X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (1360) 1360
proadifen - pharmacology (1356) 1356
rats (924) 924
male (903) 903
phenobarbital - pharmacology (382) 382
in vitro techniques (343) 343
mice (299) 299
female (292) 292
microsomes, liver - metabolism (277) 277
time factors (264) 264
liver - metabolism (262) 262
kinetics (258) 258
microsomes, liver - enzymology (249) 249
cytochrome p-450 enzyme system - metabolism (246) 246
pharmacology & pharmacy (209) 209
microsomes, liver - drug effects (200) 200
rats, inbred strains (179) 179
liver - drug effects (169) 169
liver - enzymology (142) 142
methylcholanthrene - pharmacology (137) 137
humans (136) 136
enzyme inhibitors - pharmacology (133) 133
metyrapone - pharmacology (133) 133
rabbits (122) 122
cytochrome p-450 enzyme inhibitors (116) 116
biotransformation (111) 111
dose-response relationship, drug (110) 110
oxidation-reduction (102) 102
carbon monoxide - pharmacology (95) 95
drug synergism (95) 95
toxicology (93) 93
nadp - metabolism (89) 89
drug interactions (86) 86
enzyme induction - drug effects (82) 82
metabolism (82) 82
enzyme induction (76) 76
proadifen (76) 76
mixed function oxygenases - metabolism (74) 74
species specificity (74) 74
sleep - drug effects (71) 71
biochemistry & molecular biology (69) 69
hydroxylation (69) 69
rats, sprague-dawley (68) 68
depression, chemical (65) 65
cells, cultured (63) 63
microsomes - metabolism (63) 63
dogs (62) 62
microsomes - enzymology (60) 60
carbon isotopes (59) 59
brain - metabolism (58) 58
hydrogen-ion concentration (57) 57
liver - cytology (56) 56
spectrophotometry (56) 56
chromatography, thin layer (55) 55
hexobarbital - pharmacology (53) 53
tritium (53) 53
aniline compounds - metabolism (52) 52
stimulation, chemical (52) 52
benzoflavones - pharmacology (47) 47
chromatography, high pressure liquid (47) 47
rats, wistar (47) 47
dealkylation (46) 46
cytochrome p450 (44) 44
guinea pigs (44) 44
pentobarbital - pharmacology (43) 43
half-life (42) 42
protein binding (42) 42
mixed function oxygenases - antagonists & inhibitors (41) 41
cyanides - pharmacology (40) 40
liver (40) 40
oxidoreductases - metabolism (40) 40
pregnancy (40) 40
chlorpromazine - pharmacology (38) 38
piperonyl butoxide - pharmacology (38) 38
structure-activity relationship (38) 38
aminopyrine - metabolism (36) 36
binding sites (36) 36
carbon radioisotopes (35) 35
cytochrome p-450 enzyme system - biosynthesis (35) 35
proadifen - metabolism (35) 35
sex factors (35) 35
microsomes (34) 34
glutathione - metabolism (33) 33
microsomes - drug effects (33) 33
research article (33) 33
hexobarbital - metabolism (32) 32
index medicus (32) 32
rat (32) 32
blood pressure - drug effects (31) 31
chromatography, gas (31) 31
cytochrome p-450 (31) 31
indomethacin - pharmacology (31) 31
administration, oral (30) 30
injections, intraperitoneal (30) 30
mice, inbred strains (30) 30
brain - drug effects (29) 29
calcium - metabolism (29) 29
inhibition (29) 29
aryl hydrocarbon hydroxylases - metabolism (28) 28
aniline compounds - pharmacology (27) 27
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1401) 1401
Russian (18) 18
German (15) 15
French (9) 9
Japanese (9) 9
Chinese (4) 4
Italian (4) 4
Spanish (3) 3
Croatian (1) 1
Dutch (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2862 - 2870
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function... 
