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1. Full Text Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase
by Urbanet, Riccardo and Nguyen Dinh Cat, Aurelie and Feraco, Alessandra and Venteclef, Nicolas and El Mogrhabi, Soumaya and Sierra-Ramos, Catalina and Alvarez de la Rosa, Diego and Adler, Gail K and Quilliot, Didier and Rossignol, Patrick and Fallo, Francesco and Touyz, Rhian M and Jaisser, Frédéric
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 07/2015, Volume 66, Issue 1, pp. 149 - 157
prostaglandin D2 synthase 21kDa, brain | spironolactone | aldosterone | obesity | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Intramolecular Oxidoreductases - biosynthesis | Lipocalins - biosynthesis | Metabolic Syndrome - etiology | Receptors, Mineralocorticoid - genetics | Up-Regulation | Intra-Abdominal Fat - physiopathology | Humans | Male | Metabolic Syndrome - drug therapy | Obesity - genetics | Receptors, Mineralocorticoid - biosynthesis | Receptors, Mineralocorticoid - physiology | RNA, Messenger - biosynthesis | Subcutaneous Fat - metabolism | Spironolactone - pharmacology | Piperidines - pharmacology | Lipocalins - genetics | Metabolic Syndrome - physiopathology | Mineralocorticoid Receptor Antagonists - pharmacology | Enzyme Induction - drug effects | Dibenzocycloheptenes - pharmacology | Spironolactone - therapeutic use | RNA, Messenger - genetics | Insulin Resistance | Aldosterone - pharmacology | Mice, Transgenic | Obesity - physiopathology | 3T3-L1 Cells | Intra-Abdominal Fat - metabolism | Mineralocorticoid Receptor Antagonists - therapeutic use | Receptors, Leptin - deficiency | Animals | Intramolecular Oxidoreductases - genetics | Cell Line, Tumor | Mice, Obese | Adipocytes, White | Mice | Intra-Abdominal Fat - pathology | Index Medicus | Life Sciences
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2. Full Text Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells
by Xue, Luzheng and Salimi, Maryam and Panse, Isabel and Mjösberg, Jenny M and McKenzie, Andrew N.J and Spits, Hergen and Klenerman, Paul and Ogg, Graham
Journal of allergy and clinical immunology, ISSN 0091-6749, 04/2014, Volume 133, Issue 4, pp. 1184 - 1194.e7
Group 2 innate lymphoid cell | PGD2 | chemoattractant receptor-homologous molecule expressed on TH2 cells | adaptive type 2 immunity | IL-25 | IL-33 | innate type 2 immunity | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Biological and medical sciences | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Mast Cells - immunology | Lymphocyte Subsets - drug effects | Humans | Immunophenotyping | Receptors, Prostaglandin - metabolism | Lymphocyte Subsets - immunology | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Lymphocyte Subsets - metabolism | Lymphocyte Activation - immunology | Phenotype | Receptors, Prostaglandin - genetics | Lymphocyte Activation - drug effects | Mast Cells - metabolism | Prostaglandin D2 - pharmacology | Chemotaxis - immunology | Receptors, Immunologic - genetics | Cytokines - biosynthesis | Receptors, Immunologic - metabolism | Index Medicus | Abridged Index Medicus | CRTH2, Chemoattractant receptor-homologous molecule expressed on TH2 cells | PGD2, Prostaglandin D2 | cysLT, Cysteinyl leukotriene | CSF-1, Macrophage colony-stimulating factor | CysLT1, Cysteinyl leukotriene receptor 1 | EC50, Median effective concentration | ILC2, Group 2 innate lymphoid cell | ILC, Innate lymphoid cell | Mechanisms of Allergy and Clinical Immunology | Medicin och hälsovetenskap
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3. Full Text Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)
