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Endocrinology, ISSN 0013-7227, 02/2016, Volume 157, Issue 2, pp. 883 - 899
TGFβ has been implicated in preeclampsia, but its intracellular signaling via phosphorylated mothers against decapentaplegic (SMADs) and SMAD-independent... 
HUMAN PLACENTAL TROPHOBLAST | IN-VITRO | BEWO CELLS | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | TRANSFORMING-GROWTH-FACTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | E-CADHERIN | CELL-LINES | TRANSCRIPTION FACTOR | SYNCYTIAL FUSION | Pre-Eclampsia - genetics | Oncogene Proteins - genetics | Phosphorylation | Cyclin-Dependent Kinase 4 - genetics | Humans | Pregnancy Proteins - genetics | Male | rhoA GTP-Binding Protein - metabolism | Pregnancy Proteins - metabolism | rhoA GTP-Binding Protein - genetics | RNA, Messenger - metabolism | Cyclin E - genetics | Case-Control Studies | Gene Products, env - metabolism | Young Adult | Cell Differentiation - genetics | Smad2 Protein - genetics | Gene Products, env - genetics | Adult | Female | Pre-Eclampsia - metabolism | Nuclear Proteins - genetics | Smad7 Protein - genetics | Real-Time Polymerase Chain Reaction | Infant, Newborn | Smad7 Protein - metabolism | Cell Proliferation - genetics | Trophoblasts - metabolism | Signal Transduction | Oncogene Proteins - metabolism | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Gestational Age | Placenta - metabolism | Pregnancy | Transcription Factors - metabolism | Transforming Growth Factor beta - genetics | Adaptor Proteins, Signal Transducing - genetics | Adolescent | Cyclin E - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
American journal of medical genetics. Part A, ISSN 1552-4825, 2016, Volume 170, Issue 12, pp. 3069 - 3082
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 22, pp. 14838 - 14848
Journal Article
European Journal of Obstetrics and Gynecology, ISSN 0301-2115, 11/2018, Volume 230, pp. 32 - 35
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e110867 - e110867
Objective: Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce... 
OXIDATIVE STRESS | METABOLIC CHARACTERISTICS | TYROSINE KINASE-1 | HUMAN FETOPLACENTAL VASCULOGENESIS | ENDOTHELIAL-GROWTH-FACTOR | FACTOR RECEPTOR-1 CONCENTRATION | MULTIDISCIPLINARY SCIENCES | ANTI-ANGIOGENIC FACTORS | SOLUBLE ENDOGLIN | MATERNAL INFLAMMATORY RESPONSE | FOR-GESTATIONAL-AGE | Pre-Eclampsia - genetics | Genetic Vectors - administration & dosage | Gene Expression - genetics | Humans | Peptides - genetics | Green Fluorescent Proteins - genetics | Pregnancy Proteins - metabolism | Pre-Eclampsia - physiopathology | Litter Size - physiology | Peptides - metabolism | Protein Isoforms - metabolism | Litter Size - genetics | Proteinuria - urine | Adenoviridae - genetics | Female | Albuminuria - urine | Kidney - physiopathology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Neovascularization, Physiologic - genetics | Transgenes - genetics | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Arterial Pressure - physiology | Creatinine - urine | Genetic Vectors - genetics | Pregnancy | Microvessels - physiology | Animals | Placenta | Mice | Pregnancy Outcome - genetics | Protein Isoforms - genetics | Syngeneic grafts | Change detection | Childrens health | Confocal microscopy | Confocal | Kinases | Blood | Postpartum | Embryogenesis | Biological effects | Aorta | Blood pressure | Protein-tyrosine kinase | Cesarean section | Urine | Tyrosine | Creatinine | Hypertension | Kidneys | Gynecology | Albumin | Pre-eclampsia | Embryos | Obstetrics | Endothelium | Embryonic growth stage | Medicine | Microscopy | Preeclampsia | Adenoviruses | Proteinuria | Kidney transplantation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e62969 - e62969
Placental cortisol is inactivated in normotensive pregnancies, but is frequently present in pre-eclampsia associated placentae. Since glucocorticoids are... 
CORTICOTROPIN-RELEASING HORMONE | HUMAN-FETAL | GLUCOCORTICOID-RECEPTOR | MESSENGER-RNA | GESTATIONAL-AGE | MULTIDISCIPLINARY SCIENCES | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2 | BIRTH-WEIGHT | BETA-HYDROXYSTEROID DEHYDROGENASE | INTRAUTERINE GROWTH RESTRICTION | PRENATAL STRESS | Pre-Eclampsia - genetics | Humans | Hydrocortisone - metabolism | Labor Onset - metabolism | Male | RNA, Messenger - metabolism | Pre-Eclampsia - physiopathology | DNA Methylation | Time Factors | Glucocorticoids - metabolism | Labor Onset - genetics | Adult | Female | Pre-Eclampsia - metabolism | Stress, Physiological - genetics | RNA, Messenger - genetics | Exons - genetics | Signal Transduction - genetics | Gestational Age | Pre-Eclampsia - pathology | Placenta - metabolism | Pregnancy | Placenta - pathology | Receptors, Glucocorticoid - genetics | Hydrocortisone - biosynthesis | Hypertension | Sulfites | Corticosteroids | Genes | Cytochrome P-450 | ACTH | Analysis | Preeclampsia | DNA | Neurohormones | Methylation | Protein binding | Steroids | Cytochrome | Bisulfite | Dehydrogenases | Glucocorticoids | Pregnancy complications | Hormones | Dehydrogenase | Hydrocortisone | Proteins | Aromatase | 11β-Hydroxysteroid dehydrogenase | Eclampsia | DNA methylation | Stress response | Deoxyribonucleic acid--DNA | CpG islands | Fetuses | Pre-eclampsia | Bioavailability | Corticotropin-releasing hormone | Tea | Pathology | Signaling | Placenta | Womens health | Epigenetics | Birth weight | Index Medicus | Deoxyribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33666 - e33666
Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for... 
PATHOGENESIS | ACTIVIN-A | HYPERTENSIVE DISORDERS | WORKING GROUP | MANAGEMENT | HAPLOTYPE MAP | CHROMOSOME-2 | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | SUSCEPTIBILITY LOCUS | PREGNANCY | Pre-Eclampsia - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Humans | Risk Factors | Computational Biology | Gene Expression Regulation | Genetic Loci - genetics | Sequence Analysis, DNA | Genome, Human - genetics | Pregnancy | Chromosomes, Human, Pair 2 - genetics | Norway | Finland | Polymorphism, Single Nucleotide - genetics | Female | Australia | Inhibin-beta Subunits - genetics | Inhibin-beta Subunits - metabolism | Cohort Studies | RNA | Preeclampsia | Genes | Genomics | Inhibin | Genetic aspects | Genomes | Haplotypes | Biomedical research | Transcription | Linkage disequilibrium | Cardiovascular disease | Single-nucleotide polymorphism | Gene sequencing | Consortia | Conserved sequence | Genetics | Deoxyribonucleic acid--DNA | Hypertension | Medical research | Mortality | Gynecology | Cloning | Pre-eclampsia | Metabolism | Decidua | Gene expression | Obstetrics | Chromosome 2 | Medicine | Studies | Hospitals | Womens health | Diabetes | Health risk assessment | Cancer | DNA sequencing | Index Medicus | decidua | Regulatory sequences | chromosome 2 | INHBB gene | Bioinformatics | Genotypes | Deoxyribonucleic acid | DNA
Journal Article