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Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 728 - 739
The t(8;21) rearrangement, which creates the AML1-ETO fusion protein, represents the most common chromosomal translocation in acute myeloid leukemia (AML).... 
MUTATED C-CBL | CANCER GENOMICS | ONCOLOGY | T(8/21) AML | HEMATOPOIETIC STEM-CELLS | MOUSE MODEL | JUVENILE MYELOMONOCYTIC LEUKEMIA | ACQUIRED UNIPARENTAL DISOMY | SELF-RENEWAL | MYELOPROLIFERATIVE NEOPLASMS | HEMATOLOGY | TYROSINE-PHOSPHATASE | Myeloid Cells - cytology | RNA, Small Interfering - genetics | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Proto-Oncogene Proteins c-cbl - metabolism | Cell Proliferation | Humans | Leukemia, Myeloid, Acute - metabolism | Preleukemia - pathology | MicroRNAs - metabolism | Protein Tyrosine Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein Tyrosine Phosphatases - genetics | Heterografts | Preleukemia - genetics | src-Family Kinases - metabolism | Myeloid Cells - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Transgenes | Chromosomes, Human, Pair 21 | Proto-Oncogene Proteins c-cbl - genetics | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Chromosomes, Human, Pair 8 | Thrombopoietin - pharmacology | Fetal Blood - cytology | Gene Expression Regulation, Leukemic | Fetal Blood - drug effects | Fetal Blood - metabolism | Mice, SCID | RUNX1 Translocation Partner 1 Protein | Preleukemia - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Myeloid Cells - metabolism | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Mice | MicroRNAs - genetics | src-Family Kinases - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | RNA, Small Interfering - metabolism | Molecular targeted therapy | Gene mutations | Translocation (Genetics) | Health aspects | Innovations | Index Medicus | AML1-ETO | miR-9 | UBASH3B | acute myeloid leukemia | CBL | Sts-1
Journal Article
Blood, ISSN 0006-4971, 07/2012, Volume 120, Issue 4, pp. 709 - 719
AML1-ETO (AE) is a fusion product of translocation (8;21) that accounts for 40% of M2 type acute myeloid leukemia (AML). In addition to its role in promoting... 
MURINE MODEL | DEFINITIVE HEMATOPOIESIS | PROTEIN | NUCLEAR | BCL-XL | HEMATOPOIETIC STEM-CELLS | GENE-EXPRESSION | C-MPL | ACUTE MYELOID-LEUKEMIA | DIFFERENTIATION | HEMATOLOGY | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Humans | Leukemia, Myeloid, Acute - metabolism | Fetus - metabolism | Preleukemia - pathology | bcl-X Protein - genetics | Gene Expression Profiling | Immunoenzyme Techniques | Flow Cytometry | Biomarkers, Tumor - metabolism | Cell Differentiation | Real-Time Polymerase Chain Reaction | Thrombopoietin - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Fetal Blood - cytology | Fetal Blood - metabolism | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Thrombopoietin - metabolism | Blotting, Western | Fetus - cytology | RUNX1 Translocation Partner 1 Protein | Preleukemia - metabolism | Receptors, Thrombopoietin - genetics | Thrombopoietin - genetics | Animals | Cell Cycle | Oncogene Proteins, Fusion - genetics | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Liver - cytology | Mice | bcl-X Protein - metabolism | Core Binding Factor Alpha 2 Subunit - genetics | Apoptosis | Leukemia, Myeloid, Acute - genetics | Index Medicus | Abridged Index Medicus | Plenary Paper | Myeloid Neoplasia
Journal Article
Science, ISSN 0036-8075, 8/2011, Volume 333, Issue 6043, pp. 765 - 769
The chromosomal translocations found in acute myelogenous leukemia (AML) generate oncogenic fusion transcription factors with aberrant transcriptional... 
Cell growth | Myeloid leukemia | Leukemia | Genes | REPORTS | Antibodies | Histones | Amino acids | Acetylation | Leukocytes | Cells | DNA-BINDING | DOMAIN | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | T(8/21) | TRANSCRIPTION | FUSION PROTEIN | MYELOID-LEUKEMIA | SELF-RENEWAL | DIFFERENTIATION | INHIBITOR | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Transcriptional Activation | Preleukemia - pathology | E1A-Associated p300 Protein - metabolism | Gene Expression Profiling | Oncogene Proteins, Fusion - chemistry | Core Binding Factor Alpha 2 Subunit - chemistry | E1A-Associated p300 Protein - antagonists & inhibitors | Hematopoietic Stem Cells - physiology | Lysine - metabolism | Protein Interaction Domains and Motifs | Tumor Cells, Cultured | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Mutant Proteins - metabolism | Fetal Blood - cytology | RUNX1 Translocation Partner 1 Protein | Preleukemia - metabolism | Animals | Cell Transformation, Neoplastic | Hematopoietic Stem Cells - cytology | Cell Line, Tumor | Protein Binding | Mice | Protein Processing, Post-Translational | Genetic aspects | Research | Lysine | Health aspects | Cancer cells | Proteins | Biochemistry | Cellular biology | Chromosomes | Rope | Mathematical models | Transformations | Leukemias | Blood | Index Medicus
Journal Article
Journal Article
Journal Article
Annals of Hematology, ISSN 0939-5555, 8/2012, Volume 91, Issue 8, pp. 1221 - 1233
Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but... 
