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The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 11, pp. 1005 - 1015
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Adolescence | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B | Cell lines | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 252 - 257
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 26, pp. 6226 - 6233
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 17, pp. 3510 - 3518
CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia... 
MAMMALIAN TARGET | RAPAMYCIN | IN-VITRO | ABERRANT STAT5 | RECEPTOR | OF-FUNCTION MUTATIONS | HEMATOLOGY | B-PROGENITOR | GENETIC ALTERATIONS | STAT5 ACTIVATION | CRLF2 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Immunoglobulins - genetics | Molecular Targeted Therapy | Immunoglobulins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Janus Kinase 1 - metabolism | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | TOR Serine-Threonine Kinases - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Cytokine - metabolism | Drug Evaluation, Preclinical | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Pyrazoles - pharmacology | Acute Disease | Janus Kinase 2 - genetics | Survival Rate | Signal Transduction - genetics | Janus Kinase 1 - antagonists & inhibitors | Sirolimus - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2016, Volume 126, Issue 10, pp. 3814 - 3826
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with... 
CHIMERIC RECEPTORS | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | EFFECTOR FUNCTIONS | B-CELL | ACUTE-LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | ALPHA CHAIN | ACUTE MYELOID-LEUKEMIA | BLINATUMOMAB | RECEPTOR T-CELLS | Immunotherapy - methods | Interleukin-3 Receptor alpha Subunit - administration & dosage | Neoplasm Recurrence, Local - prevention & control | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - administration & dosage | Mice, SCID | T-Lymphocytes - transplantation | Xenograft Model Antitumor Assays | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Neoplastic Stem Cells - metabolism | Cell Line, Tumor | Receptors, Antigen, T-Cell - administration & dosage | Mice, Inbred NOD | T-Lymphocytes - immunology | Antigens, CD19 - metabolism | Interleukin-3 Receptor alpha Subunit - metabolism | Antigen-antibody reactions | Cellular proteins | Care and treatment | Immunotherapy | Patient outcomes | Development and progression | Genetic aspects | Acute lymphocytic leukemia | Properties | Health aspects | Methods | Antigens | Pediatrics | Medical research | Flow cytometry | Immunoglobulins | Leukemia | Colleges & universities | Clinical trials | T cell receptors | Experiments | Cancer therapies | Patients | Genotype & phenotype | Institutional repositories | Lymphocytes | Medical prognosis | Response rates | Stem cells | Laboratory animals | Tumors | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2016, Volume 30, Issue 5, pp. 737 - 749
Journal Article
Journal Article