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Publication DateCancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate...
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
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Loading RightsEuropean Journal of Endocrinology, ISSN 0804-4643, 06/2017, Volume 176, Issue 6, pp. 685 - 693
Objective, design and methods: Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease....
MINERAL DENSITY | METABOLISM | DISTAL RADIUS | MICROARCHITECTURE | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | BARIATRIC SURGERY | MORBID-OBESITY | QUANTITATIVE COMPUTED-TOMOGRAPHY | POSTMENOPAUSAL WOMEN | FRACTURE RISK | Postoperative Complications - etiology | Obesity, Morbid - surgery | Humans | Leptin - metabolism | Middle Aged | Postoperative Complications - metabolism | Male | Tomography, X-Ray Computed | Luteinizing Hormone - metabolism | Osteoporosis - etiology | Peptides - metabolism | Osteoporosis - metabolism | Parathyroid Hormone - metabolism | Osteoporosis - diagnostic imaging | Adiponectin - metabolism | Adult | Female | Follicle Stimulating Hormone - metabolism | Peptide Fragments - metabolism | Bone Density | Bone Diseases, Metabolic - diagnostic imaging | Collagen Type I - metabolism | Lumbar Vertebrae - diagnostic imaging | Bone Diseases, Metabolic - etiology | Tibia - diagnostic imaging | Gastric Bypass - adverse effects | Procollagen - metabolism | Absorptiometry, Photon | Bone Diseases, Metabolic - metabolism | Hip Joint - diagnostic imaging | Insulin - metabolism | Weight Loss | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Bone Remodeling | Longitudinal Studies | Postoperative Complications - diagnostic imaging | Radius - diagnostic imaging
MINERAL DENSITY | METABOLISM | DISTAL RADIUS | MICROARCHITECTURE | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | BARIATRIC SURGERY | MORBID-OBESITY | QUANTITATIVE COMPUTED-TOMOGRAPHY | POSTMENOPAUSAL WOMEN | FRACTURE RISK | Postoperative Complications - etiology | Obesity, Morbid - surgery | Humans | Leptin - metabolism | Middle Aged | Postoperative Complications - metabolism | Male | Tomography, X-Ray Computed | Luteinizing Hormone - metabolism | Osteoporosis - etiology | Peptides - metabolism | Osteoporosis - metabolism | Parathyroid Hormone - metabolism | Osteoporosis - diagnostic imaging | Adiponectin - metabolism | Adult | Female | Follicle Stimulating Hormone - metabolism | Peptide Fragments - metabolism | Bone Density | Bone Diseases, Metabolic - diagnostic imaging | Collagen Type I - metabolism | Lumbar Vertebrae - diagnostic imaging | Bone Diseases, Metabolic - etiology | Tibia - diagnostic imaging | Gastric Bypass - adverse effects | Procollagen - metabolism | Absorptiometry, Photon | Bone Diseases, Metabolic - metabolism | Hip Joint - diagnostic imaging | Insulin - metabolism | Weight Loss | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Bone Remodeling | Longitudinal Studies | Postoperative Complications - diagnostic imaging | Radius - diagnostic imaging
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Nature Genetics, ISSN 1061-4036, 02/2008, Volume 40, Issue 2, pp. 170 - 180
HIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we...
