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2011, 2nd ed., Methods in molecular biology, ISBN 9781617790799, Volume 731., xiv, 502
Book
European Journal of Immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2433 - 2445
CD8+ T cells are important for immunity against human cytomegalovirus (HCMV). The HCMV‐specific CD8+ T‐cell response is characterized by the accumulation of... 
Tissue distribution | Metabolism | HCMV | CD45RA+ CD8+ effector T cell | CD4+ T cell | NK cell | CD4 | CD8 | T cell | CD45RA | effector T cell | VIRUS-SPECIFIC EFFECTOR | NATURAL-KILLER-CELLS | BONE-MARROW | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | CUTTING EDGE | TRANSCRIPTION FACTOR EOMESODERMIN | HUMAN CYTOMEGALOVIRUS-INFECTION | CHRONIC LYMPHOCYTIC-LEUKEMIA | CD45RA(+) CD8(+) effector T cell | PRIMARY CMV INFECTION | CD4(+) T cell | HUMAN PRIMARY MACROPHAGES | CD8-Positive T-Lymphocytes - pathology | Humans | Cytomegalovirus Infections - immunology | Killer Cells, Natural - pathology | Granzymes - genetics | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | CD28 Antigens - genetics | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Transcription, Genetic | Cytomegalovirus Infections - pathology | Granzymes - immunology | CD4-Positive T-Lymphocytes - virology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | Signal Transduction | Killer Cells, Natural - virology | Lymphocyte Activation | Gene Expression Regulation | CD28 Antigens - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Immunity, Innate | Host-Pathogen Interactions | Cell Differentiation - immunology | Cytomegalovirus - immunology | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - immunology | Killer cells | Immune response | Cytomegalovirus infections | Chemical properties | T cells | Cell differentiation | Health aspects
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 1, pp. 126 - 136.e6
Background & Aims We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) and... 
Gastroenterology and Hepatology | Stomach Cancer | Gastric Epithelium | Primary Cells | Tissue Engineering | Cell Proliferation | Biological Markers | Humans | Middle Aged | Male | Wnt Proteins | Helicobacter Infections | Stem Cells | Helicobacter pylori | Organoids | Time Factors | Aged, 80 and over | Adult | Female | Cell Culture Techniques | Niacinamide | Stomach | Cell Separation | Cells, Cultured | Gene Expression Regulation | Epithelial Cells | Cell Lineage | Phenotype | Ploidies | Aged | PROGENITOR CELLS | HOMEOSTASIS | PATHOGENICITY ISLAND | BETA-CATENIN | IDENTIFICATION | CANCER | STOMACH EPITHELIUM | DISEASE | INTESTINAL CRYPT | HELICOBACTER-PYLORI-INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Helicobacter pylori - immunology | Stem Cells - immunology | Epithelial Cells - metabolism | Stomach - immunology | Epithelial Cells - drug effects | Helicobacter pylori - pathogenicity | Stomach - metabolism | Stem Cells - metabolism | Wnt Proteins - metabolism | Helicobacter Infections - pathology | Stem Cells - microbiology | Helicobacter Infections - metabolism | Stomach - drug effects | Biomarkers - metabolism | Stomach - pathology | Epithelial Cells - pathology | Helicobacter Infections - immunology | Epithelial Cells - immunology | Epithelial Cells - microbiology | Stem Cells - drug effects | Stem Cells - pathology | Niacinamide - pharmacology | Stomach - microbiology | Helicobacter Infections - microbiology | Stem cell research | Bacterial infections | Developmental biology | Health aspects | Stem cells | gastric epithelium | tissue engineering | stomach cancer | primary cells
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57020
Lung cancer (LC) with its different subtypes is generally known as a therapy resistant cancer with the highest morbidity rate worldwide. Therapy resistance of... