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Educational Forum - Regulatory requirements and ICH guidelines on carcinogenicity testing of pharmaceuticals: A review on current status, 12/2005
International regulatory guidelines require that new chemical entities (NCEs) be tested first on animals (preclinical studies) for safety and efficacy before... 
Carcinogenicity bioassay, cancer risk assessment, drug safety, cancer chemotherapy, preclinical toxicity tests, transgenic models
Journal
Science (New York, N.Y.), ISSN 0036-8075, 09/2016, Volume 353, Issue 6303, pp. 976 - 977
Journal Article
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 07/2010, Volume 57, Issue 2-3, pp. 291 - 299
Journal Article
Toxicologic Pathology, ISSN 0192-6233, 6/2011, Volume 39, Issue 4, pp. 716 - 744
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, pp. e9310 - e9310
Background: Tenofovir gel has entered into clinical trials for use as a topical microbicide to prevent HIV-1 infection but has no published data regarding... 
TOPICAL MICROBICIDES | SOUTH-AFRICA | MULTIDISCIPLINARY SCIENCES | FEMALE SEX WORKERS | CLINICAL-TRIALS | NONOXYNOL-9 VAGINAL GEL | DOUBLE-BLIND | NEISSERIA-GONORRHOEAE | RECTAL TRANSMISSION | EXPLANT CULTURE | PLACEBO-CONTROLLED TRIAL | Anti-HIV Agents - pharmacology | Colon - cytology | Humans | Colon - drug effects | Leukocytes, Mononuclear - virology | Rectum - virology | Tenofovir | HIV-1 - growth & development | Rectum - drug effects | Female | Colon - virology | Drug Evaluation, Preclinical | Caco-2 Cells | Cervix Uteri - drug effects | Cell Survival - drug effects | Adenine - analogs & derivatives | Leukocytes, Mononuclear - drug effects | Cervix Uteri - virology | Gels | HIV-1 - drug effects | Tissue Culture Techniques | Cells, Cultured | Adenine - pharmacology | Organophosphonates - pharmacology | Rectum - cytology | Leukocytes, Mononuclear - cytology | Cervix Uteri - cytology | Infection | Medical research | Algorithms | Microbiota (Symbiotic organisms) | Analysis | Medicine, Experimental | Permeability | HIV (Viruses) | Health aspects | Enzyme-linked immunosorbent assay | Viscosity | Immunohistochemistry | Epithelial cells | Prophylaxis | Clinical trials | Infections | Tissues | Prevention | Genital microflora | Microbicides | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Safety | Explants | Effectiveness | Computer simulation | Vagina | Cultures | Data processing | Flora | Condoms | Osmotic pressure | Viability | Index Medicus | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2013, Volume 272, Issue 1, pp. 245 - 255
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2013, Volume 19, Issue 11, pp. 2828 - 2833
Journal Article