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1. Full Text Suppression of Natural Killer Cell Activity and Promotion of Tumor Metastasis by Ketamine, Thiopental, and Halothane, but Not by Propofol: Mediating Mechanisms and Prophylactic Measures
by Melamed, Rivka and Bar-Yosef, Shahar and Shakhar, Guy and Shakhar, Keren and Ben-Eliyahu, Shamgar
Anesthesia & Analgesia, ISSN 0003-2999, 11/2003, Volume 97, Issue 5, pp. 1331 - 1339
Postoperative immunosuppression is partly ascribed to anesthesia and has been suggested to compromise patients’ resistance to infection and tumor metastasis.... 
SURGERY | ANESTHESIA | RESPONSES | ACID | IN-VIVO | ATTENUATION | RATS | ANESTHESIOLOGY | AGENTS | STRESS | COMPROMISES RESISTANCE | Halothane - pharmacology | Anesthetics, Inhalation - pharmacology | Antiviral Agents - pharmacology | Poly I-C - pharmacology | Adjuvants, Immunologic - pharmacology | Anesthetics, Dissociative - pharmacology | Rats, Inbred F344 | Propofol - pharmacology | Rats | Anesthetics - pharmacology | Lung Neoplasms - pathology | Male | Thiopental - pharmacology | Adrenergic beta-Antagonists - pharmacology | Anesthetics, Intravenous - pharmacology | Animals | Flow Cytometry | Neoplasm Metastasis - pathology | Neoplasm Metastasis - prevention & control | Female | Killer Cells, Natural - drug effects | Nadolol - pharmacology | Tumor Cells, Cultured | Ketamine - pharmacology
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2. Full Text Neonatal clinical pharmacology
by Allegaert, Karel and Velde, Marc and Anker, John and Anderson, Brian
Pediatric Anesthesia, ISSN 1155-5645, 01/2014, Volume 24, Issue 1, pp. 30 - 38
Summary Effective and safe drug administration in neonates should be based on integrated knowledge on the evolving physiological characteristics of the infant... 
pharmacokinetics | newborn | infant | ontogeny | pharmacodynamics | anesthesia | INTRAVENOUS PARACETAMOL | MORPHINE | MATURATION | PROPOFOL | ACETAMINOPHEN | INFANTS | ANESTHESIOLOGY | PEDIATRICS | PHARMACOGENETICS | DEVELOPMENTAL PHARMACOLOGY | PRETERM | Kidney - metabolism | Pharmaceutical Preparations - metabolism | Pharmacogenetics | Infant, Newborn - metabolism | Humans | Liver - metabolism | Kidney - growth & development | Pharmacology, Clinical | Infant, Newborn - physiology | Body Weight - physiology | Pharmacokinetics | Liver - growth & development | Infants (Newborn) | Pharmacology
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3. Full Text Perioperative gabapentin improves patient-centered outcomes after inguinal hernia repair
by Quail, Jacob and Spence, Dennis and Hannon, Matthew
Military Medicine, ISSN 0026-4075, 11/2017, Volume 182, Issue 11, pp. e2052 - e2055
Introduction: Over 5,300 inguinal hernia repairs (IHR) were performed in the Military Health System in 2015. Chronic pain can be a debilitating complication,... 
