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Cell Metabolism, ISSN 1550-4131, 2006, Volume 4, Issue 3, pp. 245 - 254
In pancreatic β cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthesis and the folding of newly synthesized proinsulin. Here, we... 
PROTEINS | HUMDISEASE | SIGNALING | HOMEOSTASIS | MESSENGER-RNA | PROINSULIN BIOSYNTHESIS | UNFOLDED-PROTEIN | ENDOCRINOLOGY & METABOLISM | TRANSCRIPTION FACTOR XBP-1 | DIFFERENTIATION | STRESS | MAMMALIAN-CELLS | TRANSLATIONAL CONTROL | CELL BIOLOGY | Phosphorylation | Molecular Chaperones - metabolism | Proinsulin - metabolism | Endoplasmic Reticulum - metabolism | Insulin - biosynthesis | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Insulin-Secreting Cells - metabolism | RNA Interference | Stress, Physiological - metabolism | Up-Regulation - physiology | Membrane Proteins - metabolism | Hyperglycemia - physiopathology | Nuclear Proteins - genetics | Insulin Secretion | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | Molecular Chaperones - genetics | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation - physiology | Rats | Nuclear Proteins - metabolism | Stress, Physiological - physiopathology | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Down-Regulation - genetics | Hyperglycemia - metabolism | Insulin - metabolism | Animals | Cell Line, Tumor | Glucose - metabolism | Signal Transduction - physiology | Mice | Transcription Factors | Proinsulin | Proteins | Pancreatic beta cells | Synthesis | Physiological aspects | Lipids | Glucose | Gene expression | Protein kinases | Insulin | Dextrose
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2014, Volume 452, Issue 3, pp. 581 - 587
Dental tissue-derived mesenchymal stem cells have been proposed as an alternative source for mesenchymal stem cells. Here, we investigated the differentiation... 
Periodontal ligament stem cells | Differentiation | Insulin producing cells | Notch signaling | Dental pulp stem cells | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELLS | TRANSPLANTATION | BIOPHYSICS | PANCREATIC ENDOCRINE | GENERATION | EXPRESSION | Osteocytes - drug effects | Transcription Factor HES-1 | Proinsulin - metabolism | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Adipocytes - cytology | Receptors, Notch - genetics | Adipocytes - drug effects | Dental Pulp - metabolism | Periodontal Ligament - drug effects | Periodontal Ligament - metabolism | RNA, Messenger - metabolism | Periodontal Ligament - cytology | Insulin-Secreting Cells - metabolism | Mesenchymal Stromal Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Tooth Extraction | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Cell Differentiation | Insulin-Secreting Cells - cytology | C-Peptide - metabolism | Biomarkers - metabolism | Mesenchymal Stromal Cells - drug effects | Gene Expression | Basic Helix-Loop-Helix Transcription Factors - genetics | Osteocytes - metabolism | Signal Transduction | Osteocytes - cytology | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Dental Pulp - cytology | Mesenchymal Stromal Cells - metabolism | Dental Pulp - drug effects | Proinsulin - genetics | Glucose - pharmacology | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Insulin-Secreting Cells - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Adipocytes - metabolism | Glucose - metabolism | Trans-Activators - metabolism | Primary Cell Culture | C-Peptide - genetics | Glucose metabolism | Glucose | Cell differentiation | Insulin | Dextrose | Stem cells
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0176391
Journal Article
Human molecular genetics, ISSN 0964-6906, 12/2014, Volume 23, Issue 24, pp. 6419 - 6431
Genome-wide association studies have revealed > 60 loci associated with type 2 diabetes ( T2D), but the underlying causal variants and functional mechanisms... 