SKELETAL-MUSCLE | OXIDATIVE STRESS | HIF | ANGIOGENESIS | GENETICS & HEREDITY | INCREASES | ISCHEMIA | ACTIVATED RECEPTOR-ALPHA | MICE | EXPRESSION | INDUCIBLE-FACTOR | Immunohistochemistry | Embryo, Mammalian | Glutamates - metabolism | Muscle, Skeletal - metabolism | Tomography, X-Ray Computed | Mitochondria - ultrastructure | Oxygen Consumption - physiology | Hypoxia - metabolism | Nuclear Magnetic Resonance, Biomolecular | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Basal Metabolism | Energy Metabolism - genetics | Energy Metabolism - physiology | Fibroblasts - metabolism | Carbon Dioxide - metabolism | Oxidation-Reduction | Mitochondria - metabolism | Carbon Isotopes - metabolism | Homozygote | Animals | Procollagen-Proline Dioxygenase - deficiency | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Oxygen Consumption - genetics | Glucose - metabolism | Carbon Radioisotopes - metabolism | Mice | Physiological aspects | Glucose metabolism | Hypoxia | Research | Hydroxylases | Genetics | Oxygen | Metabolism
SKELETAL-MUSCLE | OXIDATIVE STRESS | HIF | ANGIOGENESIS | GENETICS & HEREDITY | INCREASES | ISCHEMIA | ACTIVATED RECEPTOR-ALPHA | MICE | EXPRESSION | INDUCIBLE-FACTOR | Immunohistochemistry | Embryo, Mammalian | Glutamates - metabolism | Muscle, Skeletal - metabolism | Tomography, X-Ray Computed | Mitochondria - ultrastructure | Oxygen Consumption - physiology | Hypoxia - metabolism | Nuclear Magnetic Resonance, Biomolecular | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Basal Metabolism | Energy Metabolism - genetics | Energy Metabolism - physiology | Fibroblasts - metabolism | Carbon Dioxide - metabolism | Oxidation-Reduction | Mitochondria - metabolism | Carbon Isotopes - metabolism | Homozygote | Animals | Procollagen-Proline Dioxygenase - deficiency | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Oxygen Consumption - genetics | Glucose - metabolism | Carbon Radioisotopes - metabolism | Mice | Physiological aspects | Glucose metabolism | Hypoxia | Research | Hydroxylases | Genetics | Oxygen | Metabolism
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Loading RightsCANCER RESEARCH, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2550 - 2560
Lactate generated from pyruvate fuels production of intracellular NAD(+) as an end result of the glycolytic process in tumors. Elevated lactate concentration...
ACTIVATION | MALIGNANT-TUMORS | METASTASIS | METABOLISM | ONCOLOGY | AEROBIC GLYCOLYSIS | GROWTH-FACTOR | NF-KAPPA-B | EXPRESSION | CANCER-THERAPY | HYPOXIA-INDUCIBLE FACTOR-1 | Reactive Oxygen Species - metabolism | Humans | Cell Growth Processes - physiology | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Breast Neoplasms - metabolism | Procollagen-Proline Dioxygenase - metabolism | Lactic Acid - pharmacokinetics | Monocarboxylic Acid Transporters - metabolism | Ketoglutaric Acids - pharmacology | Muscle Proteins - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Interleukin-8 - metabolism | Ketoglutaric Acids - metabolism | Lactic Acid - pharmacology | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - blood supply | Signal Transduction | Interleukin-8 - biosynthesis | Hypoxia-Inducible Factor-Proline Dioxygenases | Breast Neoplasms - blood supply | Symporters - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Neovascularization, Pathologic - metabolism | Colorectal Neoplasms - pathology
ACTIVATION | MALIGNANT-TUMORS | METASTASIS | METABOLISM | ONCOLOGY | AEROBIC GLYCOLYSIS | GROWTH-FACTOR | NF-KAPPA-B | EXPRESSION | CANCER-THERAPY | HYPOXIA-INDUCIBLE FACTOR-1 | Reactive Oxygen Species - metabolism | Humans | Cell Growth Processes - physiology | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Breast Neoplasms - metabolism | Procollagen-Proline Dioxygenase - metabolism | Lactic Acid - pharmacokinetics | Monocarboxylic Acid Transporters - metabolism | Ketoglutaric Acids - pharmacology | Muscle Proteins - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Interleukin-8 - metabolism | Ketoglutaric Acids - metabolism | Lactic Acid - pharmacology | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - blood supply | Signal Transduction | Interleukin-8 - biosynthesis | Hypoxia-Inducible Factor-Proline Dioxygenases | Breast Neoplasms - blood supply | Symporters - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Neovascularization, Pathologic - metabolism | Colorectal Neoplasms - pathology
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Loading RightsAmerican Journal of Gastroenterology, ISSN 0002-9270, 02/2015, Volume 110, Issue 2, pp. 336 - 345
INTRODUCTION: Because of deteriorating exocrine function, malabsorption renders chronic pancreatitis (CP) patients at risk of osteoporosis and fracture....
