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The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2014, Volume 133, Issue 4, pp. 1184 - 1194.e7
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2006, Volume 103, Issue 17, pp. 6682 - 6687
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108595
PGD₂ has long been implicated in allergic diseases. Recent cloning of a second PGD₂ receptor, DP2 (also known as CRTh2), led to a greater understanding of the... 
Prostaglandin D2 - antagonists & inhibitors | Leukocytes, Mononuclear - metabolism | Calcium - metabolism | Humans | Cytosol - drug effects | RNA, Messenger - metabolism | Receptors, Prostaglandin - metabolism | Receptors, Immunologic - antagonists & inhibitors | Receptors, Prostaglandin - genetics | Receptors, Immunologic - agonists | RNA, Messenger - antagonists & inhibitors | Mast Cells - metabolism | Prostaglandin D2 - analogs & derivatives | Ion Transport | Aspirin - pharmacology | Nasal Polyps - metabolism | Receptors, Prostaglandin - antagonists & inhibitors | Pertussis Toxin - pharmacology | Cell Line | Gene Expression | Leukocytes, Mononuclear - drug effects | RNA, Messenger - genetics | Mast Cells - drug effects | RNA, Messenger - agonists | Receptors, Prostaglandin - agonists | K562 Cells | Mast Cells - cytology | Cytosol - metabolism | Leukocytes, Mononuclear - cytology | Prostaglandin D2 - biosynthesis | Prostaglandin D2 - pharmacology | Primary Cell Culture | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Cell Degranulation - drug effects | Immunohistochemistry | Flow cytometry | Calcium | Laboratories | Allergic diseases | Antagonists | Lymphocytes T | mRNA | Cell surface | Pertussis toxin | Pertussis | Bone marrow | Dopamine D2 receptors | Immune system | Antigens | Aspirin | Calcium (intracellular) | Leukocytes (eosinophilic) | Cloning | Inflammation | Prostaglandin D2 | Asthma | Medicine | Cytometry | Signaling | Degranulation | Mast cells | Intracellular | Leukocytes (basophilic) | Polyps | Eosinophils
Journal Article
Journal of Investigative Dermatology Symposium Proceedings, ISSN 1087-0024, 10/2017, Volume 18, Issue 2, pp. S81 - S84
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit... 
Free Radical Scavengers - pharmacology | Alopecia | Reactive Oxygen Species - metabolism | Signal Transduction | Keratinocytes - metabolism | Humans | Acetylcysteine - pharmacology | Cells, Cultured | Testosterone - biosynthesis | Prostaglandin D2 - pharmacology | Aldehydes - metabolism | Androstenedione - metabolism
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2001, Volume 193, Issue 2, pp. 255 - 261
Prostaglandin (PG)D-2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor... 
Gαi-type G protein | Allergic inflammation | Prostanoid receptor | T cells | Cell migration | PGD2 | MEDICINE, RESEARCH & EXPERIMENTAL | allergic inflammation | ACTIVATION | RAT | G alpha i-type G protein | CHEMOKINES | PROSTANOID DP RECEPTOR | RELEASE | IMMUNOLOGY | IDENTIFICATION | PHARMACOLOGY | BIOLOGY | cell migration | prostanoid receptor | AGONIST
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17558 - 17563
Proinflammatory macrophages are key mediators in several pathologies; thus, controlling their activation is necessary. The endocannabinoid system is implicated... 
Enzymes | Receptors | Antiinflammatories | Messenger RNA | Cell lines | Macrophage activation | Inflammation | Macrophages | Endocannabinoids | Cannabinoid receptors | FAAH | Glyceryl prostaglandin | COX-2 | Anandamide | Prostaglandin synthase | prostaglandin synthase | CELLS | MONOACYLGLYCEROL LIPASE | 2-ARACHIDONYL GLYCEROL | MULTIDISCIPLINARY SCIENCES | ARACHIDONIC-ACID | INTERNATIONAL-UNION | CANNABINOID RECEPTORS | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | ACID AMIDE HYDROLASE | glyceryl prostaglandin | INHIBITORS | BLOCKADE | anandamide | Endocannabinoids - metabolism | Inflammation - chemically induced | Endocannabinoids - pharmacology | Gene Expression - drug effects | Monoacylglycerol Lipases - antagonists & inhibitors | Male | Interleukin-1beta - genetics | Monoacylglycerol Lipases - genetics | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Cyclooxygenase 2 - genetics | Esters - chemistry | Interleukin-1beta - metabolism | Lipocalins - genetics | Prostaglandin D2 - metabolism | Female | Glycerol - chemistry | Intramolecular Oxidoreductases - metabolism | Carbamates - pharmacology | Lipocalins - metabolism | Cell Line | Lipopolysaccharides - toxicity | Enzyme-Linked Immunosorbent Assay | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Glycerides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Arachidonic Acids - pharmacology | Prostaglandin D2 - chemistry | Glycerides - pharmacology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Intramolecular Oxidoreductases - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Inflammation - prevention & control | Mice | Prostaglandin D2 - pharmacology | Macrophage Activation - drug effects | Prostaglandins | Physiological aspects | Lipid metabolism | Research | Health aspects | Biological Sciences
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2015, Volume 135, Issue 5, pp. 1358 - 1366.e11
Prostaglandin D (PGD ) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate T 2 cells. The combination of PGD and... 
