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neurology (139) 139
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transfection (121) 121
brain - drug effects (120) 120
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dose-response relationship, drug (105) 105
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Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Index Medicus | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2011, Volume 31, Issue 31, pp. 11328 - 11337
The concentration of amyloid-beta (A beta) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species... 
ALPHA-SECRETASE | RAT HIPPOCAMPAL-NEURONS | ALZHEIMERS-DISEASE | INTERSTITIAL FLUID | A-BETA | PRECURSOR PROTEIN | CEREBROSPINAL-FLUID | NEUROSCIENCES | METHYL-D-ASPARTATE | GENE-TRANSCRIPTION | TRANSGENIC MICE | Enzyme-Linked Immunosorbent Assay - methods | Action Potentials - genetics | Calcium - metabolism | Humans | Extracellular Space - drug effects | Receptors, N-Methyl-D-Aspartate - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Synapses - pathology | Serotonin - pharmacology | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Extracellular Space - metabolism | Synapses - metabolism | Piperidines - pharmacology | Amyloid beta-Peptides - metabolism | Egtazic Acid - analogs & derivatives | Brain Waves - drug effects | Tetrodotoxin - pharmacology | Action Potentials - drug effects | Flavones - pharmacology | Synapses - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Presenilin-1 - genetics | Mice, Transgenic | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Chelating Agents - pharmacology | Mutation - genetics | Electroencephalography - methods | Piperazines - pharmacology | Amyloid beta-Protein Precursor - genetics | Animals | Egtazic Acid - pharmacology | Pregnanolone - pharmacology | Analysis of Variance | Presenilin-1 - metabolism | Mice | Index Medicus
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2012, Volume 31, Issue 1, pp. 207 - 223
Ginseng extracts show cognition-enhancing effects in Alzheimer's disease (AD) patients. However, little is known about the active components and molecular... 
amyloid-β protein precursor | memory | transgenic mice | Alzheimer's disease | ALPHA-SECRETASE | ACTIVATION | PHOSPHORYLATION | KINASE | COGNITIVE IMPAIRMENT | amyloid-beta protein precursor | NEUROSCIENCES | NEUROBLASTOMA SH-SY5Y | PATHWAY | MICE | PRECURSOR PROTEIN | BRAIN | Calcium - metabolism | Humans | Glycoproteins - pharmacology | Alzheimer Disease - pathology | Brain - metabolism | Piperidines - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Phytotherapy - methods | Disease Models, Animal | Cell Survival - drug effects | Glycoproteins - therapeutic use | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Mutation - genetics | Brain - drug effects | Analysis of Variance | Panax - chemistry | Signal Transduction - drug effects | Ligands | Mice | Nootropic Agents - pharmacology | Protein Binding - physiology | Propionates - pharmacology | Receptors, Lysophosphatidic Acid - metabolism | Amyloid beta-Peptides - pharmacology | Peptide Fragments - pharmacology | Metalloproteases - metabolism | Dose-Response Relationship, Drug | Transfection | Amyloid beta-Protein Precursor - metabolism | Egtazic Acid - analogs & derivatives | Microfilament Proteins - metabolism | Neuroblastoma - pathology | Calcium-Binding Proteins - metabolism | Plant Proteins - therapeutic use | Peptide Fragments - metabolism | Plant Proteins - pharmacology | Presenilin-1 - genetics | Maze Learning - drug effects | Isoxazoles - pharmacology | Amyloid beta-Protein Precursor - genetics | Animals | Egtazic Acid - pharmacology | Memory Disorders - drug therapy | Indans - pharmacology | Memory Disorders - chemically induced | Index Medicus | Amyloidogenesis | Brain | Animal models | Calcium | Neurodegenerative diseases | Cognitive ability | Recovery of function | Cytotoxicity | Neuropathy | Amyloid precursor protein | Neuroblastoma cells | Lysophosphatidic acid receptors | Neurotoxicity | Lysophosphatidic acid | Long term memory | Amyloid | Chelating agents | Ginseng
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2011, Volume 31, Issue 31, pp. 11100 - 11109
It is proposed that intracellular amyloid-beta (A beta), before extracellular plaque formation, triggers cognitive deficits in Alzheimer disease (AD). Here we... 