FRACTURE | MARKER STANDARDS | MINERAL DENSITY | METABOLISM | BOWEL DISEASES | RISK | SMOKING | VITAMIN-D STATUS | POSTMENOPAUSAL WOMEN | GASTROENTEROLOGY & HEPATOLOGY | Prospective Studies | Humans | Middle Aged | Male | Case-Control Studies | Femur Neck - diagnostic imaging | Inflammation - metabolism | C-Reactive Protein - metabolism | Osteoporosis - metabolism | Bone Diseases, Metabolic - complications | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Osteoporosis - diagnostic imaging | Bone Resorption - metabolism | Adult | Female | Interleukin-6 - metabolism | Gonadal Steroid Hormones - metabolism | Peptide Fragments - metabolism | Bone Density | Bone Diseases, Metabolic - diagnostic imaging | Collagen Type I - metabolism | Lumbar Vertebrae - diagnostic imaging | Osteocalcin - metabolism | Procollagen - metabolism | Absorptiometry, Photon | Bone Diseases, Metabolic - metabolism | Pancreatitis, Chronic - complications | Thyroid Hormones - metabolism | Osteoporosis - complications | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Pancreatitis, Chronic - metabolism | Osteogenesis | Smoking
FRACTURE | MARKER STANDARDS | MINERAL DENSITY | METABOLISM | BOWEL DISEASES | RISK | SMOKING | VITAMIN-D STATUS | POSTMENOPAUSAL WOMEN | GASTROENTEROLOGY & HEPATOLOGY | Prospective Studies | Humans | Middle Aged | Male | Case-Control Studies | Femur Neck - diagnostic imaging | Inflammation - metabolism | C-Reactive Protein - metabolism | Osteoporosis - metabolism | Bone Diseases, Metabolic - complications | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Osteoporosis - diagnostic imaging | Bone Resorption - metabolism | Adult | Female | Interleukin-6 - metabolism | Gonadal Steroid Hormones - metabolism | Peptide Fragments - metabolism | Bone Density | Bone Diseases, Metabolic - diagnostic imaging | Collagen Type I - metabolism | Lumbar Vertebrae - diagnostic imaging | Osteocalcin - metabolism | Procollagen - metabolism | Absorptiometry, Photon | Bone Diseases, Metabolic - metabolism | Pancreatitis, Chronic - complications | Thyroid Hormones - metabolism | Osteoporosis - complications | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Pancreatitis, Chronic - metabolism | Osteogenesis | Smoking
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Loading RightsMolecular Cell, ISSN 1097-2765, 05/2008, Volume 30, Issue 4, pp. 393 - 402
HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl hydroxylases plays a...
DEHYDROGENASE-DEFICIENT CELLS | ASPARAGINYL HYDROXYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA-INDUCIBLE-FACTOR | IN-VIVO | GENE-EXPRESSION | RENAL-CELL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | PAS DOMAIN PROTEIN | PROLYL HYDROXYLASE | FACTOR-ALPHA | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Isoenzymes - genetics | Humans | Enzyme Stability | Gene Expression Regulation | Repressor Proteins - genetics | Transcription Factors - genetics | Hypoxia-Inducible Factor 1 - metabolism | Iron - metabolism | Oxygen - metabolism | Ascorbic Acid - metabolism | Citric Acid Cycle | Hypoxia-Inducible Factor 1 - genetics | Procollagen-Proline Dioxygenase - metabolism | Mixed Function Oxygenases | Transcription Factors - metabolism | Animals | Procollagen-Proline Dioxygenase - genetics | Isoenzymes - metabolism | Asparagine - metabolism | Signal Transduction - physiology | Transcription, Genetic | Nitric Oxide - metabolism | Repressor Proteins - metabolism | Physiological aspects | Hydroxylases | Metabolites | Hydroxylation | Nitric oxide
DEHYDROGENASE-DEFICIENT CELLS | ASPARAGINYL HYDROXYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA-INDUCIBLE-FACTOR | IN-VIVO | GENE-EXPRESSION | RENAL-CELL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | PAS DOMAIN PROTEIN | PROLYL HYDROXYLASE | FACTOR-ALPHA | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Isoenzymes - genetics | Humans | Enzyme Stability | Gene Expression Regulation | Repressor Proteins - genetics | Transcription Factors - genetics | Hypoxia-Inducible Factor 1 - metabolism | Iron - metabolism | Oxygen - metabolism | Ascorbic Acid - metabolism | Citric Acid Cycle | Hypoxia-Inducible Factor 1 - genetics | Procollagen-Proline Dioxygenase - metabolism | Mixed Function Oxygenases | Transcription Factors - metabolism | Animals | Procollagen-Proline Dioxygenase - genetics | Isoenzymes - metabolism | Asparagine - metabolism | Signal Transduction - physiology | Transcription, Genetic | Nitric Oxide - metabolism | Repressor Proteins - metabolism | Physiological aspects | Hydroxylases | Metabolites | Hydroxylation | Nitric oxide
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Loading RightsThe Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2017, Volume 102, Issue 6, pp. 1807 - 1815
Context: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be...
