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PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e73404
Hepatic immune regulation is associated with the progression from simple steatosis to non-alcoholic steatohepatitis, a severe condition of inflamed fatty... 
OBESITY | TRYPTOPHAN-METABOLISM | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | REGULATORY T-CELLS | NONALCOHOLIC STEATOHEPATITIS | PRENEOPLASTIC LESIONS | LIVER-DISEASE | UP-REGULATION | CRYPTOGENIC CIRRHOSIS | ADIPOSE-TISSUE | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Inflammation - pathology | Liver Cirrhosis - immunology | Liver - pathology | Fatty Liver - pathology | Diet, High-Fat - adverse effects | Male | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Liver - immunology | Non-alcoholic Fatty Liver Disease | Liver Cirrhosis - genetics | Fatty Liver - genetics | Liver Cirrhosis - etiology | Interleukin-6 - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Inflammation - immunology | Inflammation - etiology | Mice, Knockout | Animals | Fatty Liver - immunology | Inflammation - genetics | Liver Cirrhosis - pathology | Mice | Fatty Liver - etiology | Enzymes | Liver diseases | Diet | RNA | Analysis | Liver | Tryptophan | Genetic engineering | Inflammation | Transforming growth factors | T cells | Oxidative stress | Adipose tissue | Hydroxyproline | Cytotoxicity | Tryptophan 2,3-dioxygenase | Lymphocytes T | mRNA | Macrophages | High fat diet | Interleukin 6 | Hepatitis | Fatty liver | Lymphocytes | Rodents | Hepatology | L-Tryptophan | Tumor necrosis factor-TNF | University graduates | Medical research | Obesity | Internal medicine | Immunoregulation | Triglycerides | Tumor necrosis factor-α | Gene expression | Carbon | Steatosis | Medicine | Gene silencing | γ-Interferon | Fibrosis | Catabolism | Infiltration | Gastrointestinal surgery | Clinical medicine | Laboratory animals
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 61, Issue 5, pp. 1088 - 1096
Background & Aims Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which... 
Gastroenterology and Hepatology | Preneoplastic stages | HCC | Verteporfin | TCPOBOP | Hippo pathway | YES-ASSOCIATED PROTEIN | RAT | ORGAN SIZE CONTROL | REGENERATION | CELL-PROLIFERATION | LESIONS | CARCINOGENESIS | PATHWAY | HEPATOCELLULAR-CARCINOMA DEVELOPMENT | GASTROENTEROLOGY & HEPATOLOGY | TUMORIGENESIS | Adenoma, Liver Cell - drug therapy | Precancerous Conditions - etiology | Adenoma, Liver Cell - etiology | Humans | Middle Aged | Rats, Inbred F344 | Male | MicroRNAs - metabolism | Precancerous Conditions - metabolism | Phosphoproteins - metabolism | Liver Neoplasms - etiology | Precancerous Conditions - drug therapy | Young Adult | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Apoptosis Regulatory Proteins - genetics | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - etiology | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Signal Transduction | Adenoma, Liver Cell - metabolism | Liver Neoplasms - drug therapy | Rats | Porphyrins - pharmacology | Liver Neoplasms, Experimental - etiology | Apoptosis Regulatory Proteins - metabolism | Animals | Liver Neoplasms, Experimental - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Liver Neoplasms - metabolism | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Liver cancer | Health aspects | Index Medicus
Journal Article
2005, Medical clinics of North America, ISBN 1416027238, Volume 89, no. 2., xiv p., p. [219]-418
Book
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2011, Volume 300, Issue 6, pp. 1094 - 1104
Angiotensin II type I receptor blocker and iron chelator reportedly exert suppressive effects on nonalcoholic steatohepatitis (NASH) progression, including... 
