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Circulation (New York, N.Y.), ISSN 0009-7322, 10/2015, Volume 132, Issue 17, pp. 1648 - 1666
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the regulation of cholesterol homeostasis... 
Antibodies, monoclonal | Clinical trial | PCSK9 protein, human | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Serine Endopeptidases - physiology | Antibodies, Monoclonal - therapeutic use | Intestines - metabolism | Structure-Activity Relationship | Cardiovascular Diseases - enzymology | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Incidence | Brain - metabolism | RNA Interference | Oligonucleotides, Antisense - therapeutic use | Serine Endopeptidases - genetics | Cardiovascular Diseases - epidemiology | Protein Structure, Tertiary | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Serine Endopeptidases - deficiency | Liver - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Clinical Trials as Topic | Proprotein Convertases - chemistry | Proprotein Convertases - deficiency | Proprotein Convertases - physiology | Animals | RNA, Small Interfering - therapeutic use | Adipocytes - metabolism | Cholesterol, LDL - metabolism | Hyperlipoproteinemias - genetics | Mice | Peptide Fragments - therapeutic use | Mutation | Proprotein Convertase 9 | Monoclonal antibodies | Clinical trials | Usage | Care and treatment | Dosage and administration | Cardiovascular diseases | Index Medicus | Abridged Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 03/2014, Volume 114, Issue 6, pp. 1022 - 1036
Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has attracted a lot of attention from the scientific community and pharmaceutical companies... 
hyperlipoproteinemia type II | clinical trials | LDL cholesterol | phase III as topic | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Hepatitis C - metabolism | Vertebrates - genetics | Humans | Serine Endopeptidases - physiology | Male | Risk | Hepatocytes - metabolism | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Endosomes - metabolism | Clinical Trials, Phase III as Topic | Lysosomes - metabolism | Insulin Resistance - physiology | Serine Endopeptidases - genetics | Cardiovascular Diseases - blood | Adult | Cholesterol, LDL - blood | Female | Lipoproteins, LDL - metabolism | Hyperlipoproteinemia Type II - drug therapy | Chromosomes, Human, Pair 1 - genetics | Child | Disease Models, Animal | Genetic Predisposition to Disease | Serine Endopeptidases - deficiency | Cardiovascular Diseases - metabolism | Rodentia | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Organ Specificity | Proprotein Convertases - deficiency | Gene Expression Regulation, Enzymologic | Hyperlipoproteinemia Type II - metabolism | Pregnancy | Proprotein Convertases - physiology | Animals | Diet | Protein Processing, Post-Translational | Mutation | Aging - metabolism | Hyperlipoproteinemia Type II - genetics | Proprotein Convertase 9 | Index Medicus
Journal Article
2006, ISBN 9781402047930, x, 157
Convertases are widely expressed activating enzymes involved in various physiological and pathological processes... 
Enzyme inhibitors | Treatment | Genetic aspects | Carcinogenesis | Molecular aspects | Therapeutic use | Cancer
Book
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2003, Volume 100, Issue 3, pp. 928 - 933
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 07/2014, Volume 130, Issue 5, pp. 431 - 441
Journal Article
Nature (London), ISSN 1476-4687, 04/2015, Volume 520, Issue 7546, pp. 186 - 191
The RNA-guided endonuclease Cas9 has emerged as a versatile genom-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Enzymes | Usage | Genetic engineering | Genetic aspects | Methods | Staphylococcus aureus | Bacteria | Genomes | Biomedical research | Molecular weight | Index Medicus
Journal Article