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1. Full Text ACTH analogues medications for the treatment of crystal-induced acute inflammation. A target to be explored?
by Perez-Ruiz, Fernando and Herrero-Beites, Ana María
Joint Bone Spine, ISSN 1297-319X, 2013, Volume 80, Issue 3, pp. 236 - 237
Internal Medicine | Rheumatology | ACTH | Tetracosactide | Treatment | Gout flares | Gout | ACUTE GOUT | INDOMETHACIN | RHEUMATOLOGY | ARTHRITIS | TRIAL | ORAL PREDNISOLONE | DOUBLE-BLIND | ADRENOCORTICOTROPIC HORMONE | Adrenocorticotropic Hormone - adverse effects | Arthritis, Gouty - drug therapy | Humans | Gout - drug therapy | Female | Male | Adrenocorticotropic Hormone - administration & dosage | Index Medicus
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2. Full Text Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy
by Tian-tian LI Xiao-hui ZHANG Jing-feng JING Xin LI Xiao-qian YANG Feng-hua ZHU Wei TANG Jian-ping ZUO
中国药理学报：英文版, ISSN 1671-4083, 2015, Volume 36, Issue 2, pp. 188 - 199
Aim： SM934 is a novel water-soluble artemisinin derivative with immunoregulatory activities that has been used to treat murine lupus nephritis. In the current... 
肾小球肾炎 | SD大鼠 | 实验性 | 青蒿素 | 蛋白尿 | 肾间质纤维化 | artemisinin | prednisolone | TGFβ1 | passive Heymann nephritis | SM934 | proteinuria | podocyte | epithelial-mesenchymal transition | Smad | renal fibrosis | membranous nephropathy | GLOMERULONEPHRITIS | TGF beta 1 | TGF-BETA | MECHANISM | CISPLATIN-INDUCED NEPHROTOXICITY | INJURY | MESENCHYMAL TRANSITION | CHEMISTRY, MULTIDISCIPLINARY | INFLAMMATION | TUBULAR EPITHELIAL-CELLS | PHARMACOLOGY & PHARMACY | EXPRESSION | HEYMANN NEPHRITIS | Artemisinins - pharmacology | Fibrosis - drug therapy | Animals | Kidney - drug effects | Proteinuria - drug therapy | Glomerulonephritis, Membranous - drug therapy | Kidney Diseases - drug therapy | Rats | Male | Models, Animal | Rats, Sprague-Dawley | Index Medicus | Original
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3. Full Text VBP15, a Glucocorticoid Analogue, Is Effective at Reducing Allergic Lung Inflammation in Mice
by Damsker, Jesse M and Dillingham, Blythe C and Rose, Mary C and Balsley, Molly A and Heier, Christopher R and Watson, Alan M and Stemmy, Erik J and Jurjus, Roslyn A and Huynh, Tony and Tatem, Kathleen and Uaesoontrachoon, Kitipong and Berry, Dana M and Benton, Angela S and Freishtat, Robert J and Hoffman, Eric P and McCall, John M and Gordish-Dressman, Heather and Constant, Stephanie L and Reeves, Erica K. M and Nagaraju, Kanneboyina
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63871 - e63871
Asthma is a chronic inflammatory condition of the lower respiratory tract associated with airway hyperreactivity and mucus obstruction in which a majority of... 
