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Immunology, ISSN 0019-2805, 06/2013, Volume 139, Issue 2, pp. 141 - 150
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 10/2019, Volume 10, Issue 1, pp. 4768 - 15
B-1a cells are long-lived, self-renewing innate-like B cells that predominantly inhabit the peritoneal and pleural cavities. In contrast to conventional B-2... 
B-CELLS | STEM-CELLS | POSITIVE SELECTION | LIGHT-CHAIN RECOMBINATION | MULTIDISCIPLINARY SCIENCES | TRANSITIONAL CELLS | BONE-MARROW | IMMUNOGLOBULIN-HEAVY | EXPRESSION | T-CELLS | STAT5 ACTIVATION | Immunoglobulin Light Chains, Surrogate - immunology | Bone Marrow - immunology | Pre-B Cell Receptors - immunology | STAT5 Transcription Factor - immunology | Receptors, Antigen, B-Cell - metabolism | Liver - embryology | Cell Differentiation - genetics | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Liver - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Receptors, Interleukin-7 - genetics | Bone Marrow - metabolism | B-Lymphocyte Subsets - immunology | Immunoglobulin Light Chains, Surrogate - genetics | Pre-B Cell Receptors - genetics | Receptors, Interleukin-7 - immunology | B-Lymphocytes - metabolism | Receptors, Interleukin-7 - metabolism | Liver - metabolism | Mice, Inbred C57BL | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | Immunoglobulin Light Chains, Surrogate - metabolism | B-Lymphocyte Subsets - metabolism | Receptors, Antigen, B-Cell - genetics | Pre-B Cell Receptors - metabolism | Cell culture | Antigens | Recombination | Fetuses | Autoantigens | Stat5 protein | B-cell receptor | Cell differentiation | Receptors | Lymphocytes B | Bone marrow | Peritoneum | Apoptosis
Journal Article
European Journal of Immunology, ISSN 0014-2980, 03/2018, Volume 48, Issue 3, pp. 509 - 521
Age‐associated B cells (ABCs) represent a distinct cell population expressing low levels of CD21 (CD21−/low). The Ig repertoire expressed by ABCs in aged mice... 
Autoimmunity | H‐CDR3 repertoire | CD21−/low B cells | SLE animal model | Memory B cells | B cells | CD21 | H-CDR3 repertoire | Complementarity Determining Regions - genetics | Pre-B Cell Receptors - immunology | Autoimmunity - genetics | Autoantibodies - biosynthesis | Genes, Immunoglobulin Heavy Chain | Immunoglobulin M - metabolism | Aging - immunology | Mice, Inbred MRL lpr | Aging - genetics | Lupus Erythematosus, Systemic - immunology | B-Lymphocyte Subsets - immunology | Pre-B Cell Receptors - genetics | Immunologic Memory - genetics | Immunoglobulin M - genetics | Amino Acid Sequence | Somatic Hypermutation, Immunoglobulin | Lymphocyte Activation | Pre-B Cell Receptors - deficiency | Mice, Inbred NZB | Antigen-Presenting Cells - immunology | Mice, Knockout | Sequence Homology, Amino Acid | Animals | Lupus Erythematosus, Systemic - genetics | Hybridomas - immunology | Mice | Receptors, Complement 3d - metabolism | Autoantibodies - genetics | Immunoglobulin Heavy Chains - genetics | Lupus | Autoantibodies | Systemic lupus erythematosus | B cells | Memory (Computers) | Immunoglobulin M | Memory cells | Antibodies | T cell receptors | Computer memory | Somatic hypermutation | Chronic conditions | Lymphocytes B | Autoimmune diseases | Complementarity-determining region 3 | Deoxyribonucleic acid--DNA | Immunologi inom det medicinska området | CD21 B cells −/low | Immunology in the medical area
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2013, Volume 19, Issue 8, pp. 1014 - 1022
The B cell-specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated activation of p53 is required... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL6 | MYC | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | TRANSCRIPTION | STAT5 | IDENTIFICATION | CHAIN GENE | EXPRESSION | CELL BIOLOGY | Basic-Leucine Zipper Transcription Factors - metabolism | Precursor Cells, B-Lymphoid - metabolism | Cell Survival - genetics | Molecular Sequence Data | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | STAT5 Transcription Factor - metabolism | Precursor Cells, B-Lymphoid - pathology | Gene Deletion | Cell Death | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | PAX5 Transcription Factor - metabolism | Green Fluorescent Proteins - metabolism | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Immunoglobulin mu-Chains - metabolism | Treatment Outcome | Basic-Leucine Zipper Transcription Factors - genetics | Gene Expression Regulation, Leukemic | Proto-Oncogene Proteins c-myc - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | V(D)J Recombination - genetics | Animals | Mice | Cell Transformation, Neoplastic - pathology | Pre-B Cell Receptors - metabolism | Proto-Oncogene Proteins c-bcl-6 | Cell receptors | Physiological aspects | Development and progression | Tumor suppressor genes | Lymphomas | Genetic aspects | Research | B cells | Oncology | Genetic testing | Cellular biology | Leukemia | Tumors
Journal Article
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6331, pp. 1324 - 1330
Activating mutations in , the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)-positive breast cancer. PI3Kα... 
