEASE INHIBITORS | ORGANIC CATION TRANSPORTERS | CULTURED RAT HEPATOCYTES | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ANION TRANSPORTER | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Corticosterone - pharmacology | Digoxin - metabolism | Taurocholic Acid - metabolism | Humans | Middle Aged | Male | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | Cryopreservation | Organic Anion Transporters, Sodium-Independent - metabolism | Prazosin - pharmacology | Adult | Membrane Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - metabolism | Solute Carrier Organic Anion Transporter Family Member 1B3 | Estradiol - metabolism | Organic Cation Transport Proteins - metabolism | RNA, Messenger - genetics | Symporters - metabolism | Estrone - analogs & derivatives | Estrone - metabolism | Adolescent | Organic Cation Transporter 1 - antagonists & inhibitors | Rifampin - pharmacology | Organic Anion Transporters, Sodium-Dependent - metabolism | Messenger RNA | Gastrointestinal agents | Peptides | Digoxin | Corticosterone | Analysis | Drug interactions | Sulfates | Rifampin | Estradiol
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2009, Volume 64, Issue 3, pp. 575 - 583
ABCG2 overexpression has been linked to resistance to topoisomerase inhibitors, leading us to examine the potential interaction between ABCG2 and... 
Rebecamycin derivative | Becatecarin | Biomedicine | Drug-resistance | Cancer Research | Oncology | Topoisomerase inhibitor | Pharmacology/Toxicology | ABCG2 | MULTIDRUG TRANSPORTER | INDOLOCARBAZOLE COMPOUND | PHASE-II | CONFERS RESISTANCE | P-GLYCOPROTEIN | BREAST-CANCER | ONCOLOGY | PHARMACOLOGY & PHARMACY | TOPOISOMERASE-I INHIBITORS | IMATINIB MESYLATE | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Lung Neoplasms - drug therapy | Iodine Radioisotopes | Humans | Carbazoles - administration & dosage | Adenosine Triphosphatases - drug effects | Fluorescence | Prazosin - metabolism | Drug Resistance, Neoplasm | Immunoblotting | Lung Neoplasms - pathology | Prazosin - analogs & derivatives | Glucosides - pharmacokinetics | Neoplasm Proteins - drug effects | Dose-Response Relationship, Drug | Flow Cytometry | ATP-Binding Cassette Transporters - genetics | Biological Transport | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Azides - metabolism | Neoplasm Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Glucosides - pharmacology | Carcinoma, Non-Small-Cell Lung - genetics | Adenosine Triphosphatases - metabolism | Glucosides - administration & dosage | ATP-Binding Cassette Transporters - drug effects | Carbazoles - pharmacokinetics | Cell Line, Tumor | Carcinoma, Non-Small-Cell Lung - drug therapy | Carbazoles - pharmacology | Carcinoma | Oncology, Experimental | Lung cancer | Research | Drug resistance | Adenosine triphosphatase | Cancer | rebecamycin derivative | drug-resistance | topoisomerase inhibitor
Journal Article