PROMOTER ACTIVITY | RESPONSES | DNA-BINDING | EPITHELIUM | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | INHALED CORTICOSTEROIDS | ASTHMA | RECEPTOR | MECHANISMS | INTERLEUKIN-10 | Asthma - metabolism | Glucocorticoids - therapeutic use | Epithelial Cells - drug effects | Humans | Male | NF-kappa B - metabolism | Hypersensitivity - complications | Leukocytes - physiology | Hypersensitivity - drug therapy | Tibia - pathology | Epithelial Cells - secretion | Female | Disease Models, Animal | Ovalbumin | Lung - pathology | Osteogenesis - drug effects | Cytokines - secretion | Epithelial Cells - pathology | Tibia - drug effects | Cell Movement - drug effects | Pregnadienediols - pharmacology | Animals | Pneumonia - drug therapy | Asthma - complications | Lung - drug effects | Pregnadienediols - therapeutic use | Glucocorticoids - chemistry | Glucocorticoids - pharmacology | Pneumonia - complications | Leukocytes - drug effects | Mice | Mice, Inbred BALB C | Asthma - pathology | Pregnadienediols - chemistry | Cell Degranulation - drug effects | Allergens | Corticosteroids | Analysis | Respiratory agents | Inflammation | Genetic aspects | Prednisone | Prednisolone | Asthma | Steroids | Health sciences | Glucocorticoids | Transcription | Physicians | Epithelial cells | Lung | Mucus | Biology | Inflammatory diseases | Respiratory tract | Proteins | Immunology | Tibia | Rodents | Antiinflammatory agents | Cytokines | Hypersensitivity | Medical treatment | Gene expression | Allergies | Children & youth | White blood cells | Medicine | Side effects | Degranulation | Ligands | Health risk assessment | Index Medicus
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4. Full Text Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
by Richards, Juliet and Lim, Ai Chiin and Hay, Colin W and Taylor, Angela E and Wingate, Anna and Nowakowska, Karolina and Pezaro, Carmel and Carreira, Suzanne and Goodall, Jane and Arlt, Wiebke and McEwan, Iain J and De Bono, Johann S and Attard, Gerhardt
Cancer Research, ISSN 0008-5472, 05/2012, Volume 72, Issue 9, pp. 2176 - 2182
Prostate cancer progression can be associated with androgen receptor (AR) mutations acquired following treatment with castration and/or an antiandrogen.... 
CELLS | GLUCOCORTICOIDS | CYP17A1 INHIBITION | PHARMACOKINETICS | ANTIANDROGEN | ONCOLOGY | GROWTH | RESISTANT PROSTATE-CANCER | ANTITUMOR-ACTIVITY | ACETATE | I CLINICAL-TRIAL | Binding, Competitive | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - metabolism | Nitriles - pharmacology | Androstenols - pharmacology | Humans | Receptors, Androgen - metabolism | Androstenes | Male | Androgen Receptor Antagonists - pharmacology | Prednisolone - pharmacology | Phenylthiohydantoin - analogs & derivatives | Tosyl Compounds - pharmacology | Metribolone - metabolism | Drug Interactions | Prostatic Neoplasms - genetics | Receptors, Androgen - genetics | Spironolactone - pharmacology | Androgens - pharmacology | Anilides - pharmacology | Cell Line, Tumor | Spironolactone - antagonists & inhibitors | Spironolactone - analogs & derivatives | Prostatic Neoplasms - drug therapy | Index Medicus
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5. Full Text Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia
by Jones, Christopher M and Mallappa, Ashwini and Reisch, Nicole and Nikolaou, Nikolaos and Krone, Nils and Hughes, Beverly A and O’Neil, Donna M and Whitaker, Martin J and Tomlinson, Jeremy W and Storbeck, Karl-Heinz and Merke, Deborah P and Ross, Richard J and Arlt, Wiebke
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2017, Volume 102, Issue 6, pp. 1797 - 1806
Context: The classic androgen synthesis pathway proceeds via dehydroepiandrosterone, androstenedione, and testosterone to 5 alpha-dihydrotestosterone. However,... 
