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Neuron, ISSN 0896-6273, 11/2012, Volume 76, Issue 4, pp. 735 - 749
Axons must switch responsiveness to guidance cues during development for correct pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons... 
SLIT | RESPONSIVENESS | KINASE-A | CHEMOATTRACTANT | GROWTH-CONE ATTRACTION | NETRIN-1 | SPINAL-CORD | GUIDANCE | SPECIFICATION | NEUROSCIENCES | INTERNEURONS | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Hedgehog Proteins - pharmacology | Embryo, Mammalian | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Axons - physiology | Green Fluorescent Proteins - genetics | Spinal Cord Injuries - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Neurons - metabolism | Cyclic AMP - metabolism | 14-3-3 Proteins - genetics | Gene Expression Regulation, Developmental - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Simplexvirus - genetics | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Rats | Mice, Transgenic | Piperazines - pharmacology | Rats, Sprague-Dawley | 14-3-3 Proteins - metabolism | Analysis of Variance | Signal Transduction - drug effects | Chickens | Luminescent Proteins - genetics | Mice | beta-Galactosidase - genetics | Carbazoles - pharmacology | Kruppel-Like Transcription Factors - genetics | RNA, Small Interfering - metabolism | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Wnt1 Protein - metabolism | DNA-Binding Proteins - metabolism | Neurons - classification | Protein Isoforms - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | beta-Galactosidase - metabolism | Female | Pyrazoles - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Bacterial Proteins - genetics | Cells, Cultured | Axons - drug effects | Electroporation | DNA-Binding Proteins - genetics | Chemotaxis | Amino Acids | Pregnancy | Pyrroles - pharmacology | Animals | Protein Isoforms - genetics | Proteins | Neurons | Medical research | Spinal cord | Rodents | Migration | Mammals
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 31 - 44
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks... 
Clodronic Acid - pharmacology | Gene Expression - genetics | Dendritic Cells - immunology | Humans | Pregnancy Proteins - genetics | Microvessels - pathology | Pregnancy Proteins - metabolism | Chemotactic Factors - metabolism | Neoplasm Metastasis - immunology | Antibodies - immunology | Neovascularization, Pathologic - immunology | Macrophages, Peritoneal - drug effects | Macrophages - pathology | Neoplasms - blood supply | Down-Regulation - genetics | Mice, Knockout | Macrophages - metabolism | Neoplasms - immunology | Cell Line, Tumor | Placenta Growth Factor | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Macrophages, Peritoneal - metabolism | Neoplasms - metabolism | CD8-Positive T-Lymphocytes - pathology | Gene Expression - drug effects | Regional Blood Flow - genetics | Dendritic Cells - pathology | Culture Media, Conditioned - pharmacology | Lung Neoplasms - pathology | Hypoxia - metabolism | Neovascularization, Pathologic - pathology | Regional Blood Flow - drug effects | Transfection | Lung Neoplasms - secondary | Neoplasms - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Lung Neoplasms - genetics | Microvessels - ultrastructure | Cytokines - metabolism | Mice, Inbred C57BL | Microvessels - drug effects | Pregnancy Proteins - immunology | Antibodies - pharmacology | Proteins - genetics | Neoplasm Metastasis - genetics | Hypoxia - genetics | Lung Neoplasms - immunology | Animals | Proteins - metabolism | Endothelial Cells - cytology | Neoplasm Metastasis - pathology | Macrophages - drug effects | Neovascularization, Pathologic - genetics | Cell Proliferation - drug effects | Proteins - pharmacology | Neoplasms - pathology | Endothelial Cells - drug effects
Journal Article
Science, ISSN 0036-8075, 9/2005, Volume 309, Issue 5742, pp. 1829 - 1833
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2002, Volume 8, Issue 8, pp. 831 - 840
The therapeutic potential of placental growth factor (PlGF) and its receptor Flt1 in angiogenesis is poorly understood. Here, we report that PlGF stimulated... 
