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Science, ISSN 0036-8075, 9/2011, Volume 333, Issue 6049, pp. 1630 - 1632
Pyrazinamide (PZA) is a first-line tuberculosis drug that plays a unique role in shortening the duration of tuberculosis chemotherapy. PZA is hydrolyzed... 
Proteins | Tuberculosis | Mycobacterium tuberculosis | REPORTS | Ribosomes | Power of attorney | Amino acids | Bacteria | Geometric lines | Codons | Genetic mutation | PYRAZINOIC ACID | SYNTHASE | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SUSCEPTIBILITY | RESISTANCE | PNCA MUTATIONS | BINDING | RIBOSOMAL-PROTEIN S1 | TMRNA | Ribosomal Proteins - chemistry | Bacterial Proteins - chemistry | Drug Resistance, Bacterial | Molecular Sequence Data | Ribosomes - metabolism | RNA, Messenger - metabolism | Mycobacterium tuberculosis - drug effects | Prodrugs - metabolism | Ribosomal Proteins - metabolism | Pyrazinamide - pharmacology | Mycobacterium tuberculosis - metabolism | RNA, Bacterial - metabolism | Pyrazinamide - metabolism | Amidohydrolases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Pyrazinamide - analogs & derivatives | RNA, Transfer - metabolism | Ribosomal Proteins - genetics | Amidohydrolases - genetics | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Mutant Proteins - metabolism | Protein Binding | Bacterial Proteins - metabolism | Protein Biosynthesis - drug effects | Mutation | Antitubercular Agents - metabolism | Prodrugs - pharmacology | Mycobacterium tuberculosis - genetics | Physiological aspects | Development and progression | Genetic aspects | Research | Pyrazinamide | Health aspects | Genetic translation | Enzymes | Chemotherapy | Inhibitor drugs
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2007, Volume 35, Issue 12, pp. 2166 - 2176
Olmesartan, a novel angiotensin II AT1-receptor antagonist, is excreted into both bile and urine, with minimal metabolism... 
MRP2 | INVOLVEMENT | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-4 | ORGANIC ANION TRANSPORTERS | IDENTIFICATION | EXCRETION | EXPRESSION | OATP1B1 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Membrane Transport Proteins - drug effects | Hepatocytes - metabolism | Imidazoles - pharmacokinetics | Neoplasm Proteins - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Sincalide - metabolism | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Prodrugs - metabolism | Tetrazoles - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Protein Isoforms - metabolism | Transfection | Liver - drug effects | Membrane Transport Proteins - genetics | Organic Anion Transporters, Sodium-Independent - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Imidazoles - metabolism | Olmesartan Medoxomil | Cell Line | Liver - metabolism | Probenecid - pharmacology | Penicillin G - pharmacology | Mice, Knockout | p-Aminohippuric Acid - pharmacology | Animals | Estrone - analogs & derivatives | Multidrug Resistance-Associated Proteins - deficiency | Prodrugs - pharmacokinetics | Estrone - metabolism | Dogs | Protein Binding | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | In Vitro Techniques | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Tetrazoles - pharmacokinetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18203 - 18216
Journal Article
Science, ISSN 0036-8075, 11/2008, Volume 322, Issue 5906, pp. 1392 - 1395
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2017, Volume 61, Issue 12
Journal Article
Journal Article
ACS Nano, ISSN 1936-0851, 07/2014, Volume 8, Issue 7, pp. 7305 - 7317
Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced... 
nitric oxide | autophagy | AMP-activated protein kinase | fumagillin prodrug | angiogenesis | nanotherapy | RHEUMATOID-ARTHRITIS | ACTIVATED PROTEIN-KINASE | ANTIANGIOGENIC NANOTHERAPY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | CELL-DEATH | DOUBLE-EDGED-SWORD | MOUSE MODEL | AMPK | ANTIGEN-INDUCED ARTHRITIS | NF-KAPPA-B | Inflammation - pathology | AMP-Activated Protein Kinases - metabolism | Sesquiterpenes - metabolism | Arthritis - metabolism | Male | Prodrugs - metabolism | Nanoparticles | Cyclohexanes - metabolism | Inflammation - metabolism | Inflammation - drug therapy | Arthritis - immunology | Cyclohexanes - chemistry | Nanomedicine | Sesquiterpenes - chemistry | Cytokines - metabolism | Arthritis - pathology | Endothelial Cells - metabolism | Inflammation - immunology | Fatty Acids, Unsaturated - metabolism | Lipase - metabolism | Macrophages - cytology | Enzyme Activation - drug effects | Angiogenesis Inhibitors - metabolism | Animals | Fatty Acids, Unsaturated - chemistry | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Arthritis - drug therapy | Macrophages - drug effects | Mice | Prodrugs - therapeutic use | Nitric Oxide - metabolism | Prodrugs - pharmacology | Angiogenesis Inhibitors - chemistry | Endothelial Cells - drug effects
Journal Article
Haematologica, ISSN 0390-6078, 07/2015, Volume 100, Issue 7, pp. 927 - 934
We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using hypoxia-activated prodrugs.... 
STEM-CELLS | INHIBITION | PR-104A | ACUTE MYELOGENOUS LEUKEMIA | BONE-MARROW | I TRIAL | KETO REDUCTASE 1C3 | HIF-1-ALPHA | HEMATOLOGY | CANCER-THERAPY | CHEMOTHERAPY | Recurrence | Humans | Middle Aged | Male | Antineoplastic Agents, Alkylating - administration & dosage | Carbonic Anhydrases - metabolism | Thrombocytopenia - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Anemia - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Bone Marrow - metabolism | Enterocolitis - genetics | Antigens, Neoplasm - metabolism | Bone Marrow - drug effects | Biomarkers - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications | Gene Expression | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Leukemia, Myeloid, Acute - pathology | Anemia - chemically induced | Hypoxia - complications | Thrombocytopenia - chemically induced | Thrombocytopenia - pathology | Nitrogen Mustard Compounds - adverse effects | Remission Induction | Hypoxia - pathology | Antineoplastic Agents, Alkylating - adverse effects | Enterocolitis - pathology | Prodrugs - administration & dosage | Hypoxia - drug therapy | Neutropenia - metabolism | Nitrogen Mustard Compounds - administration & dosage | Carbonic Anhydrases - genetics | Anemia - pathology | Leukemia, Myeloid, Acute - complications | Prodrugs - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neutropenia - pathology | Adult | Female | Neutropenia - chemically induced | Neutropenia - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Carbonic Anhydrase IX | Enterocolitis - chemically induced | Antigens, Neoplasm - genetics | Nitroimidazoles - pharmacology | Thrombocytopenia - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Anemia - metabolism | Prodrugs - adverse effects | Hypoxia - genetics | Nitrogen Mustard Compounds - metabolism | Bone Marrow - pathology | Aged | Enterocolitis - metabolism | Antineoplastic Agents, Alkylating - metabolism | Leukemia, Myeloid, Acute - genetics
Journal Article
Critical Reviews in Biochemistry and Molecular Biology, ISSN 1040-9238, 6/2011, Volume 46, Issue 3, pp. 181 - 199
Journal Article