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Journal of International Medical Research, ISSN 0300-0605, 8/2019, Volume 47, Issue 8, pp. 3898 - 3904
Objectives Prostate cancer (PCA) is the deadliest urological disease affecting men worldwide. Long noncoding RNA activated by DNA damage (NORAD) levels are... 
MEDICINE, RESEARCH & EXPERIMENTAL | prostate cancer | INVASION | NORAD | proliferation | migration | apoptosis | PHARMACOLOGY & PHARMACY | long non-coding RNA | OUTCOMES | AXIS | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 8/2019, Volume 47, Issue 8, pp. 3831 - 3840
Objective To assess the effectiveness of pre-treatment with aripiprazole and quetiapine to prevent acute cocaine toxicity in a mouse model of cocaine toxicity.... 
toxicology | MEDICINE, RESEARCH & EXPERIMENTAL | cocaine | quetiapine | PREVENTION | RISK | Aripiprazole | antipsychotic agents | PRETREATMENT | DRUGS | PHARMACOLOGY & PHARMACY | RECEPTORS | ZIPRASIDONE | Index Medicus | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 8/2019, Volume 47, Issue 8, pp. 3757 - 3762
Objectives Down syndrome (DS) is associated with multiple complications, including a high risk of leukemia and thyroid dysfunction. This clinical study aimed... 
MEDICINE, RESEARCH & EXPERIMENTAL | leukemia | hypothyroidism | ABNORMALITIES | eosinophils | Down syndrome | peripheral blood | TRISOMY-21 | CHILDREN | OVEREXPRESSION | IMPACT | myelopoiesis | PHARMACOLOGY & PHARMACY | thyroid dysfunction | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 8/2019, Volume 47, Issue 8, pp. 3874 - 3885
Objective To study the effects of D-methionine in a mouse model of noise-induced hearing loss (NIHL). Methods We investigated changes in auditory function and... 
MEDICINE, RESEARCH & EXPERIMENTAL | cochlea | connexin 26 | D-methionine | PHARMACOLOGY & PHARMACY | noise-induced hearing loss | oxidative stress | connexin 30 | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 5/2019, Volume 47, Issue 5, pp. 2207 - 2214
Objective To investigate the safety and efficacy of acitinib mesylate combined with chemotherapy in the treatment of patients with gastroesophageal junction... 
second-line | adverse events | chemotherapy | apatinib mesylate | Gastroesophageal junction adenocarcinoma | survival | MEDICINE, RESEARCH & EXPERIMENTAL | PHARMACOLOGY & PHARMACY | EXPRESSION | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 7/2019, Volume 47, Issue 7, pp. 3261 - 3270
Objective To measure the inductive effect of kartogenin on matrix metalloproteinase-2 levels during the differentiation of human bone marrow mesenchymal stem... 
kartogenin | CARTILAGE DEFECTS | MEDICINE, RESEARCH & EXPERIMENTAL | matrix metalloproteinase-2 | collagen type II | Stem cells | cartilage | GROWTH | PHARMACOLOGY & PHARMACY | INHIBITORS | EXPRESSION | MMP-9 | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 7/2019, Volume 47, Issue 7, pp. 3307 - 3319
Background MicroRNA (miR)-145-5p is a respiratory disease biomarker, and is upregulated in asthma pathogenesis. However, its underlying mechanisms were... 
MEDICINE, RESEARCH & EXPERIMENTAL | CILIARY | SPUTUM | asthma | chemokines | KIF3A SUBUNIT | miR-145-5p | epithelial barrier | KIF3A | inflammation | DISEASE | PHARMACOLOGY & PHARMACY | MIRNAS | DYSFUNCTION | INSIGHTS | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 7/2019, Volume 47, Issue 7, pp. 3282 - 3298
Objective To determine the effect of the upregulation or knockdown of the ephrinB2 (Efnb2) gene and the effect of EphB4/EphrinB2 signalling in rat bone marrow... 
EphrinB2 | MEDICINE, RESEARCH & EXPERIMENTAL | EPHB RECEPTORS | DISRUPTION | neural stem cells | ROLES | migration | PHARMACOLOGY & PHARMACY | EXPRESSION | BMSCs | EphB4 | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 7/2019, Volume 47, Issue 7, pp. 3344 - 3353
Objective Patients with interstitial lung disease (ILD) are at increased risk of developing lung cancer. We aimed to investigate the clinical significance of... 
