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1. Full Text An IL‐27/Stat3 axis induces expression of programmed cell death 1 ligands (PD‐L1/2) on infiltrating macrophages in lymphoma
by Horlad, Hasita and Ma, Chaoya and Yano, Hiromu and Pan, Cheng and Ohnishi, Koji and Fujiwara, Yukio and Endo, Shinya and Kikukawa, Yoshitaka and Okuno, Yutaka and Matsuoka, Masao and Takeya, Motohiro and Komohara, Yoshihiro
Cancer science, ISSN 1347-9032, 11/2016, Volume 107, Issue 11, pp. 1696 - 1704
macrophage | CD163 | tumor‐associated macrophages | PD‐L2 | PD‐L1 | PD-L1 | PD-L2 | tumor-associated macrophages | Life Sciences & Biomedicine | Oncology | Science & Technology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Humans | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Culture Media, Conditioned - pharmacology | B7-H1 Antigen - genetics | Interleukins - metabolism | Leukemia-Lymphoma, Adult T-Cell - immunology | Up-Regulation - drug effects | B7-H1 Antigen - metabolism | Macrophages - metabolism | Minor Histocompatibility Antigens - metabolism | Leukemia-Lymphoma, Adult T-Cell - metabolism | B7-H1 Antigen - biosynthesis | Programmed Cell Death 1 Ligand 2 Protein - biosynthesis | Cell Line, Tumor | Macrophages - drug effects | STAT3 Transcription Factor - metabolism | Immunotherapy | Development and progression | Lymphomas | Biochemistry | T cells | Macrophages | Apoptosis | Cell culture | Phosphorylation | Transcription | Leukemia | Cytotoxicity | Paraffin | Cell activation | Immunoglobulins | Cytokines | Review boards | Research & development--R&D | Cloning | Stat3 protein | Tumor cell lines | Lymphoma | Immunological tolerance | Studies | Mucin | Immune checkpoint | Lymphocytes B | Cell death | Cancer | Tumors | Index Medicus | Original
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2. Full Text Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
by Saha, Asim and Saha, Asim and Aoyama, Kazutoshi and Aoyama, Kazutoshi and Taylor, Patricia A and Taylor, Patricia A and Koehn, Brent H and Koehn, Brent H and Veenstra, Rachelle G and Veenstra, Rachelle G and Panoskaltsis-Mortari, Angela and Panoskaltsis-Mortari, Angela and Munn, David H and Munn, David H and Murphy, William J and Murphy, William J and Azuma, Miyuki and Azuma, Miyuki and Yagita, Hideo and Yagita, Hideo and Fife, Brian T and Fife, Brian T and Sayegh, Mohammed H and Sayegh, Mohammed H and Najafian, Nader and Najafian, Nader and Socie, Gerard and Socie, Gerard and Ahmed, Rafi and Ahmed, Rafi and Freeman, Gordon J and Freeman, Gordon J and Sharpe, Arlene H and Sharpe, Arlene H and Blazar, Bruce R and Blazar, Bruce R
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 17, pp. 3062 - 3073
Life Sciences & Biomedicine | Hematology | Science & Technology | Glucose Transport Proteins, Facilitative - metabolism | Liver - pathology | Cell Proliferation | Spleen - immunology | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Intestines - metabolism | Graft vs Host Disease - metabolism | CD4-Positive T-Lymphocytes - pathology | Graft vs Host Disease - immunology | Intestines - immunology | CD4-Positive T-Lymphocytes - immunology | Liver - immunology | Glucose Transport Proteins, Facilitative - immunology | Graft vs Host Disease - mortality | Bone Marrow Transplantation | Apoptosis Regulatory Proteins - genetics | Glucose Transport Proteins, Facilitative - genetics | Spleen - pathology | Transplantation Tolerance - immunology | Acute Disease | Apoptosis Regulatory Proteins - immunology | Intestines - pathology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Liver - metabolism | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | Oxidative Phosphorylation | Programmed Cell Death 1 Receptor - metabolism | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Apoptosis Regulatory Proteins - metabolism | Graft vs Host Disease - pathology | Programmed Cell Death 1 Ligand 2 Protein - immunology | B7-H1 Antigen - metabolism | Animals | Spleen - metabolism | Peripheral Tolerance - immunology | Survival Analysis | Glycolysis | Mice | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Index Medicus | Abridged Index Medicus | 12 | 17 | Transplantation
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3. Full Text Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1