leukotriene E4 | TH2 cells | Prostaglandin D2 | chemoattractant receptor-homologous molecule expressed on TH2 cells | neutrophils | leukotriene E | Prostaglandin D | chemoattractant receptor-homologous molecule expressed on T | 2 cells | Leukotriene E4 - metabolism | Cell Communication - immunology | Cell Adhesion Molecules - genetics | Apoptosis - drug effects | Humans | Gene Expression Profiling | Th2 Cells - immunology | Th2 Cells - drug effects | Leukotriene E4 - pharmacology | Chemotaxis, Leukocyte - genetics | Chemotaxis, Leukocyte - drug effects | Prostaglandin D2 - metabolism | Inflammation Mediators - metabolism | Neutrophils - metabolism | Gene Expression | Neutrophils - drug effects | Neutrophils - immunology | Cell Communication - genetics | Cell Adhesion Molecules - metabolism | Th2 Cells - metabolism | Drug Synergism | Apoptosis - immunology | Cell Communication - drug effects | Prostaglandin D2 - pharmacology | Chemotaxis, Leukocyte - immunology | Cluster Analysis | Index Medicus | Abridged Index Medicus | LTE4, Cysteinyl leukotriene E4 | CysLT2, Cysteinyl leukotriene receptor 2 | CRTH2, Chemoattractant receptor-homologous molecule expressed on TH2 cells | PMA, Phorbol 12-myristate 13-acetate | LTC4, Cysteinyl leukotriene C4 | PGD2, Prostaglandin D2 | CAIA, Cell activation–induced aggregation | cysLT, Cysteinyl leukotriene | qPCR, Quantitative PCR | PI3K, Phosphoinositide 3-kinase | LTD4, Cysteinyl leukotriene D4 | CysLT1, Cysteinyl leukotriene receptor 1 | ICAM, Intercellular adhesion molecule | RORγt, Retinoic acid–related orphan receptor γt | Mechanisms of Allergy and Clinical Immunology
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 3, pp. 833 - 843
Background Prostaglandin (PG) D2 is an early-phase mediator in inflammation, but its action and the roles of the 2 D-type prostanoid receptors (DPs) DP1 and... 
Allergy and Immunology | macrophages | prostaglandin D2 | hematopoietic prostaglandin D synthase | pulmonary inflammation | D-type prostanoid receptor 2/chemoattractant receptor–homologous molecule expressed on TH2 cells | D-type prostanoid receptor 1 | neutrophils | D-type prostanoid receptor 2/chemoattractant receptor-homologous molecule expressed on T | 2 cells | prostaglandin D | Respiratory Distress Syndrome, Adult - pathology | Lung Injury - pathology | Humans | Respiratory Distress Syndrome, Adult - metabolism | Receptors, Prostaglandin - metabolism | Lung Injury - etiology | Respiratory Distress Syndrome, Adult - etiology | Receptors, Prostaglandin - genetics | Inflammation Mediators - metabolism | Lung Injury - metabolism | Lung - metabolism | Neutrophils - metabolism | Calcium Signaling | Macrophages - immunology | Neutrophil Infiltration - immunology | Gene Expression | Lung - pathology | Neutrophils - drug effects | Neutrophils - immunology | Macrophages - metabolism | Animals | Endotoxins - immunology | Macrophages - drug effects | Mice | Prostaglandin D2 - pharmacology | Chemotaxis, Leukocyte - immunology | Receptors, Immunologic - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Lung - immunology | Receptors, Immunologic - metabolism | Endotoxins - adverse effects | D-type prostanoid receptor 2 | chemoattractant receptor–homologous molecule expressed on TH2 cells
Journal Article