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Journal of allergy and clinical immunology, ISSN 0091-6749, 2017, Volume 139, Issue 1, pp. 335 - 346.e3
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 5, pp. 2046 - 2058
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NI( cells... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE | LIGANDS | DNAM-1 | INHIBITORY RECEPTORS | CHRONIC VIRAL-INFECTION | NECTIN-2 CD112 | UP-REGULATION | PVR CD155 | EXPRESSION | POLIOVIRUS RECEPTOR CD155 | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Oncology | Immunology | Dermatology | Therapeutics
Journal Article
Journal of thoracic oncology, ISSN 1556-0864, 2015, Volume 10, Issue 6, pp. 910 - 923
Epidermal growth factor receptor (EGFR) mutation status was reported to be associated with programmed death-ligand 1 (PD-L1) expression... 
PD-L1 | NSCLC | PD-1 | EGFR | Tyrosine kinase inhibitors | LUNG | CELLS | B7-H1 EXPRESSION | DEATH-LIGAND 1 | MELANOMA | ONCOLOGY | PATHWAY | IMMUNOTHERAPY | RESPIRATORY SYSTEM | POOR-PROGNOSIS | GROWTH | INHIBITORS | Tumor Escape - drug effects | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Sequence Deletion | Up-Regulation | Exons | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Epidermal Growth Factor - metabolism | T-Lymphocytes - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - immunology | Lung Neoplasms - enzymology | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Programmed Cell Death 1 Receptor - metabolism | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Carcinoma, Non-Small-Cell Lung - immunology | B7-H1 Antigen - metabolism | Lung Neoplasms - immunology | Apoptosis - immunology | B7-H1 Antigen - antagonists & inhibitors | Interferon-gamma - immunology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | T-Lymphocytes - immunology | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Interferon-gamma - biosynthesis
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 17, pp. 11771 - 11785
PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target... 
SECONDARY STRUCTURE DETERMINATION | NMR ASSIGNMENT | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL DOMAIN | TISSUE INHIBITOR | QUANTITATIVE-ANALYSIS | MOLECULAR-BASIS | HCV INFECTION | T-CELLS | PD-1 EXPRESSION | Surface Plasmon Resonance | Cell Communication - immunology | Programmed Cell Death 1 Receptor - chemistry | B7-1 Antigen - genetics | Humans | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Structure-Activity Relationship | B7-H1 Antigen - chemistry | Programmed Cell Death 1 Ligand 2 Protein - chemistry | T-Lymphocytes - metabolism | B7-1 Antigen - chemistry | Nuclear Magnetic Resonance, Biomolecular | Antigen-Presenting Cells - metabolism | Protein Structure, Secondary | B7-1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - genetics | Programmed Cell Death 1 Receptor - metabolism | B7-1 Antigen - metabolism | Antigen-Presenting Cells - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Programmed Cell Death 1 Ligand 2 Protein - immunology | Antigen-Presenting Cells - chemistry | B7-H1 Antigen - metabolism | Models, Immunological | Animals | T-Lymphocytes - chemistry | Protein Binding | T-Lymphocytes - immunology | Mice | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Nuclear Magnetic Resonance | Signaling | Thermodynamics | Receptors | Immunology | Surface Plasmon Resonance (SPR) | Cell Surface Protein | Complex Formation | Affinity
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2014, Volume 41, Issue 5, pp. 802 - 814
Journal Article
Journal Article
Blood, ISSN 1528-0020, 2012, Volume 120, Issue 24, pp. 4772 - 4782
...). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitory pathways... 