MEDICINE, GENERAL & INTERNAL | QUALITY-OF-LIFE | HERNIORRHAPHY | POSTOPERATIVE PAIN | Lidocaine - pharmacology | Adjuvants, Anesthesia - pharmacology | Ondansetron - pharmacology | Adjuvants, Anesthesia - therapeutic use | Fentanyl - therapeutic use | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Propofol - pharmacology | Lidocaine - therapeutic use | Male | Fentanyl - pharmacology | Hernia, Inguinal - drug therapy | Hypnotics and Sedatives - therapeutic use | Anesthetics, Local - pharmacology | Placebos - therapeutic use | Hernia, Inguinal - surgery | Antiemetics - therapeutic use | Amines - therapeutic use | Midazolam - therapeutic use | Adult | Androstanols - therapeutic use | Female | Anesthetics, Local - therapeutic use | Neuromuscular Depolarizing Agents - therapeutic use | Quality of Life - psychology | Succinylcholine - pharmacology | gamma-Aminobutyric Acid - therapeutic use | Neuromuscular Depolarizing Agents - pharmacology | Succinylcholine - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Double-Blind Method | Reconstructive Surgical Procedures - methods | gamma-Aminobutyric Acid - pharmacology | Treatment Outcome | Androstanols - pharmacology | Cyclohexanecarboxylic Acids - pharmacology | Ondansetron - therapeutic use | Hypnotics and Sedatives - pharmacology | Amines - pharmacology | Midazolam - pharmacology | Propofol - therapeutic use | Antiemetics - pharmacology | Cholecystectomy | Laparoscopy | FDA approval | Patients | Bone surgery | Quality of life | Studies | Airway management | Pain | Analgesics | Hernias | Surgeons | Anesthesia | Drug dosages
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4. Full Text The direct actions of GABA, 2'-methoxy-6-methylflavone and general anaesthetics at β3γ2L GABAA receptors: Evidence for receptors with different subunit stoichiometries
by Chua, Han Chow and Absalom, Nathan L and Hanrahan, Jane R and Viswas, Raja and Chebib, Mary
PLoS ONE, ISSN 1932-6203, 2015, Volume 10, Issue 10, p. e0141359
2'-Methoxy-6-methylflavone (2'MeO6MF) is an anxiolytic flavonoid which has been shown to display GABAA receptor (GABAAR) β2/3-subunit selectivity, a... 
Chlorides - pharmacology | Humans | Xenopus laevis | Cells, Cultured | Propofol - pharmacology | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Flumazenil - pharmacology | Anesthetics, Intravenous - pharmacology | Animals | Zinc Compounds - pharmacology | GABA-A Receptor Agonists - pharmacology | Etomidate - pharmacology | GABA Modulators - pharmacology | Female | Receptors, GABA-A - metabolism | Drug Evaluation, Preclinical | Flavones - pharmacology | Stoichiometry | Neurosciences | Effectiveness | γ-Aminobutyric acid A receptors | Pharmacology | Injection | Anesthetics | Etomidate | Oocytes | Receptors | γ-Aminobutyric acid | Acids | Rodents | Pharmacy | Ligands | Physiology | Propofol | Binding sites
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5. Full Text Consciousness and Complexity during Unresponsiveness Induced by Propofol, Xenon, and Ketamine
by Sarasso, Simone and Boly, Melanie and Napolitani, Martino and Gosseries, Olivia and Charland-Verville, Vanessa and Casarotto, Silvia and Rosanova, Mario and Casali, Adenauer Girardi and Brichant, Jean-Francois and Boveroux, Pierre and Rex, Steffen and Tononi, Giulio and Laureys, Steven and Massimini, Marcello
Current Biology, ISSN 0960-9822, 12/2015, Volume 25, Issue 23, pp. 3099 - 3105
A common endpoint of general anesthetics is behavioral unresponsiveness [ ], which is commonly associated with loss of consciousness. However, subjects can... 
RESPONSES | CORTEX IN-VIVO | ACETYLCHOLINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMANS | SLOW-WAVE SLEEP | STATE | INDUCED UNCONSCIOUSNESS | GENERAL-ANESTHESIA | EFFECTIVE CONNECTIVITY | REM-SLEEP | CELL BIOLOGY | Consciousness - drug effects | Anesthetics, Inhalation - pharmacology | Wakefulness - drug effects | Xenon - pharmacology | Anesthetics, Dissociative - pharmacology | Humans | Propofol - pharmacology | Male | Electroencephalography | Transcranial Magnetic Stimulation | Young Adult | Anesthetics, Intravenous - pharmacology | Anesthetics, General - pharmacology | Adolescent | Adult | Anesthesia | Female | Ketamine - pharmacology | Coma | Phenols | Ketamine | Propofol | Central nervous system agents
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6. Full Text Impact of Anesthetic Regimen on Remote Ischemic Preconditioning in the Rat Heart In Vivo
by Behmenburg, Friederike and van Caster, Patrick and Bunte, Sebastian and Brandenburger, Timo and Heinen, André and Hollmann, Markus W and Huhn, Ragnar
Anesthesia & Analgesia, ISSN 0003-2999, 04/2018, Volume 126, Issue 4, pp. 1377 - 1380
Remote ischemic preconditioning (RIPC) seems to be a promising cardioprotective strategy with contradictive clinical data suggesting the anesthetic regimen... 
