X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (315) 315
humans (265) 265
index medicus (239) 239
mice (233) 233
alzheimer's disease (209) 209
neurosciences (169) 169
presenilin-1 - genetics (163) 163
presenilin-1 (159) 159
mice, transgenic (148) 148
alzheimers-disease (140) 140
amyloid beta-protein precursor - genetics (130) 130
amyloid precursor protein (121) 121
alzheimer disease - metabolism (116) 116
amyloid beta-peptides - metabolism (112) 112
presenilin-1 - metabolism (107) 107
biochemistry & molecular biology (104) 104
amyloid beta-protein precursor - metabolism (103) 103
alzheimer disease - genetics (101) 101
disease models, animal (99) 99
amyloid precursor protein secretases - antagonists & inhibitors (94) 94
amyloid precursor protein secretases - metabolism (85) 85
alzheimer disease - pathology (83) 83
male (80) 80
alzheimer disease - drug therapy (79) 79
mice, inbred c57bl (74) 74
transgenic mice (68) 68
cell biology (64) 64
cells, cultured (63) 63
membrane proteins - genetics (63) 63
mutation (63) 63
enzyme inhibitors - pharmacology (62) 62
membrane proteins - metabolism (62) 62
in-vivo (59) 59
neurons - metabolism (59) 59
cell line (57) 57
brain - metabolism (52) 52
female (52) 52
a-beta (51) 51
gamma-secretase (51) 51
peptide fragments - metabolism (49) 49
amyloid beta-peptides - antagonists & inhibitors (48) 48
brain (47) 47
proteins (47) 47
neurology (46) 46
rats (46) 46
alzheimers disease (45) 45
neurons - drug effects (45) 45
precursor protein (45) 45
article (43) 43
presenilin (42) 42
mouse model (41) 41
familial alzheimers-disease (40) 40
amyloid precursor protein secretases (39) 39
alzheimer’s disease (38) 38
amyloid beta-protein (37) 37
cell line, tumor (37) 37
mental disorders (37) 37
apoptosis (36) 36
expression (36) 36
neurodegenerative diseases (36) 36
presenilin 1 (36) 36
alzheimer disease (35) 35
cleavage (35) 35
pathology (35) 35
alzheimer disease - physiopathology (34) 34
phosphorylation (34) 34
research (34) 34
γ-secretase (34) 34
amyloid beta-peptides - biosynthesis (33) 33
alzheimer disease - enzymology (32) 32
endopeptidases - metabolism (32) 32
memory (32) 32
mice, knockout (32) 32
mutation - genetics (32) 32
peptides (32) 32
pharmacology & pharmacy (31) 31
amyloid beta-peptides - genetics (30) 30
cells (30) 30
nervous system (30) 30
rodents (30) 30
hippocampus - metabolism (29) 29
amyloid precursor protein secretases - genetics (28) 28
blotting, western (28) 28
brain - drug effects (28) 28
calcium - metabolism (28) 28
mutant presenilin-1 (28) 28
neurodegeneration (28) 28
neurons (28) 28
transfection (28) 28
activation (27) 27
analysis (27) 27
hek293 cells (27) 27
multidisciplinary sciences (26) 26
presenilin-1 - antagonists & inhibitors (26) 26
brain - pathology (25) 25
long-term potentiation (25) 25
presenilin-2 (25) 25
protein (25) 25
research article (24) 24
signal transduction (24) 24
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Neuroscience, ISSN 0306-4522, 07/2019, Volume 410, pp. 118 - 127
Alzheimer's disease (AD) is the neurodegenerative disorder with no cure. Recent studies suggest that dysregulated postsynaptic store-operated calcium entry... 
nSOCE | EVP4593 | Alzheimer disease | PS1 delta E9 mutation | HOMEOSTASIS | STABILITY | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | PATHOGENESIS | MUSHROOM SPINES | MUTATIONS | THIN | PRESENILIN-1
Journal Article
Nutrients, ISSN 2072-6643, 11/2016, Volume 8, Issue 11, pp. 692 - 692
Altered cholesterol metabolism is believed to play a causal role in major pathophysiological changes in neurodegeneration. Several studies have demonstrated... 