SERUM-INSULIN | OBESE CHILDREN | HOMEOSTASIS MODEL ASSESSMENT | SKELETAL-MUSCLE MASS | HEALTHY MALE SIBLINGS | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | POSTMENOPAUSAL WOMEN | TYPE-2 DIABETES-MELLITUS | FRACTURE RISK | BETA-CELL FUNCTION | Body Composition | Radius - pathology | Humans | Leptin - metabolism | Middle Aged | Male | Tomography, X-Ray Computed | Cortical Bone - pathology | Tibia - pathology | Tandem Mass Spectrometry | Testosterone - metabolism | Peptides - metabolism | Parathyroid Hormone - metabolism | Chromatography, Liquid | Adiponectin - metabolism | Adult | Muscle Strength | Estradiol - metabolism | Peptide Fragments - metabolism | Bone Density | Collagen Type I - metabolism | Osteocalcin - metabolism | Insulin Resistance | Tibia - diagnostic imaging | Organ Size | Sex Hormone-Binding Globulin - metabolism | Procollagen - metabolism | Absorptiometry, Photon | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Muscle, Skeletal - pathology | Blood Glucose - metabolism | Cortical Bone - diagnostic imaging | Insulin-Like Growth Factor I - metabolism | Radius - diagnostic imaging | Serum Albumin - metabolism | Radius | Sex | Homeostasis | Population studies | Bone (trabecular) | Body composition | Adiponectin | Computed tomography | Body composition (biology) | Bone (cortical) | Age | Bone composition | Dual energy X-ray absorptiometry | Diabetes mellitus | Health risks | Muscles | Excavation | Bone turnover | Insulin | Geometry | Bone mass | Leptin | Body size | Men | Insulin resistance | Bone mineral density | Bone
SERUM-INSULIN | OBESE CHILDREN | HOMEOSTASIS MODEL ASSESSMENT | SKELETAL-MUSCLE MASS | HEALTHY MALE SIBLINGS | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | POSTMENOPAUSAL WOMEN | TYPE-2 DIABETES-MELLITUS | FRACTURE RISK | BETA-CELL FUNCTION | Body Composition | Radius - pathology | Humans | Leptin - metabolism | Middle Aged | Male | Tomography, X-Ray Computed | Cortical Bone - pathology | Tibia - pathology | Tandem Mass Spectrometry | Testosterone - metabolism | Peptides - metabolism | Parathyroid Hormone - metabolism | Chromatography, Liquid | Adiponectin - metabolism | Adult | Muscle Strength | Estradiol - metabolism | Peptide Fragments - metabolism | Bone Density | Collagen Type I - metabolism | Osteocalcin - metabolism | Insulin Resistance | Tibia - diagnostic imaging | Organ Size | Sex Hormone-Binding Globulin - metabolism | Procollagen - metabolism | Absorptiometry, Photon | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Muscle, Skeletal - pathology | Blood Glucose - metabolism | Cortical Bone - diagnostic imaging | Insulin-Like Growth Factor I - metabolism | Radius - diagnostic imaging | Serum Albumin - metabolism | Radius | Sex | Homeostasis | Population studies | Bone (trabecular) | Body composition | Adiponectin | Computed tomography | Body composition (biology) | Bone (cortical) | Age | Bone composition | Dual energy X-ray absorptiometry | Diabetes mellitus | Health risks | Muscles | Excavation | Bone turnover | Insulin | Geometry | Bone mass | Leptin | Body size | Men | Insulin resistance | Bone mineral density | Bone
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Loading Rights世界胃肠病学杂志：英文版（电子版）, ISSN 1007-9327, 2014, Volume 20, Issue 26, pp. 8525 - 8534
AIM:To develop an animal model that encompasses the different facets of non-alcoholic steatohepatitis(NASH),which has been a challenge.METHODS:In this study,we...