by Guzik, Katarzyna and Zak, Krzysztof M and Grudnik, Przemyslaw and Magiera, Katarzyna and Musielak, Bogdan and Törner, Ricarda and Skalniak, Lukasz and Dömling, Alexander and Dubin, Grzegorz and Holak, Tad A
Journal of medicinal chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5857 - 5867
unclassified drug | protein interaction | 4 [[[4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2methylphenyl]methoxy] 2,5 difluorophenyl]methyl]amino] 3 hydroxybutanoic acid hydrochloride | drug synthesis | 3 [4 chloro 5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formylphenoxymethyl]benzonitrile | 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2,5 difluorobenzaldehyde | drug structure | protein function | 2 [[[2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]amino] 3 methylbutan 1 ol hydrochloride | X ray analysis | 2 [[[2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 5 methylphenyl] methyl]amino] 3 hydroxypropanoic acid hydrochloride | 1 [[3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]piperidine 2 carboxylic acid | protein structure | oligomerization | 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxy 5 methylbenzaldehyde | drug determination | 3 [5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile | IC50 | immunomodulating agent | 2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde | 5 chloro 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxybenzaldehyde | human | protein expression | [3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methanol | n [2 [[[2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridin 3 yl]methyl]amino]ethyl]acetamide hydrochloride | 3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde | dimerization | nuclear magnetic resonance spectroscopy | programmed death 1 ligand 1 | heteronuclear multiple quantum coherence | 1 [[5 chloro 2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy]phenyl] methyl] 4 hydroxypyrrolidine 2 carboxylic acid hydrochloride | protein inhibitor | (2 methyl 3 biphenylyl)methanol | article | To be checked by Faculty | hydrophobicity | 2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridine 3 carbaldehyde | cancer immunotherapy | crystallization | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Small Molecule Libraries - pharmacology | Programmed Cell Death 1 Receptor - chemistry | Protein Interaction Maps - drug effects | Humans | Programmed Cell Death 1 Receptor - metabolism | Crystallography, X-Ray | Programmed Cell Death 1 Receptor - antagonists & inhibitors | B7-H1 Antigen - chemistry | Small Molecule Libraries - chemistry | B7-H1 Antigen - metabolism | B7-H1 Antigen - antagonists & inhibitors | Molecular Docking Simulation | Protein Multimerization - drug effects | Index Medicus
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4. Full Text Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis
by Jurado, Javier O and Alvarez, Ivana B and Pasquinelli, Virginia and Martinez, Gustavo J and Quiroga, Maria F and Abbate, Eduardo and Musella, Rosa M and Chuluyan, H. Eduardo and Garcia, Veronica E
The Journal of immunology (1950), ISSN 0022-1767, 07/2008, Volume 181, Issue 1, pp. 116 - 125
Life Sciences & Biomedicine | Immunology | Science & Technology | Antigens, CD - immunology | Apoptosis Regulatory Proteins - immunology | B7-H1 Antigen | Humans | Programmed Cell Death 1 Ligand 2 Protein | Cells, Cultured | Mycobacterium tuberculosis - immunology | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - immunology | Antigens, CD - metabolism | Tuberculosis - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | T-Lymphocytes - metabolism | Interferon-gamma - immunology | Protein Binding | Antigens - immunology | Programmed Cell Death 1 Receptor | T-Lymphocytes - immunology | Tuberculosis - metabolism | Intercellular Signaling Peptides and Proteins - immunology | Interferon-gamma - biosynthesis | Index Medicus | Abridged Index Medicus
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5. Full Text Structure and interactions of the human programmed cell death 1 receptor
