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Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 138, Issue 5, pp. 1810 - 1822.e2
Background & Aims The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown. Recognizing that Hedgehog signaling is... 
Gastroenterology and Hepatology | BMP4 | Hedgehog Signaling | SOX9 | Barrett's Esophagus | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Precancerous Conditions - etiology | Adenocarcinoma - pathology | Epithelial Cells - metabolism | Humans | Hedgehog Proteins - metabolism | Bile - metabolism | Precancerous Conditions - metabolism | Barrett Esophagus - etiology | Bone Morphogenetic Protein 4 - metabolism | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | Barrett Esophagus - pathology | Keratins - metabolism | Transfection | Hedgehog Proteins - genetics | RNA Interference | Esophageal Neoplasms - metabolism | Precancerous Conditions - pathology | Cell Differentiation | Patched Receptors | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Barrett Esophagus - metabolism | Cell Line | Gastroesophageal Reflux - metabolism | Esophagus - metabolism | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Mice, Transgenic | Signal Transduction - genetics | Cell Communication - genetics | Metaplasia | Esophagus - pathology | Phenotype | Animals | Gastroesophageal Reflux - complications | Bile Reflux - complications | Bile Reflux - metabolism | Mesoderm - metabolism | Mice | Mesoderm - pathology | Patched-1 Receptor | Hydrogen-Ion Concentration | Receptors, Cell Surface - genetics | RNA | Oncology, Experimental | Brain tumors | Barrett's esophagus | Bone morphogenetic proteins | Research | Universities and colleges | Cancer | Index Medicus | Abridged Index Medicus | Hedgehog signaling
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 02/2008, Volume 134, Issue 2, pp. 511 - 522
Background & Aims: Loss of gastric parietal cells is a critical precursor to gastric metaplasia and neoplasia. However, the origin of metaplasia remains... 
Gastroenterology and Hepatology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Metaplasia - metabolism | Humans | Parietal Cells, Gastric - metabolism | Stomach Neoplasms - metabolism | Gastric Mucosa - pathology | Precancerous Conditions - metabolism | Stomach Neoplasms - pathology | beta-Defensins | Fetal Proteins - metabolism | Gastric Mucosa - metabolism | Stomach Neoplasms - physiopathology | Minichromosome Maintenance Complex Component 3 | Atrophy | DNA-Binding Proteins - metabolism | Peptides - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Mucins - metabolism | Muscle Proteins - metabolism | Precancerous Conditions - pathology | Trefoil Factor-2 | Gastric Fundus - metabolism | Chief Cells, Gastric - metabolism | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Microtubule-Associated Proteins | Nuclear Proteins - metabolism | Gastrins - metabolism | Cell Transformation, Neoplastic - metabolism | Metaplasia - pathology | Mice, Knockout | Animals | Carrier Proteins - metabolism | Parietal Cells, Gastric - pathology | Epididymal Secretory Proteins - metabolism | Chief Cells, Gastric - pathology | Mice | Cell Transformation, Neoplastic - pathology | Gastric Fundus - pathology | Intrinsic Factor - metabolism | Vasoactive intestinal peptides | Analysis | Polypeptides | Index Medicus | Abridged Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 01/2017, Volume 541, Issue 7638, pp. 494 - 499
We are just beginning to understand how translational control affects tumour initiation and malignancy. Here we use an epidermis-specific, in vivo ribosome... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetic aspects | Metastasis | Genetic translation | Health aspects | Tumors | Proteins | Phosphorylation | Peptides | Protein synthesis | Genomes | Tumorigenesis | Cancer | Index Medicus
Journal Article
Journal of hepatology, ISSN 0168-8278, 11/2014, Volume 61, Issue 5, pp. 1088 - 1096
Background & Aims Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which... 