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSFORMATION | THERAPY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | GROWTH | HMGA2 | MICE | CARCINOMA | PROGRESSION | TUMOR-INITIATING CELLS | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Cadherins - metabolism | Vimentin - metabolism | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Antigens, CD - genetics | Antigens, CD - metabolism | Octamer Transcription Factor-3 - genetics | Small Cell Lung Carcinoma - metabolism | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Vimentin - genetics | Thy-1 Antigens - genetics | Hyaluronan Receptors - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Cadherins - genetics | Lung Neoplasms - genetics | Carcinoma, Large Cell - metabolism | Nanog Homeobox Protein | Immunophenotyping | Small Cell Lung Carcinoma - genetics | Mice, SCID | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Thy-1 Antigens - metabolism | Small Cell Lung Carcinoma - pathology | Animals | Octamer Transcription Factor-3 - metabolism | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Primary Cell Culture | Care and treatment | Analysis | Stem cells | Cancer cells | Physiological aspects | Research | Cancer | Adenocarcinoma | Vimentin | Cell culture | Therapy | Biotechnology | Thoracic surgery | Mesenchyme | Oct-4 protein | Lung cancer | Radiation | Population studies | Identification | Biology | mRNA | Metastasis | Cancer therapies | CD90 antigen | N-Cadherin | Immunology | CD44 antigen | Population | Medical research | Squamous cell carcinoma | Hematology | Small cell lung carcinoma | Cell division | Tumor cell lines | Gene expression | Cadherin | Spheroids | Morbidity | Medicine | Pathology | Lungs | Medical prognosis | Pancreatic cancer | Irradiation | Prostate | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0166589
LIGHT (HVEM-L, TNFSF14, or CD258), an entity homologous to lymphotoxins, with inducible nature and the ability to compete with herpes simplex virus... 
VIRUS ENTRY MEDIATOR | MULTIDISCIPLINARY SCIENCES | CO-STIMULATION | METHODOLOGICAL APPROACH | ALPHA | AMYOTROPHIC-LATERAL-SCLEROSIS | LYMPHOTOXIN/LIGHT | SOLUBLE DECOY RECEPTOR-3 | STROMAL CELLS | VERSUS-HOST-DISEASE | TRANSPLANTATION | Osteocytes - drug effects | Cyclin-Dependent Kinases - metabolism | Humans | Cyclins - genetics | Adipocytes - drug effects | Lymphotoxin beta Receptor - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Mesenchymal Stromal Cells - cytology | Cyclins - metabolism | Microarray Analysis | STAT3 Transcription Factor - genetics | Cell Survival - drug effects | Cyclin-Dependent Kinase 2 - metabolism | Mesenchymal Stromal Cells - drug effects | Signal Transduction | Osteocytes - cytology | Cyclin-Dependent Kinase 2 - genetics | Mesenchymal Stromal Cells - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | Lymphotoxin beta Receptor - genetics | CDC2 Protein Kinase | Chondrocytes - cytology | Tumor Necrosis Factor Ligand Superfamily Member 14 - pharmacology | Adipocytes - cytology | Smad3 Protein - metabolism | Platelet-Derived Growth Factor - genetics | Tumor Necrosis Factor Ligand Superfamily Member 14 - genetics | Chondrocytes - drug effects | Smad3 Protein - genetics | Bone Marrow Cells - drug effects | Cyclin-Dependent Kinases - genetics | Chondrocytes - metabolism | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Osteocytes - metabolism | Bone Marrow Cells - cytology | Gene Expression Regulation | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Platelet-Derived Growth Factor - metabolism | Transforming Growth Factor beta - genetics | Cell Cycle | Cell Differentiation - drug effects | Adipocytes - metabolism | Cell Proliferation - drug effects | Primary Cell Culture | Transforming Growth Factor beta - metabolism | Bone Marrow Cells - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Platelet-derived growth factor | Dendritic cells | Tumor necrosis factor | Stem cells | Transplantation | B cells | T cells | Transforming growth factors | Enzyme-linked immunosorbent assay | Herpes simplex | Immunoblotting | Adipocytes | Alizarin | Proteins | Signal transduction | Receptors | Cell growth | Light | Bone marrow | CD25 antigen | Biocompatibility | Chondrogenesis | Glycoprotein D | Glycoprotein | Survival | Hospitals | Stromal cells | Herpes viruses | Lymphomas | Viability | Cell proliferation | Biomedical research | Mesenchyme | Leukemia | Multiple myeloma | Staining | Homology | Viruses | Oncology | Lymphocytes T | Smad3 protein | Bone diseases | Cell surface | Cyclin B1 | Biomedical materials | Lymphocytes | Cell cycle | Tumor necrosis factor-TNF | Adipogenesis | Cell survival | Hematology | Research & development--R&D | Stat3 protein | Cyclins | Cyclin-dependent kinase 2 | Medicine | Cell number | Osteogenesis | Research & development | R&D
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e35685
We have previously shown that mesenchymal stem cells (MSC) improve function upon integration in ischemic myocardium. We examined whether specific cytokines and... 