Chromatin - metabolism | Receptors, Estrogen - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Epigenesis, Genetic | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - therapy | DNA-Binding Proteins - metabolism | MCF-7 Cells | HEK293 Cells | Female | Transcription, Genetic | Lysine - metabolism | Neoplasm Proteins - genetics | Pre-B-Cell Leukemia Transcription Factor 1 | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Estrogen - genetics | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 3-alpha - genetics | DNA-Binding Proteins - genetics | Hepatocyte Nuclear Factor 3-alpha - metabolism | Lysine - genetics | Animals | Breast Neoplasms - genetics | Metabolic Networks and Pathways | Mice, Nude | Mice | Protein Processing, Post-Translational | Epigenetic inheritance | Receptors | Estrogen | Breast cancer | Genetic aspects | Health aspects | Phosphotransferases | Drugs | Regulators | Chromatin | Transcription | Estrogens | Estrogen receptors | AKT protein | Activation | Drug resistance | Kinases | Recruitment | Signal transduction | Developmental stages | Histone methyltransferase | Inhibition | Activation analysis | 1-Phosphatidylinositol 3-kinase | Inhibitors | Lysine | Epigenetics | Breast | Mutation | Histone H3 | Tumors | Cancer | Histones
Journal Article
Oncogene, ISSN 0950-9232, 06/2016, Volume 35, Issue 25, pp. 3227 - 3238
ZFP521 was previously identified as a putative gene involved in induction of B-cell lymphomagenesis. However, the contribution of ZFP521 to lymphomagenesis has... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | LOCUS | CELL BIOLOGY | HEAVY-CHAINS | RETROVIRUS INTEGRATION | GENE | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENETICS & HEREDITY | ZINC-FINGER PROTEIN | BTK | NF-KAPPA-B | BCR CHECKPOINT | Immunohistochemistry | Protein-Tyrosine Kinases - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Immunoblotting | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Protein-Tyrosine Kinases - genetics | RNA Interference | Cyclin D3 - genetics | Pre-B Cell Receptors - genetics | Cyclin D3 - metabolism | Disease Models, Animal | Cell Line | Cell Proliferation - genetics | Proto-Oncogene Proteins c-jun - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Signal Transduction - genetics | Transcription Factors - genetics | Mice, Inbred Strains | Reverse Transcriptase Polymerase Chain Reaction | Proto-Oncogene Proteins c-myc - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | Animals | Proto-Oncogene Proteins c-jun - metabolism | Adaptor Proteins, Signal Transducing - genetics | Proto-Oncogene Proteins c-myc - genetics | Adaptor Proteins, Signal Transducing - metabolism | Pre-B Cell Receptors - metabolism | Research | B cells | Interleukins | Mitogen-activated protein kinases | Cell division | Lymphomas | Cytokines | Gene expression | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 04/2008, Volume 28, Issue 4, pp. 499 - 508
The pre-B cell receptor (pre-BCR) plays a crucial role in the development of immature B cells. Although certain aspects of proximal pre-BCR signaling have been... 
MOLIMMUNO | ALLELIC EXCLUSION | ACTIVATION | PROTEIN-TYROSINE KINASES | GENE | PHOSPHORYLATION | C-MYC | DEFICIENT MICE | DIFFERENTIATION | IMMUNOLOGY | G1 PHASE | NUR77 EXPRESSION | Stem Cells - immunology | Cell Proliferation | Pre-B Cell Receptors - physiology | B-Lymphocyte Subsets - cytology | Mitogen-Activated Protein Kinase 1 - deficiency | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Signal Transduction - immunology | Stem Cells - enzymology | Gene Deletion | Mitogen-Activated Protein Kinase 1 - genetics | B-Lymphocyte Subsets - immunology | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Cells, Cultured | Mice, Transgenic | Signal Transduction - genetics | B-Lymphocyte Subsets - enzymology | Mitogen-Activated Protein Kinase 3 - physiology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Lymphocyte Subsets - metabolism | Transcription, Genetic - immunology | Mice | Mitogen-Activated Protein Kinase 3 - deficiency | Pre-B Cell Receptors - metabolism | Phosphotransferases | Genetic aspects | Cell culture | Phosphorylation | Transcription factors | Rodents | Bone marrow | Kinases | Gene expression | Expansion | Immune system | Pre-B Cell Receptors | Signal Transduction | Biochemistry, Molecular Biology | Stem Cells | Life Sciences | B-Lymphocyte Subsets | Transcription, Genetic | Cell Differentiation | Mitogen-Activated Protein Kinase 1 | Molecular biology | Mitogen-Activated Protein Kinase 3 | Cancer
Journal Article
Blood, ISSN 0006-4971, 10/2011, Volume 118, Issue 15, pp. 4174 - 4178
Journal Article
Nature Immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found... 
MAINTENANCE | ACTIVATION | PROTEIN | DISRUPTION | SUPER-ENHANCERS | IKAROS | ACUTE LYMPHOBLASTIC-LEUKEMIA | RECEPTOR | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Bruton's tyrosine kinase | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4
Journal Article