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CANCER RESEARCH, ISSN 0008-5472, 12/2011, Volume 71, Issue 24, pp. 7463 - 7470
Journal Article
Respiratory Research, ISSN 1465-9921, 02/2007, Volume 8, Issue 1, pp. 16 - 16
Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor... 
Inflammation - pathology | Bronchial Hyperreactivity - immunology | Receptors, Immunologic - antagonists & inhibitors | Inflammation - drug therapy | Bronchial Hyperreactivity - physiopathology | Sensitivity and Specificity | Asthma - immunology | Female | Prostaglandin Antagonists - pharmacology | Bronchoalveolar Lavage Fluid - cytology | Radioligand Assay | Receptors, Prostaglandin - antagonists & inhibitors | Disease Models, Animal | Pulmonary Eosinophilia - immunology | Immunization | Enzyme-Linked Immunosorbent Assay | Cells, Cultured | Sulfonamides - pharmacology | Asthma - drug therapy | Pulmonary Eosinophilia - pathology | Animals | Mice | Mice, Inbred BALB C | Carbazoles - pharmacology | In Vitro Techniques | Asthma - pathology | Allergens | Prostaglandins | Inflammation | Histochemistry | Asthma | Research | Disease Models | Inflammation: pathology | Inbred BALB C | Medical and Health Sciences | Prostaglandin Antagonists: pharmacology | Medicin och hälsovetenskap | Pulmonary Eosinophilia: immunology | Klinisk medicin | Asthma: drug therapy | Receptors | Pulmonary Eosinophilia: pathology | Cultured | Lungmedicin och allergi | Asthma: immunology | Bronchoalveolar Lavage Fluid: cytology | Bronchial Hyperreactivity: immunology | Respiratory Medicine and Allergy | Immunologic: antagonists & inhibitors | Prostaglandin: antagonists & inhibitors | Sulfonamides: pharmacology | Cells | Inflammation: drug therapy | Clinical Medicine | Carbazoles: pharmacology | Bronchial Hyperreactivity: physiopathology | Animal | Asthma: pathology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2011, Volume 339, Issue 1, pp. 173 - 185
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 04/2007, Volume 6, Issue 4, pp. 313 - 325
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 473 - 482
D prostanoid receptor 2 (DP2) [also known as chemoattractant receptor-homologous molecule expressed on T helper 2 (Th2) cells (CRTH2)] is selectively expressed... 
ALLERGIC INFLAMMATION | LATE ASTHMATIC REACTION | TH2 CELLS | CYTOKINE PRODUCTION | CYCLOSPORINE-A | CRTH2 RECEPTOR | CHEMOATTRACTANT | AIRWAY INFLAMMATION | PHARMACOLOGY & PHARMACY | HELPER TYPE-2 CELLS | PROSTAGLANDIN D-2 RECEPTOR | Eosinophils - drug effects | Apoptosis - drug effects | Humans | Th2 Cells - immunology | Eosinophils - immunology | Th2 Cells - drug effects | Quinolines - pharmacokinetics | Lymphocyte Activation - immunology | Prostaglandin D2 - analogs & derivatives | Cell Membrane - metabolism | Indoleacetic Acids - pharmacokinetics | Chemotaxis - immunology | Radioligand Assay | Guinea Pigs | Rats | Chemotaxis - drug effects | Interleukin-13 - metabolism | Indoleacetic Acids - therapeutic use | Rats, Sprague-Dawley | Calcium Signaling - drug effects | Prostaglandin D2 - pharmacology | Receptors, Immunologic - genetics | Eosinophilia - chemically induced | Pulmonary Eosinophilia - chemically induced | Cell Shape - immunology | Culture Media, Conditioned - pharmacology | Receptors, Prostaglandin - metabolism | Quinolines - pharmacology | Receptors, Prostaglandin - genetics | Transfection | Prostaglandin D2 - metabolism | Mast Cells - metabolism | Prostaglandin Antagonists - pharmacology | CHO Cells | Binding, Competitive | Recombinant Proteins - metabolism | Mast Cells - immunology | Cricetinae | Prostaglandin Antagonists - pharmacokinetics | Pulmonary Eosinophilia - prevention & control | Interleukin-5 - pharmacology | Chemokine CCL11 - pharmacology | Th2 Cells - cytology | Prostaglandin Antagonists - therapeutic use | Th2 Cells - metabolism | Arachidonic Acids - pharmacology | Cell Shape - drug effects | Leukotriene B4 - pharmacology | Animals | Complement C5a - pharmacology | Indoleacetic Acids - pharmacology | Lymphocyte Activation - drug effects | Eosinophilia - prevention & control | Quinolines - therapeutic use | Eosinophils - cytology | Receptors, Immunologic - metabolism
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2005, Volume 165, Issue 1, pp. 139 - 149
Inflammation is a complex phenomenon involving multiple cellular and molecular interactions which must be tightly regulated. Cyclooxygenase-2 (COX) is the key... 