MIGRATION | SURVIVAL | BAD | PHOSPHORYLATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | H9C2 CELLS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INHIBIT APOPTOSIS | CHEMOKINE RECEPTORS | STROMAL CELLS | Neovascularization, Physiologic - drug effects | Gene Expression - drug effects | Apoptosis - drug effects | Caspase 3 - metabolism | Culture Media, Conditioned - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Mesenchymal Stromal Cells - cytology | Caspase 3 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Endothelial Cells - metabolism | Cytokines - secretion | Mesenchymal Stromal Cells - metabolism | Chemotaxis - drug effects | Mesenchymal Stromal Cells - secretion | Phosphatidylinositol 3-Kinases - genetics | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Endothelial Cells - cytology | Dogs | Mice | Primary Cell Culture | Cytokines - biosynthesis | Cytokines - pharmacology | Endothelial Cells - drug effects | Cytokines | Comparative analysis | Vascular endothelial growth factor | Stem cells | Apoptosis | Heart | Phosphorylation | Leukocyte migration | Mesenchyme | Intracellular signalling | AKT protein | Kinases | Macrophages | Caspase-3 | Proteins | Angiogenesis | Signal transduction | Mitochondria | Cell growth | Ischemia | Rodents | Cell cycle | Tumor necrosis factor-TNF | Conditioning | Localization | Cardiology | Growth factors | Extracellular signal-regulated kinase | Caspase | Cardiomyocytes | Inflammation | Ribonucleic acid--RNA | Chemotaxis | Endothelial cells | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Inhibitors | γ-Interferon | Myocardium | Hypoxia | Interferon | Laboratory animals | Cell migration | Monocyte chemoattractant protein 1 | RNA | Ribonucleic acid
Journal Article
STEM CELLS, ISSN 1066-5099, 06/2019, Volume 37, Issue 6, pp. 754 - 765
There has been considerable interest in the generation of functional mesenchymal stromal cell (MSC) preparations from induced pluripotent stem cells (iPSCs)... 
Mesenchymal stromal cells | iPSC‐derived mesenchymal stromal cells | Vascular progenitor cells | Induced pluripotent stem cells | DERIVATION | PLATELET LYSATE | TYROSINE KINASE | RECEPTOR | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MESODERM | THERAPY | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENDOTHELIAL-CELLS | iPSC-derived mesenchymal stromal cells | GROWTH-FACTOR | HEMATOLOGY | EXPRESSION | 5'-Nucleotidase - genetics | Chondrocytes - cytology | Mesenchymal Stem Cells - classification | Homeodomain Proteins - metabolism | Humans | Adipocytes - cytology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Mesenchymal Stem Cells - cytology | Thy-1 Antigens - genetics | Endoglin - genetics | Cell Differentiation | Osteoblasts - cytology | Induced Pluripotent Stem Cells - cytology | Mesenchymal Stem Cells - metabolism | Chondrocytes - metabolism | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Gene Expression | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Bone Marrow Cells - cytology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Organ Specificity | GPI-Linked Proteins - metabolism | Homeodomain Proteins - genetics | Thy-1 Antigens - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Endoglin - metabolism | Primary Cell Culture | 5'-Nucleotidase - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | GPI-Linked Proteins - genetics | Gene expression | Chromosomes | Analysis | Stem cells | Cell culture | Mesenchyme | Therapeutic applications | Progenitor cells | Regeneration (physiology) | Regeneration | CD90 antigen | Biomedical materials | Msx2 protein | Stromal cells | Cells (biology) | Bone marrow | CD73 antigen | Biocompatibility | Pluripotency | CD105 antigen | Inhibitory postsynaptic potentials | Embryonic Stem Cells | Induced Pluripotent Stem Cells
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2018, Volume 141, Issue 4, pp. 1417 - 1426.e1
Allogeneic hematopoietic stem cell transplantation (HSCT) is used as a therapeutic approach for primary immunodeficiencies (PIDs). The best outcomes have been... 