TRANSCRANIAL MAGNETIC STIMULATION | CALCIUM-CHANNELS | SYNAPTIC DYSFUNCTION | ALZHEIMERS-DISEASE | CA2+-ACTIVATED K+ CHANNELS | IN-VIVO | A-BETA | METABOTROPIC GLUTAMATE RECEPTORS | LONG-TERM POTENTIATION | PYRAMIDAL CELL EXCITABILITY | NEUROSCIENCES | Action Potentials - genetics | Calcium - metabolism | Amyloid beta-Peptides - pharmacology | Male | Peptide Fragments - pharmacology | Nimodipine - pharmacology | Potassium Channels - metabolism | tau Proteins - genetics | Charybdotoxin - pharmacology | Amyloid beta-Peptides - metabolism | Homer Scaffolding Proteins | Female | Indoles - pharmacology | Neurons - metabolism | Neurons - drug effects | 4-Aminopyridine - pharmacology | Action Potentials - drug effects | Potassium Channel Blockers - pharmacology | Carboxylic Acids - pharmacology | Animals, Newborn | Neural Inhibition - genetics | Peptide Fragments - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Presenilin-1 - genetics | Rats | Mice, Transgenic | Calcium Channel Blockers - pharmacology | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Phenanthrenes - pharmacology | Patch-Clamp Techniques | Amyloid beta-Protein Precursor - genetics | Animals | Carrier Proteins - metabolism | Electroshock - methods | Gene Expression Regulation - radiation effects | Neocortex - cytology | Mice | In Vitro Techniques | Neural Inhibition - drug effects | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 40, pp. 13701 - 13708
Glucagon-like peptide-1 (GLP-1) is an endogenous intestinal peptide that enhances glucose-stimulated insulin secretion. Its natural cleavage product... 
HIPPOCAMPUS | OVEREXPRESSION | OXIDATIVE STRESS | SUPEROXIDE | GLP-1 | PROTEIN-KINASE | LONG-TERM DEPRESSION | MOUSE MODEL | MITOCHONDRIA | RECEPTOR | NEUROSCIENCES | Memory Disorders - physiopathology | Glycogen Synthase Kinase 3 - physiology | Reactive Oxygen Species - metabolism | Amyloid beta-Peptides - pharmacology | Neuronal Plasticity - drug effects | Glycogen Synthase Kinase 3 beta | Male | Peptide Fragments - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Ubiquinone - pharmacology | Excitatory Postsynaptic Potentials - physiology | CA3 Region, Hippocampal - drug effects | Amyloid beta-Peptides - genetics | CA3 Region, Hippocampal - metabolism | Organophosphorus Compounds - pharmacology | Female | Drug Evaluation, Preclinical | Alzheimer Disease - psychology | Disease Models, Animal | Alzheimer Disease - physiopathology | Glucagon-Like Peptide 1 - analogs & derivatives | Ubiquinone - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Presenilin-1 - genetics | Mice, Transgenic | Mitochondria - metabolism | Proto-Oncogene Proteins c-akt - physiology | Antioxidants - pharmacology | Mitochondria - drug effects | Association Learning - drug effects | Peptides - pharmacology | Fear | Antioxidants - therapeutic use | Animals | Memory Disorders - drug therapy | Signal Transduction - drug effects | Mice | Alzheimer Disease - genetics | Nootropic Agents - pharmacology | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 3/2008, Volume 131, Issue 3, pp. 651 - 664
Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia... 
Transgenic | Inflammation | Memory | NSAIDs | Synaptic plasticity | memory | MICROGLIAL ACTIVATION | ALZHEIMERS-DISEASE | NEUROSCIENCES | COGNITIVE FUNCTION | CLINICAL NEUROLOGY | PRESENILIN-1 TRANSGENIC MICE | inflammation | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | MOUSE MODEL | IN-VIVO | A-BETA | transgenic | ANIMAL-MODEL | synaptic plasticity | LONG-TERM POTENTIATION | Memory - drug effects | Tumor Necrosis Factor-alpha - metabolism | Ibuprofen - therapeutic use | Dinoprostone - physiology | Amyloid beta-Peptides - pharmacology | Furans - pharmacology | Naproxen - pharmacology | Memory Disorders - metabolism | Neuronal Plasticity - drug effects | Male | Peptide Fragments - pharmacology | Hippocampus - drug effects | Furans - therapeutic use | Interleukin-1beta - metabolism | Cyclooxygenase 2 Inhibitors - therapeutic use | Inflammation Mediators - metabolism | Ibuprofen - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Synapses - physiology | Mice, Inbred C57BL | Rats | Naproxen - therapeutic use | Cyclooxygenase Inhibitors - pharmacology | Hippocampus - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Memory Disorders - prevention & control | Animals | Memory Disorders - drug therapy | Cyclooxygenase 2 - metabolism | Mice | Cyclooxygenase Inhibitors - therapeutic use | Index Medicus | Abridged Index Medicus
Journal Article
Nature Communications, 06/2016, Volume 7, pp. 11915 - 11915
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2009, Volume 29, Issue 28, pp. 9078 - 9089
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2012, Volume 120, Issue 3, pp. 461 - 472
Anti‐inflammatory effect of resveratrol: Can it help with Alzheimer's disease? 