by Sturino, Claudio F and O'Neill, Gary and Lachance, Nicolas and Boyd, Michael and Berthelette, Carl and Labelle, Marc and Li, Lianhai and Roy, Bruno and Scheigetz, John and Tsou, Nancy and Aubin, Yves and Bateman, Kevin P and Chauret, Nathalie and Day, Stephen H and Lévesque, Jean-François and Seto, Carmai and Silva, Jose H and Trimble, Laird A and Carriere, Marie-Claude and Denis, Danielle and Greig, Gillian and Kargman, Stacia and Lamontagne, Sonia and Mathieu, Marie-Claude and Sawyer, Nicole and Slipetz, Deborah and Abraham, William M and Jones, Tom and McAuliffe, Malia and Piechuta, Hana and Nicoll-Griffith, Deborah A and Wang, Zhaoyin and Zamboni, Robert and Young, Robert N and Metters, Kathleen M
Journal of medicinal chemistry, ISSN 0022-2623, 02/2007, Volume 50, Issue 4, pp. 794 - 806
Biological and medical sciences | Medical sciences | Histamine and antagonists. Allergy | Pharmacology. Drug treatments | Microsomes - metabolism | Nasal Decongestants - pharmacokinetics | Stereoisomerism | Humans | Nasal Decongestants - chemical synthesis | Indoles - chemical synthesis | Macaca fascicularis | Bile - metabolism | Male | Structure-Activity Relationship | Hepatocytes - metabolism | Receptors, Immunologic - antagonists & inhibitors | Indoles - pharmacology | Receptors, Prostaglandin - antagonists & inhibitors | Binding, Competitive | Nasal Decongestants - pharmacology | Rats | Rats, Sprague-Dawley | Animals | Dogs | Protein Binding | Indoles - pharmacokinetics | Sheep | Mice | Airway Obstruction - drug therapy | In Vitro Techniques | Index Medicus
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4. Full Text Effects of prostaglandin D2 on tetrodotoxin-resistant Na + currents in DRG neurons of adult rat
by Ebersberger, Andrea and Natura, Gabriel and Eitner, Annett and Halbhuber, Karl-Jürgen and Rost, Reinhard and Schaible, Hans-Georg
Pain (Amsterdam), ISSN 0304-3959, 05/2011, Volume 152, Issue 5, pp. 1114 - 1126
Excitability | CRTH2 | Sensory neuron | DP2 receptor | Sodium channel | DP1 receptor | Neurology | Analgesics | Pharmacology. Drug treatments | Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction | Biological and medical sciences | Medical sciences | Neuropharmacology | Nervous system (semeiology, syndromes) | Membrane Potentials - drug effects | Prostaglandin D2 - antagonists & inhibitors | Hydantoins - pharmacology | Rats, Wistar | Cells, Cultured | Rats | Male | Sodium Channel Blockers - pharmacology | Ganglia, Spinal - cytology | Sulfonamides - pharmacology | Receptors, Prostaglandin - metabolism | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Animals | Sensory Receptor Cells - drug effects | Platelet Aggregation Inhibitors - pharmacology | Prostaglandin D2 - pharmacology | Tetrodotoxin - pharmacology | Carbazoles - pharmacology | Action Potentials - drug effects | Receptors, Immunologic - metabolism | Ganglia, Spinal - metabolism | Index Medicus
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5. Full Text Endogenous Prostaglandin D2 and Its Metabolites Protect the Heart Against Ischemia–Reperfusion Injury by Activating Nrf2
by Katsumata, Yoshinori and Shinmura, Ken and Sugiura, Yuki and Tohyama, Shugo and Matsuhashi, Tomohiro and Ito, Hideyuki and Yan, Xiaoxiang and Ito, Kentaro and Yuasa, Shinsuke and Ieda, Masaki and Urade, Yoshihiro and Suematsu, Makoto and Fukuda, Keiichi and Sano, Motoaki
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 01/2014, Volume 63, Issue 1, pp. 80 - 87