Brain | Neuroinflammation | ApoE | Neurodegeneration | mice | Genistein | MITOCHONDRIAL OXIDATIVE STRESS | ALZHEIMERS-DISEASE | neurodegeneration | brain | COGNITIVE FUNCTION | APOLIPOPROTEIN-E | TAU-HYPERPHOSPHORYLATION | NUTRITION & DIETETICS | genistein | neuroinflammation | ApoE(-/-) mice | AMYLOID-BETA | INSULIN-RESISTANCE | SOY ISOFLAVONES | CENTRAL-NERVOUS-SYSTEM | TRANSGENIC MOUSE MODEL | Alzheimer Disease - etiology | Neuroprotective Agents - therapeutic use | Amyloid Precursor Protein Secretases - genetics | Oxidative Stress | Diet, High-Fat - adverse effects | Male | Aspartic Acid Endopeptidases - genetics | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Presenilin-1 - antagonists & inhibitors | Alzheimer Disease - prevention & control | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Genistein - therapeutic use | Hippocampus - enzymology | Neurons - metabolism | Neuroprotective Agents - adverse effects | Alzheimer Disease - immunology | Genistein - adverse effects | Nerve Tissue Proteins - antagonists & inhibitors | Cerebral Cortex - enzymology | Hippocampus - immunology | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Gene Expression Regulation | Neurons - immunology | Presenilin-1 - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Cerebral Cortex - immunology | Apolipoproteins E - genetics | Aspartic Acid Endopeptidases - metabolism | Endoplasmic Reticulum Stress | Neurons - enzymology | Presenilin-1 - metabolism | Alzheimer Disease - metabolism | Antioxidants - adverse effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Dietary Supplements | ApoE−/− mice
Journal Article
PLOS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179859
Journal Article
EMBO Journal, ISSN 0261-4189, 2012, Volume 31, Issue 21, pp. 4106 - 4123
Journal Article
Nature Communications, 06/2016, Volume 7, p. 11915
Journal Article
Brain, ISSN 0006-8950, 05/2010, Volume 133, Issue 5, pp. 1342 - 1351
Reduction of glucose metabolism in brain is one of the main features of Alzheimer's disease. Thiamine (vitamin B1)-dependent processes are critical in glucose... 
Glycogen synthase kinase-3 | Alzheimer's disease | Benfotiamine | Thiamine | OXIDATIVE STRESS | PROTEIN | ALZHEIMERS-DISEASE | PHOSPHATE-ESTERS | RISK | NEUROSCIENCES | CLINICAL NEUROLOGY | benfotiamine | glycogen synthase kinase-3 | POSITRON-EMISSION-TOMOGRAPHY | thiamine | THIAMINE-DEFICIENCY | DERIVATIVES | BRAIN | HYPERGLYCEMIC DAMAGE | Memory - drug effects | tau Proteins - metabolism | Cognition Disorders - metabolism | Plaque, Amyloid - drug effects | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Dose-Response Relationship, Drug | Amyloid beta-Peptides - genetics | Isoenzymes - metabolism | Cognition Disorders - etiology | Amyloid beta-Peptides - metabolism | Swimming | Phosphorylation - drug effects | Alzheimer Disease - psychology | Cognition Disorders - psychology | Drug Administration Schedule | Plaque, Amyloid - pathology | Presenilin-1 - genetics | Mice, Transgenic | Cognition - drug effects | Thiamine - analogs & derivatives | Thiamine - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Maze Learning | Fursultiamin - pharmacology | Glycogen Synthase Kinases - antagonists & inhibitors | Presenilin-1 - metabolism | Alzheimer Disease - metabolism | Thiamine - administration & dosage | Mice | Alzheimer Disease - genetics | Glycogen Synthase Kinases - metabolism | Isoenzymes - antagonists & inhibitors
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e34095
Gangliosides are important players for controlling neuronal function and are directly involved in AD pathology. They are among the most potent stimulators of A... 
HUMAN BRAIN | GM1 GANGLIOSIDE | INTRAMEMBRANE PROTEOLYSIS | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GAMMA-SECRETASE CLEAVAGE | BETA-PROTEIN | TARGETING SIGNAL | INTRACELLULAR DOMAIN | CELL BIOLOGY | Cell Line | Immunoprecipitation | Presenilin-2 - antagonists & inhibitors | Cercopithecus aethiops | Homeostasis | Presenilin-1 - genetics | Presenilin-2 - metabolism | Sialyltransferases - metabolism | Alzheimer Disease - pathology | Presenilin-1 - antagonists & inhibitors | Amyloid beta-Protein Precursor - genetics | Animals | RNA Interference | Presenilin-2 - genetics | Gangliosides - metabolism | Presenilin-1 - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Protein Binding | Mice | Amyloid beta-Protein Precursor - antagonists & inhibitors | COS Cells | RNA, Small Interfering - metabolism | Physiological aspects | Enzymes | Gangliosides | Alzheimer's disease | Amyloid beta-protein | Neurophysiology | Brain | Regulations | Neurosciences | Membranes | Peptides | Gene regulation | Neurobiology | Ganglioside GM3 | Lipids | Biosynthesis | Neuroblastoma | Protein turnover | Neuroblastoma cells | Deletion mutant | Proteins | Stimulators | Enzymatic activity | Clonal deletion | Neurodegeneration | Precursors | Rodents | Deletion | Fibroblasts | Cleavage | Plaques | Iodine | Neurodegenerative diseases | Metabolism | Gene expression | Disease control | Amyloid precursor protein | Gene silencing | Pathology | Neurology | Molecular modelling | Presenilin 2 | Presenilin 1 | Scientific imaging | Alzheimers disease | Mass spectrometry
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2005, Volume 102, Issue 34, pp. 12171 - 12176
Journal Article
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 04/2013, Volume 19, Issue 4, pp. 262 - 268
Journal Article
Journal Article