Melatonin | COX-2 | Raw 264.7 macrophage | INOS | AFMK | Lps | AMK | CYCLOOXYGENASE-2 | raw 264.7 macrophage | INHIBITS EXPRESSION | INDUCED APOPTOSIS | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | IMMUNOLOGY | NEUROSCIENCES | IN-VITRO | COLORECTAL-CANCER | INFLAMMATION | melatonin | NF-KAPPA-B | Dinoprostone - secretion | Prostaglandin-Endoperoxide Synthases - biosynthesis | Apoptosis - drug effects | Cyclooxygenase 2 | Nitric Oxide Synthase - antagonists & inhibitors | Nitrites - metabolism | Melatonin - physiology | Nitric Oxide Synthase Type II | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Macrophages - secretion | Superoxides - metabolism | Kynuramine - analogs & derivatives | Indoles - pharmacology | Nitric Oxide Synthase - biosynthesis | Prostaglandin Antagonists - pharmacology | Kynuramine - pharmacology | Cell Line | Macrophage Activation - immunology | Enzyme Inhibitors - pharmacology | Antioxidants - pharmacology | Macrophages - cytology | Kynuramine - metabolism | Cyclooxygenase Inhibitors - pharmacology | Macrophages - enzymology | Animals | Apoptosis - immunology | Cyclooxygenase 2 Inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Lipopolysaccharides - pharmacology | Melatonin - metabolism | Macrophages - drug effects | Mice | Dinoprostone - antagonists & inhibitors | Macrophage Activation - drug effects | Nitrites - antagonists & inhibitors | Enzymes | Biological products | Anti-inflammatory drugs | Arachidonic acid | Macrophages | Unsaturated fatty acids | Metabolites | Analysis | Prostaglandins E | Nitric oxide | Physiological aspects | Mitogens
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 10/2017, Volume 74, Issue 19, pp. 3491 - 3507
Platelets are anucleated cells that circulate in the blood as sentinels of tissue integrity. In fact, they are rich in a plethora of proteins and other factors... 
Life Sciences | Biomedicine, general | Biochemistry, general | Aspirin | Life Sciences, general | Epithelial–mesenchymal transitions | Cancer cells | Metastasis | Platelets | Prostaglandin E 2 | Antiplatelet agents | Cell Biology | Prostaglandin E | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADHESION IN-VITRO | Prostaglandin E-2 | EP3 RECEPTOR | Epithelial-mesenchymal transitions | MESENCHYMAL TRANSITION | VON-WILLEBRAND-FACTOR | CELL BIOLOGY | SIGNAL-TRANSDUCTION | PROTEASE-ACTIVATED RECEPTORS | LOW-DOSE ASPIRIN | LYSOPHOSPHATIDIC ACID | P-SELECTIN | Blood Platelets - pathology | Purinergic P2Y Receptor Antagonists - pharmacology | Lysophospholipids - metabolism | Receptors, Prostaglandin E, EP3 Subtype - metabolism | Humans | Epithelial-Mesenchymal Transition - drug effects | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Platelet Membrane Glycoproteins - antagonists & inhibitors | Animals | Neoplasm Metastasis - drug therapy | Blood Platelets - metabolism | Neoplasm Metastasis - pathology | Eicosanoids - metabolism | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Platelet Membrane Glycoproteins - metabolism | Receptors, Prostaglandin E, EP3 Subtype - antagonists & inhibitors | Platelet Aggregation Inhibitors - pharmacology | Aspirin - therapeutic use | Aspirin - pharmacology | Blood Platelets - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Molecular Targeted Therapy - methods | Purinergic P2Y Receptor Antagonists - therapeutic use | Proteins | Neurosciences | Prostaglandins | Stem cells | Development and progression | Lipids | Cancer | Tissue | Pharmacology | Cells | Tumors
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2016, Volume 111, pp. 208 - 216
The chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTh2) is a G protein-coupled receptor expressed on the leukocytes most... 
Blood eosinophilia | Long receptor residence time | CRTh2 receptor | Long duration of action | Asthma | POTENT ANTAGONIST | ALLERGIC INFLAMMATION | NASAL CHALLENGE | KINETIC RELATIONSHIPS SKR | HOMOLOGOUS MOLECULE | ACTIVITY-RELATIONSHIPS SAR | PHARMACOLOGY & PHARMACY | HUMAN TH2 CELLS | HELPER TYPE-2 CELLS | ASTHMATIC-PATIENTS | PROSTAGLANDIN D-2 | Anti-Asthmatic Agents - blood | Eosinophils - metabolism | Pyrroles - pharmacokinetics | Cricetulus | Eosinophils - drug effects | Rats, Wistar | Pyridines - chemistry | Half-Life | Pyridines - pharmacokinetics | Male | Receptors, Immunologic - antagonists & inhibitors | Dose-Response Relationship, Drug | Anti-Asthmatic Agents - pharmacokinetics | Receptors, Prostaglandin - genetics | Transfection | Chemotaxis, Leukocyte - drug effects | Drug Design | Prostaglandin Antagonists - pharmacology | Receptors, Prostaglandin - blood | Prostaglandin Antagonists - chemistry | Receptors, Prostaglandin - antagonists & inhibitors | Receptors, Immunologic - blood | Anti-Asthmatic Agents - chemistry | CHO Cells | Anti-Asthmatic Agents - pharmacology | Prostaglandin Antagonists - pharmacokinetics | Guinea Pigs | Pyrroles - blood | Cell Shape - drug effects | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Pyridines - blood | Pyrroles - pharmacology | Animals | Dogs | Protein Binding | Pyrroles - chemistry | Mice | Pyridines - pharmacology | Kinetics | Receptors, Immunologic - genetics | Prostaglandin Antagonists - blood
Journal Article
Journal Article