SURGERY | INJURY | ANESTHESIOLOGY | PROTECTION | CARDIOPROTECTION | KINASE | Anesthetics, Inhalation - pharmacology | Rats, Wistar | Propofol - toxicity | Analgesics, Opioid - pharmacology | Pentobarbital - pharmacology | Propofol - pharmacology | Remifentanil - pharmacology | Male | Myocardium - pathology | Anesthetics, Intravenous - toxicity | Sevoflurane - pharmacology | Anesthetics, Intravenous - pharmacology | Myocardial Reperfusion Injury - pathology | Animals | Time Factors | Myocardial Infarction - pathology | Ischemic Preconditioning, Myocardial - methods | Hypnotics and Sedatives - pharmacology | Myocardial Infarction - prevention & control | Myocardial Reperfusion Injury - prevention & control | Disease Models, Animal
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7. Full Text Tranexamic acid concentrations associated with human seizures inhibit glycine receptors
by Lecker, Irene and Wang, Dian-Shi and Romaschin, Alexander D and Peterson, Mark and Mazer, C. David and Orser, Beverley A
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4654 - 4666
Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SUBSTANTIA-GELATINOSA NEURONS | INDUCED EPILEPTIFORM ACTIVITY | ENTORHINAL CORTEX | INHERITED MYOCLONUS | CARDIAC-SURGERY | SODIUM-CHANNELS | GABAERGIC TONIC INHIBITION | GABA(A) RECEPTORS | HIPPOCAMPAL-NEURONS | FLUID DRAINAGE | Isoflurane - pharmacology | Humans | Middle Aged | Tranexamic Acid - pharmacology | Propofol - pharmacology | Mice, 129 Strain | Anticonvulsants - pharmacology | Receptors, Glycine - antagonists & inhibitors | Seizures - chemically induced | Young Adult | Aprotinin - pharmacology | Spinal Cord - pathology | Neurons - physiology | Aged, 80 and over | Inhibitory Concentration 50 | Adult | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | GABA-A Receptor Antagonists - pharmacology | Binding, Competitive | Membrane Potentials - drug effects | Aminocaproic Acid - adverse effects | GABA-A Receptor Antagonists - pharmacokinetics | Mice, Inbred C57BL | Cells, Cultured | gamma-Aminobutyric Acid - pharmacology | GABA-A Receptor Antagonists - adverse effects | Tranexamic Acid - adverse effects | Aminocaproic Acid - pharmacology | Patch-Clamp Techniques | Animals | Glycine - pharmacology | Protein Binding | Tranexamic Acid - pharmacokinetics | Aged | Mice | Receptors, GABA-A - metabolism | In Vitro Techniques | Inhibitory Postsynaptic Potentials - drug effects | Dose-response relationship (Biochemistry) | Complications and side effects | Care and treatment | Glycine receptors | Tranexamic acid | Research | Seizures (Medicine) | Diagnosis | Properties
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8. Full Text Disruption of Frontal–Parietal Communication by Ketamine, Propofol, and Sevoflurane
by Lee, UnCheol and Ku, SeungWoo and Noh, GyuJeong and Baek, SeungHye and Choi, ByungMoon and Mashour, George A
Anesthesiology, ISSN 0003-3022, 06/2013, Volume 118, Issue 6, pp. 1264 - 1275
INTRODUCTION:Directional connectivity from anterior to posterior brain regions (or “feedback” connectivity) has been shown to be inhibited by propofol and... 
