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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2701 - 2710
Context: Patients with 21-hydroxylase deficiency (21OHD) have long-term complications, resulting from poor disease control and/or glucocorticoid overtreatment.... 
ADRENOGENITAL SYNDROME | STIMULATION | FINAL HEIGHT | ADULT MALES | TISSUE | ENDOCRINOLOGY & METABOLISM | PATIENT | PREVALENCE | LONGITUDINAL ANALYSIS | 19-CARBON STEROIDS | HYPERPLASIA | Adrenal Glands - pathology | Hydroxytestosterones - metabolism | 17-alpha-Hydroxypregnenolone - analogs & derivatives | Adrenal Rest Tumor - metabolism | Humans | Middle Aged | Child, Preschool | Male | Hirsutism - metabolism | Testosterone - analogs & derivatives | Age Determination by Skeleton | Androstenedione - metabolism | Pregnenolone - metabolism | Young Adult | Androstenedione - analogs & derivatives | Menstruation Disturbances - metabolism | Testosterone - metabolism | Adult | Female | Child | 17-alpha-Hydroxypregnenolone - metabolism | Cross-Sectional Studies | Adrenal Hyperplasia, Congenital - metabolism | Testicular Neoplasms - metabolism | Organ Size | Cortodoxone - metabolism | Adolescent | Androstenes - metabolism | Aged | Androgens - metabolism | Drugs | Correlation | Glucocorticoids | Disorders | Bone tumors | Hormones | Males | Sulfates | Pregnenolone | Spectrometry | Bioindicators | Children | Pituitary hormones | Menstruation | Complications | Hydroxylase | Hirsutism | Disease control | Patients | Testosterone | Androgens | Pregnenolone sulfate | Pituitary | Biomarkers | Adults | Sulfate | Females | Testes | Oxygenation | Steroid hormones | Tumors | Steroids | Index Medicus | Abridged Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 10/2013, Volume 379, Issue 1-2, pp. 62 - 73
Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the steroidogenic cells of the adrenal, gonad, placenta and brain contain... 
Cholesterol transport | Steroidogenesis | Steroidogenic acute regulatory protein | Cholesterol side chain cleavage | Vitamin D | Outer mitochondrial membrane | VITAMIN-D 1-ALPHA-HYDROXYLASE | DEPENDENT ANION CHANNEL | CHAIN CLEAVAGE ENZYME | CHOLESTEROL-BINDING PROTEIN | LIPOID ADRENAL-HYPERPLASIA | ACUTE-REGULATORY-PROTEIN | LEYDIG TUMOR-CELLS | CELL BIOLOGY | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | ELECTRON-TRANSFER | PERIPHERAL BENZODIAZEPINE-RECEPTOR | ENDOCRINOLOGY & METABOLISM | Mitochondria - enzymology | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Humans | Gonadal Steroid Hormones - biosynthesis | Voltage-Dependent Anion Channel 1 - metabolism | Mitochondria - metabolism | Cholesterol - metabolism | Phosphoproteins - metabolism | Mitochondrial Membranes - metabolism | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism | Adrenal Cortex Hormones - biosynthesis | Receptors, GABA - metabolism | Vitamin D - metabolism | Biological Transport - physiology | Membrane Proteins - metabolism | Mitochondrial Membranes - enzymology | Placental Hormones - biosynthesis | Adaptor Proteins, Signal Transducing - metabolism | Pregnenolone - biosynthesis | Enzymes | Physiological aspects | Calcifediol | Mitochondrial DNA | Alfacalcidol | Steroid hormones | Index Medicus | Proteins | Regulators | Mitochondria | Hormones | Kinases | Cholesterol | Steroids
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 32, pp. 13168 - 13185
Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17 alpha-hydroxylation of pregnenolone and progesterone and... 
