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animals (663) 663
procollagen-proline dioxygenase - metabolism (648) 648
humans (562) 562
biochemistry & molecular biology (424) 424
index medicus (316) 316
procollagen-proline dioxygenase - genetics (279) 279
procollagen-proline dioxygenase - antagonists & inhibitors (190) 190
mice (186) 186
hydroxylation (183) 183
rats (179) 179
cell biology (171) 171
hypoxia (171) 171
male (169) 169
procollagen-proline dioxygenase - chemistry (152) 152
amino acid sequence (145) 145
molecular sequence data (145) 145
collagen (144) 144
hypoxia-inducible factor-proline dioxygenases (142) 142
cell line (139) 139
female (139) 139
kinetics (138) 138
chick embryo (137) 137
collagen - biosynthesis (134) 134
cells, cultured (131) 131
hypoxia-inducible factor 1, alpha subunit - metabolism (131) 131
expression (105) 105
hypoxia-inducible factor (105) 105
collagen - metabolism (95) 95
protein binding (95) 95
oxygen - metabolism (90) 90
hydroxylases (85) 85
prolyl 4-hydroxylase (84) 84
hif-1-alpha (83) 83
hif-alpha (83) 83
prolyl hydroxylase (82) 82
gene expression (80) 80
oxygen (78) 78
proline - metabolism (78) 78
rna, messenger - metabolism (77) 77
protein (75) 75
proteins (73) 73
enzymes (72) 72
binding sites (69) 69
cell line, tumor (69) 69
time factors (69) 69
gene-expression (67) 67
base sequence (66) 66
procollagen-proline dioxygenase (66) 66
research (66) 66
enzyme inhibitors - pharmacology (65) 65
hypoxia-inducible factor 1, alpha subunit - genetics (64) 64
procollagen-proline dioxygenase - biosynthesis (64) 64
research article (64) 64
protein conformation (62) 62
transcription factors - metabolism (62) 62
protein structure, tertiary (60) 60
hif (59) 59
hypoxia-inducible factor 1, alpha subunit (59) 59
hydroxyproline - metabolism (57) 57
rna, messenger - genetics (57) 57
procollagen-proline dioxygenase - analysis (56) 56
family (55) 55
article (54) 54
biophysics (53) 53
substrate specificity (53) 53
gene expression regulation (52) 52
macromolecular substances (52) 52
cloning, molecular (51) 51
fibroblasts - metabolism (51) 51
procollagen-proline dioxygenase - isolation & purification (51) 51
adult (48) 48
hydroxyproline (48) 48
recombinant proteins - metabolism (48) 48
hydroxylase (47) 47
protein processing, post-translational (47) 47
biochemistry (46) 46
physiological aspects (45) 45
proline (45) 45
signal transduction (45) 45
ascorbic acid - pharmacology (44) 44
cancer (44) 44
molecular weight (44) 44
identification (43) 43
mutation (43) 43
procollagen-lysine, 2-oxoglutarate 5-dioxygenase - metabolism (42) 42
proline hydroxylation (41) 41
protein disulfide-isomerase (41) 41
beta-subunit (40) 40
dna-binding proteins - metabolism (40) 40
genes (40) 40
nuclear proteins - metabolism (40) 40
recombinant proteins - chemistry (40) 40
analysis (39) 39
cell hypoxia (39) 39
dose-response relationship, drug (39) 39
genetic aspects (39) 39
cells (38) 38
mice, inbred c57bl (38) 38
transcription factors (38) 38
fibroblasts (37) 37
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Journal of Biological Chemistry, ISSN 0021-9258, 02/2007, Volume 282, Issue 7, pp. 4524 - 4532
The stability and transcriptional activity of the hypoxia-inducible factors (HIFs) are regulated by two oxygen-dependent events that are catalyzed by three HIF... 
Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Vascular Endothelial Growth Factor A - biosynthesis | Fibroblasts - enzymology | Fumarate Hydratase - chemistry | Mixed Function Oxygenases - metabolism | Fumarate Hydratase - deficiency | Mixed Function Oxygenases - chemistry | Succinate Dehydrogenase - chemistry | Procollagen-Proline Dioxygenase - metabolism | Dose-Response Relationship, Drug | Fumarate Hydratase - metabolism | Neoplasms - chemistry | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Erythropoietin - biosynthesis | Fibroblasts - chemistry | Cell Line | Enzyme Inhibitors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Citric Acid Cycle - drug effects | Neoplasms - enzymology | Mixed Function Oxygenases - antagonists & inhibitors | Fibroblasts - pathology | Succinate Dehydrogenase - deficiency | p300-CBP Transcription Factors - metabolism | Citric Acid Cycle - genetics | Procollagen-Proline Dioxygenase - genetics | Gene Expression Regulation, Enzymologic - genetics | Succinate Dehydrogenase - metabolism | Mixed Function Oxygenases - genetics | Neoplasms - pathology | Procollagen-Proline Dioxygenase - chemistry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2006, Volume 103, Issue 26, pp. 9814 - 9819
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 2005, Volume 74, Issue 1, pp. 115 - 128
Hypoxia-inducible factor (HIF) is a master transcriptional regulator of hypoxia-inducible genes and consists of a labile a subunit (such as HIF1 alpha) and a... 