Resveratrol is a natural polyphenol associated with anti‐inflammatory... 
NF‐κB | Alzheimer’s disease | microglia | resveratrol | TLR4 | NF-κB | Alzheimer's disease | Tumor Necrosis Factor-alpha - metabolism | Stilbenes - therapeutic use | Amyloid beta-Peptides - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | Male | I-kappa B Proteins - metabolism | Stilbenes - pharmacology | I-kappa B Proteins - genetics | Alzheimer Disease - pathology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Drug Interactions | Time Factors | Inflammation Mediators - pharmacology | Statistics, Nonparametric | Toll-Like Receptors - metabolism | Disease Models, Animal | NF-KappaB Inhibitor alpha | Cytokines - metabolism | Microglia - drug effects | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Amyloid beta-Protein Precursor - genetics | Animals | Signal Transduction - drug effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Toll-Like Receptors - genetics | Lipopolysaccharides - pharmacology | Mice | Alzheimer Disease - genetics | Cell Line, Transformed | Index Medicus | Brain | Cell culture | Animal models | Phosphorylation | Transcription | Clinical trials | beta -Amyloid | Macrophages | IKK protein | Lipopolysaccharides | Interleukin 6 | Cell activation | Resveratrol | Microglial cells | Polyphenols | Toll-like receptors | Amyloid | Stat1 protein | Plaques | Antiinflammatory agents | Oligomerization | Neurodegenerative diseases | Stat3 protein | Inflammation | TLR4 protein | Microglia | NF- Kappa B protein | Lymphocytes B | Tumor necrosis factor- alpha | STAT | lipopolysaccharide
Journal Article
Science, ISSN 0036-8075, 12/2001, Volume 294, Issue 5549, pp. 2179 - 2181
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 67, Issue 5, pp. 769 - 780
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 06/2009, Volume 109, Issue 6, pp. 1636 - 1647
Cerebral amyloid angiopathy (CAA), characterized by extracellular beta-amyloid peptide (A beta) deposits in vessel walls, is present in the majority of cases... 
MMP inhibitor | Oxidative stress | Transgenic mouse | Matrix metalloproteinases | Antioxidant | Multiphoton microscopy | antioxidant | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED MATRIX-METALLOPROTEINASE-9 | PLAQUES | transgenic mouse | NEUROSCIENCES | CEREBROVASCULAR-DISEASE | PLASMINOGEN-ACTIVATOR | ALZHEIMER MOUSE MODEL | multiphoton microscopy | A-BETA | INTRACEREBRAL HEMORRHAGE | SMOOTH-MUSCLE-CELLS | matrix metalloproteinases | oxidative stress | BRAIN | Reactive Oxygen Species - metabolism | Minocycline - pharmacology | Humans | Fluorescent Dyes - metabolism | Statistics as Topic | Cerebral Amyloid Angiopathy - metabolism | Simvastatin - pharmacology | Protease Inhibitors - pharmacology | Stilbenes | Time Factors | Amyloid beta-Peptides - genetics | Cyclic N-Oxides - pharmacology | Amyloid beta-Peptides - metabolism | Cerebral Amyloid Angiopathy - genetics | Benzene Derivatives - pharmacology | Cerebral Amyloid Angiopathy - physiopathology | Dipeptides - pharmacology | Presenilin-1 - genetics | Mice, Transgenic | Amyloid beta-Protein Precursor - genetics | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Matrix Metalloproteinase Inhibitors | Mice | Matrix Metalloproteinases - metabolism | Oxidative Stress - drug effects | Alkenes - pharmacology | Antioxidants | Peptides | Simvastatin | Genetic engineering | Alzheimer's dis