HUMAN P450C17 | ACTIVE-SITE | ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | 17-ALPHA-HYDROXYLASE-17,20-LYASE CYP17 | INHIBITOR | MICROSOMAL CYTOCHROME-P-450 | ORTERONEL TAK-700 | ISOLATED 17,20-LYASE DEFICIENCY | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | NADPH-Ferrihemoprotein Reductase - genetics | Stereoisomerism | Humans | Imidazoles - chemistry | Cytochrome P-450 Enzyme Inhibitors - metabolism | Cytochromes b5 - metabolism | Androstenedione - metabolism | Cytochromes b5 - genetics | Pregnenolone - metabolism | Progesterone - chemistry | Biocatalysis - drug effects | Dehydroepiandrosterone - chemistry | Cytochrome P-450 Enzyme Inhibitors - chemistry | Dehydroepiandrosterone - metabolism | Naphthalenes - metabolism | Binding Sites | 17-alpha-Hydroxypregnenolone - metabolism | Imidazoles - metabolism | Naphthalenes - chemistry | Recombinant Proteins - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Models, Molecular | Rats | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Naphthalenes - pharmacology | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Progesterone - metabolism | Androstenedione - chemistry | Ligands | Pregnenolone - chemistry | Protein Conformation | Steroid 17-alpha-Hydroxylase - genetics | 17-alpha-Hydroxypregnenolone - chemistry | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Steroid 17-alpha-Hydroxylase - chemistry | Index Medicus | pre-steady-state kinetics | steroid metabolism | oxidation-reduction (redox) | steroidogenesis | cytochrome P450 | Enzymology | steady-state kinetics | enzyme kinetics
Journal Article
Journal Article
Hormones and Behavior, ISSN 0018-506X, 2010, Volume 57, Issue 1, pp. 46 - 55
Neuropathy and encephalopathy represent important complications of diabetes. Recent observations obtained in experimental models have suggested that, in male... 
Peripheral nervous system | Testosterone | Dehydroepiandrosterone | Rat | Neurosteroids | Central nervous system | Liquid chromatography–tandem mass spectrometry | Diabetes | Progesterone | Pregnenolone | Liquid chromatography-tandem mass spectrometry | MESSENGER-RNA EXPRESSION | ALZHEIMERS-DISEASE | NEUROPROTECTIVE AGENTS | MELLITUS | COGNITIVE DYSFUNCTION | GABA(A) RECEPTOR | NEUROPATHY | TRAUMATIC BRAIN-INJURY | ENDOCRINOLOGY & METABOLISM | BEHAVIORAL SCIENCES | GENDER-DIFFERENCES | HIPPOCAMPAL NEUROGENESIS | Brain Diseases - metabolism | Spinal Cord - metabolism | Male | Case-Control Studies | Neuroprotective Agents - metabolism | Pregnenolone - metabolism | Brain - metabolism | Peripheral Nervous System - pathology | Testosterone - metabolism | Spinal Cord - pathology | Female | Dehydroepiandrosterone - metabolism | Diabetes Mellitus, Experimental - metabolism | Gonadal Steroid Hormones - metabolism | Diabetic Neuropathies - prevention & control | Rats | Sex Characteristics | Rats, Sprague-Dawley | Animals | Brain Diseases - pathology | Brain Diseases - prevention & control | Peripheral Nervous System - metabolism | Diabetic Neuropathies - pathology | Progesterone - metabolism | Sex Factors | Brain - pathology | Diabetes Mellitus, Experimental - pathology | Diabetic Neuropathies - metabolism | Estrous Cycle - metabolism | Nervous system diseases | Metabolites | Streptozocin | Mass spectrometry | Steroids | Gender differences | Rodents | Neurological disorders | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 10/2016, Volume 163, pp. 183 - 192
16-dehydropregnenolone (DHP) is a promising novel antihyperlipidemic agent developed and patented by Central Drug Research Institute (CDRI), India. The purpose... 
16-dehydropregnenolone | Cocktail | Pharmacokinetics | CYP450 | Real time RT-PCR | Microsomes | COCKTAIL PROBE DRUGS | IN-VITRO COCKTAIL | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | TANDEM MASS-SPECTROMETRY | INHIBITION | METABOLISM | ENDOCRINOLOGY & METABOLISM | SCHISANDRA-CHINENSIS | DRUG-DRUG INTERACTIONS | Tolbutamide - pharmacology | Liver - enzymology | Chlorzoxazone - metabolism | Pregnenolone - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - genetics | Dextromethorphan - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Microsomes, Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Caffeine - pharmacology | Cytochrome P450 Family 2 - genetics | Microsomes, Liver - enzymology | Tolbutamide - metabolism | Caffeine - metabolism | Dextromethorphan - pharmacology | Administration, Oral | Gene Expression Regulation | Rats | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Dapsone - metabolism | Animals | Pregnenolone - analogs & derivatives | Cytochrome P450 Family 2 - metabolism | Cytochrome P-450 CYP3A - metabolism | Chlorzoxazone - pharmacology | Hypolipidemic Agents - administration & dosage | Steroid 16-alpha-Hydroxylase - genetics | Dapsone - pharmacology | Hypolipidemic Agents - pharmacokinetics | Pregnenolone - administration & dosage | Physiological aspects | Enzymes | Liquid chromatography | Gastrointestinal agents | RNA | Mass spectrometry | Cytochrome P-450 | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1256 - 1264
textabstractAndrogen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might... 