Angiogenesis | Oxidative stress | Hepatic stellate cells | Vascular endothelial growth factor | CONVERTING ENZYME-INHIBITOR | hepatic stellate cells | FIBROSIS DEVELOPMENT | PHYSIOLOGY | OXIDATIVE DNA-DAMAGE | angiogenesis | FATTY LIVER-DISEASE | ACID-DEFINED DIET | AMINO-ACID | HEPATOCELLULAR-CARCINOMA | vascular endothelial growth factor | INSULIN-RESISTANCE | GASTROENTEROLOGY & HEPATOLOGY | ALTERED PRENEOPLASTIC LESIONS | oxidative stress | ENDOTHELIAL GROWTH-FACTOR | Triazoles - administration & dosage | Fatty Liver - pathology | Carcinoma, Hepatocellular - prevention & control | Rats, Inbred F344 | Transforming Growth Factor beta1 - metabolism | Liver Cirrhosis, Experimental - etiology | Hepatic Stellate Cells - metabolism | Choline Deficiency - complications | Male | Liver Neoplasms, Experimental - prevention & control | Neovascularization, Pathologic - etiology | Liver Cirrhosis, Experimental - prevention & control | Liver Neoplasms, Experimental - metabolism | Angiogenesis Inhibitors - administration & dosage | Time Factors | Non-alcoholic Fatty Liver Disease | Neovascularization, Pathologic - prevention & control | Carcinoma, Hepatocellular - etiology | Iron Chelating Agents - administration & dosage | Drug Therapy, Combination | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Hepatic Stellate Cells - drug effects | Fatty Liver - metabolism | Angiotensin II - metabolism | Administration, Oral | Cells, Cultured | Rats | Disease Progression | Fatty Liver - drug therapy | Liver Neoplasms, Experimental - etiology | Benzoates - administration & dosage | Animals | Antioxidants - administration & dosage | Cell Proliferation - drug effects | Losartan - administration & dosage | Oxidative Stress - drug effects | Liver Cirrhosis, Experimental - metabolism | Carcinoma, Hepatocellular - metabolism | Fatty Liver - etiology | Prevention | Angiotensin | Iron in the body | Properties | Health aspects | Chelates | Enterovirus diseases
Journal Article
Journal Article
Archives of Toxicology, ISSN 0340-5761, 1/2018, Volume 92, Issue 1, pp. 83 - 119
A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome... 
Biomedicine, general | Liver cancer | Oxidative stress | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Human relevancy framework | NF-kB | Peroxisome proliferator-activated receptor α (PPARα) | Key events | Pharmacology/Toxicology | Mode of action | HEPATIC PEROXISOME PROLIFERATION | TRANSFERASE TRANSPEPTIDASE ACTIVITY | PROLIFERATOR-ACTIVATED-RECEPTOR | CIPROFIBRATE-INDUCED HEPATOCARCINOGENESIS | MOUSE HEPATOCYTE APOPTOSIS | CONSTITUTIVE ANDROSTANE RECEPTOR | Peroxisome proliferator-activated receptor alpha (PPAR alpha) | PUTATIVE PRENEOPLASTIC CELLS | TOXICOLOGY | ACYL-COA OXIDASE | RETINOID-X-RECEPTOR | NF-KAPPA-B | Guinea Pigs | Species Specificity | Apoptosis - drug effects | Humans | Liver - metabolism | Oxidative Stress - physiology | Rodentia | Liver Neoplasms - chemically induced | Macaca fascicularis | Hepatocytes - pathology | Hepatocytes - metabolism | Adverse Outcome Pathways | Dose-Response Relationship, Drug | Animals | Liver - drug effects | Liver Neoplasms - metabolism | Diethylhexyl Phthalate - toxicity | Liver Neoplasms - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | PPAR alpha - metabolism | Hepatocytes - drug effects | NF-κB protein | Cell survival | Toxicity | Liver | Rats | Hepatocellular carcinoma | Activation | Pharmacology | Monkeys | Chemical compounds | Hamsters | Neoplasms | Cell activation | Cell growth | Pathways | Hepatocytes | Guinea pigs | Rodents | Tumors | Cancer | human relevancy framework | mode of action | key events | liver cancer | peroxisome proliferator-activated receptor α (PPARα) | oxidative stress
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2004, Volume 315, Issue 1, pp. 187 - 195
Non-alcoholic steatohepatitis (NASH) may progress to liver cirrhosis, and NASH patients with liver cirrhosis have a risk of development of hepatocellular... 
