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Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38734
Pregnane X receptor (PXR) is known to function as a xenobiotic sensor to regulate xenobiotic metabolism through selective transcription of genes responsible... 
CROSS-TALK | MOUSE STRAINS | METABOLISM | GENE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | PPAR-GAMMA | BROWN ADIPOSE-TISSUE | PXR | EXPRESSION | NUCLEAR RECEPTOR | Glucose-6-Phosphatase - genetics | Receptors, Steroid - metabolism | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Pregnenolone Carbonitrile - administration & dosage | Adipocytes - cytology | Male | Insulin - blood | Receptors, Steroid - agonists | Liver - drug effects | Lipid Metabolism - genetics | Obesity - etiology | Glucose Tolerance Test | Adiposity - drug effects | Pregnenolone Carbonitrile - pharmacology | Liver - metabolism | Insulin Resistance | Protein-Serine-Threonine Kinases - genetics | Obesity - metabolism | Gene Expression Regulation - drug effects | Animals | Adipocytes - metabolism | Obesity - prevention & control | Lipid Metabolism - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Adipose Tissue, White - drug effects | Mice, Inbred AKR | Cytochrome | Energy metabolism | Adipose tissue | Transcription | Growth rate | Pathogenesis | Liver | Genes | Homeostasis | Lipids | Activation | Glucose | Phosphatase | Pregnenolone | High fat diet | ABCA1 protein | Energy | Metabolites | Rodents | Transcription activation | Animal tissues | Sterol regulatory element-binding protein | Lipid metabolism | Adipose tissue (brown) | Lipogenesis | Gluconeogenesis | Obesity | Polypeptides | Inflammation | CD36 antigen | Metabolism | Gene expression | Insulin | Fatty acids | Polymerase chain reaction | Energy balance | Musculoskeletal system | Thermogenesis | Pharmacy | Fatty acid-binding protein | Ligands | Insulin resistance | ATP-binding protein | Diabetes | Pharmaceuticals
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e16703
The nuclear receptor superfamily of ligand-activated transcription factors plays a central role in the regulation of cellular responses to chemical challenge.... 
OXIDATIVE STRESS | HUMAN HEPATOCYTES | CONSTITUTIVE ANDROSTANE RECEPTOR | NUCLEAR RECEPTORS | BIOLOGY | GENE-EXPRESSION | INTERACTION NETWORKS | LITHOCHOLIC ACID | PREGNANE-X-RECEPTOR | TRANSCRIPTIONAL REGULATION | MICROARRAY DATA | Gene Expression Regulation, Enzymologic - drug effects | Receptors, Steroid - metabolism | Pregnenolone Carbonitrile - pharmacology | Cells, Cultured | Rats | Gene Expression Profiling | Hepatocytes - metabolism | Down-Regulation - drug effects | Receptors, Steroid - agonists | Rats, Sprague-Dawley | Xenobiotics - pharmacology | Dose-Response Relationship, Drug | Animals | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Microarray Analysis | Models, Biological | Receptors, Steroid - physiology | Feedback, Physiological - drug effects | Feedback, Physiological - physiology | Hepatocytes - drug effects | Hepatocytes - physiology | Cluster Analysis | Hepatocytes - enzymology | Transcription factors | Phosphorylation | Genes | Homeostasis | Activation | Feedback loops | Genomes | Biology | Receptors | Toxicology | Negative feedback | Activated carbon | Rodents | Transcription activation | Xenobiotics | Bioinformatics | Deoxyribonucleic acid--DNA | Enzymes | Pharmacology | Metabolism | Gene expression | Nuclear receptors | Chemicals | DNA microarrays | Hepatocytes | Simulation | Ligands | Genetic engineering | Vitamin D receptors | Bile | Deoxyribonucleic acid | DNA
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 636, Issue 1, pp. 145 - 154
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2001, Volume 98, Issue 6, pp. 3369 - 3374
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2016, Volume 44, Issue 7, pp. 1038 - 1049
xenobiotic-sensing transcription factors (xeno-sensors) AhR, CAR, and PXR upregulate the expression of many drug-processing genes (DPGs) in liver. Previous... 
CYTOCHROME-P450 3A | ENZYME-INDUCTION | METABOLISM | TRANSPORTERS | TISSUE DISTRIBUTION | RECEPTOR | PHARMACOLOGY & PHARMACY | HEPATIC ONTOGENY | RNA-SEQUENCING QUANTIFICATION | PHASE-I | DEVELOPMENTAL EXPRESSION | Receptors, Steroid - metabolism | Age Factors | Cytochrome P-450 Enzyme System - metabolism | Male | RNA, Messenger - metabolism | Receptors, Steroid - agonists | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver - drug effects | Gene Expression Regulation, Developmental | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Animals, Newborn | Sulfotransferases - genetics | Basic Helix-Loop-Helix Transcription Factors - agonists | Organic Cation Transport Proteins - metabolism | Pregnenolone Carbonitrile - pharmacology | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | Gene Expression Profiling - methods | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Aryl Hydrocarbon - agonists | Gene Expression Regulation, Enzymologic | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | Ligands | Pyridines - pharmacology | Organic Cation Transport Proteins - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Special Section on Pediatric Drug Disposition and Pharmacokinetics
Journal Article
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2016, Volume 1859, Issue 9, pp. 1198 - 1217
Journal Article