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Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2781 - 2789
Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid beta-protein (A beta), the central component of... 
BACE1 | MEDICINE, RESEARCH & EXPERIMENTAL | NOTCH LIGANDS | GLYCOGEN-SYNTHASE KINASE-3 | PRESENILIN/GAMMA-SECRETASE | GAMMA-SECRETASE CLEAVAGE | GENERATION | PRECURSOR PROTEIN | RELEASE | IMMUNOLOGY | MISSENSE MUTATIONS | INTRACELLULAR DOMAIN
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 10/2017, Volume 177, Issue 4, pp. 895 - 896
Linked Article: Frew et al. Br J Dermatol 2017; 177:987–998 . 
GENE-MUTATIONS | PRESENILIN/GAMMA-SECRETASE | NICASTRIN | ASSOCIATION | ACNE INVERSA | DERMATOLOGY | Hidradenitis Suppurativa | Humans | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1472 - 1472
Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the... 
SYNAPTIC DYSFUNCTION | RETICULUM-ASSOCIATED DEGRADATION | MULTIDISCIPLINARY SCIENCES | UBIQUITIN PROTEASOME SYSTEM | PRESENILIN/GAMMA-SECRETASE | NICASTRIN | ENDOPLASMIC-RETICULUM | BETA-PEPTIDE PRODUCTION | NEURODEGENERATIVE DISEASES | COGNITIVE DEFICITS | LIGASE | Index Medicus
Journal Article
Biophysical Journal, ISSN 0006-3495, 03/2015, Volume 108, Issue 5, pp. 1229 - 1237
Intramembrane proteolysis has emerged as a key mechanism required for membrane proteostasis and cellular signaling. One of the intramembrane-cleaving proteases... 
LIPIDOMICS | CELLS | COMPLEX | BIOPHYSICS | PATHWAY | MEMBRANE | MODULATORS | PRESENILIN/GAMMA-SECRETASE | FAMILIAL ALZHEIMERS-DISEASE | MUTATIONS | INHIBITOR | Amyloid Precursor Protein Secretases - metabolism | Proteolysis | Amyloid beta-Protein Precursor - chemistry | Humans | HEK293 Cells | Kinetics | Intracellular Membranes - chemistry | Index Medicus | Proteins and Nucleic Acids
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 37, pp. 13349 - 13354
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 4, pp. 2762 - 2773
Neurexins (NRXNs) are synaptic cell adhesion molecules having essential roles in the assembly and maturation of synapses into fully functional units.... 
BACE1 | NEUROLIGIN | NEURITE OUTGROWTH | SYNAPSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRESENILIN/GAMMA-SECRETASE | RECEPTOR | NECROSIS-FACTOR-ALPHA | MEDIATED CLEAVAGE | AMYLOID PRECURSOR PROTEIN | MUTATIONS | Membrane Proteins | ADAM ADAMTS | Neurexin | Membrane Enzymes | Secretases | Alzheimer disease | Neurobiology | Metalloprotease | TACE | Microsomes | Synapses
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 3716 - 14
Normal brain development depends on tight temporal and spatial regulation of connections between cells. Mutations in L1cam, a member of the immunoglobulin (Ig)... 
ECTODOMAIN CLEAVAGE | DOMAIN | MOLECULE | AXON INTERACTIONS | MULTIDISCIPLINARY SCIENCES | GROWTH | PRESENILIN/GAMMA-SECRETASE | NEURAL-CELL-ADHESION | MEDIATED RELEASE | CRASH SYNDROME | Immunoglobulins | b-Site APP cleaving enzyme 1 | Hydrocephalus | Axonogenesis | Proteinase | Spasticity | Nervous system | Cell surface | Corpus callosum | Fibronectin | Myelination | Aplasia | Proteolysis | Ventricle
Journal Article
PLOS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11
Upsilon-secretase is a large ubiquitously expressed protease complex composed of four core subunits: presenilin, Aph1, PEN-2, and nicastrin. The function of... 
COMPLEX-FORMATION | APH-1 INTERACTS | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | PRESENILIN/GAMMA-SECRETASE | GENE-EXPRESSION | TUMOR-SUPPRESSOR | AMYLOID PRECURSOR PROTEIN | BETA-CATENIN | GAMMA-SECRETASE | ESTROGEN-RECEPTOR
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2011, Volume 30, Issue 5, pp. 800 - 813
Glioblastomas (GBMs) are highly lethal brain tumours with current therapies limited to palliation due to therapeutic resistance. We previously demonstrated... 
DNA damage checkpoint | L1CAM | glioblastoma stem cells | NBS1 | radioresistance | OVARIAN-CARCINOMA CELLS | STRAND BREAK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRESENILIN/GAMMA-SECRETASE | THERAPEUTIC ANTIBODIES | TUMOR-INITIATING CELLS | CELL BIOLOGY | GENE-EXPRESSION | MALIGNANT GLIOMAS | CYCLE CHECKPOINTS | GROWTH-FACTOR | ADHESION MOLECULE L1 | RNA, Small Interfering - genetics | Phosphorylation | Humans | Neural Cell Adhesion Molecule L1 - genetics | Radiation Tolerance | Immunoblotting | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Neural Cell Adhesion Molecule L1 - antagonists & inhibitors | Cell Nucleus - radiation effects | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Neural Cell Adhesion Molecule L1 - metabolism | Tumor Cells, Cultured | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | Signal Transduction | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Comet Assay | Proto-Oncogene Proteins c-myc - metabolism | Cell Nucleus - genetics | DNA Repair | Glioblastoma - pathology | Fluorescent Antibody Technique | Proto-Oncogene Proteins c-myc - genetics | DNA Damage | Proteins | DNA damage | Brain cancer | Stem cells | Radiation therapy | Gene expression | Molecular biology | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 08/2010, Volume 29, Issue 34, pp. 4766 - 4778
L1 cell adhesion molecule (L1CAM) overexpression is often associated with bad prognosis in various human carcinomas. Recent studies also suggest a role of... 
integrins | pancreatic tumour | L1CAM signalling | CARCINOMA-CELLS | MIGRATION | INTEGRIN-LINKED KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRESENILIN/GAMMA-SECRETASE | THERAPEUTIC ANTIBODIES | MALIGNANT-MELANOMA | CELL BIOLOGY | ONCOLOGY | COLORECTAL-CANCER | GENETICS & HEREDITY | GENE-EXPRESSION | OVARIAN CARCINOMAS | ADHESION MOLECULE L1
Journal Article