BACKDOOR PATHWAY | 21-HYDROXYLASE DEFICIENCY | OXIDOREDUCTASE | ENDOCRINOLOGY & METABOLISM | ADULTS | INSUFFICIENCY | TAMMAR WALLABY | TESTES | 19-CARBON STEROIDS | DIHYDROTESTOSTERONE | HYDROCORTISONE | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Gas Chromatography-Mass Spectrometry | Adrenal Hyperplasia, Congenital - drug therapy | 17-alpha-Hydroxypregnenolone - urine | Humans | Middle Aged | Hydrocortisone - therapeutic use | Male | Young Adult | Hydrocortisone - administration & dosage | Cortodoxone - analogs & derivatives | Androsterone - urine | Adult | Female | Prednisolone - therapeutic use | Pregnanetriol - urine | Cortodoxone - urine | Androgens - secretion | Adrenal Hyperplasia, Congenital - metabolism | Circadian Rhythm | Androsterone - analogs & derivatives | Dexamethasone - therapeutic use | Adolescent | Adrenal Hyperplasia, Congenital - urine | Pregnanetriol - analogs & derivatives | Delayed-Action Preparations | Therapy | Excretion | Dexamethasone | Glucocorticoids | Adrenal glands | Hyperplasia | Mass spectroscopy | Hydrocortisone | Patients | Diurnal | Impact analysis | Testosterone | Gas chromatography | Androgens | Dihydrotestosterone | Dehydroepiandrosterone | Synthesis | Metabolites | Adults | Androstenedione | Mass spectrometry | Prednisolone | Steroid hormones | Steroids | Index Medicus | Abridged Index Medicus
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6. Full Text Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN Nephritis Trial
by Houssiau, Frédéric A and D'Cruz, David and Sangle, Shirish and Remy, Philippe and Vasconcelos, Carlos and Petrovic, Radmila and Fiehn, Christoph and de Ramon Garrido, Enrique and Gilboe, Inge-Magrethe and Tektonidou, Maria and Blockmans, Daniel and Ravelingien, Isabelle and le Guern, Véronique and Depresseux, Geneviève and Guillevin, Loïc and Cervera, Ricard and MAINTAIN Nephritis Trial Grp and MAINTAIN Nephritis Trial Group and the MAINTAIN Nephritis Trial Group
Annals of the Rheumatic Diseases, ISSN 0003-4967, 12/2010, Volume 69, Issue 12, pp. 2083 - 2089
Background Long-term immunosuppressive treatment does not efficiently prevent relapses of lupus nephritis (LN). This investigator-initiated randomised trial... 
INTRAVENOUS CYCLOPHOSPHAMIDE | THERAPY | RHEUMATOLOGY | METHYLPREDNISOLONE | ERYTHEMATOSUS | DISEASE-ACTIVITY | Azathioprine - therapeutic use | Glucocorticoids - therapeutic use | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Lupus Nephritis - drug therapy | Male | Treatment Outcome | Secondary Prevention | Cyclophosphamide - therapeutic use | Young Adult | Mycophenolic Acid - adverse effects | Mycophenolic Acid - analogs & derivatives | Mycophenolic Acid - therapeutic use | Adult | Female | Immunosuppressive Agents - adverse effects | Prednisolone - therapeutic use | Drug Therapy, Combination | Azathioprine - adverse effects | Nephritis | Safety and security measures | Patient outcomes | Dosage and administration | Research | Mycophenolate mofetil | Azathioprine | Drug therapy | Lupus | Pregnancy | Biopsy | Laboratories | Rodents | Blood pressure | Kidney diseases | Drug dosages | Index Medicus
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7. Full Text Clastogenic and Anticlastogenic Activity of Glucocorticoid Hormones Hydrocortisone and Its Synthetic Analogs Prednisolone and Dexamethasone
by Koshpaeva, E S and Semenov, V V
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 5/2013, Volume 155, Issue 1, pp. 78 - 80
Clastogenic and anticlastogenic activity of glucocorticoid hormones hydrocortisone, prednisolone, and dexamethasone was studied by counting chromosome... 
