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Journal Article
Pharmacology Research & Perspectives, ISSN 2052-1707, 10/2016, Volume 4, Issue 5, pp. e00252 - n/a
Polymorphic expression of metabolic enzymes have been identified as one of the key factors responsible for the interindividual/ethnic/racial variability in... 
proguanil | sickle‐cell disease | CYP2C19 | genetic polymorphism | sickle-cell disease | Enzymes | Pediatrics | Malaria | Family medical history | Metabolism | Patients | Chromatography | Genotype & phenotype | Metabolites | Population | Dihydrofolate reductase | Mutation | Drug dosages | Polymorphism
Journal Article
PLoS One, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e112910
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2014, Volume 462, Issue 3, pp. 475 - 487
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of... 
ATP synthase | Complex I | Biguanide | Metformin | Reactive oxygen species (ROS) | Nadh:quinone oxidoreductase | CELLS | FLAVIN | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NADH:quinone oxidoreductase | biguanide | metformin | reactive oxygen species (ROS) | RAT-LIVER MITOCHONDRIA | HEART | NADH | INHIBITION | METABOLISM | OXIDOREDUCTASE COMPLEX-I | PURIFICATION | complex I | Biguanides - pharmacology | Triazines - pharmacology | Electron Transport Complex I - antagonists & inhibitors | Metformin - therapeutic use | Biguanides - therapeutic use | Humans | Metformin - pharmacology | Rats | Plasmodium - drug effects | Mitochondria, Heart - drug effects | Electron Transport Complex I - drug effects | Mitochondrial Proton-Translocating ATPases - metabolism | Antimalarials - pharmacology | Hep G2 Cells | Mitochondria, Liver - drug effects | Oxidative Phosphorylation - drug effects | Animals | Reperfusion Injury - prevention & control | Cattle | Antineoplastic Agents - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Mitochondrial Proton-Translocating ATPases - antagonists & inhibitors | Proguanil - pharmacology | SMP, submitochondrial particle | HAR, hexaammineruthenium(III) | OCR, oxygen consumption rate | AMPK, AMP-activated protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | ECAR, extracellular acidification rate | FeCN, ferricyanide | ROS, reactive oxygen species | OCT1, organic cation transporter 1
Journal Article
Journal Article
Structure, ISSN 0969-2126, 01/2014, Volume 22, Issue 1, pp. 94 - 103
Journal Article