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British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 787 - 796
Background and purpose:  Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors... 
fluorescent ligand binding | endothelium | adrenoceptor | vascular smooth muscle | adventitia | confocal microscopy | cannabinoid | angiotensin | α1B/D-adrenoceptor knockout | α1B/D‐adrenoceptor knockout | Adventitia | adrenoceptor knockout | Fluorescent ligand binding | Angiotensin | Confocal microscopy | Vascular smooth muscle | Cannabinoid | Adrenoceptor | Endothelium | MESENTERIC-ARTERIES | SUBTYPES | ANANDAMIDE | GPR55 | SURFACE EXPRESSION | ANGIOTENSIN-II | ALPHA(1D)-ADRENERGIC RECEPTORS | alpha(1B/D)-adrenoceptor knockout | PHARMACOLOGY | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | Receptors, Adrenergic, alpha-1 - metabolism | Molecular Probe Techniques | Propanolamines - metabolism | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Fluorescent Dyes - metabolism | Prazosin - metabolism | Male | Molecular Imaging | Prazosin - analogs & derivatives | Receptors, Cannabinoid - metabolism | Receptors, Adrenergic - genetics | Tail - blood supply | Receptors, Adrenergic, beta - metabolism | Mesenteric Arteries - cytology | Boron Compounds - metabolism | Angiotensin II - metabolism | Receptors, Adrenergic - metabolism | Mice, Inbred C57BL | Rats | Pyrazoles - metabolism | Mesenteric Arteries - metabolism | Connective Tissue - metabolism | Mice, Knockout | Receptors, Adrenergic - deficiency | Microscopy, Confocal | Animals | Endothelium, Vascular - metabolism | Ligands | Mice | Localization | Rodents | Veins & arteries | Research Papers | Themed Section | D-adrenoceptor knockout | α1B
Journal Article
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 43, Issue 4, pp. 297 - 307
While the utility of cryopreserved human hepatocyte suspensions (CHHS) for drug metabolism assays has been established, less is known about the effects of... 
Drug transport | Cryopreserved human hepatocytes | Drug interaction | OATP | Hepatic drug uptake | NTCP | COLLAGEN-SANDWICH CONFIGURATION | CHOLYL-GLYCYLAMIDO-FLUORESCEIN | METABOLIC-CLEARANCE | HEPATIC-UPTAKE | HEPATOBILIARY DISPOSITION | PROTEASE INHIBITORS | ORGANIC CATION TRANSPORTERS | CULTURED RAT HEPATOCYTES | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ANION TRANSPORTER | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Corticosterone - pharmacology | Digoxin - metabolism | Taurocholic Acid - metabolism | Humans | Middle Aged | Male | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | Cryopreservation | Organic Anion Transporters, Sodium-Independent - metabolism | Prazosin - pharmacology | Adult | Membrane Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - metabolism | Solute Carrier Organic Anion Transporter Family Member 1B3 | Estradiol - metabolism | Organic Cation Transport Proteins - metabolism | RNA, Messenger - genetics | Symporters - metabolism | Estrone - analogs & derivatives | Estrone - metabolism | Adolescent | Organic Cation Transporter 1 - antagonists & inhibitors | Rifampin - pharmacology | Organic Anion Transporters, Sodium-Dependent - metabolism | Messenger RNA | Gastrointestinal agents | Peptides | Digoxin | Corticosterone | Analysis | Drug interactions | Sulfates | Rifampin | Estradiol
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2015, Volume 16, Issue 12, pp. 1228 - 1234
The molecular mechanisms that link the sympathetic stress response and inflammation remain obscure. Here we found that the transcription factor Nr4a1 regulated... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NGFI-B | PRAZOSIN TREATMENT | MULTIPLE-SCLEROSIS | CELL-DEVELOPMENT | GENE-EXPRESSION | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | BLOOD-BRAIN-BARRIER | LEWIS RAT | NUCLEAR RECEPTOR | Tyrosine 3-Monooxygenase - metabolism | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Norepinephrine - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Nuclear Receptor Subfamily 4, Group A, Member 1 - immunology | Sympathetic Nervous System - immunology | Sympathetic Nervous System - metabolism | Central Nervous System - immunology | Inflammation - metabolism | Tyrosine 3-Monooxygenase - immunology | Myeloid Cells - immunology | Gene Expression - immunology | Encephalomyelitis, Autoimmune, Experimental - genetics | Macrophages - immunology | Disease Models, Animal | Cell Line | Rabbits | Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Microscopy, Confocal | Tyrosine 3-Monooxygenase - genetics | Macrophages - metabolism | Animals | Norepinephrine - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Myeloid Cells - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Transcription factors | Immune response | Encephalomyelitis | Development and progression | Genetic aspects | Properties | Macrophages | Noradrenaline
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2006, Volume 26, Issue 2, pp. 467 - 478
In Alzheimer's disease ( AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons. However, functional and anatomical evidence indicates... 