steatohepatitis | I | Gender | Non-alcoholic | differences | Gender differences | Inflammasome | Non-alcoholic steatohepatitis | High fat diet | FIBROSIS | CHOLESTEROL | CHRONIC HEPATITIS-C | NONALCOHOLIC STEATOHEPATITIS | LIVER-DISEASE | PATHOGENESIS | HEPATOCELLULAR-CARCINOMA | ANIMAL-MODELS | MICE | SEX-DIFFERENCES | GASTROENTEROLOGY & HEPATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Inflammasomes - metabolism | Actins - metabolism | Diet, High-Fat - adverse effects | Non-alcoholic Fatty Liver Disease - etiology | Caspase 1 - metabolism | Male | Alanine Transaminase - blood | Insulin - blood | RNA, Messenger - metabolism | Actins - genetics | DNA-Binding Proteins - metabolism | Liver - immunology | Collagen Type I - genetics | Time Factors | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Liver Cirrhosis - metabolism | Female | Chemokine CCL2 - metabolism | Weight Gain | Liver Cirrhosis - etiology | Procollagen - genetics | Collagen Type I - metabolism | Fructose - adverse effects | Non-alcoholic Fatty Liver Disease - genetics | Liver - metabolism | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - immunology | Insulin Resistance | Chemokine CCL2 - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Procollagen - metabolism | DNA-Binding Proteins - genetics | Inflammasomes - genetics | Animals | Inflammasomes - immunology | Sex Factors | Triglycerides - blood | Liver Cirrhosis - pathology | Dietary Sucrose - adverse effects | Blood Glucose - metabolism | Original
steatohepatitis | I | Gender | Non-alcoholic | differences | Gender differences | Inflammasome | Non-alcoholic steatohepatitis | High fat diet | FIBROSIS | CHOLESTEROL | CHRONIC HEPATITIS-C | NONALCOHOLIC STEATOHEPATITIS | LIVER-DISEASE | PATHOGENESIS | HEPATOCELLULAR-CARCINOMA | ANIMAL-MODELS | MICE | SEX-DIFFERENCES | GASTROENTEROLOGY & HEPATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Inflammasomes - metabolism | Actins - metabolism | Diet, High-Fat - adverse effects | Non-alcoholic Fatty Liver Disease - etiology | Caspase 1 - metabolism | Male | Alanine Transaminase - blood | Insulin - blood | RNA, Messenger - metabolism | Actins - genetics | DNA-Binding Proteins - metabolism | Liver - immunology | Collagen Type I - genetics | Time Factors | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Liver Cirrhosis - metabolism | Female | Chemokine CCL2 - metabolism | Weight Gain | Liver Cirrhosis - etiology | Procollagen - genetics | Collagen Type I - metabolism | Fructose - adverse effects | Non-alcoholic Fatty Liver Disease - genetics | Liver - metabolism | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - immunology | Insulin Resistance | Chemokine CCL2 - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Procollagen - metabolism | DNA-Binding Proteins - genetics | Inflammasomes - genetics | Animals | Inflammasomes - immunology | Sex Factors | Triglycerides - blood | Liver Cirrhosis - pathology | Dietary Sucrose - adverse effects | Blood Glucose - metabolism | Original
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Loading RightsScience, ISSN 0036-8075, 6/2011, Volume 332, Issue 6036, pp. 1401 - 1403
Root hairs are single cells that develop by tip growth and are specialized in the absorption of nutrients. Their cell walls are composed of polysaccharides and...