MEDICINE, RESEARCH & EXPERIMENTAL | ceruloplasmin | C-reactive protein | interstitial lung disease | Lung cancer | immune factor | PHARMACOLOGY & PHARMACY | COPPER | risk factor | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 7/2019, Volume 47, Issue 7, pp. 3271 - 3281
Objective To identify differentially expressed long noncoding RNAs (lncRNAs) in nasopharyngeal carcinoma (NPC) compared with chronic nasopharyngitis (CNP)... 
MIGRATION | HOTAIR | MEDICINE, RESEARCH & EXPERIMENTAL | nasopharyngeal carcinoma | ENSG00000230489 | metastasis | PHARMACOLOGY & PHARMACY | ENSG00000227084 | Long noncoding RNA | INHIBITS CELL-PROLIFERATION | PROGRESSION | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 7/2019, Volume 47, Issue 7, pp. 3299 - 3306
Objectives We investigated the role of long non-coding (lnc) RNA-NEF (neighboring enhancer of FoxA2), a characterized oncogene in cancer biology, in... 
recurrence | MEDICINE, RESEARCH & EXPERIMENTAL | treatment | LONG NONCODING RNAS | PHARMACOLOGY & PHARMACY | long non-coding RNA | Postmenopausal osteoporosis | lncRNA-NEF | IL-6 | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 6/2019, Volume 47, Issue 6, pp. 2655 - 2665
Objective To test the antifibrotic effect of dermatan sulphate in a bleomycin-induced mouse model of pulmonary fibrosis. Methods C57 mice were randomly divided... 
MEDICINE, RESEARCH & EXPERIMENTAL | bleomycin | CELLS | pulmonary fibrosis | MOUSE MODEL | RATS | PHARMACOLOGY & PHARMACY | Dermatan sulphate | MICE | MODULATION | INDUCED LUNG FIBROSIS | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 4/2019, Volume 47, Issue 4, pp. 1705 - 1716
Objectives This study sought to describe events related to the degradation/resorption of a device composed of polylactic acid (PLA) after implantation into... 
MEDICINE, RESEARCH & EXPERIMENTAL | phagocytosis | BIOCOMPATIBILITY | PLA | Foreign body reaction | TISSUE | osteoblast | DELIVERY | polylactic acid | hydrolytic degradation | resorption | PHARMACOLOGY & PHARMACY | SCAFFOLDS | extracellular matrix | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 2/2019, Volume 47, Issue 2, pp. 936 - 950
Objective Acute lung injury is responsible for mortality in seriously ill patients. Previous studies have shown that systemic inflammation is attenuated by... 
cytokine | ischemic preconditioning | survival rate | Acute lung injury | inflammation | mice | PULMONARY | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | MECHANISMS | PROTECTS | SHOCK | LIPOPOLYSACCHARIDE | PHARMACOLOGY & PHARMACY | OUTCOMES | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 4/2019, Volume 47, Issue 4, pp. 1685 - 1695
Objectives Paris polyphylla 26 (PP-26) is a monomer purified from Paris polyphylla, which has traditionally been used as an antimicrobial, hemostatic, and... 
MEDICINE, RESEARCH & EXPERIMENTAL | proliferation | cell cycle | PENNOGENYL SAPONINS | KINASE | apoptosis | Akt signaling | Paris polyphylla | MYT1 | caspase | PHARMACOLOGY & PHARMACY | PP-26 | Hepatocellular cancer | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 4/2019, Volume 47, Issue 4, pp. 1758 - 1765
Objective The aim of this study was to identify important pathways regulated by a set of long non-coding RNAs (lncRNAs) in oral squamous cell carcinoma (OSCC).... 
endocytosis | pathway | oral squamous cell carcinoma | lncRNA | cell cycle | network | MEDICINE, RESEARCH & EXPERIMENTAL | PHARMACOLOGY & PHARMACY | CANCER | P53 | Pre-Clinical Research Reports
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 4/2019, Volume 47, Issue 4, pp. 1731 - 1739
Objective To investigate the role of alteplase, a widely-used thrombolytic drug, in platelet function. Methods Human platelets were incubated with different... 
MEDICINE, RESEARCH & EXPERIMENTAL | RETEPLASE | Alteplase | surface receptors | THROMBOSIS | OUTSIDE-IN | ACUTE MYOCARDIAL-INFARCTION | PHARMACOLOGY & PHARMACY | clot retraction | activation | HEMOSTASIS | platelet aggregation | Pre-Clinical Research Reports
Journal Article