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Neuron (Cambridge, Mass.), ISSN 0896-6273, 02/2006, Volume 49, Issue 4, pp. 489 - 502
Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques... 
PROTEINS | STEMCELL | HUMDISEASE | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Presenilin-1 | Age Factors | Gene Expression - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Imaging, Three-Dimensional - methods | Bone Marrow Cells - physiology | Peptide Fragments - pharmacology | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Bone Marrow Transplantation - methods | Alzheimer Disease - pathology | Microglia - physiology | Time Factors | Amyloid beta-Protein Precursor - metabolism | Membrane Cofactor Protein - metabolism | Membrane Proteins - metabolism | Indoles | In Situ Hybridization - methods | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Green Fluorescent Proteins - metabolism | Interleukin-1 - metabolism | Microglia - drug effects | Plaque, Amyloid - pathology | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Phagocytosis - physiology | Mice, Transgenic | Toll-Like Receptor 2 - metabolism | Microscopy, Confocal - methods | Immunohistochemistry - methods | Whole-Body Irradiation - methods | Amyloid beta-Protein Precursor - genetics | Animals | Microfilament Proteins | Alzheimer Disease - metabolism | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Injections, Intraventricular - methods | Lysosomal-Associated Membrane Protein 2 - metabolism | Proteins | Physiological aspects | Neurons | Alzheimer's disease | Analysis | Studies | Medical research | Brain | Neurotoxicity | Brain research | Microscopy | Transgenic animals | Software | Nonsteroidal anti-inflammatory drugs | Alzheimers disease | Exports | Immune system | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0143345 - e0143345
Amyloid precursor protein (APP) has been modified by beta and gamma-secretase that cause amyloid deposits (plaques) in neuronal cells. Glyceraldhyde-derived... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Alzheimer Disease - etiology | Sirtuin 1 - metabolism | Neurons - pathology | Neuroprotective Agents | Up-Regulation | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Plaque, Amyloid - pathology | Heat-Shock Proteins - metabolism | Humans | Caspase 3 - metabolism | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Stilbenes - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Aspartic Acid Endopeptidases - metabolism | Endoplasmic Reticulum Stress | Glycation End Products, Advanced - metabolism | Presenilin-1 - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Cell Death | Cell Line, Tumor | Advanced glycation end products | Amyloid beta-protein | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Neuroprotection | Oxidative stress | Bax protein | Bcl-2 protein | Pathogenesis | Downstream effects | p53 Protein | Glyceraldehyde | Science | Neuroblastoma | Caspase-3 | Antioxidants | Neurotoxicity | Rodents | Penicillin | Age | Plaques | Medical research | Immunoglobulins | Advanced glycosylation end products | Neurodegenerative diseases | Mortality | Caspase | Glycosylation | Gene expression | SIRT1 protein | Amyloid precursor protein | Medicine | Studies | Cell death | Presenilin 1 | b-Site APP cleaving enzyme | Alzheimers disease | Endoplasmic reticulum | Secretase | Apoptosis | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 06/2016, Volume 15, Issue 10, pp. 2226 - 2238
Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and... 
Life Sciences & Biomedicine | Science & Technology |