Enzymes | Cell growth | Phenotypes | Polysaccharides | Cell walls | RESEARCH ARTICLES | Hair cells | Root hairs | Biochemistry | Plants | Plant cells | MOLECULAR CHARACTERIZATION | MUTANTS | EXTENSIN | CODES | MULTIDISCIPLINARY SCIENCES | GENES | REQUIRES | ARABIDOPSIS | IDENTIFICATION | PROLYL 4-HYDROXYLASE | TOBACCO | Arabidopsis - growth & development | Genes, Plant | Proline - metabolism | Glycoproteins - metabolism | Pentosyltransferases - metabolism | Procollagen-Proline Dioxygenase - metabolism | Arabidopsis Proteins - metabolism | Pentosyltransferases - chemistry | Plant Proteins - chemistry | Arabinose - metabolism | Gene Expression Regulation, Plant | Polysaccharides - chemistry | Plant Proteins - metabolism | Glycosyltransferases - genetics | Glycoproteins - chemistry | Plant Roots - growth & development | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Hydroxylation | Protein Structure, Secondary | Hydroxyproline - metabolism | Glycosylation | Plant Roots - cytology | Arabidopsis - metabolism | Arabidopsis - genetics | Glycosyltransferases - metabolism | Phenotype | Arabidopsis Proteins - chemistry | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Cell Wall - metabolism | Protein Conformation | Protein Processing, Post-Translational | Mutation | Carbohydrate Conformation | Hair | Physiological aspects | Glycoproteins | Genetic aspects | Growth
Enzymes | Cell growth | Phenotypes | Polysaccharides | Cell walls | RESEARCH ARTICLES | Hair cells | Root hairs | Biochemistry | Plants | Plant cells | MOLECULAR CHARACTERIZATION | MUTANTS | EXTENSIN | CODES | MULTIDISCIPLINARY SCIENCES | GENES | REQUIRES | ARABIDOPSIS | IDENTIFICATION | PROLYL 4-HYDROXYLASE | TOBACCO | Arabidopsis - growth & development | Genes, Plant | Proline - metabolism | Glycoproteins - metabolism | Pentosyltransferases - metabolism | Procollagen-Proline Dioxygenase - metabolism | Arabidopsis Proteins - metabolism | Pentosyltransferases - chemistry | Plant Proteins - chemistry | Arabinose - metabolism | Gene Expression Regulation, Plant | Polysaccharides - chemistry | Plant Proteins - metabolism | Glycosyltransferases - genetics | Glycoproteins - chemistry | Plant Roots - growth & development | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Hydroxylation | Protein Structure, Secondary | Hydroxyproline - metabolism | Glycosylation | Plant Roots - cytology | Arabidopsis - metabolism | Arabidopsis - genetics | Glycosyltransferases - metabolism | Phenotype | Arabidopsis Proteins - chemistry | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Cell Wall - metabolism | Protein Conformation | Protein Processing, Post-Translational | Mutation | Carbohydrate Conformation | Hair | Physiological aspects | Glycoproteins | Genetic aspects | Growth
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Loading RightsJournal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 120 - 123
Cardiovascular | Cardiac fibrosis | Marker | Proto-myofibroblast | Fibroblast activating protein | Myofibroblast | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | TISSUE | THY-1 | IDENTIFICATION | CELL BIOLOGY | HEART | CARDIAC FIBROBLASTS | EXPRESSION | Cell Adhesion Molecules - genetics | Vimentin - metabolism | Humans | Actins - metabolism | Ectodysplasins - metabolism | Actins - genetics | Procollagen-Proline Dioxygenase - metabolism | Myofibroblasts - metabolism | Discoidin Domain Receptors | Endomyocardial Fibrosis - diagnosis | Vimentin - genetics | Thy-1 Antigens - genetics | Gelatinases - metabolism | Serine Endopeptidases - genetics | Endomyocardial Fibrosis - genetics | Cell Differentiation | Endomyocardial Fibrosis - pathology | Membrane Proteins - metabolism | Fibroblasts - metabolism | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | Myofibroblasts - pathology | Ectodysplasins - genetics | Membrane Proteins - genetics | Gene Expression Regulation | Receptors, Mitogen - metabolism | Fibroblasts - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Cell Adhesion Molecules - metabolism | Thy-1 Antigens - metabolism | Animals | Procollagen-Proline Dioxygenase - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gelatinases - genetics | Endomyocardial Fibrosis - metabolism | Serine Endopeptidases - metabolism | Calcium-Binding Proteins - genetics | Receptors, Mitogen - genetics
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Loading RightsJournal of Orthopaedic Research, ISSN 0736-0266, 10/2009, Volume 27, Issue 10, pp. 1392 - 1398
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in the treatment of tendinitis....
