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Blood, ISSN 0006-4971, 2013, Volume 122, Issue 17, pp. 3062 - 3073
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. We explored the role of PD-1... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BONE-MARROW-TRANSPLANTATION | T-CELL-ACTIVATION | GASTROINTESTINAL-TRACT | ENDOTHELIAL-CELLS | IN-VIVO | TNF-ALPHA | HEMATOLOGY | PD-1 | GAMMA-DEPENDENT MECHANISM | LYMPHOCYTES | Glucose Transport Proteins, Facilitative - metabolism | Liver - pathology | Cell Proliferation | Spleen - immunology | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Intestines - metabolism | Graft vs Host Disease - metabolism | CD4-Positive T-Lymphocytes - pathology | Graft vs Host Disease - immunology | Intestines - immunology | CD4-Positive T-Lymphocytes - immunology | Liver - immunology | Glucose Transport Proteins, Facilitative - immunology | Graft vs Host Disease - mortality | Bone Marrow Transplantation | Apoptosis Regulatory Proteins - genetics | Glucose Transport Proteins, Facilitative - genetics | Spleen - pathology | Transplantation Tolerance - immunology | Acute Disease | Apoptosis Regulatory Proteins - immunology | Intestines - pathology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Liver - metabolism | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | Oxidative Phosphorylation | Programmed Cell Death 1 Receptor - metabolism | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Apoptosis Regulatory Proteins - metabolism | Graft vs Host Disease - pathology | Programmed Cell Death 1 Ligand 2 Protein - immunology | B7-H1 Antigen - metabolism | Animals | Spleen - metabolism | Peripheral Tolerance - immunology | Survival Analysis | Glycolysis | Mice | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Index Medicus | Abridged Index Medicus | Transplantation
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2017, Volume 23, Issue 12, pp. 3158 - 3167
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 17, pp. 11771 - 11785
PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and... 
SECONDARY STRUCTURE DETERMINATION | NMR ASSIGNMENT | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL DOMAIN | TISSUE INHIBITOR | QUANTITATIVE-ANALYSIS | MOLECULAR-BASIS | HCV INFECTION | T-CELLS | PD-1 EXPRESSION | Surface Plasmon Resonance | Cell Communication - immunology | Programmed Cell Death 1 Receptor - chemistry | B7-1 Antigen - genetics | Humans | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Structure-Activity Relationship | B7-H1 Antigen - chemistry | Programmed Cell Death 1 Ligand 2 Protein - chemistry | T-Lymphocytes - metabolism | B7-1 Antigen - chemistry | Nuclear Magnetic Resonance, Biomolecular | Antigen-Presenting Cells - metabolism | Protein Structure, Secondary | B7-1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Programmed Cell Death 1 Receptor - metabolism | B7-1 Antigen - metabolism | Antigen-Presenting Cells - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Antigen-Presenting Cells - chemistry | B7-H1 Antigen - metabolism | Models, Immunological | Animals | T-Lymphocytes - chemistry | Protein Binding | T-Lymphocytes - immunology | Mice | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Nuclear Magnetic Resonance | Signaling | Thermodynamics | Receptors | Immunology | Surface Plasmon Resonance (SPR) | Cell Surface Protein | Complex Formation | Affinity | Naturvetenskap | Natural Sciences
Journal Article
Cellular Immunology, ISSN 0008-8749, 07/2014, Volume 290, Issue 1, pp. 72 - 79
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137783
CD4(+) T cells producing interferon-y are crucial for protection against Mycobacterium tuberculosis infection and are the cornerstone of tuberculosis... 
EFFECTOR | CYTOKINE PRODUCTION | PROTECTION | IFN-GAMMA | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | MHC | INFECTION | BCG VACCINATION | EXPRESSION | Cell Proliferation | Mice, Inbred C57BL | Vaccination | Antigens, Bacterial - immunology | Cells, Cultured | Mycobacterium tuberculosis - immunology | Programmed Cell Death 1 Receptor - metabolism | Acyltransferases - immunology | Vaccines, Subunit - immunology | Th1 Cells - immunology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Interferon-gamma - immunology | Interleukins - immunology | Female | Bacterial Proteins - immunology | Mice | Tuberculosis Vaccines - immunology | Phosphatidylinositol 3-Kinase - metabolism | Immunologic Memory - immunology | Cytokines - immunology | Interleukin | Interleukin 22 | Infections | Activation | Lymphocytes T | Feedback loops | Vaccines | Experiments | Proteins | Cell activation | Immunology | Lymphocytes | Recall | Deoxyribonucleic acid--DNA | Spleen | Antigens | Immunological memory | Memory cells | Cytokines | 1-Phosphatidylinositol 3-kinase | CD4 antigen | Tuberculosis | Lymphocytes B | Antigen-presenting cells | γ-Interferon | Ligands | Regulation | Interferon | Diagnostic systems | Control theory | Cell size | Laboratory animals | Viral infections | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Human Gene Therapy, ISSN 1043-0342, 06/2017, Volume 28, Issue 6, pp. 493 - 509
Use of adeno-associated virus (AAV) to transduce genes into skeletal muscles can be associated with T-cell responses to viral capsid and/or to transgenic... 