PROVIDES INSIGHTS | COMMON VARIANTS | RISK LOCI | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | GENETICS & HEREDITY | GENE-EXPRESSION | PANCREATIC BETA-CELLS | TYPE-2 DIABETES-MELLITUS | PROINSULIN LEVELS | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | LIM-Homeodomain Proteins - metabolism | Proinsulin - metabolism | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Humans | Diabetes Mellitus, Type 2 - metabolism | Genetic Loci | Transcription Factor 7-Like 2 Protein - metabolism | Maf Transcription Factors, Large - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Maf Transcription Factors, Large - genetics | Islets of Langerhans - metabolism | Trans-Activators - genetics | Transcription, Genetic | Insulin - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Basic Helix-Loop-Helix Transcription Factors - genetics | Transcription Factor 7-Like 2 Protein - genetics | Islets of Langerhans - pathology | Signal Transduction | Gene Expression Regulation | Mice, Transgenic | Proinsulin - genetics | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Insulin - metabolism | LIM-Homeodomain Proteins - genetics | Animals | Alleles | Trans-Activators - metabolism | High-Throughput Nucleotide Sequencing | Mice | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | Biological Sciences | Biochemistry and Molecular Biology | Naturvetenskap | Natural Sciences | Biokemi och molekylärbiologi | Biologiska vetenskaper
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 04/2018, Volume 217, Issue 4, pp. 1287 - 1301
In mammalian pancreatic beta cells, the IRE1 alpha-XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise... 
XBP1 | PROTEIN DISULFIDE-ISOMERASE | ER-STRESS | INSULIN-SECRETION | IRE1 | IRE1-ALPHA | KINASE | ENDOPLASMIC-RETICULUM STRESS | IDENTIFICATION | PROTEOSTASIS | CELL BIOLOGY | Diabetes Mellitus - blood | Diabetes Mellitus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Endoribonucleases - genetics | Phosphorylation | Molecular Chaperones - metabolism | Proinsulin - chemistry | Proinsulin - metabolism | Diabetes Mellitus - genetics | Protein Disulfide-Isomerases - metabolism | eIF-2 Kinase - metabolism | Insulinoma - genetics | Male | Thioredoxins - genetics | Thioredoxins - metabolism | Membrane Proteins - metabolism | Endoribonucleases - deficiency | Insulin - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Promoter Regions, Genetic | Endoribonucleases - metabolism | Oxidation-Reduction | Signal Transduction | Membrane Proteins - genetics | Molecular Chaperones - genetics | Pancreatic Neoplasms - enzymology | Protein-Serine-Threonine Kinases - genetics | Pancreatic Neoplasms - genetics | Proinsulin - genetics | Insulinoma - enzymology | Protein Folding | Mice, Knockout | Activating Transcription Factor 6 - metabolism | Insulin - metabolism | Protein Disulfide-Isomerases - genetics | Animals | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Blood Glucose - metabolism | X-Box Binding Protein 1 - genetics | Insulin-Secreting Cells - enzymology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2017, Volume 127, Issue 1, pp. 293 - 305
Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are... 
MEDICINE, RESEARCH & EXPERIMENTAL | PLASMA GHRELIN | BODY-WEIGHT | HORMONE-RELEASING-HORMONE | HYPERPHAGIA | FOOD-INTAKE | PROPROTEIN CONVERTASE-1 | ONSET OBESITY | KNOCKOUT MICE | CIRCULATING GHRELIN LEVELS | CHILDREN | Diabetes Mellitus - pathology | Neurons - pathology | Proinsulin - metabolism | Diabetes Mellitus - genetics | Humans | Male | Obesity - genetics | RNA, Small Nucleolar - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypogonadism - metabolism | Prader-Willi Syndrome - genetics | Female | Neurons - metabolism | Induced Pluripotent Stem Cells - metabolism | Hypogonadism - pathology | Induced Pluripotent Stem Cells - pathology | Basic Helix-Loop-Helix Transcription Factors - genetics | Protein Precursors - genetics | Diabetes Mellitus - metabolism | Proinsulin - genetics | Prader-Willi Syndrome - metabolism | Growth Hormone-Releasing Hormone - genetics | Hyperphagia - metabolism | Proprotein Convertase 1 - deficiency | RNA, Small Nucleolar - genetics | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Protein Precursors - metabolism | Hyperphagia - genetics | Hyperphagia - pathology | Hypogonadism - genetics | Growth Hormone-Releasing Hormone - metabolism | Animals | Prader-Willi Syndrome - pathology | Prader-Willi syndrome | Gene expression | Neurons | Analysis | Risk factors | Proteins | Enzymes | Plasma | Obesity | Rodents | Fibroblasts | Patients | Binding sites
Journal Article
Diabetologia, ISSN 0012-186X, 4/2005, Volume 48, Issue 4, pp. 720 - 731
Mutations in genes encoding HNF-4α, HNF-1α and IPF-1/Pdx-1 are associated with, respectively, MODY subtypes-1, -3 and -4. Impaired glucose-stimulated insulin... 
