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The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 44, pp. 18227 - 18239
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e70430
.... Proliferating cell nuclear antigen (PCNA) is a multifunctional protein essential for DNA replication and repair that is often overexpressed in cancer cells... 
SURVIVAL | PCNA-BINDING | REPLICATION | DNA | MULTIDISCIPLINARY SCIENCES | DISEASE | SENSITIVITY | THERAPIES | DISRUPTS | IDENTIFICATION | INHIBITOR | Apoptosis - drug effects | Humans | Molecular Sequence Data | Antineoplastic Agents - metabolism | Cell-Penetrating Peptides - pharmacology | Multiple Myeloma - drug therapy | Proliferating Cell Nuclear Antigen - genetics | U937 Cells | Protein Binding - drug effects | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Tumor Cells, Cultured | Amino Acid Sequence | Cell Survival - drug effects | Cell-Penetrating Peptides - genetics | Cells, Cultured | Mice, SCID | Multiple Myeloma - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Microscopy, Confocal | Multiple Myeloma - pathology | Animals | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | HeLa Cells | Amino Acid Motifs - genetics | Proliferating Cell Nuclear Antigen - metabolism | Cell-Penetrating Peptides - metabolism | Proteins | Antigens | DNA replication | Therapeutics | Multiple myeloma | Homeopathy | Materia medica and therapeutics | Apoptosis | Peptides | DNA damage | Science | Homology | Amino acids | Malignancy | DNA repair | Anticancer properties | Cell growth | Antitumor agents | Pathways | Lymphocytes | Melphalan | Proliferating cell nuclear antigen | Xenografts | Cell cycle | Bone marrow | Deoxyribonucleic acid--DNA | Medical research | Hematology | Amino acid sequence | Caspase | Tumor cell lines | Medicine | DNA biosynthesis | Sensitivity | Bone cancer | Stromal cells | Strategy | Protein interaction | Cellular stress response | Cancer | Deoxyribonucleic acid
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 10, pp. 3768 - 3773
... nuclear antigen at its Lys-164 residue. A requirement of HLTF for error-free postreplication repair of damaged DNA is in keeping with its cancer-suppression role. 
Yeasts | Enzymes | Plasmids | Ubiquitins | DNA | DNA damage | Antibodies | Small interfering RNA | Lesions | DNA repair | Yeast Rad5 | Damage bypass | K63 polyubiquitination | Tumor suppressor | DAMAGED DNA | MULTIDISCIPLINARY SCIENCES | tumor suppressor | damage bypass K63 polyubiquitination | SACCHAROMYCES-CEREVISIAE | GENE | HUMAN SHPRH | CLONING | yeast Rad5 | POSTREPLICATION REPAIR | TRANSLESION DNA-SYNTHESIS | PROTEINS | TRANSCRIPTION FACTOR | BINDING | Humans | Saccharomyces cerevisiae - drug effects | Genetic Complementation Test | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Ubiquitination - drug effects | Ultraviolet Rays | Protein Binding - drug effects | Protein Binding - radiation effects | Drug Resistance - radiation effects | Lysine - metabolism | Polyubiquitin - metabolism | Cell Line | Saccharomyces cerevisiae - radiation effects | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Ligases - metabolism | Drug Resistance - drug effects | Mutation - genetics | Transcription Factors - metabolism | DNA Helicases | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Ubiquitination - radiation effects | Proliferating Cell Nuclear Antigen - metabolism | Methyl Methanesulfonate - pharmacology | DNA replication | Ligases | Tumor suppressor genes | Influence | Research | DNA binding proteins | Ubiquitin-proteasome system | Properties | Index Medicus | damage bypass | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 12/2008, Volume 105, Issue 52, pp. 20689 - 20694
.... By using model DNA templates, purified DNA pols β and λ and knockout cell extracts, we show here that the auxiliary proteins replication protein A and proliferating cell nuclear antigen act as molecular switches to activate the DNA pol λ... 
Enzymes | Cell growth | Gels | DNA | Cell nucleus | Cell lines | Fibroblasts | Lesions | DNA repair | Tumors | MUTAGENESIS | BASE EXCISION-REPAIR | INTERACTS | MULTIDISCIPLINARY SCIENCES | 2-HYDROXYADENINE | CANCER | EXPRESSION | DAMAGE | FIBROBLASTS | LAMBDA | BETA | Reactive Oxygen Species - metabolism | Guanine - analogs & derivatives | Humans | DNA Repair - genetics | Tumor Suppressor Protein p53 - genetics | Guanine - metabolism | Cell Transformation, Neoplastic - genetics | Replication Protein A - genetics | DNA Polymerase beta - metabolism | DNA Polymerase beta - genetics | DNA Glycosylases - metabolism | DNA Glycosylases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Replication Protein A - metabolism | DNA - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | DNA - genetics | Animals | Cell-Free System - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | DNA Replication - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Mutation | Tumor Suppressor Protein p14ARF - genetics | Proliferating Cell Nuclear Antigen - metabolism | Tumor Suppressor Protein p14ARF - metabolism | Cell Line, Transformed | DNA polymerases | Antigens | Genetic aspects | Chemical properties | Biological Sciences
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 21, pp. 3212 - 3231
.... In proliferating cells, formin inhibition abolishes nuclear transport and initiation of DNA replication, as well as general transcription... 
actin | DNA replication | cyclin‐dependent kinase | nuclear transport | formin | cyclin-dependent kinase | RNA-POLYMERASE-II | NUCLEAR ACTIN | F-ACTIN | XENOPUS EGG EXTRACTS | DEPENDENT TRANSCRIPTION | IMPORTIN-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-FREE SYSTEM | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | CHROMATIN REMODELING COMPLEX | EPITHELIAL-CELLS | Chromatin - metabolism | Epithelial Cells - metabolism | ran GTP-Binding Protein - genetics | Humans | Actins - metabolism | Cytoplasm - metabolism | Fetal Proteins - metabolism | Actins - genetics | Cell Nucleus - metabolism | Proliferating Cell Nuclear Antigen - genetics | Transcription, Genetic | Microfilament Proteins - metabolism | Epithelial Cells - cytology | Nuclear Proteins - genetics | Active Transport, Cell Nucleus - genetics | Formins | Microfilament Proteins - genetics | Chromatin - chemistry | Signal Transduction | Xenopus laevis | Gene Expression Regulation | DNA Replication | Nuclear Proteins - metabolism | ran GTP-Binding Protein - metabolism | Complex Mixtures - chemistry | Nuclear Localization Signals | Animals | Karyopherins - metabolism | Cell Line, Tumor | Karyopherins - genetics | Fetal Proteins - genetics | HeLa Cells | Zygote - chemistry | Proliferating Cell Nuclear Antigen - metabolism | Regulators | Chromatin | Transcription | DNA damage | Replication initiation | Polymerization | Embryos | Nuclear transport | Loads (forces) | DNA biosynthesis | Proteins | Cyclin-dependent kinase | Replicating | Somatic cells | Actin | Dynamics | Proliferating cell nuclear antigen | Replication | Inhibition | Transport | Localization | Elongation | Deoxyribonucleic acid--DNA | Life Sciences | Cellular Biology | DNA Replication, Repair & Recombination | Cell Adhesion, Polarity & Cytoskeleton
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 08/2008, Volume 105, Issue 34, pp. 12411 - 12416
Journal Article
Journal Article