MEDICINE, RESEARCH & EXPERIMENTAL | COLLAGEN-INDUCED ARTHRITIS | CELLS | TYROSINE KINASE | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLT-1 | CELL BIOLOGY | RECEPTOR-DEFICIENT MICE | ARTERIOGENESIS | DISEASE | GENE-THERAPY | ENDOTHELIAL GROWTH-FACTOR | Neovascularization, Physiologic - drug effects | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor A | Arthritis, Experimental - drug therapy | Arteriosclerosis - drug therapy | Vascular Endothelial Growth Factors | Blood Vessels - pathology | Humans | Pregnancy Proteins - genetics | Receptor Protein-Tyrosine Kinases - immunology | Antibodies, Monoclonal - therapeutic use | Endothelial Growth Factors - pharmacology | Recombinant Fusion Proteins - metabolism | Pregnancy Proteins - pharmacology | Vascular Endothelial Growth Factor Receptor-1 | Arthritis, Experimental - pathology | Receptors, Growth Factor - immunology | Proto-Oncogene Proteins - immunology | Myocardial Ischemia - physiopathology | Pregnancy Proteins - physiology | Arteriosclerosis - immunology | Female | Lymphokines - pharmacology | Ischemia - pathology | Disease Models, Animal | Hematopoietic Stem Cells - drug effects | Proto-Oncogene Proteins - metabolism | Antibodies, Monoclonal - pharmacology | Rats | Joints - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Myocardial Ischemia - drug therapy | Blood Vessels - cytology | Myocardial Ischemia - pathology | Animals | Ischemia - drug therapy | Hindlimb - blood supply | Mice, Nude | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Placenta Growth Factor | Recombinant Fusion Proteins - genetics | Mice | Arteriosclerosis - pathology | Receptors, Growth Factor - metabolism | Research | Neovascularization | Growth factors | Analysis | Tumors
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2003, Volume 9, Issue 7, pp. 936 - 943
Journal Article
Circulation, ISSN 0009-7322, 04/2007, Volume 115, Issue 13, pp. 1789 - 1797
Background-Preeclampsia is characterized clinically by hypertension and proteinuria. Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth... 
Pregnancy | Angiogenesis | Endothelium-derived factors | Preeclampsia | Heme oxygenase-1 | Statins | Endothelium | VITAMIN-C | endothelium | PREGNANCY-INDUCED HYPERTENSION | CARDIAC & CARDIOVASCULAR SYSTEMS | HUMAN PLACENTA | angiogenesis | pregnancy | TISSUE-DAMAGE | heme oxygenase-1 | preeclampsia | MEDIATED ANGIOGENESIS | endothelium-derived factors | TYROSINE KINASE-1 | CYTOKINE PRODUCTION | CARBON-MONOXIDE | statins | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | ENDOTHELIAL GROWTH-FACTOR | Endothelium, Vascular - cytology | Oxidative Stress | Humans | Recombinant Fusion Proteins - physiology | Vascular Endothelial Growth Factor Receptor-1 - physiology | Heme Oxygenase-1 - deficiency | Pregnancy Proteins - pharmacology | Cell Hypoxia | Endoglin | Carbon Monoxide - pharmacology | Swine | Heme Oxygenase-1 - physiology | Female | Pre-Eclampsia - metabolism | Receptors, Cell Surface - physiology | Vascular Endothelial Growth Factor Receptor-2 - physiology | Culture Media, Serum-Free - pharmacology | Heme Oxygenase (Decyclizing) - genetics | Vascular Endothelial Growth Factor A - pharmacology | Organ Culture Techniques | Cells, Cultured - drug effects | Heme Oxygenase (Decyclizing) - physiology | Endothelial Cells - metabolism | RNA, Small Interfering - pharmacology | Solubility | Rats | Antioxidants - pharmacology | Pre-Eclampsia - pathology | Mice, Knockout | Tumor Necrosis Factor-alpha - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Placenta - pathology | Placenta Growth Factor | Antigens, CD - physiology | Mice | Genetic Vectors | Interferon-gamma - pharmacology | Organometallic Compounds - pharmacology | Endothelial Cells - drug effects | Oxidases | Care and treatment | Physiological aspects | Diagnosis | Research | Vascular endothelial growth factor
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 36, pp. 21915 - 21924
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2014, Volume 90, Issue 3, p. 54
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0171858
In ruminants, Interferon tau (IFNT) is the pregnancy recognition protein produced by the mononuclear trophectoderm of the conceptus, and is secreted into the... 