Research Articles | gene therapy | muscular dystrophy | PD1 | neuromuscular junction | AAV | lymphocyte | CT GALNAC TRANSFERASE | GLUCOCORTICOID TREATMENT | MEDICINE, RESEARCH & EXPERIMENTAL | MEDIATED GENE-TRANSFER | DEFICIENT MICE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | VASCULAR DELIVERY | IMMUNE-RESPONSES | HEMOPHILIA-B | MOUSE MODEL | FACTOR-IX | GENETICS & HEREDITY | DUCHENNE MUSCULAR-DYSTROPHY | Dependovirus - genetics | CD8-Positive T-Lymphocytes - pathology | Genetic Vectors - administration & dosage | Muscular Dystrophies - therapy | Macaca mulatta | Muscular Dystrophies - genetics | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Immunity, Cellular - drug effects | Muscle, Skeletal - immunology | Muscle, Skeletal - drug effects | Muscular Dystrophies - immunology | N-Acetylgalactosaminyltransferases - genetics | Cell Death | Capsid Proteins - immunology | Transgenes | Immunosuppressive Agents - pharmacology | Programmed Cell Death 1 Ligand 2 Protein - agonists | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - immunology | Administration, Oral | Programmed Cell Death 1 Ligand 2 Protein - genetics | Programmed Cell Death 1 Receptor - agonists | Dependovirus - immunology | Injections, Intramuscular | Muscular Dystrophies - pathology | Programmed Cell Death 1 Ligand 2 Protein - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | CD8-Positive T-Lymphocytes - drug effects | N-Acetylgalactosaminyltransferases - immunology | Prednisone - pharmacology | Muscle, Skeletal - pathology | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Capsid Proteins - genetics | Genetic Therapy - methods | Injections, Intra-Arterial | Gene transfer | Immunoregulation | CD8 antigen | Mortality | Transgenic | Antibodies | Muscles | Caspase | Viruses | Lymphocytes T | Prednisone | Caspase-3 | Skeletal muscle | Proteins | Musculoskeletal system | Lymphocytes | Cell death | Foxp3 protein | Ligands | Infiltration | Apoptosis
Journal Article
European Journal of Immunology, ISSN 0014-2980, 10/2011, Volume 41, Issue 10, pp. 2977 - 2986
Programmed death‐1 receptor (PD‐1) is expressed on T cells following TCR activation. Binding of this receptor to its cognate ligands, programmed death ligand... 
Programmed death‐1 receptor | Cancer immunotherapy | Vaccine | Programmed death-1 receptor | CARCINOMA PATIENTS | PROGNOSTIC-FACTORS | INCREASED POPULATIONS | FACILITATED ADOPTIVE IMMUNOTHERAPY | PANCREATIC-CANCER | PERIPHERAL-BLOOD | IMMUNOLOGY | TUMOR-INFILTRATING LYMPHOCYTES | REGULATORY T-CELLS | IMMUNOLOGICAL SELF-TOLERANCE | CLINICAL-SIGNIFICANCE | T-Lymphocytes, Regulatory - metabolism | Cyclophosphamide - administration & dosage | Papillomavirus E7 Proteins - immunology | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Receptors, Antigen, T-Cell | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - immunology | Female | Antibodies, Monoclonal - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Neoplasms, Experimental - therapy | B7-H1 Antigen - immunology | Apoptosis Regulatory Proteins - metabolism | Programmed Cell Death 1 Ligand 2 Protein - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Papillomavirus E7 Proteins - administration & dosage | Antibodies, Monoclonal - administration & dosage | CD8-Positive T-Lymphocytes - drug effects | Cyclophosphamide - pharmacology | Mice | CD8-Positive T-Lymphocytes - immunology | Apoptosis | Medical research | T cell receptors | Vaccines | Immune system
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2012, Volume 18, Issue 7, pp. 1925 - 1935
Purpose: Respiratory papillomas, caused by human papillomaviruses types 6 and 11 (HPV6/11), are premalignant lesions with potential for malignant conversion.... 
MYCOBACTERIUM-TUBERCULOSIS | RECRUITMENT | POPULATION | RESPONSIVENESS | HOMEOSTASIS | ONCOLOGY | TRANSCRIPTION FACTOR FOXP3 | PD-1 | LINEAGE | VIRAL-INFECTION | LYMPHOCYTES | Forkhead Transcription Factors - immunology | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Human papillomavirus 6 - immunology | Humans | Gene Expression Regulation, Neoplastic | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Chemokine CCL17 - genetics | Male | Precancerous Conditions - metabolism | Chemokine CCL22 - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Chemokine CCL22 - immunology | Flow Cytometry | Forkhead Transcription Factors - metabolism | Leukocytes, Mononuclear - immunology | Chemokine CCL17 - immunology | Papillomavirus Infections - immunology | Female | Human papillomavirus 11 - immunology | Papilloma - metabolism | Papilloma - genetics | Respiratory Tract Neoplasms - immunology | Respiratory Tract Neoplasms - genetics | Programmed Cell Death 1 Ligand 2 Protein - genetics | CD4-Positive T-Lymphocytes - metabolism | Programmed Cell Death 1 Receptor - metabolism | Reverse Transcriptase Polymerase Chain Reaction | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Precancerous Conditions - genetics | Respiratory Tract Neoplasms - metabolism | Papillomavirus Infections - genetics | Programmed Cell Death 1 Ligand 2 Protein - immunology | Tumor Microenvironment - immunology | B7-H1 Antigen - metabolism | Chemokine CCL22 - genetics | Precancerous Conditions - immunology | Papillomavirus Infections - metabolism | Papilloma - immunology | Programmed Cell Death 1 Receptor - immunology | Chemokine CCL17 - metabolism | Programmed Cell Death 1 Receptor - genetics | PD-L1 | PD-L2 | immune suppression | CCL17 | Tregs | Recurrent Respiratory Papillomatosis
Journal Article