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European Journal of Heart Failure, ISSN 1388-9842, 08/2005, Volume 7, Issue 5, pp. 710 - 721
Surveys of prescribing patterns in both hospitals and primary care have usually shown delays in translating the evidence from clinical trials of... 
Heart failure | Isosorbide dinitrate | Beta‐blockers | Digoxin | Angiotensin receptor blockers | Pharmacology | Aldosterone antagonists | Treatment | Eplerenone | Spironolactone | Hydralazine | ACE inhibitors | Clinical recommendations | Beta-blockers | VENTRICULAR SYSTOLIC DYSFUNCTION | heart failure | treatment | CARDIAC & CARDIOVASCULAR SYSTEMS | angiotensin receptor blockers | QUALITY-OF-CARE | hydralazine | eplerenone | isosorbide dinitrate | RANDOMIZED INTERVENTION TRIAL | beta-blockers | MEDICAL-TREATMENT | GENERAL-PRACTICE | digoxin | spironolactone | CONVERTING-ENZYME-INHIBITORS | clinical recommendations | CARDIAC-INSUFFICIENCY | pharmacology | NATIONAL-SURVEY | aldosterone antagonists | ELDERLY-PATIENTS | Benzopyrans - therapeutic use | Valsartan | Angiotensin Receptor Antagonists | Bisoprolol - therapeutic use | Humans | Carbazoles - administration & dosage | Heart Failure - physiopathology | Valine - administration & dosage | Enalapril - therapeutic use | Ethanolamines - administration & dosage | Indoles - administration & dosage | Ramipril - administration & dosage | Captopril - therapeutic use | Propanolamines - therapeutic use | Lisinopril - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Benzimidazoles - administration & dosage | Tetrazoles - administration & dosage | Ramipril - therapeutic use | Drug Therapy, Combination | Enalapril - administration & dosage | Spironolactone - therapeutic use | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - therapeutic use | Benzimidazoles - therapeutic use | Lisinopril - administration & dosage | Nebivolol | Valine - analogs & derivatives | Metoprolol - therapeutic use | Metoprolol - administration & dosage | Evidence-Based Medicine | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Bisoprolol - administration & dosage | Heart Failure - drug therapy | Mineralocorticoid Receptor Antagonists - therapeutic use | Stroke Volume | Benzopyrans - administration & dosage | Captopril - administration & dosage | Guideline Adherence | Ethanolamines - therapeutic use | Indoles - therapeutic use | Metoprolol - analogs & derivatives | Tetrazoles - therapeutic use | Valine - therapeutic use | Carbazoles - therapeutic use | Propanolamines - administration & dosage | Practice Guidelines as Topic | Prescription writing | Corticosteroids | Isosorbide mononitrate | Family medicine | Nitrates | Peptide hormones | Aldosterone | Preventive health services | Cardiac patients | Angiotensin | Antiandrogens | Medicine, Preventive | Steroids | Kardiologi | converting-enzyme-inhibitors | Cardiac and Cardiovascular Systems | randomized intervention trial | quality-of-care | elderly-patients | cardiac-insufficiency | national-survey | medical-treatment | ventricular systolic dysfunction | general-practice
Journal Article
Clinical Pharmacology in Drug Development, ISSN 2160-763X, 11/2015, Volume 4, Issue 6, pp. 407 - 417
LCZ696 is a first-in-class angiotensin receptor neprilysin inhibitor in development for treatments of hypertension and heart failure indications. In 3 separate... 