Von Hippel-Lindau | EGLN | FIH | Hydroxylation | Hypoxia-inducible factor (HIF) | HYPOXIA-INDUCIBLE FACTOR | hydroxylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPEL-LINDAU PROTEIN | FACTOR 1-ALPHA | hypoxia-inducible factor (HIF) | MITOCHONDRIAL RESPIRATORY-CHAIN | von Hippel-Lindau | NITRIC-OXIDE | PROLYL-HYDROXYLASES | TUMOR-SUPPRESSOR PROTEIN | ENDOTHELIAL GROWTH-FACTOR | UBIQUITIN-PROTEASOME PATHWAY | PAS DOMAIN PROTEIN | Transcription Factors - chemistry | Humans | Multiprotein Complexes | Hypoxia-Inducible Factor 1, alpha Subunit | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Immediate-Early Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Immediate-Early Proteins - chemistry | Nuclear Proteins - genetics | Tumor Suppressor Proteins - metabolism | Hypoxia-Inducible Factor 1 | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Proline - chemistry | Transcription Factors - metabolism | Animals | Immediate-Early Proteins - genetics | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Von Hippel-Lindau Tumor Suppressor Protein | Procollagen-Proline Dioxygenase - chemistry | Ubiquitin-Protein Ligases - genetics | Proline | Research | Gene expression | Proteins | Oxygen | Biochemistry | Tumors
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46902
PHD fingers represent one of the largest families of epigenetic readers capable of decoding post-translationally modified or unmodified histone H3 tails.... 
PROTEIN-PROTEIN RECOGNITION | COMPLEX | METHYLATION | EPIGENETIC MARKS | GENE | CHROMATIN | AIRE | AUTOIMMUNE REGULATOR | MULTIDISCIPLINARY SCIENCES | HISTONE MODIFICATIONS | Transcription Factors - chemistry | Histones - chemistry | Humans | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Transcription Factors - genetics | Nuclear Proteins - chemistry | Molecular Dynamics Simulation | Procollagen-Proline Dioxygenase - metabolism | Transcription Factors - metabolism | Thermodynamics | Histones - genetics | Procollagen-Proline Dioxygenase - genetics | Protein Binding | Protein Conformation | Protein Interaction Domains and Motifs | Histones - metabolism | Mutation | Methylation | Nuclear Proteins - genetics | Procollagen-Proline Dioxygenase - chemistry | Principal Component Analysis | Physiological aspects | Research | Comparative analysis | Properties | Protein-protein interactions | Immunoproteins | Peptides | Laboratories | Genomics | Molecular dynamics | Amino acids | Kinases | Proteins | Case studies | Immunology | Energy | Covariance | Mathematical analysis | Fingers | Post-translation | Qualitative analysis | Bioinformatics | Dissection | Flapping | Antigens | Alanine | Computer simulation | Decoding | Covariance matrix | Gene expression | Free energy | Readers | Mutants | Studies | Solvation | Simulation | Binding energy | Computer applications | Epigenetics | Ligands | AIRE protein | Surface area | Histone H3 | Recognition
Journal Article
Journal Article
Science, ISSN 0036-8075, 11/2001, Volume 294, Issue 5545, pp. 1337 - 1340
Mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha... 
Enzymes | Transcriptional regulatory elements | Messenger RNA | RNA | Drosophila | Cell lines | Hypoxia | Amino acids | Reports | Genetic mutation | Enzyme substrates | INDUCIBLE FACTOR 1-ALPHA | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR PROTEIN | HIF-1-ALPHA | O-2 HOMEOSTASIS | HYPOXIA | EXPRESSION | BINDING | UBIQUITIN-PROTEASOME PATHWAY | TRANSGENIC MICE | L-Lactate Dehydrogenase - metabolism | Humans | Molecular Sequence Data | Substrate Specificity | Drosophila melanogaster - genetics | Hypoxia-Inducible Factor 1, alpha Subunit | Oxygen - metabolism | Procollagen-Proline Dioxygenase - metabolism | Cell Hypoxia | DNA-Binding Proteins - metabolism | Transfection | Cloning, Molecular | Conserved Sequence | Genes, Reporter | Genes, Insect | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Hydroxylation | Hypoxia-Inducible Factor 1 | Hydroxyproline - metabolism | Nuclear Proteins - metabolism | Gene Expression Regulation, Enzymologic | Sequence Alignment | Animals | L-Lactate Dehydrogenase - genetics | Procollagen-Proline Dioxygenase - genetics | RNA, Double-Stranded - genetics | Drosophila melanogaster - enzymology | Transcription Factors | Mutation | Procollagen-Proline Dioxygenase - chemistry | Amino Acid Substitution | Hydroxylases | Research | Observations | Mammals | Cells
Journal Article