Oxidative stress | receptor | Nrf2 | Prostaglandin F | Prostaglandin D2 | PPAR gamma | 15-deoxyprostaglandin J2 | Cardiology. Vascular system | Biological and medical sciences | Arterial hypertension. Arterial hypotension | Medical sciences | Blood and lymphatic vessels | Lipocalins - metabolism | PPAR gamma - metabolism | Receptors, Prostaglandin - metabolism | Mice, Knockout | Myocardial Reperfusion Injury - metabolism | Animals | Dexamethasone - pharmacology | Prostaglandin D2 - metabolism | Myocardium - metabolism | NF-E2-Related Factor 2 - metabolism | Glucocorticoids - pharmacology | Heart - drug effects | Myocytes, Cardiac - metabolism | Prostaglandin D2 - analogs & derivatives | NF-E2-Related Factor 2 - genetics | Mice | Intramolecular Oxidoreductases - metabolism | Index Medicus
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6. Full Text Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
by Uller, Lena and Mathiesen, Jesper M and Alenmyr, Lisa and Korsgren, Magnus and Ulven, Trond and Högberg, Thomas and Andersson, Gunnar and Persson, Carl G.A and Kostenis, Evi
Respiratory research, ISSN 1465-9921, 02/2007, Volume 8, Issue 1, pp. 16 - 16
Inflammation - pathology | Bronchial Hyperreactivity - immunology | Receptors, Immunologic - antagonists & inhibitors | Inflammation - drug therapy | Bronchial Hyperreactivity - physiopathology | Sensitivity and Specificity | Asthma - immunology | Female | Prostaglandin Antagonists - pharmacology | Bronchoalveolar Lavage Fluid - cytology | Radioligand Assay | Receptors, Prostaglandin - antagonists & inhibitors | Disease Models, Animal | Pulmonary Eosinophilia - immunology | Immunization | Enzyme-Linked Immunosorbent Assay | Cells, Cultured | Sulfonamides - pharmacology | Asthma - drug therapy | Pulmonary Eosinophilia - pathology | Animals | Mice | Mice, Inbred BALB C | Carbazoles - pharmacology | In Vitro Techniques | Asthma - pathology | Allergens | Prostaglandins | Inflammation | Histochemistry | Asthma | Index Medicus | Research | Disease Models | Inflammation: pathology | Inbred BALB C | Medical and Health Sciences | Prostaglandin Antagonists: pharmacology | Medicin och hälsovetenskap | Pulmonary Eosinophilia: immunology | Klinisk medicin | Asthma: drug therapy | Receptors | Pulmonary Eosinophilia: pathology | Cultured | Lungmedicin och allergi | Asthma: immunology | Bronchoalveolar Lavage Fluid: cytology | Bronchial Hyperreactivity: immunology | Respiratory Medicine and Allergy | Immunologic: antagonists & inhibitors | Prostaglandin: antagonists & inhibitors | Sulfonamides: pharmacology | Cells | Inflammation: drug therapy | Clinical Medicine | Carbazoles: pharmacology | Bronchial Hyperreactivity: physiopathology | Animal | Asthma: pathology
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7. Full Text Suppression of Niacin‐induced Vasodilation with an Antagonist to Prostaglandin D2 Receptor Subtype 1
by Lai, E and De Lepeleire, I and Crumley, T M and Liu, F and Wenning, L A and Michiels, N and Vets, E and O'Neill, G and Wagner, J A and Gottesdiener, K
Clinical pharmacology and therapeutics, ISSN 0009-9236, 06/2007, Volume 81, Issue 6, pp. 849 - 857
Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Humans | Middle Aged | Male | Regional Blood Flow | Indoles - administration & dosage | Receptors, Immunologic - antagonists & inhibitors | Cross-Over Studies | Dose-Response Relationship, Drug | Niacin - administration & dosage | Skin - blood supply | Indoles - adverse effects | Adolescent | Niacin - adverse effects | Adult | Female | Indoles - therapeutic use | Aspirin - pharmacology | Vasodilation - drug effects | Vasodilator Agents - adverse effects | Delayed-Action Preparations | Receptors, Prostaglandin - antagonists & inhibitors | Vasodilator Agents - administration & dosage | Index Medicus | Abridged Index Medicus