hematopoietic stem cell transplantation | CD3+ T-cell receptor αβ+ cell depletion | haploidentical | mismatched unrelated | Primary immunodeficiency | cell depletion | CD3 | T-cell receptor αβ | Busulfan - analogs & derivatives | Immunologic Deficiency Syndromes - therapy | Humans | Antilymphocyte Serum - immunology | Child, Preschool | Hematopoietic Stem Cell Transplantation | Infant | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | Thiotepa - immunology | Vidarabine - analogs & derivatives | Graft vs Host Disease - immunology | CD3 Complex - immunology | Vidarabine - immunology | Female | Graft vs Host Disease - prevention & control | Retrospective Studies | Transplantation Conditioning - methods | Busulfan - immunology | Immunologic Deficiency Syndromes - immunology | Child | Alemtuzumab - immunology | Antigens, CD19 - immunology | Graft-versus-host reaction | Transplants & implants | Liver | Prophylaxis | Stem cell transplantation | Transplantation | Lymphocytes T | Infections | Treosulfan | Drug resistance | Grafting | Hematopoietic stem cells | T-cell receptor | Demographics | Lymphocytes | Children | Busulfan | Conditioning | Cytomegalovirus | Immunoglobulins | CD19 antigen | Neutrophils | Health risks | Immunodeficiency | Transplants | CD3 antigen | T cell receptors | Patients | Survival | Hemopoiesis | Graft rejection | Rejection | Fludarabine | Grafts | Depletion | Globulins | Thymocytes | Adenoviruses | Stem cells | Monoclonal antibodies | Histocompatibility antigen HLA | Methods | Viral infections
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 849 - 862
Tumor relapse is associated with dismal prognosis, but responsible biological principles remain incompletely understood. To isolate and characterize... 
RNA single-cell sequencing | minimal residual disease (MRD) | acute lymphoblastic leukemia | patient-derived xenograft (PDX) cells | Cancer stem cells | primary patients' ALL MRD cells | dormant tumor cells | treatment resistance | INITIATING CELLS | STEM-CELLS | ONCOLOGY | MYELOID-LEUKEMIA | PROPAGATING CELLS | MINIMAL RESIDUAL DISEASE | CANCER | CHILDHOOD | CHEMOTHERAPY | DISCOVERY | XENOGRAFTS | CELL BIOLOGY | Neoplasm, Residual - pathology | Neoplasm Transplantation | Cell Proliferation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Neoplasm Recurrence, Local - pathology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Neoplastic Stem Cells - pathology | Adult | Tumor Cells, Cultured | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Single-Cell Analysis | Child | Antineoplastic Combined Chemotherapy Protocols - metabolism | Gene Expression Profiling - methods | Neoplasm, Residual - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Sequence Analysis, RNA - methods | Disease-Free Survival | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasm Recurrence, Local - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Medical colleges | Genetic vectors | Genetically modified organisms | Genetic engineering | Research institutes | Acute lymphocytic leukemia | Health aspects | Index Medicus
Journal Article