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Annals of internal medicine, ISSN 0003-4819, 07/2015, Volume 163, Issue 1, pp. 40 - 51
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hypercholesterolemia - blood | Creatine Kinase - blood | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Cause of Death | Proprotein Convertases - immunology | Anticholesteremic Agents - therapeutic use | Serine Endopeptidases - immunology | Angina, Unstable - prevention & control | Cardiovascular Diseases - mortality | Female | Myocardial Infarction - prevention & control | Lipoprotein(a) - blood | Proprotein Convertase 9 | Monoclonal antibodies | Complications and side effects | Dosage and administration | Hypercholesterolemia | Research | Drug therapy | Proteins | Patient safety | Lipids | Adults | Clinical outcomes | Index Medicus | Abridged Index Medicus
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2012, Volume 380, Issue 9858, pp. 1995 - 2006
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Metabolic diseases | General aspects | Medical sciences | Disorders of blood lipids. Hyperlipoproteinemia | Proprotein Convertases - antagonists & inhibitors | Double-Blind Method | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Hypercholesterolemia - drug therapy | Proprotein Convertases - immunology | Young Adult | Anticholesteremic Agents - therapeutic use | Immunoglobulin G - immunology | Adolescent | Serine Endopeptidases - immunology | Aged, 80 and over | Adult | Female | Aged | Proprotein Convertase 9 | Monoclonal antibodies | Usage | Hypercholesterolemia | Research | Drug therapy | Heart | Thyroid diseases | Clinical trials | Cardiovascular disease | Mutation | Apolipoproteins | Cholesterol | Statins | Index Medicus | Abridged Index Medicus
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2012, Volume 380, Issue 9858, pp. 2007 - 2017
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Metabolic diseases | General aspects | Medical sciences | Disorders of blood lipids. Hyperlipoproteinemia | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Proprotein Convertases - antagonists & inhibitors | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Ezetimibe | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Young Adult | Immunoglobulin G - immunology | Serine Endopeptidases - immunology | Aged, 80 and over | Adult | Cholesterol, LDL - blood | Female | Drug Therapy, Combination | Double-Blind Method | Azetidines - adverse effects | Treatment Outcome | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Azetidines - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Analysis of Variance | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Adolescent | Cholesterol, HDL - blood | Aged | Proprotein Convertase 9 | Monoclonal antibodies | Usage | Hypercholesterolemia | Research | Drug therapy | Clinical trials | Cardiovascular disease | Apolipoproteins | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
European heart journal, ISSN 0195-668X, 08/2017, Volume 38, Issue 32, pp. 2499 - U143
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Biomarkers - metabolism | Hypercholesterolemia - immunology | Antibodies - metabolism | Cholesterol, HDL - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Plaque, Atherosclerotic - prevention & control | Mice, Transgenic | Vaccines, Subunit - immunology | Vasculitis - prevention & control | Proprotein Convertase 9 - immunology | Vasculitis - immunology | Coronary Disease - prevention & control | Intercellular Adhesion Molecule-1 - metabolism | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Proprotein Convertase 9 - antagonists & inhibitors | Vaccines, Subunit - administration & dosage | Apolipoprotein E3 - deficiency | Aortic Diseases - prevention & control | Female | Hypercholesterolemia - prevention & control | Atherosclerosis - prevention & control | Disease Models, Animal | Index Medicus | Basic Science | Systemic and vascular inflammation | APOE3Leiden.CETP mice | Editor's Choice | Atherosclerosis | Anti-PCSK9 vaccine
Journal Article
Annals of internal medicine, ISSN 0003-4819, 05/2016, Volume 164, Issue 9, pp. 600 - 607
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Recurrence | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - pharmacokinetics | Antibodies, Monoclonal - therapeutic use | Proprotein Convertase 9 - immunology | Acute Coronary Syndrome - blood | Immunologic Factors - pharmacokinetics | Acute Coronary Syndrome - complications | Plaque, Atherosclerotic - therapy | Proprotein Convertase 9 - antagonists & inhibitors | Time Factors | Fibrinolytic Agents - therapeutic use | Proprotein Convertase 9 - blood | Anti-Inflammatory Agents - therapeutic use | Acute Coronary Syndrome - therapy | Immunologic Factors - pharmacology | Lipoproteins, LDL - blood | Immunologic Factors - therapeutic use | Enzyme inhibitors | Atherosclerotic plaque | Development and progression | Genetic aspects | Lipid metabolism | Acute coronary syndrome | Health aspects | Monoclonal antibodies | Coronary heart disease | Cardiac patients | Medical research | Cardiovascular disease | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Circulation journal : official journal of the Japanese Circulation Society, ISSN 1346-9843, 2017, Volume 81, Issue 10, pp. 1386 - 1387
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Subtilisins | Humans | Serine Endopeptidases - immunology | Cholesterol, LDL | Lipids | Antibodies, Monoclonal | Proprotein Convertases - immunology | Proprotein Convertase 9 | Index Medicus
Journal Article
Journal of clinical lipidology, ISSN 1933-2874, 2017, Volume 11, Issue 3, pp. 667 - 673
Cardiovascular | Low-density lipoprotein | Proprotein convertase subtilisin/kexin type 9 | Lipoprotein(a) | Cholesterol | Discordance | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Middle Aged | Cholesterol, LDL - blood | Female | Male | Lipoprotein(a) - blood | Proprotein Convertase 9 - immunology | Antibodies, Monoclonal - immunology | Cohort Studies | Monoclonal antibodies | Cholesterol, LDL | Research | Lipoprotein A | Index Medicus
Journal Article
Cardiovascular research, ISSN 0008-6363, 03/2019, Volume 115, Issue 3, pp. 510 - 518
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hypercholesterolemia - immunology | Cholesterol - blood | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Vaccines - therapeutic use | Proprotein Convertase 9 - immunology | Serine Proteinase Inhibitors - therapeutic use | Hypercholesterolemia - enzymology | Serine Proteinase Inhibitors - adverse effects | Hypercholesterolemia - therapy | Gene Targeting | Receptors, LDL - antagonists & inhibitors | Gene Silencing | Receptors, LDL - metabolism | Treatment Outcome | Proprotein Convertase 9 - genetics | Biomarkers - blood | Proprotein Convertase 9 - metabolism | Anticholesteremic Agents - adverse effects | Vaccines - adverse effects | Animals | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Hypercholesterolemia - genetics | Genetic Therapy - adverse effects | Genetic Therapy - methods | Index Medicus | Monoclonal antibodies | Gene silencing | PCSK9 | Reviews | LDL-C | Editor's Choice
Journal Article
Journal of lipid research, ISSN 0022-2275, 11/2014, Volume 55, Issue 11, pp. 2370 - 2379
Anti-proprotein convertase subtilisin/kexin type 9 antibody | Proprotein convertase subtilisin/kexin type 9 | Low density lipoprotein receptor | Apolipoprotein E | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Cholesterol - blood | Humans | Proprotein Convertases - genetics | Atherosclerosis - enzymology | Liver - drug effects | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Antibodies - immunology | Female | Serine Endopeptidases - deficiency | Liver - metabolism | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Gene Knockout Techniques | Proprotein Convertases - deficiency | Atherosclerosis - metabolism | Proprotein Convertases - immunology | Atherosclerosis - blood | Animals | Mice | Serine Endopeptidases - metabolism | Cholesterol Ester Transfer Proteins - metabolism | Proprotein Convertase 9 | Index Medicus | kexin type 9 antibody | apolipoprotein E | kexin type 9 | low density lipoprotein receptor | proprotein convertase subtilisin | anti-proprotein convertase subtilisin
Journal Article