Arachidonic acid metabolites | Retina | Calcium | Glia | ATP | Blood flow | arachidonic acid metabolites | NEURONAL-ACTIVITY | 20-HETE | calcium | RAT | ASTROCYTE-MEDIATED CONTROL | CALCIUM WAVES | ARACHIDONIC-ACID | glia | NEUROSCIENCES | HEMODYNAMIC-RESPONSE | retina | NITRIC-OXIDE | blood flow | MULLER CELLS | BRAIN | Arterioles - physiology | Cytochrome P-450 Enzyme Inhibitors | Rats, Long-Evans | Arterioles - enzymology | Nitric Oxide Synthase - physiology | Male | Vasodilation - radiation effects | Retinal Vessels - enzymology | Retinal Vessels - physiology | Hydroxyeicosatetraenoic Acids - biosynthesis | Vasoconstriction - radiation effects | Photolysis | Cyclic N-Oxides - pharmacology | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Eye Proteins - antagonists & inhibitors | Purinergic Antagonists | Signal Transduction - radiation effects | Cytochrome P-450 Enzyme System - physiology | Hydrazines - pharmacology | Rats | Imidazoles - pharmacology | Retinal Vessels - drug effects | Arterioles - drug effects | Vasoconstriction - drug effects | Cytochrome P-450 CYP4A - physiology | Signal Transduction - drug effects | Miconazole - pharmacology | Eye Proteins - physiology | Retinal Vessels - radiation effects | Vasodilation - drug effects | Arterioles - radiation effects | Nitric Oxide - pharmacology | Caproates - pharmacology | Vasomotor System - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Inositol 1,4,5-Trisphosphate - pharmacology | Adenosine Triphosphate - pharmacology | Vasoconstriction - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Proadifen - pharmacology | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Calcium Signaling - radiation effects | Cytochrome P-450 CYP4A - antagonists & inhibitors | Neuroglia - physiology | Nitric Oxide - physiology | Vasomotor System - radiation effects | Animals | Vasomotor System - physiology | Amidines - pharmacology | In Vitro Techniques
Journal Article
Journal Article
NEUROENDOCRINOLOGY LETTERS, ISSN 0172-780X, 2012, Volume 33, Issue 3, pp. 33 - 40
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2008, Volume 578, Issue 2-3, pp. 261 - 269
Angiotensin II is an octapeptide whose effects are mediated by two types of receptors. AT receptors are responsible for the vasoconstrictor, positive inotropic... 
receptor | Endocardial endothelium | Angiotensin II | Inotropism | Bradykinin - analogs & derivatives | Depression, Chemical | Nitric Oxide Synthase - antagonists & inhibitors | Apamin - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Endocardium - metabolism | Dose-Response Relationship, Drug | Time Factors | Charybdotoxin - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Proadifen - pharmacology | Papillary Muscles - metabolism | Endocardium - cytology | Bradykinin - pharmacology | Hydroxocobalamin - pharmacology | Potassium Channel Blockers - pharmacology | Myocardial Contraction | Rabbits | Receptor, Angiotensin, Type 2 - agonists | Angiotensin II - metabolism | Endothelial Cells - metabolism | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Indomethacin - pharmacology | Cardiovascular Agents - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Animals | Receptor, Angiotensin, Type 2 - metabolism | Potassium Channels, Calcium-Activated - drug effects | Receptor, Bradykinin B2 - metabolism | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | In Vitro Techniques | Nitric Oxide - metabolism | Oligopeptides - pharmacology | Papillary Muscles - drug effects | Receptor, Bradykinin B2 - drug effects | Naphthyridines - pharmacology | Endocardium - drug effects | Endothelial Cells - drug effects
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2013, Volume 108, Issue 3, pp. 570 - 578
Background: As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different... 
PAXILLIN | METASTASIS | TRANSMIGRATION | acetohexamide | PHOSPHORYLATION | KINASE | tumour spheroid | SMOOTH-MUSCLE MYOSIN | proadifen | ONCOLOGY | CELL-MIGRATION | RETRACTION | nifedipin | NF-KAPPA-B | isoxsuprine | lymphendothelial intravasation | ENZYME-INHIBITORS | Coculture Techniques | Humans | NF-kappa B - metabolism | Breast Neoplasms - metabolism | Lymphatic Vessels - drug effects | Lymphatic Vessels - blood supply | Carcinoma, Ductal, Breast - drug therapy | Acetohexamide - pharmacology | Endothelium, Lymphatic - drug effects | Proadifen - pharmacology | Carcinoma, Ductal, Breast - pathology | Female | Endothelium, Lymphatic - metabolism | Tumor Cells, Cultured | Carcinoma, Ductal, Breast - metabolism | Real-Time Polymerase Chain Reaction | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - metabolism | NF-kappa B - antagonists & inhibitors | Nifedipine - pharmacology | Vasodilator Agents - pharmacology | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Antineoplastic Combined Chemotherapy Protocols | Lymphatic Metastasis | Chemotaxis - drug effects | Cell Adhesion - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Hypoglycemic Agents - pharmacology | Drug Synergism | NF-kappa B - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Lymphatic Vessels - pathology | Endothelium, Lymphatic - cytology | Isoxsuprine - pharmacology | Cell Movement | Translational Therapeutics
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2004, Volume 499, Issue 1, pp. 171 - 178
The present study was designed to investigate the effects of hydroxyl radicals ( OH), generated via the Fe -mediated Fenton reaction, on isolated rat aortic... 
