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Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61903 - e61903
Aims/hypothesis: Recently, the novel myokine irisin was described to drive adipose tissue 'browning', to increase energy expenditure, and to improve obesity... 
THERMOGENESIS | FETUIN-A LEVELS | SKELETAL-MUSCLE | WHITE FAT | HOMEOSTASIS | GLUCOSE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RESISTANCE | RISK | ADIPOSE-TISSUE | Glucose Intolerance - metabolism | Prediabetic State - metabolism | Prediabetic State - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Genetic Loci - genetics | Male | Muscle Fibers, Skeletal - metabolism | Overweight - metabolism | Adult | Female | Body Fat Distribution | Insulin Secretion | Genetic Predisposition to Disease - genetics | Glucose Intolerance - genetics | Reproducibility of Results | Gene Frequency | Gene Expression Regulation | Overweight - genetics | Fibronectins - metabolism | Insulin - metabolism | Phenotype | Insulin Resistance - genetics | Fibronectins - genetics | Polymorphism, Single Nucleotide | Blood Glucose - metabolism | Type 2 diabetes | Adipose tissues | Obesity | Genes | Insulin resistance | Genetic aspects | Single nucleotide polymorphisms | Glucose | Gene expression | Insulin | Prediabetic state | Dextrose | Elderly people | Nephrology | Adipose tissue | Intravenous administration | Body weight | Single-nucleotide polymorphism | Hormones | Adipocytes | Subgroups | Consortia | Proteins | Interrogation | Genetics | Spectroscopy | Sensitivity analysis | Myotubes | Internal medicine | Environmental health | Cultures | Intolerance | Browning | Thermogenesis | Gene loci | Endocrinology | Metabolic disorders | Geriatrics | Lipids | Clamps | Ethics | Rodents | Desensitization | Muscles | Energy expenditure | Data processing | Genetic diversity | Preventive medicine | Loci | Glucose tolerance | Musculoskeletal system | Sensitivity | Magnetic resonance imaging | Tagging | In vivo methods and tests | Diabetes | Elderly | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2003, Volume 100, Issue 14, pp. 8466 - 8471
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable... 
Body mass index | Biological Sciences | Fasting | Diabetes complications | Genes | Insulin resistance | Type 2 diabetes mellitus | Diabetes | Lipid metabolism | Family history | Insulin | OBESE PATIENTS | PIMA-INDIANS | MITOCHONDRIAL BIOGENESIS | LIPID-CONTENT | MULTIDISCIPLINARY SCIENCES | EXPRESSION PROFILE | FATTY-ACIDS | MELLITUS | HUMAN SKELETAL-MUSCLE | GAMMA COACTIVATOR-1 | MICROARRAY DATA | Prediabetic State - metabolism | Prediabetic State - genetics | Oligonucleotide Array Sequence Analysis | Diabetes Mellitus - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Transcription Factors - deficiency | Male | Muscle, Skeletal - metabolism | Gene Expression Profiling | Nuclear Respiratory Factors | Trans-Activators - physiology | Glycolysis - genetics | Adult | Female | Transcription, Genetic | Nuclear Respiratory Factor 1 | Obesity | DNA-Binding Proteins - physiology | Genetic Predisposition to Disease | Transcription Factors - physiology | Gene Expression Regulation - genetics | Oxidative Phosphorylation | Diabetes Mellitus - metabolism | Receptors, Cytoplasmic and Nuclear - physiology | Transcription Factors - genetics | Citric Acid Cycle - genetics | Mexican Americans - genetics | Biopsy | Insulin Resistance - genetics | NF-E2-Related Factor 1 | Lipid Peroxidation - genetics | Muscle, Skeletal - pathology | Type 2 diabetes | Genetic aspects | Genetics | Metabolism | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 12/2013, Volume 62, Issue 12, pp. 4270 - 4276
Journal Article
Diabetes, ISSN 0012-1797, 02/2013, Volume 62, Issue 2, pp. 543 - 550
Journal Article
Diabetes, ISSN 0012-1797, 04/2018, Volume 67, Issue 4, pp. 697 - 703
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0119941 - e0119941
Type 2 diabetes (T2D) is a complex metabolic disease that is more prevalent in ethnic groups such as Mexican Americans, and is strongly associated with the... 