Score | Prognosis | Medicine & Public Health | Hematology | Splicing | Oncology | Gene expression | MDS | AML | RING SIDEROBLASTS | PROFILES | NORMAL CYTOGENETICS | RISK | ACUTE MYELOID-LEUKEMIA | DNMT3A MUTATIONS | GENE | HEMATOPOIETIC STEM-CELLS | GROUP-B | HEMATOLOGY | Transcriptional Regulator ERG | Predictive Value of Tests | Humans | Leukemia, Myeloid, Acute - metabolism | Middle Aged | Male | Gene Expression Profiling | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Proto-Oncogenes - genetics | Cell Transformation, Neoplastic - genetics | Preleukemia - genetics | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Aged, 80 and over | Adult | Female | Neoplasm Proteins - genetics | Gene Expression | Myelodysplastic Syndromes - metabolism | Tumor Suppressor Proteins - metabolism | Preleukemia - diagnosis | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Disease Progression | Transcription Factors - metabolism | Preleukemia - metabolism | Myelodysplastic Syndromes - diagnosis | Leukemia, Myeloid, Acute - diagnosis | Validation Studies as Topic | Myelodysplastic Syndromes - mortality | Trans-Activators - metabolism | Aged | Myelodysplastic Syndromes - genetics | MDS1 and EVI1 Complex Locus Protein | Cohort Studies | Leukemia, Myeloid, Acute - genetics | Medical colleges | Care and treatment | Leukemia | Oncology, Experimental | Genes | Transplantation | Research | Myelodysplastic syndromes | Anopheles | Analysis | Stem cells | Cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2010, Volume 327, Issue 5967, pp. 879 - 883
The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy... 
Transcription factors | Thymocytes | Transgenic animals | Acute T cell leukemia | Genes | Leukemia | Reports | Mice | Progenitor cells | Hematopoietic stem cells | Oncogenes | CHROMOSOMAL TRANSLOCATIONS | ACTIVATION | HEMATOPOIESIS | SCID-X1 | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | TRANSCRIPTION | T-CELL LEUKEMIA | GENE-THERAPY | PROTEIN RBTN2 | RETROVIRAL INSERTION | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | T-Lymphocytes - physiology | Up-Regulation | Oligonucleotide Array Sequence Analysis | Humans | Preleukemia - pathology | Gene Expression Profiling | T-Lymphocytes - transplantation | DNA-Binding Proteins - metabolism | Metalloproteins - metabolism | Cell Transformation, Neoplastic - genetics | Preleukemia - genetics | Metalloproteins - genetics | Thymus Gland - pathology | Transcription, Genetic | Cell Differentiation | Proto-Oncogene Proteins | Thymus Gland - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | T-Lymphocyte Subsets | Precursor Cells, T-Lymphoid - physiology | LIM Domain Proteins | Down-Regulation | Mice, Transgenic | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Preleukemia - metabolism | Adaptor Proteins, Signal Transducing | Animals | Precursor Cells, T-Lymphoid - transplantation | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Development and progression | Thymoma | Properties | Cancer cells | Mutation | Cellular biology | Gene expression | Lymphocytes | Rodents | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 01/2013, Volume 121, Issue 1, pp. 178 - 187
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2008, Volume 319, Issue 5861, pp. 336 - 339
Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they... 
Medical research | Cord blood | B lymphocytes | Blood cells | Leukemia | Stem cells | Childhood | Bone marrow | Reports | Twins | Blood | STEM-CELLS | LESSONS | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | ADP-ribosyl Cyclase 1 - analysis | Neoplasm Transplantation | Antigens, CD34 - analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Diseases in Twins - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Preleukemia - pathology | Child, Preschool | Male | Transplantation, Heterologous | Core Binding Factor Alpha 2 Subunit - analysis | Core Binding Factor Alpha 2 Subunit - physiology | Oncogene Proteins, Fusion - analysis | Oncogene Proteins, Fusion - physiology | Preleukemia - genetics | Recombination, Genetic | Bone Marrow Transplantation | Neoplastic Stem Cells - pathology | Female | Acute Disease | Antigens, CD19 - analysis | Fetal Blood - transplantation | Mice, SCID | Twins, Monozygotic | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Preleukemia - metabolism | Animals | Gene Rearrangement, B-Lymphocyte, Heavy Chain | Oncogene Proteins, Fusion - genetics | Diseases in Twins - metabolism | Precursor Cells, B-Lymphoid - chemistry | Mice, Inbred NOD | Mice | Precursor Cells, B-Lymphoid - physiology | Core Binding Factor Alpha 2 Subunit - genetics | Diseases in Twins - pathology | Apoptosis | Genetic aspects | Research | Lymphocytic leukemia | Carcinogenesis | Leukemia in children | Biomedical research | Cellular biology | Rodents | Genetics | Mutation | Children & youth | Index Medicus
Journal Article