dexamethasone | Pathology | prednisolone | clastogenic effect | Biomedicine | anticlastogenic effect | hydrocortisone | Internal Medicine | Laboratory Medicine | Biomedicine general | Cell Biology | MEDICINE, RESEARCH & EXPERIMENTAL | Hydrocortisone - toxicity | Mutagens - toxicity | Prednisolone - toxicity | Cells, Cultured | Dexamethasone - toxicity | Antimutagenic Agents - pharmacology | Prednisolone - pharmacology | Mutagenesis - drug effects | Ethyl Methanesulfonate - toxicity | Dexamethasone - pharmacology | Chromosome Aberrations - drug effects | Hydrocortisone - pharmacology | Crepis - drug effects | Prednisolone | Dexamethasone | Hormones | Index Medicus
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8. Full Text Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial
by Engström, Mats, MD and Berg, Thomas, MD and Stjernquist-Desatnik, Anna, MD and Axelsson, Sara, MD and Pitkäranta, Anne, MD and Hultcrantz, Malou, MD and Kanerva, Mervi, MD and Hanner, Per, MD and Jonsson, Lars, MD and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Öron-, näs- och halssjukdomar and Uppsala universitet and Institutionen för kirurgiska vetenskaper
Lancet Neurology, The, ISSN 1474-4422, 2008, Volume 7, Issue 11, pp. 993 - 1000
Summary Background Previous trials of corticosteroid or antiviral treatments for Bell's palsy have been underpowered or have had insufficient follow-up. The... 
Neurology | GRADING SYSTEM | NERVE | VALACYCLOVIR | HERPES-SIMPLEX-VIRUS | ACYCLOVIR | POLYMERASE-CHAIN-REACTION | STEROIDS | SUNNYBROOK | VARICELLA-ZOSTER-VIRUS | CLINICAL NEUROLOGY | IDIOPATHIC FACIAL PARALYSIS | Bell Palsy - physiopathology | Prednisolone - adverse effects | Prednisolone - administration & dosage | Recovery of Function - drug effects | Humans | Middle Aged | Acyclovir - adverse effects | Male | Valine - administration & dosage | Young Adult | Anti-Inflammatory Agents - adverse effects | Time Factors | Placebos | Recovery of Function - physiology | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Drug Therapy, Combination | Double-Blind Method | Drug Administration Schedule | Acyclovir - analogs & derivatives | Valine - analogs & derivatives | Treatment Outcome | Antiviral Agents - administration & dosage | Bell Palsy - drug therapy | Antiviral Agents - adverse effects | Adolescent | Herpes Simplex - complications | Aged | Valine - adverse effects | Acyclovir - administration & dosage | Clinical trials | Corticosteroids | Paralysis, Facial | Prednisolone | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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9. Full Text The requirement for a sufficient period of corticosteroid treatment in combination with nucleoside analogue for severe acute exacerbation of chronic hepatitis B
by Fujiwara, Keiichi and Yasui, Shin and Okitsu, Koichiro and Yonemitsu, Yutaka and Oda, Shigeto and Yokosuka, Osamu
Journal of Gastroenterology, ISSN 0944-1174, 12/2010, Volume 45, Issue 12, pp. 1255 - 1262
The prognosis of severe acute exacerbation of chronic hepatitis B is very poor if signs of liver failure appear. We have reported the efficacy of the early... 
Corticosteroid | Nucleoside analogue | Medicine & Public Health | Chronic hepatitis B | Severe exacerbation | Colorectal Surgery | Hepatology | Gastroenterology | Internal Medicine | Oncology | Surgical Oncology | FULMINANT-HEPATITIS | PLACEBO | CHRONIC ACTIVE HEPATITIS | LAMIVUDINE THERAPY | PREDNISOLONE | CHEMOTHERAPY | TRIAL | REACTIVATION | CIRRHOSIS | DOUBLE-BLIND | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Nucleosides - therapeutic use | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Prospective Studies | Drug Administration Schedule | Follow-Up Studies | Nucleosides - administration & dosage | Antiviral Agents - therapeutic use | Humans | Middle Aged | Liver Failure, Acute - virology | Male | Treatment Outcome | Antiviral Agents - administration & dosage | Dose-Response Relationship, Drug | Hepatitis B, Chronic - drug therapy | Time Factors | Hepatitis B, Chronic - physiopathology | Adult | Female | Aged | Liver Failure, Acute - drug therapy | Drug Therapy, Combination | Medical colleges | Corticosteroids | Medical examination | Heterocyclic compounds | Analysis | Immunotherapy | Nucleosides | Thrombin | Bilirubin | Blood | Hepatitis B | Index Medicus
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10. Full Text Proteomic identification of plasma proteins as markers of growth promoter abuse in cattle
by Kinkead, Ruth A and Elliott, Christopher T and Cannizzo, Francesca T and Biolatti, Bartolomeo and Mooney, Mark H
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 6/2015, Volume 407, Issue 15, pp. 4495 - 4507
Growth-promoting agents are continually misused for increasing animal growth and fraudulent gain in the meat industry, yet detection rates from conventional... 
