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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2016, Volume 26, Issue 9, pp. 2360 - 2364
The discovery of a new class of nonprostanoid prostaglandin I receptor (IP receptor) agonists is reported. Among them, the unique piperidine derivative... 
Benzanilide | Nonprostanoid | Agonist | Prostacyclin | Piperidine | CHEMISTRY, MEDICINAL | MIMETICS | PRODRUG | ANALOG | CHEMISTRY, ORGANIC | Animals | Receptors, Epoprostenol - agonists | Piperidines - pharmacology | Humans | Dogs | Index Medicus
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, pp. 68 - 75
The prostacyclin analogues, iloprost and treprostinil are extensively used in treating pulmonary hypertension. Their binding profile and corresponding... 
Cyclic AMP | Prostacyclin analogues | Prostanoid receptors | Radioligand binding | Calcium influx
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 04/2016, Volume 1861, Issue 4, pp. 285 - 293
Brite adipocytes recently discovered in humans are of considerable importance in energy expenditure by converting energy excess into heat. This property could... 
UCP1 | Obesity | Prostacyclin | cPGI2 | cAMP | Brown adipocyte | CELLS | STABLE PROSTACYCLIN ANALOG | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | BROWN ADIPOSE-TISSUE | ARACHIDONIC-ACID | BERAPROST SODIUM | CELL BIOLOGY | BIOPHYSICS | PHARMACOKINETICS | PATHWAY | POLYUNSATURATED FATTY-ACIDS | Receptors, Epoprostenol | Adipocytes, Brown - metabolism | Adipogenesis - drug effects | Humans | Ion Channels - genetics | Infant | Male | Mitochondrial Proteins - genetics | PPAR gamma - metabolism | Receptors, Prostaglandin - metabolism | Dose-Response Relationship, Drug | Adipocytes, White - drug effects | Transfection | RNA Interference | Time Factors | Mitochondrial Proteins - metabolism | Epoprostenol - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Adipocytes, Brown - drug effects | Cells, Cultured | PPAR alpha - genetics | Epoprostenol - analogs & derivatives | Phenotype | Receptors, Prostaglandin - agonists | Ion Channels - metabolism | Signal Transduction - drug effects | PPAR gamma - agonists | PPAR alpha - agonists | Enzyme Activation | PPAR alpha - metabolism | Thermogenesis - drug effects | Uncoupling Protein 1 | Anti-Obesity Agents - pharmacology | Adipocytes, White - metabolism | Energy Metabolism - drug effects | Unsaturated fatty acids | Metabolites | Arachidonic acid | Cells
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, pp. e0163633 - e0163633
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2007, Volume 360, Issue 4, pp. 821 - 827
Journal Article