by Cheng, Xiaoxiao and Veverka, Vaclav and Radhakrishnan, Anand and Waters, Lorna C and Muskett, Frederick W and Morgan, Sara H and Huo, Jiandong and Yu, Chao and Evans, Edward J and Leslie, Alasdair J and Griffiths, Meryn and Stubberfield, Colin and Griffin, Robert and Henry, Alistair J and Jansson, Andreas and Ladbury, John E and Ikemizu, Shinji and Carr, Mark D and Davis, Simon J
The Journal of biological chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 17, pp. 11771 - 11785
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Surface Plasmon Resonance | Cell Communication - immunology | Programmed Cell Death 1 Receptor - chemistry | B7-1 Antigen - genetics | Humans | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Structure-Activity Relationship | B7-H1 Antigen - chemistry | Programmed Cell Death 1 Ligand 2 Protein - chemistry | T-Lymphocytes - metabolism | B7-1 Antigen - chemistry | Nuclear Magnetic Resonance, Biomolecular | Antigen-Presenting Cells - metabolism | Protein Structure, Secondary | B7-1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Programmed Cell Death 1 Receptor - metabolism | B7-1 Antigen - metabolism | Antigen-Presenting Cells - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Antigen-Presenting Cells - chemistry | B7-H1 Antigen - metabolism | Models, Immunological | Animals | T-Lymphocytes - chemistry | Protein Binding | T-Lymphocytes - immunology | Mice | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Index Medicus | Nuclear Magnetic Resonance | Signaling | Thermodynamics | Receptors | Immunology | Surface Plasmon Resonance (SPR) | Cell Surface Protein | Complex Formation | Affinity
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6. Full Text Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2–positive dendritic cells in allergic asthma
by Cho, Minkyoung and Lee, Jeong-Eun and Lim, Hoyong and Shin, Hyun-Woo and Khalmuratova, Roza and Choi, Garam and Kim, Hyuk Soon and Choi, Wahn Soo and Park, Young-Jun and Shim, Inbo and Kim, Byung-Seok and Kang, Chang-Yuil and Kim, Jae-Ouk and Tanaka, Shinya and Kubo, Masato and Tung, Hui-Ying and Landers, Cameron T and Corry, David B and Kheradmand, Farrah and Chung, Yeonseok
Journal of allergy and clinical immunology, ISSN 0091-6749, 08/2018, Volume 142, Issue 2, pp. 530 - 541.e6
mast cell | Protease allergen | PD-L2+ dendritic cells | fibrinogen cleavage product | Toll-like receptor 4 | PD-L2 | dendritic cells | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Peptide Fragments - metabolism | Lymphocyte Activation | Dendritic Cells - immunology | Humans | Mice, Inbred C57BL | Hypersensitivity - immunology | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Toll-Like Receptor 4 - genetics | Th2 Cells - immunology | Immunity, Innate | Interleukin-13 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Animals | Allergens - immunology | Peptide Fragments - immunology | Asthma - immunology | Fibrinogen - metabolism | Cell Differentiation | Mice | Fibrinogen - immunology | Disease Models, Animal | Peptide Hydrolases - metabolism | Fibrin | Biochemistry | Dendritic cells | Fibrinogen | Asthma | Apoptosis | Cell culture | Allergens | Proteinase | Lymphocytes T | Experiments | Cell surface | Lymph nodes | Proteins | Respiratory tract | Protease | Lymphocytes | Toll-like receptors | Bone marrow | Cleavage | Population | Respiratory tract diseases | Immune system | Antigens | Phenotypes | Lymphoid cells | Cytokines | Hypersensitivity | Inflammation | Intranasal administration | Interleukin 13 | TLR4 protein | Allergies | Studies | Histamine | Lungs | Cell death | Ligands | Mast cells | Laboratory animals
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7. Full Text T‐cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death‐ligand 1 expression in patients with soft tissue sarcomas
by Pollack, Seth M and He, Qianchuan and Yearley, Jennifer H and Emerson, Ryan and Vignali, Marissa and Zhang, Yuzheng and Redman, Mary W and Baker, Kelsey K and Cooper, Sara and Donahue, Bailey and Loggers, Elizabeth T and Cranmer, Lee D and Spraker, Matthew B and Seo, Y. David and Pillarisetty, Venu G and Ricciotti, Robert W and Hoch, Benjamin L and McClanahan, Terrill K and Murphy, Erin and Blumenschein, Wendy M and Townson, Steven M and Benzeno, Sharon and Riddell, Stanley R and Jones, Robin L