Biochemistry, general | 2D gel electrophoresis | Corticosteroid | Chemistry | Analytical Chemistry | Food Science | Bovine | Proteomics | Characterization and Evaluation of Materials | Laboratory Medicine | Anabolic | Environmental Monitoring/Analysis | CHEMISTRY, ANALYTICAL | DEXAMETHASONE | BIOCHEMICAL RESEARCH METHODS | PREDNISOLONE | BEEF-CATTLE | 17-BETA-ESTRADIOL | VEAL CALVES | BOVINE URINE | METABOLISM | BINDING | EXPRESSION CHANGES | HORMONES | Substance Abuse Detection - methods | Estradiol - analogs & derivatives | Glucocorticoids - administration & dosage | Cattle - blood | Dexamethasone - administration & dosage | Prednisolone - administration & dosage | Contraceptive Agents - administration & dosage | Biomarkers - analysis | Electrophoresis, Gel, Two-Dimensional - methods | Estradiol - administration & dosage | Male | Biomarkers - blood | Blood Proteins - analysis | Dexamethasone - analogs & derivatives | Prednisolone - analogs & derivatives | Animals | Anabolic Agents - administration & dosage | Proteomics - methods | Tandem Mass Spectrometry - methods | Dexamethasone | Metabolites | Cattle | Growth | Analysis | Physiological aspects | Prednisolone | Blood proteins | Index Medicus | Proteins | Drugs | Markers
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11. Full Text Valacyclovir and prednisolone treatment for Bell's palsy: A multicenter, randomized, placebo-controlled study
by Hato, Naohito and Yamada, Hiroyuki and Kohno, Hisashi and Matsumoto, Shuichi and Honda, Nobumitsu and Gyo, Kiyofumi and Fukuda, Satoshi and Furuta, Yasushi and Ohtani, Fumio and Aizawa, Hiroshi and Aoyagi, Masaru and Inamura, Hiroo and Nakashima, Tsutomu and Nakata, Seiichi and Murakami, Shingo and Kiguchi, Jun and Yamano, Koji and Takeda, Taizo and Hamada, Masashi and Yamakawa, Kazuhiro
Otology and Neurotology, ISSN 1531-7129, 04/2007, Volume 28, Issue 3, pp. 408 - 413
Objective: To investigate the effects of valacyclovir and prednisolone in comparison with those of placebo and prednisolone for the treatment of Bell's palsy,... 
RCT | Zoster sine herpete | Valacyclovir | Prednisolone | Bell's palsy | CONTROLLED TRIAL | EFFICACY | ORAL ACYCLOVIR | CLINICAL NEUROLOGY | prednisolone | HERPES-SIMPLEX-VIRUS | DNA | OTORHINOLARYNGOLOGY | DOUBLE-BLIND | INFECTION | TYPE-1 | FACIAL PARALYSIS | valacyclovir | Severity of Illness Index | Bell Palsy - diagnosis | Diagnosis, Differential | Acyclovir - therapeutic use | Drug Administration Schedule | Acyclovir - analogs & derivatives | Antiviral Agents - therapeutic use | Humans | Middle Aged | Valine - analogs & derivatives | Male | Bell Palsy - drug therapy | Adolescent | Aged, 80 and over | Adult | Female | Valine - therapeutic use | Aged | Prednisolone - therapeutic use | Drug Therapy, Combination | Index Medicus
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12. Full Text Predicting the gastrointestinal behaviour of modified-release products: Utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers
by Merchant, Hamid A and Goyanes, Alvaro and Parashar, Narendra and Basit, Abdul W
International Journal of Pharmaceutics, ISSN 0378-5173, 11/2014, Volume 475, Issue 1-2, pp. 585 - 591
The establishment of physiologically relevant correlations (IV–IVCs) is key for any biorelevant dissolution test. Historically, bicarbonate buffers have... 