NITROUS-OXIDE | TRANSFER ENTROPY | ANESTHESIA | FEEDFORWARD | CONSCIOUSNESS | CONNECTIVITY | ANESTHESIOLOGY | INFORMATION-TRANSFER | MODEL | CEREBRAL-BLOOD-FLOW | BREAKDOWN | Analgesics - pharmacology | Anesthetics, Inhalation - pharmacology | Humans | Middle Aged | Propofol - pharmacology | Male | Electroencephalography | Methyl Ethers - pharmacology | Young Adult | Anesthetics, Intravenous - pharmacology | Parietal Lobe - drug effects | Frontal Lobe - drug effects | Adult | Female | Ketamine - pharmacology
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9. Full Text The Pharmacology of Cyclopropyl-Methoxycarbonyl Metomidate: A Comparison with Propofol
by Ge, Rile and Pejo, Ervin and Gallin, Hilary and Jeffrey, Spencer and Cotten, Joseph F and Raines, Douglas E
Anesthesia & Analgesia, ISSN 0003-2999, 03/2014, Volume 118, Issue 3, pp. 563 - 567
BACKGROUND:Cyclopropyl-methoxycarbonyl metomidate (CPMM) is a “soft” etomidate analogue currently being developed as a propofol alternative for anesthetic... 
ANESTHESIA | MAINTENANCE | INHIBITION | ADRENOCORTICAL SUPPRESSION | IN-VIVO | INFUSIONS | ANESTHESIOLOGY | MULTIPLE TRAUMA PATIENTS | PROTEIN-BINDING | METABOLITE | ETOMIDATE ANALOG | Xenopus laevis | Propofol - pharmacology | Rats | Male | Electroencephalography - methods | Rats, Sprague-Dawley | Reflex, Righting - drug effects | Etomidate - analogs & derivatives | Anesthetics, Intravenous - pharmacology | Animals | Reflex, Righting - physiology | Electroencephalography - drug effects | Larva | Etomidate - pharmacology | Female | Receptors, GABA-A - metabolism
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10. Full Text Kavain, the major constituent of the anxiolytic kava extract, potentiates gabaa receptors: Functional characteristics and molecular mechanism
by Chua, Han Chow and Christensen, Emilie T. H and Hoestgaard-Jensen, Kirsten and Hartiadi, Leonny Y and Ramzan, Iqbal and Jensen, Anders A and Absalom, Nathan L and Chebib, Mary
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157700
Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest... 
Benzodiazepines - pharmacology | Humans | Xenopus laevis | Anti-Anxiety Agents - pharmacology | Kava - chemistry | Propofol - pharmacology | Anesthetics - pharmacology | Mutation - genetics | Pyrones - pharmacology | Protein Subunits - metabolism | Diazepam - pharmacology | Drug Synergism | Flumazenil - pharmacology | Pyrones - chemistry | Animals | Drug Interactions | Receptors, GABA-A - genetics | Etomidate - pharmacology | Anti-Anxiety Agents - chemistry | Receptors, GABA-A - metabolism | Potentiation | Medical research | Neurosciences | γ-Aminobutyric acid A receptors | Clinical trials | Alcohol | Pharmacology | Oocytes | Benzodiazepines | Plant extracts | Receptors | Constituents | γ-Aminobutyric acid | Flumazenil | Anxieties | Rodents | Pharmacy | Point mutation | Subunit structure | Anesthesia | Ligands | Anxiety | Binding sites | Recombinant
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11. Full Text The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model
by Bruins, Benjamin and Kilbaugh, Todd J and Margulies, Susan S and Friess, Stuart H
Anesthesia and Analgesia, ISSN 0003-2999, 05/2013, Volume 116, Issue 4, pp. 838 - 844
BACKGROUND: The effect of various sedatives and anesthetics on vasopressor modulation of cerebral blood flow (CBF) in children is unclear. In adults,... 