Cancer, ISSN 0008-543X, 09/2017, Volume 123, Issue 17, pp. 3291 - 3304
leiomyosarcoma | sarcoma | pleomorphic | programmed death‐ligand 1 (PD‐L1) | T‐cell receptors | immunotherapy | liposarcoma | gene expression | programmed cell death protein (PD‐1) | T-cell receptors | programmed cell death protein (PD-1) | programmed death-ligand 1 (PD-L1) | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Sarcoma - therapy | Young Adult | Neoplasm Invasiveness - pathology | Sarcoma - mortality | Aged, 80 and over | Adult | Female | Clone Cells | Retrospective Studies | Sarcoma - genetics | Soft Tissue Neoplasms - genetics | Databases, Factual | Soft Tissue Neoplasms - therapy | Soft Tissue Neoplasms - mortality | Combined Modality Therapy | Sarcoma - pathology | Disease-Free Survival | Analysis of Variance | T-Lymphocytes - cytology | Soft Tissue Neoplasms - pathology | Survival Analysis | T-Lymphocytes - immunology | Aged | Biopsy, Needle | Neoplasm Staging | Programmed Cell Death 1 Receptor - genetics | Cluster Analysis | Cohort Studies | Care and treatment | Sarcoma | Cell death | Analysis | Research | Diagnosis | Gene expression | PD-1 protein | Lymphocytes T | Paraffin | Formaldehyde | Metastases | Gene sequencing | T-cell receptor | Immunotherapy | Immune system | Antigen presentation | Antigens | Immune response | Synovial sarcoma | Mortality | Soft tissue sarcoma | Autoantigens | Inflammation | T cell receptors | Patients | Immune checkpoint | Immunogenicity | PD-L1 protein | Liposarcoma | Ligands | Infiltration | Cancer | Tumors | Apoptosis | Index Medicus | Abridged Index Medicus | Original
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8. Full Text Clinical and Histologic Features of Lichenoid Mucocutaneous Eruptions Due to Anti–Programmed Cell Death 1 and Anti–Programmed Cell Death Ligand 1 Immunotherapy
by Shi, Veronica J and Rodic, Nemanja and Gettinger, Scott and Leventhal, Jonathan S and Neckman, Julia P and Girardi, Michael and Bosenberg, Marcus and Choi, Jennifer N
JAMA dermatology (Chicago, Ill.), ISSN 2168-6068, 10/2016, Volume 152, Issue 10, pp. 1128 - 1136
Life Sciences & Biomedicine | Dermatology | Science & Technology | Lung Neoplasms - drug therapy | Immunotherapy - methods | Skin Neoplasms - drug therapy | Humans | Lichenoid Eruptions - chemically induced | Middle Aged | Hospitals, University | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Lichenoid Eruptions - pathology | Immunotherapy - adverse effects | Melanoma - drug therapy | Aged, 80 and over | Female | Aged | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Ligand 2 Protein - antagonists & inhibitors | Drugs | Usage | Care and treatment | Immunotherapy | Analysis | Adverse and side effects | Skin diseases | Histology | Research | Apoptosis | Index Medicus | Abridged Index Medicus
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9. Full Text PD-L2 expression in human tumors: Relevance to anti-PD-1 therapy in cancer
by Yearley, Jennifer H and Gibson, Christopher and Yu, Ni and Moon, Christina and Murphy, Erin and Juco, Jonathan and Lunceford, Jared and Cheng, Jonathan and Chow, Laura Q.M and Seiwert, Tanguy Y and Handa, Masahisa and Tomassini, Joanne E and McClanahan, Terrill
Clinical cancer research, ISSN 1078-0432, 06/2017, Volume 23, Issue 12, pp. 3158 - 3167
Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Squamous Cell Carcinoma of Head and Neck | Antibodies, Monoclonal, Humanized - administration & dosage | Immunotherapy | Aged, 80 and over | Adult | Female | Programmed Cell Death 1 Ligand 2 Protein - genetics | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - immunology | Head and Neck Neoplasms - pathology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Disease-Free Survival | Head and Neck Neoplasms - immunology | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Aged | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Ligand 2 Protein - antagonists & inhibitors | Therapy | Squamous cell carcinoma | Head | PD-1 protein | Tissues | Survival | Patients | Endothelial cells | Metastases | Immune checkpoint | Experimental design | PD-L1 protein | Head and neck cancer | Ligands | Tumors | Cancer | Immune system | Index Medicus
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