Gastroenterology and Hepatology | Preneoplastic stages | HCC | Verteporfin | TCPOBOP | Hippo pathway | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Adenoma, Liver Cell - drug therapy | Precancerous Conditions - etiology | Adenoma, Liver Cell - etiology | Humans | Middle Aged | Rats, Inbred F344 | Male | MicroRNAs - metabolism | Precancerous Conditions - metabolism | Phosphoproteins - metabolism | Liver Neoplasms - etiology | Precancerous Conditions - drug therapy | Young Adult | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Apoptosis Regulatory Proteins - genetics | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - etiology | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Signal Transduction | Adenoma, Liver Cell - metabolism | Liver Neoplasms - drug therapy | Rats | Porphyrins - pharmacology | Liver Neoplasms, Experimental - etiology | Apoptosis Regulatory Proteins - metabolism | Animals | Liver Neoplasms, Experimental - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Liver Neoplasms - metabolism | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Liver cancer | Health aspects | Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2012, Volume 143, Issue 3, pp. 550 - 563
Chronic inflammation, regardless of infectious agents, plays important roles in the development of various cancers, particularly in digestive organs, including... 
Gastroenterology and Hepatology | Mutation Induction | Epigenetics | HCV | H pylori | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Genetic Therapy | Inflammation - pathology | Digestive System Neoplasms - metabolism | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Precancerous Conditions - metabolism | Digestive System Neoplasms - immunology | Digestive System Diseases - therapy | Inflammation - metabolism | Cell Transformation, Neoplastic - genetics | Digestive System Neoplasms - pathology | Inflammation Mediators - metabolism | Anti-Inflammatory Agents - therapeutic use | Digestive System Diseases - immunology | Precancerous Conditions - pathology | Digestive System Neoplasms - genetics | Precancerous Conditions - therapy | Digestive System Neoplasms - prevention & control | Inflammation - immunology | Signal Transduction - genetics | Cell Transformation, Neoplastic - metabolism | Precancerous Conditions - genetics | Digestive System Diseases - genetics | Inflammation - therapy | Cell Transformation, Neoplastic - immunology | Animals | Precancerous Conditions - immunology | Digestive System Diseases - metabolism | Inflammation - genetics | Cell Transformation, Neoplastic - pathology | Digestive System Diseases - pathology | Genes | Research | Sulfates | Liver cancer | Purines | Pyrimidines | Colon cancer | Messenger RNA | Intermedin | Immunoglobulins | Oncology, Experimental | Development and progression | Inflammation | Genetic transcription | Dextran | MicroRNA | Methyltransferases | Gastrointestinal diseases | Nitric oxide | Genetic research | Hepatitis C | Hepatitis C virus | Methylation | Mitogens | Cancer | COX-2 inhibitors | Epigenetic inheritance | Medical colleges | Interleukins | Gene mutations | Protein kinases | Colitis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
The Journal of pathology, ISSN 1096-9896, 11/2001, Volume 195, Issue 4, pp. 451 - 456
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 11/2012, Volume 109, Issue 50, pp. E3473 - E3482
Journal Article
Asian Pacific journal of cancer prevention : APJCP, ISSN 1513-7368, 2013, Volume 14, Issue 9, pp. 5199 - 5205
Background/Aim: The Hippo signaling pathway is a newly discovered and conserved signaling cascade, which regulates organ size control by governing cell... 
Hippo signaling pathway | Gastric cancer | Intestinal metaplasia | Chronic atrophic gastritis | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Up-Regulation | Metaplasia - metabolism | Homeodomain Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Apoptosis - genetics | Precancerous Conditions - metabolism | Stomach Neoplasms - pathology | Phosphoproteins - metabolism | Gastritis, Atrophic - genetics | Case-Control Studies | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Hepatocyte Growth Factor - genetics | Precancerous Conditions - pathology | Metaplasia - genetics | Carcinoma - pathology | Nuclear Proteins - genetics | Gastritis, Atrophic - pathology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Stomach Neoplasms - genetics | Cell Proliferation - genetics | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Gastritis, Atrophic - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Precancerous Conditions - genetics | Blotting, Western | Homeodomain Proteins - genetics | Hepatocyte Growth Factor - metabolism | Metaplasia - pathology | Transcription Factors - metabolism | Octamer Transcription Factor-3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Carcinoma - genetics | Signal Transduction - physiology | Carcinoma - metabolism | Adaptor Proteins, Signal Transducing - metabolism | CDX2 Transcription Factor
Journal Article