Hepatic stellate cell | Non-alcoholic steatohepatitis | Preneoplastic lesion | Peroxisome proliferator-activated receptor-γ | Fibrosis | MATRIX | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | STELLATE CELLS | NONALCOHOLIC STEATOHEPATITIS | PROLIFERATION | preneoplastic lesion | GAMMA LIGAND ROSIGLITAZONE | NATURAL-HISTORY | HEPATOCELLULAR-CARCINOMA | peroxisome proliferator-activated receptor-gamma | BIOPHYSICS | hepatic stellate cell | fibrosis | THIAZOLIDINEDIONES | non-alcoholic steatohepatitis | Immunohistochemistry | Liver - pathology | Body Weight | Rats, Wistar | Choline Deficiency - complications | Male | Liver Cirrhosis, Experimental - prevention & control | RNA, Messenger - biosynthesis | Liver - drug effects | Liver Cirrhosis, Experimental - pathology | Thiazolidinediones - pharmacology | Fatty Liver - metabolism | Liver - metabolism | Fatty Liver - prevention & control | Organ Size | Rats | Procollagen - metabolism | Biomarkers - blood | Muscle, Smooth - metabolism | Amino Acids | Tissue Inhibitor of Metalloproteinases - metabolism | Triglycerides - metabolism | Glutathione Transferase - biosynthesis | Animals | Matrix Metalloproteinases - metabolism | Liver Cirrhosis, Experimental - metabolism | Animal Feed | Fatty Liver - etiology | Prevention | Enzymes | RNA | Collagen | Choline | Amino acids | Liver cirrhosis
Journal Article
Toxicological Sciences, ISSN 1096-6080, 01/2015, Volume 143, Issue 1, pp. 6 - 15
Journal Article
BMC Genomics, ISSN 1471-2164, 10/2008, Volume 9, Issue 1, pp. 487 - 487
Background: Dichlorodiphenyltrichloroethane (DDT) is a persistent estrogenic organochlorine pesticide that is a rodent hepatic tumor promoter, with... 
CELLS | DETOXIFICATION | IN-VITRO | CAR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | ESTROGEN | MICE | PRENEOPLASTIC LESIONS | INDUCTION | PREGNANE-X-RECEPTOR | Receptors, Estrogen - metabolism | Receptors, Steroid - metabolism | Oligonucleotide Array Sequence Analysis | Species Specificity | Androstenedione - blood | Gene Expression Profiling | Transcription Factors - drug effects | Dichlorodiphenyl Dichloroethylene - metabolism | Liver - drug effects | Dichlorodiphenyl Dichloroethylene - toxicity | Female | Receptors, Estrogen - genetics | Receptors, Cytoplasmic and Nuclear - drug effects | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Rats | Receptors, Steroid - drug effects | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Dehydroepiandrosterone Sulfate - blood | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Transcription Factors - metabolism | Receptors, Estrogen - drug effects | Animals | Insecticides - metabolism | Receptors, Steroid - genetics | Steroid 17-alpha-Hydroxylase - genetics | Mice | Steroid 17-alpha-Hydroxylase - drug effects | Steroid 17-alpha-Hydroxylase - metabolism | Insecticides - toxicity | Cluster Analysis | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Liver tumors | Genetic aspects | Research | DDT (Insecticide) | Genetic regulation | Health aspects | Risk factors | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 08/2019, Volume 308, pp. 377 - 384
Among the primary neoplasias that affect the liver, hepatocellular carcinoma (HCC) is the most frequent and the third leading cause of death related to cancer.... 
NAFLD | Hepatocarcinogenesis | Isoprenoids and beta-ionone | Chemoprevention | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | MODEL | CANCER | HEPATOCELLULAR-CARCINOMA | CARCINOGENESIS | ANTIOXIDANT STATUS | PHARMACOLOGY & PHARMACY | STEATOHEPATITIS | TOXICOLOGY | PRENEOPLASTIC LESIONS | NF-KAPPA-B
Journal Article