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Science Translational Medicine, ISSN 1946-6234, 08/2012, Volume 4, Issue 149, pp. 149ra118 - 149ra118
Journal Article
Science, ISSN 0036-8075, 1/2008, Volume 319, Issue 5861, pp. 336 - 339
Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they... 
Medical research | Cord blood | B lymphocytes | Blood cells | Leukemia | Stem cells | Childhood | Bone marrow | Reports | Twins | Blood | STEM-CELLS | LESSONS | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | ADP-ribosyl Cyclase 1 - analysis | Neoplasm Transplantation | Antigens, CD34 - analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Diseases in Twins - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Preleukemia - pathology | Child, Preschool | Male | Transplantation, Heterologous | Core Binding Factor Alpha 2 Subunit - analysis | Core Binding Factor Alpha 2 Subunit - physiology | Oncogene Proteins, Fusion - analysis | Oncogene Proteins, Fusion - physiology | Preleukemia - genetics | Recombination, Genetic | Bone Marrow Transplantation | Neoplastic Stem Cells - pathology | Female | Acute Disease | Antigens, CD19 - analysis | Fetal Blood - transplantation | Mice, SCID | Twins, Monozygotic | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Preleukemia - metabolism | Animals | Gene Rearrangement, B-Lymphocyte, Heavy Chain | Oncogene Proteins, Fusion - genetics | Diseases in Twins - metabolism | Precursor Cells, B-Lymphoid - chemistry | Mice, Inbred NOD | Mice | Precursor Cells, B-Lymphoid - physiology | Core Binding Factor Alpha 2 Subunit - genetics | Diseases in Twins - pathology | Apoptosis | Genetic aspects | Research | Lymphocytic leukemia | Carcinogenesis | Leukemia in children | Biomedical research | Cellular biology | Rodents | Genetics | Mutation | Children & youth | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 24, pp. 3908 - 3917
Journal Article
Science, ISSN 0036-8075, 2/2010, Volume 327, Issue 5967, pp. 879 - 883
The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy... 
Transcription factors | Thymocytes | Transgenic animals | Acute T cell leukemia | Genes | Leukemia | Reports | Mice | Progenitor cells | Hematopoietic stem cells | Oncogenes | CHROMOSOMAL TRANSLOCATIONS | ACTIVATION | HEMATOPOIESIS | SCID-X1 | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | TRANSCRIPTION | T-CELL LEUKEMIA | GENE-THERAPY | PROTEIN RBTN2 | RETROVIRAL INSERTION | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | T-Lymphocytes - physiology | Up-Regulation | Oligonucleotide Array Sequence Analysis | Humans | Preleukemia - pathology | Gene Expression Profiling | T-Lymphocytes - transplantation | DNA-Binding Proteins - metabolism | Metalloproteins - metabolism | Cell Transformation, Neoplastic - genetics | Preleukemia - genetics | Metalloproteins - genetics | Thymus Gland - pathology | Transcription, Genetic | Cell Differentiation | Proto-Oncogene Proteins | Thymus Gland - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | T-Lymphocyte Subsets | Precursor Cells, T-Lymphoid - physiology | LIM Domain Proteins | Down-Regulation | Mice, Transgenic | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Preleukemia - metabolism | Adaptor Proteins, Signal Transducing | Animals | Precursor Cells, T-Lymphoid - transplantation | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Development and progression | Thymoma | Properties | Cancer cells | Mutation | Cellular biology | Gene expression | Lymphocytes | Rodents | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 05/2013, Volume 121, Issue 21, pp. 4377 - 4387
Journal Article
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 8/2011, Volume 333, Issue 6043, pp. 765 - 769
The chromosomal translocations found in acute myelogenous leukemia (AML) generate oncogenic fusion transcription factors with aberrant transcriptional... 
Cell growth | Myeloid leukemia | Leukemia | Genes | REPORTS | Antibodies | Histones | Amino acids | Acetylation | Leukocytes | Cells | DNA-BINDING | DOMAIN | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | T(8/21) | TRANSCRIPTION | FUSION PROTEIN | MYELOID-LEUKEMIA | SELF-RENEWAL | DIFFERENTIATION | INHIBITOR | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Transcriptional Activation | Preleukemia - pathology | E1A-Associated p300 Protein - metabolism | Gene Expression Profiling | Oncogene Proteins, Fusion - chemistry | Core Binding Factor Alpha 2 Subunit - chemistry | E1A-Associated p300 Protein - antagonists & inhibitors | Hematopoietic Stem Cells - physiology | Lysine - metabolism | Protein Interaction Domains and Motifs | Tumor Cells, Cultured | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Mutant Proteins - metabolism | Fetal Blood - cytology | RUNX1 Translocation Partner 1 Protein | Preleukemia - metabolism | Animals | Cell Transformation, Neoplastic | Hematopoietic Stem Cells - cytology | Cell Line, Tumor | Protein Binding | Mice | Protein Processing, Post-Translational | Genetic aspects | Research | Lysine | Health aspects | Cancer cells | Proteins | Biochemistry | Cellular biology | Chromosomes | Rope | Mathematical models | Transformations | Leukemias | Blood | Index Medicus
Journal Article