DEPENDENT DIABETES-MELLITUS | WHOLE-BLOOD | ALCOHOL | MULTIDISCIPLINARY SCIENCES | ETHANOL-PRODUCTION | LINKAGE ANALYSIS | FAMILY-HISTORY | TYPE-2 | EXPRESSION | GLUCOSE-TOLERANCE | GENOME-WIDE ASSOCIATION | Body Mass Index | United States - epidemiology | Genetic Predisposition to Disease - genetics | Prediabetic State - genetics | Diabetes Mellitus, Type 2 - genetics | Genomics | Humans | Middle Aged | Male | Gene Expression Profiling | Obesity - genetics | Alcohol Drinking - genetics | Diabetes Mellitus, Type 2 - epidemiology | Adipose Tissue - metabolism | Mexican Americans - genetics | Molecular Epidemiology | Obesity - epidemiology | Alcohol Dehydrogenase - genetics | Insulin Resistance - genetics | Female | United States Department of Veterans Affairs | Subcutaneous Fat, Abdominal - metabolism | Prediabetic State - epidemiology | Adipose tissues | Type 2 diabetes | Obesity | Mexican Americans | Analysis | Genes | Insulin resistance | Genomes | Genetic aspects | Gene expression | Epidemiology | Adipose tissue | Biomedical research | Multiple regression analysis | Gene regulation | Hispanic Americans | Science | Alcohol | Alcohol dehydrogenase | Risk factors | Pathways | Classification | Probes | Hypertension | Fasting | DNA probes | Ethanol | Diabetes mellitus | Regression analysis | Metabolism | Risk analysis | Ribonucleic acid--RNA | Insulin | Minority & ethnic groups | Resistance factors | Medicine | Musculoskeletal system | Body mass | Regulatory mechanisms (biology) | Metabolic pathways | Diabetes | Metabolic disorders | Index Medicus | RNA | Ribonucleic acid
Journal Article
DIABETES CARE, ISSN 0149-5992, 08/2017, Volume 40, Issue 8, pp. 1082 - 1089
OBJECTIVE In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146 risk allele confers susceptibility to impaired glucose tolerance (IGT) or... 
KIDNEY-DISEASE | INHIBITION | LIRAGLUTIDE | CARDIOVASCULAR OUTCOMES | SITAGLIPTIN | ENDOCRINOLOGY & METABOLISM | MELLITUS | TANDEM MASS-SPECTROMETRY | GLP-1 RECEPTOR | TYPE-2 | NEPHROPATHY | Prediabetic State - genetics | Follow-Up Studies | Diabetes Mellitus, Type 2 - genetics | Humans | Male | Insulin - blood | Glucose Intolerance - blood | Insulin-Secreting Cells - metabolism | Female | Child | Insulin Secretion | Body Mass Index | Genetic Predisposition to Disease | Glucose Intolerance - genetics | Glucose Tolerance Test | Prediabetic State - blood | Transcription Factor 7-Like 2 Protein - genetics | Liver - metabolism | Risk Factors | Insulin Resistance | Pediatric Obesity - blood | Pediatric Obesity - genetics | Continental Population Groups - genetics | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Adolescent | Alleles | Longitudinal Studies | Cohort Studies | Type 2 diabetes | Overweight persons | Control | Genetic aspects | Research | Glucose | Health aspects | Genetic polymorphisms | Dextrose | Risk factors | Obesity | Adolescence | Secretion | Diabetes mellitus | Liver | Health risks | Insulin | Minority & ethnic groups | Glucose tolerance | Genotype & phenotype | Sensitivity | Risk assessment | Teenagers | Research design | Diabetes | Adolescents | Index Medicus | Pathophysiology | Complications | 0409
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, pp. e0171367 - e0171367
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 1, pp. e84770 - e84770
In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study... 
HONG-KONG CHINESE | CONSERVED ROLE | METABOLIC SYNDROME | MULTIDISCIPLINARY SCIENCES | GROWTH | SUSCEPTIBILITY LOCUS | MELLITUS | TYPE-2 | EXPRESSION | GENOME-WIDE ASSOCIATION | PATHOPHYSIOLOGY | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Prediabetic State - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Genotype | Male | Transcription Factors - genetics | Cardiovascular Diseases - genetics | Case-Control Studies | Diabetes Mellitus, Type 2 - epidemiology | Cardiovascular Diseases - epidemiology | Polymorphism, Single Nucleotide - genetics | Female | Aged | Eye Proteins - genetics | Prediabetic State - epidemiology | Type 2 diabetes | Obesity | Medical research | Genomics | Medicine, Experimental | Insulin resistance | Genomes | Genetic aspects | Comparative analysis | Coronary heart disease | Prediabetic state | Science | Homology | Leukocytes (mononuclear) | Single-nucleotide polymorphism | Regulatory sequences | Small intestine | Blood | Confidence intervals | Autopsy | Instructional design | Peripheral blood mononuclear cells | Blood pressure | Bioinformatics | Heart diseases | Autopsies | Secretion | Diabetes mellitus | Health risks | Insulin | Coronary artery disease | Genetic variance | Arteriosclerosis | Alleles | Rapid prototyping | Cardiovascular diseases | Index Medicus
Journal Article