Medicine | GLP-1 receptor | Beta cell | IPF-1 | cAMP | Pdx-1 | Prohormone convertase-1 | FGFR1 | MODY4 | beta cell | PEPTIDE-1 RECEPTOR | TRANSCRIPTION FACTOR PDX-1 | MITOCHONDRIAL METABOLISM | DIABETES-MELLITUS | GENE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | NUCLEAR FACTOR 1-ALPHA | PANCREATIC BETA-CELL | MICE | prohormone convertase-1 | GLUCAGON | Islets of Langerhans - drug effects | Gene Expression - drug effects | Proinsulin - metabolism | Receptor, Fibroblast Growth Factor, Type 1 | Gene Expression - genetics | Calcium Signaling - physiology | Homeodomain Proteins - metabolism | RNA, Messenger - metabolism | Exocytosis - physiology | Proprotein Convertases - genetics | Trans-Activators - physiology | Dose-Response Relationship, Drug | Human Growth Hormone - metabolism | Transfection | Time Factors | Islets of Langerhans - metabolism | Adenosine Triphosphate - metabolism | Receptors, Fibroblast Growth Factor - genetics | Trans-Activators - genetics | Gene Expression Regulation, Neoplastic - drug effects | Cyclic AMP - metabolism | Insulin Secretion | Receptors, Glucagon - genetics | Human Growth Hormone - genetics | RNA, Messenger - genetics | Rats | Glucokinase - genetics | Glucose - pharmacology | Mitochondria - metabolism | Homeodomain Proteins - genetics | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Receptor Protein-Tyrosine Kinases - genetics | Cell Line, Tumor | Glucose - metabolism | Glycolysis | Doxycycline - pharmacology | Signal Transduction - physiology | Trans-Activators - metabolism | Mutation | Homeodomain Proteins - physiology | Receptors, Glucagon - physiology | Glucagon | Isoenzymes | Genes | Glucose | Gene expression | Insulin | Dextrose | Glucose metabolism | Somatotropin | Medical genetics | Physiological aspects | Fibroblast growth factors | Diabetes
Journal Article
Respiratory Medicine, ISSN 0954-6111, 2016, Volume 112, pp. 119 - 125
Abstract Background Insulin resistance, glucose dyshomeostasis and oxidative stress are associated to the cardiovascular consequences of obstructive sleep... 
Pulmonary/Respiratory | Glucose tolerance | Biomarkers | Oxidative stress | Long-term CPAP | Obstructive sleep apnea | Cardiovascular risk | HOMOCYSTEINE | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | SENSITIVITY | NATRIURETIC PEPTIDE | HEART | IMPACT | RESPIRATORY SYSTEM | INSULIN-RESISTANCE | DISEASE | Continuous Positive Airway Pressure | Sleep Apnea, Obstructive - therapy | Oxidative Stress | Proinsulin - metabolism | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Natriuretic Peptide, Brain - metabolism | Male | Sleep Apnea, Obstructive - complications | Homocysteine - metabolism | Case-Control Studies | Cardiovascular Diseases - diagnostic imaging | Adult | Biomarkers - metabolism | Glucose Tolerance Test | Peptide Fragments - metabolism | Cardiovascular Diseases - metabolism | Carotid Intima-Media Thickness | Cholesterol, HDL - metabolism | Risk Factors | Insulin Resistance | Treatment Outcome | Cholesterol - metabolism | Polysomnography | Triglycerides - metabolism | Sleep Apnea, Obstructive - metabolism | Insulin - metabolism | Cholesterol, LDL - metabolism | Blood Glucose - metabolism | Obesity | Haptoglobin | Continuous positive airway pressure | Physiological aspects | Insulin resistance | Sleep apnea syndromes | Glucose | Cardiovascular diseases | Dextrose | Hypertension | Fasting | Laboratories | Homeostasis | Lipids | Sleep apnea | Triglycerides | Insulin | Cholesterol | Ultrasonic imaging | Hypoxia | Diabetes | Homocysteine | Metabolic disorders | Index Medicus
Journal Article
Diabetic Medicine, ISSN 0742-3071, 12/2014, Volume 31, Issue 12, pp. 1515 - 1523
Journal Article
Diabetologia, ISSN 0012-186X, 8/2010, Volume 53, Issue 8, pp. 1656 - 1668
Journal Article