NITROUS-OXIDE | VELOCITY | OXYGEN-CONSUMPTION | TRAUMATIC BRAIN-INJURY | METABOLISM | ANESTHESIOLOGY | PERFUSION | MIDAZOLAM | ISOFLURANE ANESTHESIA | AUTOREGULATION | PROPOFOL | Intracranial Pressure - drug effects | Vasoconstrictor Agents - pharmacology | Anesthetics, Inhalation - pharmacology | Norepinephrine - pharmacology | Isoflurane - pharmacology | Cerebrovascular Circulation - drug effects | Critical Illness | Anesthetics - pharmacology | Intensive Care Units, Pediatric | Anesthesia - adverse effects | Fentanyl - pharmacology | Anesthesia, Intravenous | Arginine Vasopressin - pharmacology | Oxygen - blood | Anesthetics, Intravenous - pharmacology | Animals | Phenylephrine - pharmacology | Swine | Vascular Resistance - drug effects | Blood Pressure - drug effects | Midazolam - pharmacology
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12. Full Text Menthol shares general anesthetic activity and sites of action on the GABA A receptor with the intravenous agent, propofol
by Watt, Erin E and Betts, Brooke A and Kotey, Francesca O and Humbert, Danielle J and Griffith, Theanne N and Kelly, Elizabeth W and Veneskey, Kelley C and Gill, Nikhila and Rowan, Kathleen C and Jenkins, Andrew and Hall, Adam C
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 590, Issue 1, pp. 120 - 126
Menthol and related compounds were investigated for modulation of recombinant human γ-aminobutyric acid type A (GABA , α β γ ) receptor currents expressed in... 
Anesthesia | Modulator | Menthol | Propofol | GABA A receptor | Oocyte | POSITIVE ALLOSTERIC MODULATOR | REQUIREMENTS | menthol | propofol | SUBTYPES | ISOFLURANE | CURRENTS | IDENTIFICATION | anesthesia | A RECEPTORS | THYMOL | oocyte | INHIBITION | modulator | GABA(A) receptor | PHARMACOLOGY & PHARMACY | CHANNELS | Xenopus | Flumazenil - pharmacology | Anesthetics, Intravenous - pharmacology | Animals | Menthol - pharmacology | Pregnanolone - pharmacology | Anesthetics, General - pharmacology | Receptors, GABA-A - drug effects | Pentobarbital - pharmacology | Propofol - pharmacology | Cyclohexanols - pharmacology | Flunitrazepam - pharmacology
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13. Full Text Importance of pharmacology to avoid complications with endoscopic sedation
by Martins Do Vale, Fernando and Marques, Diogo Ferreira
Gut, ISSN 0017-5749, 05/2018, Volume 68, Issue 5, pp. 91 - 91
respiratory failure | endoscopy | OSA | sedation | pharmacology | GASTROINTESTINAL ENDOSCOPY | DEXMEDETOMIDINE | GASTROENTEROLOGY & HEPATOLOGY | MIDAZOLAM | PROPOFOL
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14. Full Text Brain protection by anesthetic agents
by Koerner, Ines P and Brambrink, Ansgar M
Current Opinion in Anaesthesiology, ISSN 0952-7907, 10/2006, Volume 19, Issue 5, pp. 481 - 486
Purpose of review Patients at risk for perioperative stroke, or those who have suffered recent cerebral injury, may benefit from neuroprotective properties of... 
Neuroprotection | Anesthesia | Neurotoxicity | Perioperative cerebral ischemia | Posttreatment | Preconditioning | neurotoxicity | perioperative cerebral ischemia | neuroprotection | ANESTHESIOLOGY | posttreatment | anesthesia | preconditioning | Anesthetics, Inhalation - pharmacology | Lidocaine - pharmacology | Xenon - pharmacology | Anesthetics, Dissociative - pharmacology | Isoflurane - pharmacology | Humans | Propofol - pharmacology | Anesthetics - pharmacology | Neuroprotective Agents - toxicity | Anesthetics, Local - pharmacology | Brain - drug effects | Anesthetics, Intravenous - pharmacology | Anesthetics - toxicity | Animals | Neuroprotective Agents - pharmacology | Cerebrovascular Disorders - prevention & control | Time Factors | Barbiturates - pharmacology | Brain - pathology | Neuroprotective Agents - adverse effects | Ketamine - pharmacology | Anesthetics - adverse effects
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