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8. Full Text Langerhans Cells Release Prostaglandin D2 in Response to Nicotinic Acid
by Maciejewski-Lenoir, Dominique and Richman, Jeremy G and Hakak, Yaron and Gaidarov, Ibragim and Behan, Dominic P and Connolly, Daniel T
Journal of investigative dermatology, ISSN 0022-202X, 12/2006, Volume 126, Issue 12, pp. 2637 - 2646
Dermatology | Biological and medical sciences | Medical sciences | Receptors, Nicotinic - metabolism | Oligonucleotide Array Sequence Analysis | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | Male | Hypolipidemic Agents - pharmacology | RNA, Messenger - metabolism | Niacin - pharmacology | Tissue Distribution | Animals | Prostaglandin D2 - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Flushing - chemically induced | In Vitro Techniques | Langerhans Cells - drug effects | Langerhans Cells - metabolism | Receptors, Nicotinic - genetics | Index Medicus
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9. Full Text Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
by Pettipher, Roy and Hansel, Trevor T and Armer, Richard
Nature reviews. Drug discovery, ISSN 1474-1776, 04/2007, Volume 6, Issue 4, pp. 313 - 325
Animals | Hypersensitivity - metabolism | Hypersensitivity - physiopathology | Prostaglandin D2 - metabolism | Humans | Prostaglandin Antagonists - pharmacology | Asthma - drug therapy | Hypersensitivity - drug therapy | Receptors, Prostaglandin - antagonists & inhibitors | Receptors, Immunologic - antagonists & inhibitors | Prostaglandins | Regulation | Immune response | Research | Analysis | Central nervous system | Index Medicus
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10. Full Text In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss
by Fong, Pedro and Tong, Henry H.Y and Ng, Kin H and Lao, Cheng K and Chong, Chon I and Chao, Chi M
Journal of ethnopharmacology, ISSN 0378-8741, 12/2015, Volume 175, pp. 470 - 480
Traditional Chinese medicines | Docking | Androgenic alopecia | Hair loss | Prostaglandin D2 synthase | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Dermatologic Agents - toxicity | Humans | Drugs, Chinese Herbal - pharmacology | Intramolecular Oxidoreductases - antagonists & inhibitors | Dermatologic Agents - therapeutic use | Cyclooxygenase Inhibitors - toxicity | Lipocalins - antagonists & inhibitors | Computer Simulation | Drugs, Chinese Herbal - therapeutic use | Quantitative Structure-Activity Relationship | Dermatologic Agents - pharmacology | Medicine, Chinese Traditional | Skin Absorption | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Dermatologic Agents - chemistry | Drugs, Chinese Herbal - toxicity | Animals | Drugs, Chinese Herbal - chemistry | Models, Biological | Alopecia - drug therapy | ROC Curve | Molecular Docking Simulation | Cyclooxygenase Inhibitors - therapeutic use | Skin - drug effects | Baldness | Prostaglandins | Alopecia | Index Medicus
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11. Full Text Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk
by Xue, Luzheng and Fergusson, Joannah and Salimi, Maryam and Panse, Isabel and Ussher, James E and Hegazy, Ahmed N and Vinall, Shân L and Jackson, David G and Hunter, Michael G and Pettipher, Roy and Ogg, Graham and Klenerman, Paul
Journal of allergy and clinical immunology, ISSN 0091-6749, 05/2015, Volume 135, Issue 5, pp. 1358 - 1366.e11
