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Haematologica (Roma), ISSN 1592-8721, 2007, Volume 92, Issue 5, pp. 612 - 618
...{at}ospedaliriuniti.bergamo.it Background and Objectives: The molecular analysis of minimal residual disease (MRD) may provide informaton on the risk of recurrence in patients with acute lymphoblastic leukemia... 
ALL | Allogeneic transplantation | MRD | Adult ALL | adult ALL | BONE-MARROW-TRANSPLANTATION | IMMUNOGLOBULIN | TIME QUANTITATIVE PCR | REARRANGEMENTS | CHILDREN | IMATINIB | EXPANSION | Ph | TARGETS | MALIGNANCIES | allogeneic transplantation | FUSION GENE TRANSCRIPTS | HEMATOLOGY | Translocation, Genetic | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Humans | Middle Aged | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - surgery | Male | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Leukemia-Lymphoma, Adult T-Cell - drug therapy | Gene Deletion | Fusion Proteins, bcr-abl - blood | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - blood | Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood | Basic Helix-Loop-Helix Transcription Factors - genetics | Hematopoietic Stem Cell Transplantation | Survival Rate | Combined Modality Therapy | Remission Induction | Adolescent | Survival Analysis | Oncogene Proteins, Fusion - blood | Kinetics | Transplantation Conditioning | Cohort Studies | Piperazines - administration & dosage | Clinical Trials as Topic - statistics & numerical data | Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery | Risk | Transplantation, Homologous | Neoplasm, Residual | Multicenter Studies as Topic | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Polymerase Chain Reaction | Adult | Female | Myeloid-Lymphoid Leukemia Protein - blood | Gene Rearrangement, B-Lymphocyte | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | T-Cell Acute Lymphocytic Leukemia Protein 1 | Leukemia-Lymphoma, Adult T-Cell - genetics | Leukemia-Lymphoma, Adult T-Cell - surgery | Pyrimidines - administration & dosage | Gene Rearrangement, T-Lymphocyte | Leukemia-Lymphoma, Adult T-Cell - mortality | Kaplan-Meier Estimate | Proto-Oncogene Proteins - genetics | Treatment Outcome | Leukemia-Lymphoma, Adult T-Cell - pathology | Imatinib Mesylate | Biomarkers, Tumor - blood | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Leukemia-Lymphoma, Adult T-Cell - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Benzamides
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2014, Volume 371, Issue 11, pp. 1005 - 1015
... responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults. METHODS We performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Adolescents | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B
Journal Article
Blood, ISSN 1528-0020, 2011, Volume 118, Issue 8, pp. 2077 - 2084
Journal Article
Blood, ISSN 0006-4971, 07/2015, Volume 126, Issue 5, pp. 589 - 596
Journal Article
Leukemia & Lymphoma, ISSN 1029-2403, 2011, Volume 52, Issue 6, pp. 1098 - 1107
.... The aim of our study was to evaluate in a large series of cases of acute lymphoblastic leukemia... 
mean fluorescence intensity (MFI) | monoclonal antibody therapy | antigen expression | antibody binding capacity (ABC) | Acute lymphoid leukemia (ALL) | B-ALL | GEMTUZUMAB OZOGAMICIN | CHEMOIMMUNOTHERAPY | CHEMOTHERAPY | IN-VITRO | INDUCTION THERAPY | ONCOLOGY | RITUXIMAB | LYMPHOMA | MONOCLONAL-ANTIBODIES | HEMATOLOGY | EXPRESSION | Antigens, CD - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Flow Cytometry - methods | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Middle Aged | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Sialic Acid Binding Ig-like Lectin 2 - immunology | Antigens, CD - metabolism | Young Adult | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Sialic Acid Binding Ig-like Lectin 2 - metabolism | Aged, 80 and over | Adult | Transcription, Genetic | Sialic Acid Binding Ig-like Lectin 3 | Child | Antibodies, Monoclonal - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Antigens, CD19 - immunology | Antigens, CD20 - immunology | Immunophenotyping | Antigens, CD20 - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Reverse Transcriptase Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Oncogene Proteins, Fusion - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Adolescent | Aged | Antigens, CD19 - metabolism
Journal Article
American journal of hematology, ISSN 0361-8609, 07/2018, Volume 93, Issue 7, pp. 971 - 977
Journal Article
Nature (London), ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 357 - 361
B cells are selected for an intermediate level of B-cell antigen receptor (BCR) signalling strength... 
