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Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 12/2005, Volume 94, Issue 6, pp. 4131 - 4144
The effects of pregnenolone sulfate (PREGS), a putative neurosteroid, on the transmission of perforant path–granule cell synapses were investigated with an... 
TRANSMITTER RELEASE | PHYSIOLOGY | GLUTAMATE RELEASE | CALCIUM-CHANNELS | LINKED-IMMUNOSORBENT-ASSAY | NICOTINIC ACETYLCHOLINE-RECEPTOR | INCREASES HIPPOCAMPAL ACETYLCHOLINE | RAT-BRAIN | ALPHA-BUNGAROTOXIN | AGED RATS | NEUROSCIENCES | METHYL-D-ASPARTATE | Excitatory Postsynaptic Potentials - radiation effects | Synaptic Transmission - physiology | Rats, Wistar | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Kainic Acid - analogs & derivatives | Male | Nicotinic Antagonists - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Drug Interactions | Time Factors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Pregnenolone - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Haloperidol - pharmacology | Nicotinic Agonists - pharmacology | Calcium - pharmacology | Presynaptic Terminals - drug effects | Kainic Acid - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Aconitine - analogs & derivatives | Bicuculline - pharmacology | Aconitine - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Ethylenediamines - pharmacology | GABA Antagonists - pharmacology | Animals | Benzylidene Compounds - pharmacology | Analysis of Variance | Dopamine Antagonists - pharmacology | Pyridines - pharmacology | In Vitro Techniques | Bungarotoxins - pharmacology
Journal Article
Pharmacopsychiatry, ISSN 0176-3679, 03/2015, Volume 48, Issue 2, pp. 72 - 77
Abstract Abstract Introduction: The treatment of anxiety disorders is still a challenge; novel pharmacological approaches that combine rapid anxiolytic... 
Original Paper | pregnenolone | TSPO ligands | benzodiazepines | anxiolytic | neurosteroids | TARGET | PSYCHIATRY | RECEPTOR | PHARMACOLOGY & PHARMACY | ETIFOXINE | MODULATION
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2010, Volume 112, Issue 3, pp. 784 - 796
J. Neurochem. (2010) 112, 784–796. The mechanisms of ethanol actions that produce its behavioral sequelae involve the synthesis of potent GABAergic neuroactive... 
ACTH | GABA | adrenal | brain | ethanol | neuroactive steroid | Brain | Neuroactive steroid | Ethanol | Adrenal | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSTEROIDS | KINASE-C | BENZODIAZEPINE-RECEPTOR | MITOCHONDRIAL CHOLESTEROL IMPORT | NEUROSCIENCES | ACUTE REGULATORY PROTEIN | ALCOHOL | ISOLATION-INDUCED INCREASE | NEUROACTIVE STEROID 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE | AXIS | Immunoprecipitation | Male | Pregnanolone - metabolism | Phosphoproteins - metabolism | Pregnenolone - metabolism | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Dexamethasone - pharmacology | Isoquinolines - pharmacology | Steroids - metabolism | Statistics, Nonparametric | Immunoglobulin G - pharmacology | Pregnenolone - pharmacology | Hypophysectomy - methods | Melphalan - pharmacology | Protein Synthesis Inhibitors - pharmacology | Adrenal Glands - drug effects | Adrenocorticotropic Hormone - blood | Rats | Imidazoles - pharmacology | Phosphoproteins - genetics | Rats, Sprague-Dawley | Cycloheximide - pharmacology | Brain - drug effects | Gene Expression Regulation - drug effects | Ethanol - pharmacology | GABA Agents - pharmacology | Animals | Pregnanolone - pharmacology | Glucocorticoids - pharmacology | Pyridines - pharmacology | Radioimmunoassay - methods | Medical colleges | Alcohol, Denatured | Metabolites | Alcoholism | Alcohol | Progesterone | Peptide hormones | Blood proteins | Endocrine system | Rodents | Steroids
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2005, Volume 25, Issue 9, pp. 2285 - 2294
Neurosteroids are produced de novo in neuronal and glial cells, which begin to express steroidogenic enzymes early in development. Studies suggest that... 