Norepinephrine | In situ hybridization | Alzheimer's disease | Hippocampus | Adrenoreceptors | Locus ceruleus | norepinephrine | SENILE DEMENTIA | HUMAN ALPHA-2-ADRENERGIC RECEPTOR | locus ceruleus | hippocampus | adrenoreceptors | TYROSINE-HYDROXYLASE | CEREBROSPINAL-FLUID | NEURONAL LOSS | NEUROSCIENCES | DUAL-PROBE MICRODIALYSIS | ADRENERGIC PROJECTION | TRANSPORTER MESSENGER-RNA | HUMAN-BRAIN | RAT-BRAIN | in situ hybridization | Receptors, Adrenergic, alpha-1 - metabolism | Receptors, Adrenergic, alpha-2 - genetics | Locus Coeruleus - chemistry | Hippocampus - chemistry | Norepinephrine - physiology | Humans | Middle Aged | Nerve Tissue Proteins - analysis | Receptors, Adrenergic, alpha-2 - metabolism | Prazosin - metabolism | RNA, Messenger - analysis | Male | Dendrites - ultrastructure | Alzheimer Disease - pathology | RNA, Messenger - biosynthesis | Receptors, Adrenergic, alpha-1 - analysis | In Situ Hybridization | Fluoxetine - analogs & derivatives | Aged, 80 and over | Adult | Female | Idazoxan - analogs & derivatives | Locus Coeruleus - pathology | Lewy Body Disease - pathology | Hippocampus - pathology | Tyrosine 3-Monooxygenase - analysis | Receptors, Adrenergic, alpha-2 - analysis | Nerve Tissue Proteins - genetics | Adrenergic alpha-Antagonists - metabolism | Lewy Body Disease - metabolism | Nerve Tissue Proteins - metabolism | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Idazoxan - metabolism | Norepinephrine - chemistry | Receptors, Adrenergic, alpha-1 - genetics | Alzheimer Disease - metabolism | Fluoxetine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - analysis | Aged | Tetralones - metabolism | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Neurobiology of Disease
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2017, Volume 13, Issue 4, p. e1006744
Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of... 
UBIQUITIN HOMEOSTASIS | MESSENGER-RNA | MITOCHONDRIAL BIOGENESIS | NEUROLOGICAL DYSFUNCTION | MOUSE MODEL | GENETICS & HEREDITY | SELECTIVE VULNERABILITY | SMN PROTEIN | CHRONIC HEMOLYTIC-ANEMIA | NEUROMUSCULAR-JUNCTIONS | NEURODEGENERATIVE DISEASES | Spinal Cord - metabolism | Spinal Cord - growth & development | Humans | Muscle, Skeletal - metabolism | Prazosin - analogs & derivatives | Prazosin - administration & dosage | Muscular Atrophy, Spinal - genetics | Gene Expression Regulation, Developmental | Spinal Cord - pathology | Adenosine Triphosphate - metabolism | Survival of Motor Neuron 1 Protein - genetics | Phosphoglycerate Kinase - antagonists & inhibitors | Muscular Atrophy, Spinal - physiopathology | Motor Neurons - drug effects | Phosphoglycerate Kinase - genetics | Disease Models, Animal | Muscular Atrophy, Spinal - metabolism | Disease Susceptibility | Axons - metabolism | Mitochondria - metabolism | Survival of Motor Neuron 1 Protein - metabolism | Zebrafish - growth & development | Zebrafish - genetics | Motor Neurons - metabolism | Animals | Energy Metabolism | Axons - pathology | Mice | Muscle, Skeletal - pathology | Zebra fish | Physiological aspects | Development and progression | Models | Genetic aspects | Research | Gene expression | Spinal muscular atrophy | Motor neurons | Neurosciences | Cell survival | SMN protein | Muscles | Zebrafish | Amyotrophic lateral sclerosis | Vulnerability | Phosphoglycerate kinase | Motor task performance | Skeletal muscle | Disease resistance | Mitochondria | Rodents | Phosphoglycerate kinase 1 | Degeneration
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e72928
Background: Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and... 
FIBROSIS | LEPTIN | LIVER-CIRRHOSIS | INHIBITION | NOREPINEPHRINE | MULTIDISCIPLINARY SCIENCES | DISEASE | RESISTANCE | RECEPTORS | EXPRESSION | PORTAL-HYPERTENSION | Norepinephrine - pharmacology | Up-Regulation | Fatty Liver - metabolism | Catecholamines - metabolism | Receptors, Adrenergic - metabolism | Humans | Cells, Cultured | Hepatic Stellate Cells - metabolism | Chromatography, High Pressure Liquid | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Sympathetic Nervous System - metabolism | Interleukins - metabolism | Neuropeptide Y - metabolism | Collagen - metabolism | Base Sequence | Liver Cirrhosis - metabolism | Non-alcoholic Fatty Liver Disease | Liver Cirrhosis - pathology | Transforming Growth Factor beta - metabolism | Hepatic Stellate Cells - pathology | Hypertension | Epinephrine | Neuropeptide Y | Obesity | Interleukins | Collagen | Leptin | Transforming growth factors | Liver cirrhosis | Cell culture | Pathogenesis | Liver | Neuropeptide Y receptors | Nervous system | Neuropeptides | Liver cancer | Signal transduction | Receptors | Synthesis | Propranolol | Liver diseases | Cytokines | Interleukin 13 | Survival | 1-Phosphatidylinositol 3-kinase | Prazosin | Pathology | Cirrhosis | Hospitals | Morphology | Fibrosis | Interleukin 10 | Transplants & implants | Laboratories | Interleukin | Antagonists | Kinases | Experiments | Interleukin 4 | Fatty liver | Prolactin | Rodents | Hepatology | Gastroenterology | Stellate cells | Catecholamines | Sympathetic nervous system | Signaling | Neurotransmitters | Norepinephrine | Adrenergic receptors | Receptors (physiology)
Journal Article
Inflammation Research, ISSN 1023-3830, 12/2010, Volume 59, Issue 12, pp. 1053 - 1059
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2004, Volume 317, Issue 1, pp. 269 - 275
Journal Article
Journal Article