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Circulation (New York, N.Y.), ISSN 0009-7322, 10/2015, Volume 132, Issue 17, pp. 1648 - 1666
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the regulation of cholesterol homeostasis... 
Antibodies, monoclonal | Clinical trial | PCSK9 protein, human | antibodies, monoclonal | clinical trial | CARDIAC & CARDIOVASCULAR SYSTEMS | LOWERING THERAPY | MONOCLONAL-ANTIBODY | DENSITY-LIPOPROTEIN-CHOLESTEROL | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | STATIN-INTOLERANT PATIENTS | HEALTHY-VOLUNTEERS | CORONARY-HEART-DISEASE | PLASMA LDL CHOLESTEROL | PCSK9 GENE | Proprotein Convertases - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Serine Endopeptidases - physiology | Antibodies, Monoclonal - therapeutic use | Intestines - metabolism | Structure-Activity Relationship | Cardiovascular Diseases - enzymology | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Incidence | Brain - metabolism | RNA Interference | Oligonucleotides, Antisense - therapeutic use | Serine Endopeptidases - genetics | Cardiovascular Diseases - epidemiology | Protein Structure, Tertiary | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Serine Endopeptidases - deficiency | Liver - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Clinical Trials as Topic | Proprotein Convertases - chemistry | Proprotein Convertases - deficiency | Proprotein Convertases - physiology | Animals | RNA, Small Interfering - therapeutic use | Adipocytes - metabolism | Cholesterol, LDL - metabolism | Hyperlipoproteinemias - genetics | Mice | Peptide Fragments - therapeutic use | Mutation | Proprotein Convertase 9 | Monoclonal antibodies | Clinical trials | Usage | Care and treatment | Dosage and administration | Cardiovascular diseases
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2011, Volume 365, Issue 26, pp. 2507 - 2518
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2003, Volume 100, Issue 3, pp. 928 - 933
Journal Article
Circulation research, ISSN 0009-7330, 03/2014, Volume 114, Issue 6, pp. 1022 - 1036
Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has attracted a lot of attention from the scientific community and pharmaceutical companies... 
hyperlipoproteinemia type II | clinical trials | LDL cholesterol | phase III as topic | PLASMA PCSK9 | PROPROTEIN CONVERTASE PCSK9 | CARDIAC & CARDIOVASCULAR SYSTEMS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | SUBTILISIN/KEXIN TYPE 9 | PCSK9-MEDIATED DEGRADATION | MONOCLONAL-ANTIBODY | OF-FUNCTION MUTATIONS | MESSENGER-RNA | PERIPHERAL VASCULAR DISEASE | CHOLESTEROL HOMEOSTASIS | LIPOPROTEIN-RECEPTOR LDLR | HEMATOLOGY | Proprotein Convertases - antagonists & inhibitors | Hepatitis C - metabolism | Vertebrates - genetics | Humans | Serine Endopeptidases - physiology | Male | Risk | Hepatocytes - metabolism | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Endosomes - metabolism | Clinical Trials, Phase III as Topic | Lysosomes - metabolism | Insulin Resistance - physiology | Serine Endopeptidases - genetics | Cardiovascular Diseases - blood | Adult | Cholesterol, LDL - blood | Female | Lipoproteins, LDL - metabolism | Hyperlipoproteinemia Type II - drug therapy | Chromosomes, Human, Pair 1 - genetics | Child | Disease Models, Animal | Genetic Predisposition to Disease | Serine Endopeptidases - deficiency | Cardiovascular Diseases - metabolism | Rodentia | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Organ Specificity | Proprotein Convertases - deficiency | Gene Expression Regulation, Enzymologic | Hyperlipoproteinemia Type II - metabolism | Pregnancy | Proprotein Convertases - physiology | Animals | Diet | Protein Processing, Post-Translational | Mutation | Aging - metabolism | Hyperlipoproteinemia Type II - genetics | Proprotein Convertase 9
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 2, p. e0191895
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 8 - 15
[Display omitted] Proprotein convertases are serine proteases responsible for the cleavage and subsequent activation of protein substrates, many of them relevant for the development of an ample variety of diseases... 
Proprotein convertases | Tumor progression | Molecular therapy | CANCER-CELLS | ALPHA-1-ANTITRYPSIN PORTLAND | HEPATOMA-CELLS | OVARIAN-CANCER | FURIN INHIBITORS | POTENT INHIBITORS | PACE4 INHIBITORS | PCSK9 INHIBITION | PHARMACOLOGY & PHARMACY | TUMORICIDAL ACTIVITY | GROWTH-FACTOR | Proprotein Convertases - antagonists & inhibitors | Activation, Metabolic | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - pharmacokinetics | Drugs, Investigational - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Isoenzymes - chemistry | Prodrugs - chemistry | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Drugs, Investigational - chemistry | Enzyme Inhibitors - pharmacokinetics | Isoenzymes - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Binding Sites | Binding, Competitive | Catalytic Domain | Proprotein Convertases - metabolism | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Neoplasm Proteins - chemistry | Proprotein Convertases - chemistry | Antineoplastic Agents - chemistry | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Animals | Prodrugs - pharmacokinetics | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Prodrugs - therapeutic use | Neoplasms - pathology | Prodrugs - pharmacology | Isoenzymes - antagonists & inhibitors | Medical research | Proteases | Communicable diseases | Low density lipoproteins | Medicine, Experimental | Development and progression | Amino acids | Ovarian cancer | Index Medicus | Dec-RVKR-CMK (PubChem CID 9962075) | tumor progression | molecular therapy
Journal Article