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Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2016, Volume 19, Issue 5, pp. 613 - 627
Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and... 
microenvironment | leukemia | inflammation | mesenchymal | hematopoietic stem cell | shwachman-diamond syndrome | niche | cancer | myelodysplastic syndrome (MDS) | S100A8 | PROGENITOR CELLS | OXIDATIVE DNA-DAMAGE | GENE | SBDS | MUTATIONS | SHWACHMAN-DIAMOND-SYNDROME | MYELODYSPLASTIC CELLS | STROMAL CELLS | EXPRESSION | DEFICIENCY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Bone and Bones - pathology | Inflammation - pathology | Leukemia - pathology | Oxidative Stress | Humans | Hematopoietic Stem Cells - pathology | Precancerous Conditions - metabolism | Leukemia - metabolism | S100 Proteins - genetics | Lipomatosis - pathology | Gene Deletion | Integrases - metabolism | Precancerous Conditions - pathology | Toll-Like Receptors - metabolism | Stem Cell Niche | Pathogen-Associated Molecular Pattern Molecules - metabolism | Signal Transduction | Exocrine Pancreatic Insufficiency - pathology | Risk Factors | Tumor Suppressor Protein p53 - metabolism | Mesenchymal Stromal Cells - metabolism | S100 Proteins - metabolism | Treatment Outcome | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Bone Marrow Diseases - pathology | Disease Progression | Transcription Factors - metabolism | Animals | Proteins - metabolism | DNA Repair | Sp7 Transcription Factor | Mice | DNA Damage | Mesenchymal Stromal Cells - pathology | Bone and Bones - abnormalities | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 07/2007, Volume 26, Issue 32, pp. 4617 - 4626
Infection with Helicobacter pylori cagA-positive strains is associated with gastric adenocarcinoma. Intestinal metaplasia is a precancerous lesion of the... 
β-catenin | Gastric adenocarcinoma | Helicobacter pylori CagA | E-cadherin | Intestinal metaplasia | beta-catenin | TARGET | ACTIVATION | PROTEIN | CDX1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL BIOLOGY | gastric adenocarcinoma | GENE | ONCOLOGY | intestinal metaplasia | WNT PATHWAY | ATROPHIC GASTRITIS | GENETICS & HEREDITY | INFECTION | EXPRESSION | Intestinal Mucosa - metabolism | Phosphorylation | Adenocarcinoma - pathology | Cadherins - metabolism | beta Catenin - analysis | Adenocarcinoma - etiology | Homeodomain Proteins - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Cytoplasm - metabolism | Gastric Mucosa - pathology | Precancerous Conditions - metabolism | Stomach Neoplasms - pathology | Bacterial Proteins - analysis | Gastric Mucosa - metabolism | Adenocarcinoma - metabolism | Cell Nucleus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Mucins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Precancerous Conditions - pathology | Stomach Neoplasms - etiology | Cytoplasm - chemistry | Cell Line | Cadherins - analysis | Cell Transformation, Neoplastic - metabolism | Precancerous Conditions - genetics | beta Catenin - metabolism | Homeodomain Proteins - genetics | Mucin-2 | Tyrosine - metabolism | Antigens, Bacterial - analysis | Bacterial Proteins - metabolism | Cell Nucleus - chemistry | Cell Transformation, Neoplastic - pathology | Antigens, Bacterial - metabolism | Intestinal Mucosa - pathology | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 61, Issue 5, pp. 1088 - 1096
Background & Aims Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which... 
Gastroenterology and Hepatology | Preneoplastic stages | HCC | Verteporfin | TCPOBOP | Hippo pathway | YES-ASSOCIATED PROTEIN | RAT | ORGAN SIZE CONTROL | REGENERATION | CELL-PROLIFERATION | LESIONS | CARCINOGENESIS | PATHWAY | HEPATOCELLULAR-CARCINOMA DEVELOPMENT | GASTROENTEROLOGY & HEPATOLOGY | TUMORIGENESIS | Adenoma, Liver Cell - drug therapy | Precancerous Conditions - etiology | Adenoma, Liver Cell - etiology | Humans | Middle Aged | Rats, Inbred F344 | Male | MicroRNAs - metabolism | Precancerous Conditions - metabolism | Phosphoproteins - metabolism | Liver Neoplasms - etiology | Precancerous Conditions - drug therapy | Young Adult | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Apoptosis Regulatory Proteins - genetics | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - etiology | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Signal Transduction | Adenoma, Liver Cell - metabolism | Liver Neoplasms - drug therapy | Rats | Porphyrins - pharmacology | Liver Neoplasms, Experimental - etiology | Apoptosis Regulatory Proteins - metabolism | Animals | Liver Neoplasms, Experimental - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Liver Neoplasms - metabolism | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Liver cancer | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 296 - 300
Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7638, pp. 494 - 499
Journal Article
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 5, pp. 1810 - 1822.e2
Background & Aims The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown. Recognizing that Hedgehog signaling is... 
Gastroenterology and Hepatology | BMP4 | Hedgehog Signaling | SOX9 | Barrett's Esophagus | CELLS | SONIC HEDGEHOG | ESOPHAGUS | GASTROINTESTINAL-TRACT | INTESTINAL EPITHELIUM | PYLORIC SPHINCTER EPITHELIUM | COLUMNAR | TERMINAL DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Precancerous Conditions - etiology | Adenocarcinoma - pathology | Epithelial Cells - metabolism | Humans | Hedgehog Proteins - metabolism | Bile - metabolism | Precancerous Conditions - metabolism | Barrett Esophagus - etiology | Bone Morphogenetic Protein 4 - metabolism | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | Barrett Esophagus - pathology | Keratins - metabolism | Transfection | Hedgehog Proteins - genetics | RNA Interference | Esophageal Neoplasms - metabolism | Precancerous Conditions - pathology | Cell Differentiation | Patched Receptors | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Barrett Esophagus - metabolism | Cell Line | Gastroesophageal Reflux - metabolism | Esophagus - metabolism | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Mice, Transgenic | Signal Transduction - genetics | Cell Communication - genetics | Metaplasia | Esophagus - pathology | Phenotype | Animals | Gastroesophageal Reflux - complications | Bile Reflux - complications | Bile Reflux - metabolism | Mesoderm - metabolism | Mice | Mesoderm - pathology | Patched-1 Receptor | Hydrogen-Ion Concentration | Receptors, Cell Surface - genetics | RNA | Oncology, Experimental | Brain tumors | Barrett's esophagus | Bone morphogenetic proteins | Research | Universities and colleges | Cancer | Index Medicus | Abridged Index Medicus | Hedgehog signaling
Journal Article
Journal Article