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Cancer discovery, ISSN 2159-8290, 03/2017, Volume 7, Issue 3, pp. 264 - 276
.... We have examined the evolving landscape of tumor neoantigens during the emergence of acquired resistance in patients with non-small cell lung cancer after initial response to immune checkpoint... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Ipilimumab - pharmacology | Immunotherapy | Ipilimumab - therapeutic use | Janus Kinase 1 - genetics | Adult | Female | Receptors, Antigen, T-Cell - immunology | Cell Cycle Checkpoints - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Antibodies, Monoclonal - pharmacology | Janus Kinase 2 - genetics | CTLA-4 Antigen - genetics | Drug Resistance, Neoplasm - immunology | Lung Neoplasms - therapy | CTLA-4 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Drug Resistance, Neoplasm - genetics | Lung Neoplasms - immunology | Antineoplastic Agents, Immunological - therapeutic use | Cell Cycle Checkpoints - drug effects | Receptors, Antigen, T-Cell - genetics | Mutation | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Cohort Studies | Index Medicus
Journal Article
Journal of thoracic oncology, ISSN 1556-0864, 06/2015, Volume 10, Issue 6, pp. 910 - 923
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1129 - 1141.e5
During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by expression of inhibitory receptors, down-modulation of effector function, and metabolic impairments... 
differentiation | memory | transcription | exhaustion | BATF | NFAT | NFAT_AP-1_IRF4 composite element | NAICE | metabolic function | chronic infection | IRF4 | CD8 | TCF1 | Life Sciences & Biomedicine | Immunology | Science & Technology | Lymphocytic choriomeningitis virus - immunology | Hepatocyte Nuclear Factor 1-alpha - immunology | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Basic-Leucine Zipper Transcription Factors - immunology | Lymphocyte Depletion | Interferon Regulatory Factors - deficiency | Lymphocytic Choriomeningitis - immunology | NFATC Transcription Factors - immunology | HEK293 Cells | Receptors, Antigen, T-Cell - immunology | Cell Differentiation | Lymphocytic Choriomeningitis - genetics | Lymphocytic Choriomeningitis - virology | Signal Transduction | Lymphocyte Activation | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Mice, Knockout | Interferon Regulatory Factors - immunology | Lymphocytic choriomeningitis virus - growth & development | Animals | CD8-Positive T-Lymphocytes - virology | Immunologic Memory | Mice | Receptors, Antigen, T-Cell - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | NFATC Transcription Factors - genetics | Regulators | Transcription factors | PD-1 protein | CD8 antigen | Genes | Memory | Chronic infection | Viruses | Infections | Lymphocytes T | T-cell receptor | Signal transduction | Receptors | Lymphocytes | Tumor necrosis factor-TNF | Hepatocyte nuclear factor 1 | Antigens | Immunological memory | Memory cells | Tumor cells | T cell receptors | Metabolism | Cell differentiation | Cells | Interferon regulatory factor 4 | Exhaustion | Receptor mechanisms | Metabolic disorders | Viral infections | Index Medicus
Journal Article
Journal Article
Cytotherapy (Oxford, England), ISSN 1465-3249, 10/2018, Volume 20, Issue 10, pp. 1259 - 1266
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e55818 - e55818
...), expression of programmed death receptor ligand 1/programmed death receptor 1 (PD-L1/PD-1), arginase 1 and soluble CD25... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antigens, CD34 - metabolism | Humans | Middle Aged | Arginase - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Young Adult | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Adult | Female | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology | Interleukin-2 Receptor alpha Subunit - blood | Programmed Cell Death 1 Receptor - metabolism | Gene Expression Regulation, Leukemic | B7-H1 Antigen - metabolism | Interleukin-2 Receptor alpha Subunit - metabolism | Adolescent | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Aged | Programmed Cell Death 1 Receptor - genetics | Medical research | Care and treatment | Immunotherapy | Medicine, Experimental | Development and progression | Interferon | Chronic myeloid leukemia | T cells | Risk factors | Cancer | Cell proliferation | Disease | PD-1 protein | Laboratories | Leukemia | Science | Clinical trials | Risk | Arginase | Lymphocytes T | Kinases | Suppressor cells | Ethics | Immunology | Interleukin 2 | Lymphocytes | Cell cycle | CD25 antigen | Protein-tyrosine kinase | Immune system | Tyrosine | CD34 antigen | Myeloid cells | Cytokines | Hematology | Myeloid leukemia | Mortality | Blood banks | Patients | Studies | Pathology | Hospitals | Medical prognosis | PD-L1 protein | Stem cells | Ligands | Death | Lymphomas | Apoptosis | Index Medicus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 5, pp. 2046 - 2058
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NI( cells... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Abridged Index Medicus | Oncology | Immunology | Dermatology | Therapeutics
Journal Article
European journal of cancer (1990), ISSN 0959-8049, 04/2016, Volume 57, pp. 91 - 103
Journal Article