LCZ696 | pharmacokinetic drug–drug interaction | amlodipine | hydrochlorothiazide | carvedilol | Pharmacokinetic drug-drug interaction | Amlodipine | Hydrochlorothiazide | Carvedilol | STEADY-STATE PHARMACOKINETICS | ANTAGONIST | NATRIURETIC PEPTIDES | pharmacokinetic drug-drug interaction | HEART-FAILURE | EXCRETION | PHARMACOLOGY & PHARMACY | DYSFUNCTION | VALSARTAN | Hydrochlorothiazide - pharmacokinetics | Diuretics - pharmacokinetics | Humans | Middle Aged | Male | Metabolic Clearance Rate | Tetrazoles - blood | Adrenergic beta-Antagonists - pharmacokinetics | Drug Interactions | Tetrazoles - administration & dosage | Adrenergic beta-Antagonists - adverse effects | Amlodipine - administration & dosage | Arizona | Diuretics - blood | Hydrochlorothiazide - adverse effects | Diuretics - administration & dosage | Administration, Oral | Amlodipine - adverse effects | Propanolamines - adverse effects | Antihypertensive Agents - adverse effects | Antihypertensive Agents - blood | Cross-Over Studies | Models, Biological | Calcium Channel Blockers - administration & dosage | Protease Inhibitors - blood | Calcium Channel Blockers - blood | Propanolamines - administration & dosage | Diuretics - adverse effects | Tetrazoles - pharmacokinetics | Angiotensin Receptor Antagonists - adverse effects | Angiotensin Receptor Antagonists - pharmacokinetics | Calcium Channel Blockers - adverse effects | Area Under Curve | Protease Inhibitors - pharmacokinetics | Carbazoles - administration & dosage | Aminobutyrates - adverse effects | Antihypertensive Agents - administration & dosage | Healthy Volunteers | Propanolamines - pharmacokinetics | Amlodipine - pharmacokinetics | Aminobutyrates - pharmacokinetics | Protease Inhibitors - administration & dosage | Protease Inhibitors - adverse effects | Adult | Female | Carbazoles - blood | Aminobutyrates - administration & dosage | Drug Therapy, Combination | Propanolamines - blood | Hydrochlorothiazide - blood | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - blood | Carbazoles - adverse effects | Amlodipine - blood | Drug Administration Schedule | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Neprilysin - metabolism | Aminobutyrates - blood | Angiotensin Receptor Antagonists - blood | Carbazoles - pharmacokinetics | Neprilysin - antagonists & inhibitors | Tetrazoles - adverse effects | Calcium Channel Blockers - pharmacokinetics | Angiotensin Receptor Antagonists - administration & dosage | Prescription drugs | Beta blockers | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0172361
Purpose Crystalloid fluid and vasoactive drugs are used in the early treatment of sepsis. The purpose of the present study was to examine how these drugs alter... 
VOLUME KINETICS | SHOCK | INFUSION | MANAGEMENT | SALINE | MULTIDISCIPLINARY SCIENCES | Norepinephrine - pharmacology | Isotonic Solutions - therapeutic use | Adrenergic beta-1 Receptor Antagonists - pharmacology | Isotonic Solutions - administration & dosage | Norepinephrine - administration & dosage | Male | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Sodium Chloride - therapeutic use | Phenylephrine - administration & dosage | Cardiotonic Agents - therapeutic use | Sepsis - drug therapy | Propanolamines - therapeutic use | Phenylephrine - pharmacology | Ringer's Lactate | Adrenergic beta-1 Receptor Antagonists - administration & dosage | Phenylephrine - therapeutic use | Dopamine - therapeutic use | Vasoconstrictor Agents - pharmacology | Vasoconstrictor Agents - therapeutic use | Norepinephrine - therapeutic use | Vasoconstrictor Agents - administration & dosage | Crystalloid Solutions | Dopamine - pharmacology | Sodium Chloride - administration & dosage | Cardiotonic Agents - pharmacology | Dopamine - administration & dosage | Animals | Cardiotonic Agents - administration & dosage | Sodium Chloride - pharmacokinetics | Sheep | Hemodynamics - drug effects | Sepsis - blood | Isotonic Solutions - pharmacokinetics | Propanolamines - administration & dosage | Propanolamines - pharmacology | Care and treatment | Analysis | Phenylephrine | Sepsis | Dosage and administration | Drug therapy | Blood plasma | Drugs | Stimulation | Tissues | Infusion | Receptors | Vasoactive agents | Hemoglobin | Anesthesia | Blood pressure | Drug dosages | Urine | Edema | Excretion | Stroke | Dopamine | Cecum | Fluid | Pharmacology | Blood levels | Stroke volume | Hospitals | Norepinephrine | Lactic acid | Hemodynamics | Kinetics | Anesthesiology | Acid-base status | Laboratory animals | Acidosis
Journal Article
Digestive Diseases and Sciences, ISSN 0163-2116, 12/2015, Volume 60, Issue 12, pp. 3814 - 3816
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2015, Volume 355, Issue 3, pp. 516 - 527
Journal Article
Journal Article
Journal Article
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 06/2012, Volume 95, pp. 1 - 9
Journal Article
Learning and Memory, ISSN 1072-0502, 04/2010, Volume 17, Issue 4, pp. 168 - 175
Journal Article
European Heart Journal, ISSN 0195-668X, 11/2005, Volume 26, Issue 21, pp. 2259 - 2268
Journal Article