XENOGRAFT MODELS | INCREASED EXPRESSION | ONCOLOGY | PATHWAY | IN-VIVO | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | AGGRESSIVENESS | RECEPTOR GENE | PROGRESSION | DIHYDROTESTOSTERONE | ANDROGEN DEPRIVATION THERAPY | Progesterone Reductase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neoplasms, Experimental - enzymology | Male | Transplantation, Heterologous | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Pregnenolone - metabolism | Neoplasms, Experimental - pathology | Testosterone - metabolism | Prostatic Neoplasms - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Neoplasms, Experimental - genetics | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Dihydrotestosterone - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Progesterone Reductase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Animals | Aldo-Keto Reductase Family 1 Member C3 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Steroid 17-alpha-Hydroxylase - genetics | Aged | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus
Journal Article
Reproduction, ISSN 1470-1626, 2017, Volume 154, Issue 4, pp. 445 - 454
Equine fetuses have substantial circulating pregnenolone concentrations and thus have been postulated to provide significant substrate for placental 5... 
PREGNANT MAMMALS | REPRODUCTIVE BIOLOGY | NEWBORN FOAL | STEROID-HORMONE TRANSFORMATIONS | MARE | PROGESTERONE | PREPARATIONS IN-VITRO | LATE-GESTATION | DEVELOPMENTAL BIOLOGY | EXPRESSION | MASS-SPECTROMETRY | ENDOCRINE ORGANS | Dehydroepiandrosterone - biosynthesis | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Testis - metabolism | Progesterone Reductase - metabolism | Gonadal Steroid Hormones - biosynthesis | Androstenedione - blood | Aromatase - metabolism | Multienzyme Complexes - metabolism | Male | Gonadal Steroid Hormones - blood | Adrenal Glands - embryology | Embryo, Mammalian - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Aromatase - genetics | Adrenal Cortex Hormones - biosynthesis | Testis - embryology | Gene Expression Regulation, Developmental | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Female | Steroid Isomerases - genetics | Pregnenolone - biosynthesis | Ovary - metabolism | Ovary - embryology | Steroid Isomerases - metabolism | Placenta - embryology | Dehydroepiandrosterone - blood | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | Gestational Age | Gene Expression Regulation, Enzymologic | Placenta - metabolism | Pregnancy | Animals | Pregnenolone - blood | Adrenal Glands - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Horses | Steroid 17-alpha-Hydroxylase - genetics | Steroid 17-alpha-Hydroxylase - metabolism | Adrenal Cortex Hormones - blood | Androstenedione - biosynthesis | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2016, Volume 44, Issue 7, pp. 1038 - 1049
xenobiotic-sensing transcription factors (xeno-sensors) AhR, CAR, and PXR upregulate the expression of many drug-processing genes (DPGs) in liver. Previous... 
MESSENGER-RNAS | ENZYME-INDUCTION | CYTOCHROMES P450 | TISSUE DISTRIBUTION | NUCLEAR RECEPTORS | PHARMACOLOGY & PHARMACY | CELL-PROLIFERATION | HEPATIC ONTOGENY | RNA-SEQUENCING QUANTIFICATION | PHASE-I | DEVELOPMENTAL EXPRESSION | Receptors, Steroid - metabolism | Age Factors | Cytochrome P-450 Enzyme System - metabolism | Male | RNA, Messenger - metabolism | Receptors, Steroid - agonists | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver - drug effects | Gene Expression Regulation, Developmental | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Animals, Newborn | Sulfotransferases - genetics | Basic Helix-Loop-Helix Transcription Factors - agonists | Organic Cation Transport Proteins - metabolism | Pregnenolone Carbonitrile - pharmacology | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | Gene Expression Profiling - methods | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Aryl Hydrocarbon - agonists | Gene Expression Regulation, Enzymologic | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | Ligands | Pyridines - pharmacology | Organic Cation Transport Proteins - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Special Section on Pediatric Drug Disposition and Pharmacokinetics
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 47, pp. 32952 - 32964
Journal Article