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Journal of Periodontology, ISSN 0022-3492, 08/2013, Volume 84, Issue 8, pp. 1145 - 1157
Background: Simvastatin is a cholesterol‐lowering drug whose pleiotropic effects may have a therapeutic impact on bone. This study evaluates the effect of... 
hydroxymethylglutaryl‐CoA reductase inhibitors | inflammation | Alveolar bone loss | periodontitis | Inflammation | Hydroxymethylglutaryl-CoA reductase inhibitors | Periodontitis | OVARIECTOMIZED RATS | STATINS | IN-VITRO | METABOLISM | DENTISTRY, ORAL SURGERY & MEDICINE | NITRIC-OXIDE | hydroxymethylglutaryl-CoA reductase inhibitors | MEVALONATE PATHWAY | KAPPA-B LIGAND | PROTEIN PRENYLATION | Interleukin-1beta - drug effects | Simvastatin - therapeutic use | Bone Morphogenetic Protein 2 - drug effects | Rats, Wistar | Matrix Metalloproteinase 8 - drug effects | Alveolar Bone Loss - prevention & control | Receptor Activator of Nuclear Factor-kappa B - drug effects | RANK Ligand - drug effects | Malondialdehyde - analysis | Alanine Transaminase - drug effects | Gingiva - drug effects | Glutathione - drug effects | Anti-Inflammatory Agents - therapeutic use | Female | Osteoprotegerin - drug effects | Interleukin-10 - analysis | Nitrates - analysis | Peroxidase - drug effects | Matrix Metalloproteinase 1 - drug effects | Nitric Oxide Synthase Type II - drug effects | Rats | Aspartate Aminotransferases - drug effects | Alkaline Phosphatase - drug effects | Periodontitis - prevention & control | Antioxidants - therapeutic use | Animals | Tumor Necrosis Factor-alpha - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Nitrites - analysis | Oxidative Stress - drug effects
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2013, Volume 497, Issue 7451, pp. 638 - 642
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e60975
Durable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death.... 
ADAPTIVE IMMUNITY | BISPHOSPHONATES | ACTIVATION | MEDIATED DRUG-RESISTANCE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | ANTITUMOR-ACTIVITY | EXPRESSION | CHEMOTHERAPY | MODULATION | P-GLYCOPROTEIN | Prenylation - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cell Death - immunology | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Terpenes - metabolism | rho-Associated Kinases - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - drug effects | Cell Death - drug effects | Dendritic Cells - metabolism | Phagocytosis - drug effects | Imidazoles - pharmacology | Down-Regulation - drug effects | Mevalonic Acid - metabolism | Signal Transduction - drug effects | Models, Biological | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Cholesterol - biosynthesis | Diphosphonates - pharmacology | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Drug resistance in microorganisms | Anthracyclines | Immune response | Dendritic cells | Biochemistry | T cells | Investigations | Prevention | Chemotherapy | Cell death | Cancer cells | Health aspects | Cancer | Drugs | Toxicity | CD8 antigen | Lung cancer | Cytotoxicity | Oncology | Lymphocytes T | Drug resistance | Kinases | Doxorubicin | Recruitment | Proteins | Signal transduction | Mevalonic acid | Lymphocytes | Zoledronic acid | P-Glycoprotein | Medical research | Hematology | Mortality | Glycoprotein | RhoA protein | Ras protein | Breast cancer | Cholesterol | Studies | Signaling | Acids | Immunogenicity | Hypoxia | Apoptosis
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 10, pp. 1167 - 1174
Journal Article