NERVOUS-SYSTEM | CELLS | BOVINE CONCEPTUSES | INTERFERON-TAU | MULTIDISCIPLINARY SCIENCES | GENES | CATTLE | OVINE TROPHOBLAST PROTEIN-1 | PROSTAGLANDIN | EXPRESSION | PREGNANCY | Epithelial Cells - metabolism | Pregnancy Proteins - antagonists & inhibitors | Epithelial Cells - drug effects | Pregnancy Proteins - genetics | Interferon Regulatory Factors - metabolism | Recombinant Proteins - biosynthesis | Pregnancy Proteins - pharmacology | Recombinant Proteins - isolation & purification | STAT1 Transcription Factor - metabolism | RNA Interference | Cattle | Forkhead Transcription Factors - metabolism | Interferon Type I - pharmacology | Female | Forkhead Transcription Factors - antagonists & inhibitors | Endometrium - cytology | Epithelial Cells - cytology | DNA Damage - drug effects | DNA Repair - drug effects | Cells, Cultured | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Forkhead Transcription Factors - genetics | Protein Isoforms - pharmacology | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Interferon Type I - genetics | STAT2 Transcription Factor - metabolism | Proteasome Endopeptidase Complex - metabolism | Protein Isoforms - antagonists & inhibitors | Interferon Type I - antagonists & inhibitors | Protein Isoforms - genetics | RNA sequencing | Pregnancy | Usage | Transcription factors | Analysis | Interferon | Research | Ruminants | Epithelial cells | Genes | Genomics | DNA damage | Nervous system | Genomes | Gene sequencing | Trophectoderm | Proteins | Uterus | Forkhead protein | Life sciences | Stat1 protein | Endometrium | Deoxyribonucleic acid--DNA | Stat2 protein | Gene expression | Ribonucleic acid--RNA | Studies | Signaling | Infectious diseases | Interferon regulatory factor 3 | Binding sites | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2015, Volume 10, Issue 1, p. e116389
Clinical studies suggest that responses to HPV16 E6E7L2 fusion protein (TA-CIN) vaccination alone are modest, and GPI-0100 is a well-tolerated, potent... 
PHASE-II TRIAL | MULTIDISCIPLINARY SCIENCES | HUMAN-PAPILLOMAVIRUS VACCINES | VIRUS-LIKE PARTICLE | VULVAL INTRAEPITHELIAL NEOPLASIA | TA-CIN | CERVICAL-CANCER | MUCOSAL VACCINATION | ANTITUMOR IMMUNITY | HEALTHY-VOLUNTEERS | DNA VACCINATION | Recombinant Fusion Proteins - immunology | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Papillomavirus Vaccines - genetics | Recombinant Fusion Proteins - pharmacology | Saponins - administration & dosage | Humans | Papillomavirus E7 Proteins - immunology | Papillomavirus E7 Proteins - genetics | Papillomavirus Infections - therapy | Neoplasms - virology | Antibodies, Neutralizing - immunology | Neoplasms - therapy | Vaccination - methods | HEK293 Cells | Capsid Proteins - immunology | Female | Oncogene Proteins, Viral - genetics | Papillomavirus Infections - virology | Antineoplastic Agents - pharmacology | Papillomavirus Vaccines - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Mice, Inbred C57BL | Repressor Proteins - genetics | Treatment Outcome | Combined Modality Therapy | Cisplatin - pharmacology | Papillomavirus Vaccines - pharmacology | Animals | Repressor Proteins - immunology | Cell Line, Tumor | Antibodies, Viral - immunology | Mice, Inbred BALB C | Oncogene Proteins, Viral - immunology | CD8-Positive T-Lymphocytes - immunology | Capsid Proteins - genetics | Saponins - pharmacology | Drug therapy | Health aspects | Papillomavirus infections | Cisplatin | Adjuvant treatment | Cancer | Animal models | CD8 antigen | Vaccination | Lymphocytes T | CD4 antigen | Chemotherapy | Immunogenicity | Lungs | Neutralizing | Remission | Mice | Fusion protein | Tumors
Journal Article