Physiological bicarbonate buffer | Biorelevant dissolution | Hydrogen carbonate buffer | pH-sensitive polymers | Enteric polymers | Gastro-resistant coatings | PROXIMAL SMALL-INTESTINE | SYSTEM | FLUIDS | TRANSIT | PROFILES | PERFORMANCE | DRUG-RELEASE | ENTERIC COATINGS | PHOSPHATE | PHARMACOLOGY & PHARMACY | Chemistry, Pharmaceutical - methods | Prednisolone - administration & dosage | Solubility | Methylcellulose - analogs & derivatives | Polymethacrylic Acids - chemistry | Methylcellulose - chemistry | Cellulose - chemistry | Prednisolone - chemistry | Models, Biological | Drug Liberation | Delayed-Action Preparations | Polyvinyls - chemistry | Cellulose - analogs & derivatives | Hydrogen-Ion Concentration | Carbonates | Index Medicus
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13. Full Text Graft rejection after Descemet's stripping automated endothelial keratoplasty: Graft survival and endothelial cell loss
by Li, Jennifer Y and Terry, Mark A and Goshe, Jeffrey and Shamie, Neda and Davis-Boozer, David
Ophthalmology, ISSN 0161-6420, 01/2012, Volume 119, Issue 1, pp. 90 - 94
Purpose: To evaluate the effects of graft rejection episodes after Descemet's stripping automated endothelial keratoplasty surgery (DSAEK) on long-term... 
OPHTHALMOLOGY | FAILURE | EYES | Graft Rejection - drug therapy | Fluprednisolone - administration & dosage | Glucocorticoids - administration & dosage | Descemet Stripping Endothelial Keratoplasty | Prednisolone - administration & dosage | Follow-Up Studies | Fuchs' Endothelial Dystrophy - surgery | Cell Count | Graft Rejection - physiopathology | Humans | Graft Rejection - etiology | Male | Endothelium, Corneal - pathology | Prednisolone - analogs & derivatives | Time Factors | Graft Survival - physiology | Female | Aged | Retrospective Studies | Fluprednisolone - analogs & derivatives | Corneal Endothelial Cell Loss - diagnosis | Corneal Endothelial Cell Loss - physiopathology | Postoperative Complications | Index Medicus
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14. Full Text Penetration and release studies of positively and negatively charged nanoemulsions—Is there a benefit of the positive charge?
by Baspinar, Yücel and Borchert, Hans-Hubert
International Journal of Pharmaceutics, ISSN 0378-5173, 07/2012, Volume 430, Issue 1-2, pp. 247 - 252
The surface of all tissues, including the stratum corneum, carries a negative charge. Following that fact it is assumed that a positively charged topical... 
High pressure homogenization | Phytosphingosine | Penetration | Positively charged nanoemulsion | Prednicarbate | HUMAN SKIN | BARRIER FUNCTION | FORMULATION | ATOPIC-DERMATITIS | SUBMICRON EMULSIONS | DRUGS | SPHINGOSINE | PHARMACOLOGY & PHARMACY | TECHNOLOGY | TOPICAL DELIVERY | LIPIDS | Glucocorticoids - administration & dosage | Emulsions | Prednisolone - administration & dosage | Skin - metabolism | Administration, Cutaneous | Drug Carriers | Nanoparticles | Prednisolone - analogs & derivatives | Prednisolone - chemistry | Glucocorticoids - metabolism | Surface Properties | Drug Compounding | Skin Absorption - drug effects | Sphingosine - metabolism | Myristic Acid - pharmacology |