DENDRITIC CELLS | PROGRAMMED DEATH-1 | PERIPHERAL TOLERANCE | IN-VIVO | EFFECTOR FUNCTION | STEADY-STATE | CHRONIC VIRAL-INFECTION | HEMATOLOGY | CD28 COSTIMULATION | SELF-TOLERANCE | CROSS-PRESENTATION | Adoptive Transfer | Vitiligo - metabolism | Receptors, OX40 - immunology | Monophenol Monooxygenase - metabolism | Autoimmune Diseases - genetics | Signal Transduction - immunology | Receptors, OX40 - metabolism | Immune Tolerance - immunology | CD8-Positive T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | Monophenol Monooxygenase - genetics | Autoimmune Diseases - metabolism | Antigen-Presenting Cells - metabolism | Lymphatic Vessels - cytology | Receptors, Antigen, T-Cell - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Vitiligo - immunology | Autoimmune Diseases - immunology | Lymph Nodes - metabolism | Programmed Cell Death 1 Receptor - metabolism | Mice, Transgenic | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Lymph Nodes - immunology | Antigen-Presenting Cells - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Mice, Knockout | Endothelial Cells - immunology | B7-H1 Antigen - metabolism | Animals | Monophenol Monooxygenase - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Vitiligo - genetics | Programmed Cell Death 1 Receptor - genetics | Microscopy, Fluorescence | Immunobiology
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 6, pp. 1129 - 1141.e5
During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by expression of inhibitory receptors, down-modulation of effector function, and metabolic impairments... 
differentiation | memory | transcription | exhaustion | BATF | NFAT | NFAT_AP-1_IRF4 composite element | NAICE | metabolic function | chronic infection | IRF4 | CD8 | TCF1 | RESPONSES | ACTIVATION | REGULATORY ELEMENT | MITOCHONDRIA | EXPANSION | DRIVER | INHIBITORY RECEPTOR PD-1 | CHECKPOINT | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | Lymphocytic choriomeningitis virus - immunology | Hepatocyte Nuclear Factor 1-alpha - immunology | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Basic-Leucine Zipper Transcription Factors - immunology | Lymphocyte Depletion | Interferon Regulatory Factors - deficiency | Lymphocytic Choriomeningitis - immunology | NFATC Transcription Factors - immunology | HEK293 Cells | Receptors, Antigen, T-Cell - immunology | Cell Differentiation | Lymphocytic Choriomeningitis - genetics | Lymphocytic Choriomeningitis - virology | Signal Transduction | Lymphocyte Activation | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Mice, Knockout | Interferon Regulatory Factors - immunology | Lymphocytic choriomeningitis virus - growth & development | Animals | CD8-Positive T-Lymphocytes - virology | Immunologic Memory | Mice | Receptors, Antigen, T-Cell - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | NFATC Transcription Factors - genetics | Regulators | Transcription factors | PD-1 protein | CD8 antigen | Genes | Memory | Chronic infection | Viruses | Infections | Lymphocytes T | T-cell receptor | Signal transduction | Receptors | Lymphocytes | Tumor necrosis factor-TNF | Hepatocyte nuclear factor 1 | Antigens | Immunological memory | Memory cells | Tumor cells | T cell receptors | Metabolism | Cell differentiation | Cells | Interferon regulatory factor 4 | Exhaustion | Receptor mechanisms | Metabolic disorders | Viral infections
Journal Article
Cancer discovery, ISSN 2159-8290, 2017, Volume 7, Issue 3, pp. 264 - 276
.... We have examined the evolving landscape of tumor neoantigens during the emergence of acquired resistance in patients with non-small cell lung cancer after initial response to immune checkpoint... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | ONCOLOGY | PD-1 BLOCKADE | COLORECTAL-CANCER | PANCREATIC-CANCER | COPY NUMBER | RESISTANCE | MUTATIONS | SEQUENCING DATA | TUMOR PURITY | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Ipilimumab - pharmacology | Immunotherapy | Ipilimumab - therapeutic use | Janus Kinase 1 - genetics | Adult | Female | Receptors, Antigen, T-Cell - immunology | Cell Cycle Checkpoints - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Antibodies, Monoclonal - pharmacology | Janus Kinase 2 - genetics | CTLA-4 Antigen - genetics | Drug Resistance, Neoplasm - immunology | Lung Neoplasms - therapy | CTLA-4 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - therapy | Drug Resistance, Neoplasm - genetics | Lung Neoplasms - immunology | Antineoplastic Agents, Immunological - therapeutic use | Cell Cycle Checkpoints - drug effects | Receptors, Antigen, T-Cell - genetics | Mutation | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Cohort Studies
Journal Article