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Circulation, ISSN 0009-7322, 11/2012, Volume 126, Issue 20, pp. 2408 - 2417
Journal Article
Circulation, ISSN 0009-7322, 08/2013, Volume 128, Issue 9, pp. 962 - 969
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9858, pp. 2007 - 2017
Journal Article
Journal Article
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2014, Volume 63, Issue 23, pp. 2541 - 2548
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 12, pp. 1108 - 1118
A monoclonal antibody to PCSK9 was studied in two single-dose trials in healthy volunteers and one multiple-dose trial in patients with familial or nonfamilial... 
POPULATION | MEDICINE, GENERAL & INTERNAL | STATIN | MICE | MUTATIONS | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2014, Volume 370, Issue 19, pp. 1809 - 1819
Patients with hyperlipidemia were assigned to receive the PCSK9 antibody evolocumab or placebo on a background of lipid-lowering therapy. At 52 weeks, the... 
MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | LDL-C | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | DOUBLE-BLIND | SUBTILISIN/KEXIN TYPE 9 | RANDOMIZED-TRIAL | PCSK9 | MONOCLONAL-ANTIBODY | SERINE-PROTEASE | AMG 145 | Proprotein Convertases - antagonists & inhibitors | Double-Blind Method | Heptanoic Acids - therapeutic use | Humans | Hyperlipidemias - drug therapy | Middle Aged | Antibodies, Monoclonal - adverse effects | Ezetimibe | Antibodies, Monoclonal - therapeutic use | Male | Combined Modality Therapy | Proprotein Convertases - immunology | Atorvastatin Calcium | Azetidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Serine Endopeptidases - immunology | Least-Squares Analysis | Adult | Cholesterol, LDL - blood | Female | Aged | Hyperlipidemias - diet therapy | Pyrroles - therapeutic use | Proprotein Convertase 9 | Monoclonal antibodies | Clinical trials | Care and treatment | Product development | Research | Hyperlipidemia | Lipoproteins (low density) | Nutrient deficiency | Rhinopharyngitis | Ultracentrifugation | Subtilisin | Triglycerides | Apolipoproteins | Patients | Low density lipoprotein | Cholesterol | Apolipoprotein B | Kexin | Pain | Diet | Influenza | Atorvastatin | Respiratory tract diseases | Drug therapy | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 711 - 721
Journal Article
JAMA, ISSN 0098-7484, 12/2012, Volume 308, Issue 23, pp. 2497 - 2506
CONTEXT An estimated 10% to 20% of patients cannot tolerate statins or adequate doses to achieve treatment goals. Plasma proprotein convertase subtilisin/kexin... 
LDL CHOLESTEROL | MEDICINE, GENERAL & INTERNAL | THERAPY | EFFICACY | SAFETY | HIGH-RISK | PRIMARY HYPERCHOLESTEROLEMIA | GUIDELINES | CARDIOVASCULAR-DISEASE | EZETIMIBE | Proprotein Convertases - antagonists & inhibitors | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Coronary Disease - epidemiology | Male | Risk | Hypercholesterolemia - drug therapy | Contraindications | Musculoskeletal Pain - chemically induced | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Cholesterol, LDL - blood | Female | Muscular Diseases - chemically induced | Syncope - chemically induced | Hip Fractures - chemically induced | Hypercholesterolemia - blood | Coronary Disease - chemically induced | Double-Blind Method | Cholesterol, LDL - drug effects | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Coronary Disease - prevention & control | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Aged | Proprotein Convertase 9 | Clinical trials | Monoclonal antibodies | Low density lipoprotein | Patients | Index Medicus | Abridged Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 11/2014, Volume 55, Issue 11, pp. 2370 - 2379
LDL cholesterol (LDL-C) contributes to coronary heart disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-C by inhibiting LDL-C... 
Anti-proprotein convertase subtilisin/kexin type 9 antibody | Proprotein convertase subtilisin/kexin type 9 | Low density lipoprotein receptor | Apolipoprotein E | proprotein convertase subtilisin/kexin type 9 | FAMILIAL HYPERCHOLESTEROLEMIA | ESTER TRANSFER PROTEIN | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBTILISIN/KEXIN TYPE 9 | anti-proprotein convertase subtilisin/kexin type 9 antibody | low density lipoprotein receptor | MONOCLONAL-ANTIBODY | KNOCKOUT MICE LACKING | REDUCES ATHEROSCLEROSIS | LOWERING PLASMA-CHOLESTEROL | apolipoprotein E | DENSITY-LIPOPROTEIN RECEPTOR | TRANSGENIC MICE | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Cholesterol - blood | Humans | Proprotein Convertases - genetics | Atherosclerosis - enzymology | Liver - drug effects | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Antibodies - immunology | Female | Serine Endopeptidases - deficiency | Liver - metabolism | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Gene Knockout Techniques | Proprotein Convertases - deficiency | Atherosclerosis - metabolism | Proprotein Convertases - immunology | Atherosclerosis - blood | Animals | Mice | Serine Endopeptidases - metabolism | Cholesterol Ester Transfer Proteins - metabolism | Proprotein Convertase 9 | Index Medicus | kexin type 9 antibody | kexin type 9 | proprotein convertase subtilisin | anti-proprotein convertase subtilisin
Journal Article
Journal Article