Steroid | Neurotransmitter | Release | Channel | Plasticity | Presynaptic | GLUTAMATE RELEASE | LINKED-IMMUNOSORBENT-ASSAY | release | presynaptic | PURKINJE-CELL | channel | plasticity | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | AMPA RECEPTORS | PREGNENOLONE SULFATE | REGIONAL EXPRESSION | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | neurotransmitter | steroid | METHYL-D-ASPARTATE | Electric Stimulation | Excitatory Postsynaptic Potentials - radiation effects | Age Factors | Calcium - metabolism | Neuronal Plasticity - drug effects | Membrane Potentials - radiation effects | Pregnenolone - immunology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Drug Interactions | Piperidines - pharmacology | Time Factors | Egtazic Acid - analogs & derivatives | Pregnenolone - pharmacology | Synaptic Transmission - drug effects | Tetrodotoxin - pharmacology | Animals, Newborn | Membrane Potentials - drug effects | Synapses - drug effects | Synapses - physiology | Rats | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Presynaptic Terminals - physiology | Chelating Agents - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Membrane Potentials - physiology | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | Antibodies - pharmacology | Animals | Egtazic Acid - pharmacology | Quinolinic Acids - pharmacology | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Dose-Response Relationship, Radiation | Development | Repair
Journal Article
Physiological Research, ISSN 0862-8408, 2014, Volume 63, pp. S191 - S203
Journal Article
Neuroscience, ISSN 0306-4522, 2010, Volume 171, Issue 1, pp. 106 - 116
Abstract Pregnenolone sulfate (PS) acts as an excitatory neuromodulator and has a variety of neuropharmacological actions, such as memory enhancement and... 
Neurology | Patch clamp | SEPSCs | Neurosteroids | Pregnenolone sulfate | Presynaptic facilitation | Hippocampus | patch clamp | hippocampus | neurosteroids | HIPPOCAMPAL MOSSY FIBER | SYNAPTIC-TRANSMISSION | CATION CHANNEL | sEPSCs | NEUROSCIENCES | TRANSMITTER RELEASE | NERVE-TERMINALS | RAT HIPPOCAMPUS | GAMMA-AMINOBUTYRIC-ACID | GABA(A) RECEPTORS | CALCIUM CURRENTS | presynaptic facilitation | pregnenolone sulfate | METHYL-D-ASPARTATE | Calcium - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Egtazic Acid - analogs & derivatives | Neurons - physiology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Pregnenolone - pharmacology | Tetrodotoxin - pharmacology | Cadmium Chloride - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Animals, Newborn | Calcium - pharmacology | Presynaptic Terminals - drug effects | Kainic Acid - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Biophysics | Chelating Agents - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Drug Interactions - physiology | Presynaptic Terminals - metabolism | Glutamic Acid - metabolism | In Vitro Techniques | Acetylcholine
Journal Article
European journal of pharmacology, ISSN 0014-2999, 10/2006, Volume 547, Issue 1-3, p. 37
GABA(A) receptors containing alpha(5)-subunit have an important role in cognitive function. As the agonistic effect of 3alpha-hydroxy ring-A reduced steroids... 
Pregnanediol - pharmacology | Androstane-3,17-diol - pharmacology | Rats, Wistar | Desoxycorticosterone - pharmacology | Male | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | RNA, Messenger - administration & dosage | GABA Modulators - pharmacology | Oocytes - drug effects | Pregnenolone - pharmacology | Female | Steroids - pharmacology | Protein Subunits - physiology | Protein Subunits - genetics | Membrane Potentials - drug effects | Microinjections | Oocytes - metabolism | RNA, Messenger - genetics | Xenopus laevis | Rats | gamma-Aminobutyric Acid - pharmacology | Pregnanes - pharmacology | Desoxycorticosterone - analogs & derivatives | GABA Antagonists - pharmacology | Animals | Oocytes - physiology | Receptors, GABA-A - genetics | GABA Agonists - pharmacology | Receptors, GABA-A - physiology | Pyridines - pharmacology | Patch-Clamp Techniques - instrumentation | Desoxycorticosterone/analogs & derivatives/pharmacology | Dose-Response Relationship; Drug | Pregnanediol/pharmacology | Steroids/pharmacology | Receptors; GABA-A/genetics/physiology | RNA; Messenger/administration & dosage/genetics | Membrane Potentials/drug effects | Protein Subunits/genetics/physiology | Oocytes/drug effects/metabolism/physiology | GABA Agonists/pharmacology | Rats; Wistar | Patch-Clamp Techniques/instrumentation/methods | Pregnenolone/pharmacology | Androstane-3;17-diol/pharmacology | GABA Modulators/pharmacology | Pregnanes/pharmacology | gamma-Aminobutyric Acid/pharmacology | GABA Antagonists/pharmacology | Pyridines/pharmacology
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 2008, Volume 89, Issue 2, pp. 171 - 178
AC-5216, a ligand for the translocator protein (18 kDa) (TSPO), previously called the peripheral benzodiazepine receptor (PBR), produces anxiolytic-like... 
