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Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 186 - 191
Journal Article
Lancet, The, ISSN 0140-6736, 2014, Volume 383, Issue 9911, pp. 60 - 68
Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | DOUBLE-STRANDED-RNA | PLASMA-CHOLESTEROL | METAANALYSIS | CARDIOVASCULAR-DISEASE | MONOCLONAL-ANTIBODY | HYPERCHOLESTEROLEMIA | STATINS | AMG 145 | ATORVASTATIN | Single-Blind Method | Serine Endopeptidases - biosynthesis | Humans | Middle Aged | RNA, Small Interfering - pharmacology | RNA, Small Interfering - adverse effects | Cholesterol, LDL - drug effects | Male | Healthy Volunteers | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Proprotein Convertases - biosynthesis | RNA Interference | Serine Endopeptidases - blood | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Proprotein Convertases - blood | RNA, Small Interfering - administration & dosage | Genetic Therapy - adverse effects | Genetic Therapy - methods | Proprotein Convertase 9 | Enzymes | Research | Gene mutations | Properties | Gene expression | Identification and classification | Medical research | RNA | Low density lipoproteins | Anticholesteremic agents | Clinical trials | Aluminum compounds | Coronary heart disease | Cholesterol | Hypercholesterolemia | Analysis | Medicine, Experimental | Product development | Trans fatty acids | Blood proteins | Studies | Heart | Nanoparticles | Plasma | Nutrition research | Cardiovascular disease | Lipids | Mutation | Drug dosages | Statins | Index Medicus | Abridged Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 06/2013, Volume 127, Issue 24, pp. 2403 - 2413
Journal Article
Circulation, ISSN 0009-7322, 07/2014, Volume 130, Issue 5, pp. 431 - 441
Journal Article
Atherosclerosis, ISSN 0021-9150, 2014, Volume 236, Issue 1, pp. 54 - 61
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e64145 - e64145
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3508 - 3519
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the... 
PLASMA PCSK9 | tumor necrosis factor (TNF) | ACTIVATION | hepatocyte | proprotein convertase subtilisin | PROTEIN | insulin | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | APOLIPOPROTEIN-B | HUMAN ENDOTHELIAL-CELLS | INSULIN-RESISTANCE | stat-3 | HepG2 | kexin type 9 (PCSK9) | SMOOTH-MUSCLE-CELLS | MUTATIONS | suppressor of cytokine signaling 3 (SOCS3) | Proprotein Convertases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Tumor Necrosis Factor-alpha - genetics | Male | Janus Kinases - metabolism | Hepatocytes - metabolism | Proprotein Convertases - genetics | Recombinant Fusion Proteins - metabolism | RNA Interference | Serine Endopeptidases - genetics | Lipogenesis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Janus Kinases - chemistry | Signal Transduction | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Insulin Resistance | Enzyme Induction | Suppressor of Cytokine Signaling Proteins - genetics | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Hep G2 Cells | Obesity - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - agonists | Obesity - enzymology | Protein Processing, Post-Translational | Serine Endopeptidases - metabolism | Mutation | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Hepatocytes - enzymology | Proprotein Convertase 9 | Index Medicus | Cell Biology
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