leukotriene E4 | TH2 cells | Prostaglandin D2 | chemoattractant receptor-homologous molecule expressed on TH2 cells | neutrophils | leukotriene E | Prostaglandin D | chemoattractant receptor-homologous molecule expressed on T | 2 cells | Leukotriene E4 - metabolism | Cell Communication - immunology | Cell Adhesion Molecules - genetics | Apoptosis - drug effects | Humans | Gene Expression Profiling | Th2 Cells - immunology | Th2 Cells - drug effects | Leukotriene E4 - pharmacology | Chemotaxis, Leukocyte - genetics | Chemotaxis, Leukocyte - drug effects | Prostaglandin D2 - metabolism | Inflammation Mediators - metabolism | Neutrophils - metabolism | Gene Expression | Neutrophils - drug effects | Neutrophils - immunology | Cell Communication - genetics | Cell Adhesion Molecules - metabolism | Th2 Cells - metabolism | Drug Synergism | Apoptosis - immunology | Cell Communication - drug effects | Prostaglandin D2 - pharmacology | Chemotaxis, Leukocyte - immunology | Cluster Analysis | Index Medicus | Abridged Index Medicus | LTE4, Cysteinyl leukotriene E4 | CysLT2, Cysteinyl leukotriene receptor 2 | CRTH2, Chemoattractant receptor-homologous molecule expressed on TH2 cells | PMA, Phorbol 12-myristate 13-acetate | LTC4, Cysteinyl leukotriene C4 | PGD2, Prostaglandin D2 | CAIA, Cell activation–induced aggregation | cysLT, Cysteinyl leukotriene | qPCR, Quantitative PCR | PI3K, Phosphoinositide 3-kinase | LTD4, Cysteinyl leukotriene D4 | CysLT1, Cysteinyl leukotriene receptor 1 | ICAM, Intercellular adhesion molecule | RORγt, Retinoic acid–related orphan receptor γt | Mechanisms of Allergy and Clinical Immunology
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12. Full Text Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung
by Jandl, Katharina, MSc and Stacher, Elvira, MD and Bálint, Zoltán, PhD and Sturm, Eva Maria, PhD and Maric, Jovana, MSc and Peinhaupt, Miriam, MSc and Luschnig, Petra, PhD and Aringer, Ida, MD and Fauland, Alexander, PhD and Konya, Viktoria, PhD and Dahlen, Sven-Erik, PhD and Wheelock, Craig E., PhD and Kratky, Dagmar, PhD and Olschewski, Andrea, MD and Marsche, Gunther, PhD and Schuligoi, Rufina, PhD and Heinemann, Akos, MD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 137, Issue 3, pp. 833 - 843
Allergy and Immunology | macrophages | prostaglandin D2 | hematopoietic prostaglandin D synthase | pulmonary inflammation | D-type prostanoid receptor 2/chemoattractant receptor–homologous molecule expressed on TH2 cells | D-type prostanoid receptor 1 | neutrophils | D-type prostanoid receptor 2/chemoattractant receptor-homologous molecule expressed on T | 2 cells | prostaglandin D | Respiratory Distress Syndrome, Adult - pathology | Lung Injury - pathology | Humans | Respiratory Distress Syndrome, Adult - metabolism | Receptors, Prostaglandin - metabolism | Lung Injury - etiology | Respiratory Distress Syndrome, Adult - etiology | Receptors, Prostaglandin - genetics | Inflammation Mediators - metabolism | Lung Injury - metabolism | Lung - metabolism | Neutrophils - metabolism | Calcium Signaling | Macrophages - immunology | Neutrophil Infiltration - immunology | Gene Expression | Lung - pathology | Neutrophils - drug effects | Neutrophils - immunology | Macrophages - metabolism | Animals | Endotoxins - immunology | Macrophages - drug effects | Mice | Prostaglandin D2 - pharmacology | Chemotaxis, Leukocyte - immunology | Receptors, Immunologic - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Lung - immunology | Receptors, Immunologic - metabolism | Endotoxins - adverse effects | Index Medicus | Abridged Index Medicus | D-type prostanoid receptor 2 | chemoattractant receptor–homologous molecule expressed on TH2 cells | Medicin och hälsovetenskap
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