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Journal of Clinical Oncology, ISSN 0732-183X, 06/2011, Volume 29, Issue 18, pp. 2493 - 2498
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2018, Volume 378, Issue 5, pp. 449 - 459
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2018, Volume 378, Issue 5, pp. 439 - 448
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 364 - 370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of g-secretase inhibitors (GSIs) that... 
NOTCH1 | INHIBITION | CHROMATIN | PATHWAY | GENES | GENETICS & HEREDITY | C-MYC | ACUTE MYELOID-LEUKEMIA | CANCER | LENTIVIRAL RNAI LIBRARY | GENOME | Chromatin - metabolism | Humans | Flow Cytometry | Chromatin Immunoprecipitation | Gene Expression Regulation, Neoplastic - drug effects | Indoles | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Enzyme-Linked Immunosorbent Assay | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Epigenesis, Genetic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Chromatin - genetics | Care and treatment | Pharmacology, Experimental | Acute lymphocytic leukemia | Research | Drug resistance | Proteins | Genotype & phenotype | Leukemia | Epigenetics | Genomes | Kinases | Gene expression | Cancer therapies | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2017, Volume 376, Issue 9, pp. 836 - 847
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7380, pp. 157 - 163
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 1, pp. 57 - 66
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2016, Volume 375, Issue 8, pp. 740 - 753
Journal Article