MOTIFS | RECEPTOR | ACTIVATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DELETION | Protein-Tyrosine Kinases - metabolism | Receptors, Antigen, B-Cell - deficiency | Humans | Precursor Cells, B-Lymphoid - metabolism | Inositol Polyphosphate 5-Phosphatases | Intracellular Signaling Peptides and Proteins - metabolism | Precursor Cells, B-Lymphoid - drug effects | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor Cells, B-Lymphoid - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Gene Deletion | Female | B-Lymphocytes - pathology | Cell Death - drug effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Syk Kinase | B-Lymphocytes - metabolism | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Enzyme Activation - drug effects | Mice, SCID | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Fusion Proteins, bcr-abl - genetics | Tyrosine - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Cell Transformation, Neoplastic | Intracellular Signaling Peptides and Proteins - agonists | Cell Line, Tumor | Mice, Inbred NOD | Receptors, Antigen, B-Cell - genetics | Mice | Amino Acid Motifs - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Receptors, Immunologic - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Receptors, Immunologic - metabolism | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Acute lymphocytic leukemia | B cells | Signal transduction | Rodents | Leukemia | Mutation | Drug resistance | Kinases | Cells
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 17, pp. 3510 - 3518
...)-like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B... 
MAMMALIAN TARGET | RAPAMYCIN | IN-VITRO | ABERRANT STAT5 | RECEPTOR | OF-FUNCTION MUTATIONS | HEMATOLOGY | B-PROGENITOR | GENETIC ALTERATIONS | STAT5 ACTIVATION | CRLF2 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Immunoglobulins - genetics | Molecular Targeted Therapy | Immunoglobulins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Janus Kinase 1 - metabolism | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | TOR Serine-Threonine Kinases - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Cytokine - metabolism | Drug Evaluation, Preclinical | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Pyrazoles - pharmacology | Acute Disease | Janus Kinase 2 - genetics | Survival Rate | Signal Transduction - genetics | Janus Kinase 1 - antagonists & inhibitors | Sirolimus - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Lymphoid Neoplasia
Journal Article
American journal of clinical pathology, ISSN 0002-9173, 2017, Volume 147, Issue 4, pp. 357 - 363
Journal Article
Leukemia, ISSN 1476-5551, 2008, Volume 23, Issue 3, pp. 557 - 564
...) and thus more thiopurine converted into 6-thioguanine nucleotides. Of 601 children with acute lymphoblastic leukemia... 
S-METHYLTRANSFERASE | MAINTENANCE CHEMOTHERAPY | DRUG-INTERACTIONS | relapse rate | HIGH-DOSE METHOTREXATE | RANDOMIZED-TRIAL | genetic polymorphisms | second malignant neoplasm | CHILDREN | 6-MERCAPTOPURINE | thiopurine methyltransferase | MERCAPTOPURINE | INFLAMMATORY-BOWEL-DISEASE | THERAPY | ONCOLOGY | acute lymphoblastic leukemia | HEMATOLOGY | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - epidemiology | Recurrence | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Neoplasm Proteins - physiology | Methyltransferases - genetics | Child, Preschool | Infant | Male | Risk | Antimetabolites, Antineoplastic - administration & dosage | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Methyltransferases - physiology | Female | Neoplasms, Second Primary - genetics | Neoplasm Proteins - genetics | Child | Mercaptopurine - pharmacokinetics | Scandinavian and Nordic Countries - epidemiology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Mercaptopurine - administration & dosage | Genotype | Neoplasms, Second Primary - enzymology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Methyltransferases - analysis | Neoplasms, Second Primary - epidemiology | Polymorphism, Genetic | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - epidemiology | Thioguanine - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Thioguanine - pharmacokinetics | Biotransformation - drug effects | Neoplasm Proteins - analysis | Inactivation, Metabolic - genetics | DNA Damage | Methylation | Methyltransferases | Physiological aspects | Genetic aspects | Acute lymphocytic leukemia | Research | Single nucleotide polymorphisms | Risk factors | Index Medicus
Journal Article