IGF‐I | gene therapy | tendinitis | in vivo | mesenchymal stem cells | In vivo | IGF-I | Tendinitis | Gene therapy | Mesenchymal stem cells | PROGENITOR CELLS | III COLLAGEN | BONE-MARROW | HORSES | DNA-SYNTHESIS | MODEL | MATRIX PROTEIN COMP | CARTILAGE | REPAIR | ORTHOPEDICS | EXPRESSION | Cell- and Tissue-Based Therapy - methods | Cell- and Tissue-Based Therapy - veterinary | Tendinopathy - metabolism | Tendinopathy - veterinary | Collagen Type III - metabolism | Glycoproteins - metabolism | Male | Insulin-Like Growth Factor I - genetics | Matrilin Proteins | Mesenchymal Stromal Cells - cytology | Procollagen N-Endopeptidase - metabolism | Tendons - diagnostic imaging | Ultrasonography | Female | Horse Diseases - pathology | Extracellular Matrix Proteins - metabolism | Tendinopathy - therapy | Collagen Type I - metabolism | Tendons - metabolism | Mesenchymal Stromal Cells - metabolism | Matrix Metalloproteinase 3 - metabolism | ADAMTS4 Protein | Matrix Metalloproteinase 13 - metabolism | Mesenchymal Stem Cell Transplantation - methods | Mesenchymal Stem Cell Transplantation - veterinary | Horse Diseases - therapy | ADAM Proteins - metabolism | Biomechanical Phenomena | Genetic Therapy - veterinary | Animals | Tendons - pathology | Horses | Horse Diseases - metabolism | Insulin-Like Growth Factor I - metabolism | Genetic Therapy - methods
IGF‐I | gene therapy | tendinitis | in vivo | mesenchymal stem cells | In vivo | IGF-I | Tendinitis | Gene therapy | Mesenchymal stem cells | PROGENITOR CELLS | III COLLAGEN | BONE-MARROW | HORSES | DNA-SYNTHESIS | MODEL | MATRIX PROTEIN COMP | CARTILAGE | REPAIR | ORTHOPEDICS | EXPRESSION | Cell- and Tissue-Based Therapy - methods | Cell- and Tissue-Based Therapy - veterinary | Tendinopathy - metabolism | Tendinopathy - veterinary | Collagen Type III - metabolism | Glycoproteins - metabolism | Male | Insulin-Like Growth Factor I - genetics | Matrilin Proteins | Mesenchymal Stromal Cells - cytology | Procollagen N-Endopeptidase - metabolism | Tendons - diagnostic imaging | Ultrasonography | Female | Horse Diseases - pathology | Extracellular Matrix Proteins - metabolism | Tendinopathy - therapy | Collagen Type I - metabolism | Tendons - metabolism | Mesenchymal Stromal Cells - metabolism | Matrix Metalloproteinase 3 - metabolism | ADAMTS4 Protein | Matrix Metalloproteinase 13 - metabolism | Mesenchymal Stem Cell Transplantation - methods | Mesenchymal Stem Cell Transplantation - veterinary | Horse Diseases - therapy | ADAM Proteins - metabolism | Biomechanical Phenomena | Genetic Therapy - veterinary | Animals | Tendons - pathology | Horses | Horse Diseases - metabolism | Insulin-Like Growth Factor I - metabolism | Genetic Therapy - methods
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