Vascular smooth muscle | rat | Signal transduction pathway | Hydroxyl radical | Contraction | Aortic ring | CELLS | SIGNALING PATHWAYS | vascular smooth muscle | RABBIT AORTA | VASCULAR SMOOTH-MUSCLE | aortic ring | hydroxyl radical | contraction | COUPLED RECEPTORS | PHARMACOLOGY & PHARMACY | HYDROGEN-PEROXIDE | CEREBRAL-ARTERIES | GROWTH-FACTOR | ACTIVATED PROTEIN-KINASES | SUPEROXIDE-DISMUTASE | signal transduction pathway | Hydroxyl Radical - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Calcium - metabolism | Maleimides - pharmacology | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Ferrous Compounds - pharmacology | Proadifen - pharmacology | Indoles - pharmacology | Muscle, Smooth, Vascular - drug effects | Calcium - pharmacology | Aorta - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Muscle, Smooth, Vascular - cytology | Vasoconstriction - drug effects | Animals | Androstadienes - pharmacology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Genistein - pharmacology | Carbazoles - pharmacology | In Vitro Techniques | Aorta - physiology | Staurosporine - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 04/2005, Volume 21, Issue 7, pp. 1859 - 1868
A gap junction is composed of two hemichannels and possesses a relatively large pore size (∼ 10–15 Å), allowing passage of ions and molecules up to 1 kDa.... 
selectivity | gap junction | metabolism | deafness | inner ear | hemichannel | Deafness | Selectivity | Hemichannel | Metabolism | Gap junction | Inner ear | GAP-JUNCTION CHANNELS | INNER-EAR | CORTIS ORGAN | GATING PROPERTIES | NEUROSCIENCES | HEARING IMPAIRMENT | NON-SYNDROMIC DEAFNESS | SELECTIVE PERMEABILITY | XENOPUS-OOCYTES | SUPPORTING CELLS | RAT COCHLEA | Spectrometry, Fluorescence - methods | Intracellular Membranes - physiology | Connexins - physiology | Cations - metabolism | Cell Count | Fluorescent Dyes - metabolism | Cell Communication - physiology | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Glycyrrhetinic Acid - pharmacology | Connexins - classification | Time Factors | Platelet Aggregation Inhibitors - pharmacology | Proadifen - pharmacology | Pyridoxal Phosphate - analogs & derivatives | Calcium - pharmacology | Guinea Pigs | Pyridoxal Phosphate - pharmacology | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Cochlea - cytology | Adenosine Triphosphate - analogs & derivatives | Anions - metabolism | Connexin 26 | Affinity Labels - pharmacology | Animals | Gap Junctions - physiology | Cell Membrane Permeability - physiology | Cochlea - drug effects | Cell Membrane Permeability - drug effects | Intracellular Membranes - drug effects
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 06/2016, Volume 118, Issue 6, pp. 415 - 420
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 01/2017, Volume 152, pp. 36 - 43
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2006, Volume 214, Issue 2, pp. 109 - 117
Two mechanisms have been proposed to explain quinone cytotoxicity: oxidative stress via the redox cycle and the arylation of intracellular nucleophiles. As the... 
Oxidative stress | Redox cycle | Hepatocyte | Cytochrome P450 | Quinone | redox cycle | SUPEROXIDE | hepatocyte | RAT HEPATOCYTES | QUINONES | DRUG-INTERACTIONS | ENDOGENOUS OXIDATIVE STRESS | cytochrome P450 | FREE-RADICALS | OXYGEN | PHARMACOLOGY & PHARMACY | RELATIVE IMPORTANCE | HYDROGEN-PEROXIDE | TOXICOLOGY | CYTOTOXICITY | oxidative stress | quinone | L-Lactate Dehydrogenase - secretion | Metyrapone - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Rats, Wistar | Male | Benzoquinones - chemistry | Glutathione Disulfide - metabolism | Hepatocytes - metabolism | Ketoconazole - pharmacology | Dose-Response Relationship, Drug | Hepatocytes - cytology | Lipid Peroxidation - drug effects | Superoxides - metabolism | Proadifen - pharmacology | Benzoquinones - toxicity | Molecular Structure | NADP - metabolism | Hepatocytes - drug effects | Cell Survival - drug effects | Enzyme Inhibitors - pharmacology | Imidazolines - pharmacology | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Antioxidants - pharmacology | Naphthoquinones - toxicity | Drug Synergism | Animals | Iron Chelating Agents - pharmacology | Naphthoquinones - chemistry | Oxidative Stress - drug effects | Catecholamines - pharmacology | Antioxidants | Cysteine | Ketoconazole | Lactate dehydrogenase | Superoxide | Universities and colleges | Cystine | Glutathione | ANIONS | OXIDATION | ANTIOXIDANTS | ARYLATION | ACETONE | RATS | CYSTEINE | TOXICITY | BENZOQUINONES | IRON IONS | 60 APPLIED LIFE SCIENCES | BIOLOGICAL STRESS | DISULFIDES | LACTATE DEHYDROGENASE | DEFEROXAMINE | INHIBITION | GLUTATHIONE | MICROSOMES | CHLORIDES | LIVER CELLS | VITAMIN E
Journal Article
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 01/2009, Volume 61, Issue 1, pp. 47 - 54
Journal Article
Journal Article