AC-5216 | Finasteride | Anxiolytic effect | Translocator protein (18 kDa) (TSPO) | Social interaction | Neurosteroid | Trilostane | Mice | Picrotoxin | Mitochondrial benzodiazepine receptor (MBR) | Peripheral benzodiazepine receptor (PBR) | PROGESTERONE | PERIPHERAL BENZODIAZEPINE-RECEPTORS | ANTI-ANXIETY | CENTRAL NERVOUS-SYSTEM | mitochondrial benzodiazepine receptor (MBR) | mice | NEUROSCIENCES | peripheral benzodiazepine receptor (PBR) | anxiolytic effect | picrotoxin | NEUROACTIVE STEROIDS | translocator protein (18 kDa) (TSPO) | trilostane | PREGNENOLONE SYNTHESIS | BEHAVIOR TEST | social interaction | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | RAT-BRAIN | GABA(A) RECEPTORS | BINDING-SITES | finasteride | neurosteroid | Dihydrotestosterone - analogs & derivatives | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Anti-Anxiety Agents - pharmacology | Male | Diazepam - pharmacology | GABA Antagonists - pharmacology | Dose-Response Relationship, Drug | Animals | Anti-Anxiety Agents - antagonists & inhibitors | Pregnanolone - pharmacology | Finasteride - pharmacology | Receptors, GABA-A - drug effects | Picrotoxin - pharmacology | Purines - antagonists & inhibitors | Dihydrotestosterone - pharmacology | Interpersonal Relations | Progesterone - pharmacology | Enzymes | Analysis | Polybrominated biphenyls | GABA | Antiandrogens | Progesterone | Diazepam
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2016, Volume 36, Issue 34, pp. 8815 - 8825
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and... 
Docosahexaenoic acid | Palmitoylation | Carboxy terminal domain | AMPA | STRUCTURE PREDICTION SERVER | D-ASPARTATE RECEPTORS | carboxy terminal domain | FATTY-ACIDS | ARACHIDONIC-ACID | MOUSE CENTRAL NEURONS | NEUROSCIENCES | KAINATE RECEPTORS | docosahexaenoic acid | ION-CHANNEL | VOLTAGE-DEPENDENT BLOCK | PREGNENOLONE SULFATE | palmitoylation | Membrane Potentials - genetics | Calcium - metabolism | Humans | Green Fluorescent Proteins - genetics | Protein Domains - genetics | Recombinant Fusion Proteins - metabolism | Pregnenolone | Protein Subunits - metabolism | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Protein Domains - physiology | Transfection | Receptors, N-Methyl-D-Aspartate - chemistry | Excitatory Amino Acid Agents - pharmacology | HEK293 Cells | Dimerization | Protein Subunits - genetics | Allosteric Regulation - drug effects | Membrane Potentials - drug effects | Green Fluorescent Proteins - metabolism | Allosteric Regulation - genetics | Kainic Acid - pharmacology | Models, Molecular | Rats | Excitatory Amino Acid Agonists - pharmacology | Protein Structure, Tertiary - genetics | Membrane Potentials - physiology | Hydroxycholesterols - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Docosahexaenoic Acids - pharmacology | Patch-Clamp Techniques | Animals | Arachidonic Acid - pharmacology | Recombinant Fusion Proteins - genetics | Protein Structure, Tertiary - drug effects
Journal Article
Journal Article