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Biochemical Pharmacology, ISSN 0006-2952, 2008, Volume 75, Issue 2, pp. 484 - 493
Aldo-keto reductase (AKR) 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase) regulates ligand access to steroid hormone and prostaglandin... 
Prostaglandin metabolism | Inhibitor design | Steroid hormone metabolism | Cancer treatment | NSAIDs | Chemoprevention | cancer treatment | ANDROGEN RECEPTOR | SIGNALING PATHWAYS | INCREASED EXPRESSION | CRYSTAL-STRUCTURE | prostaglandin metabolism | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PROLIFERATOR-ACTIVATED RECEPTOR | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | chemoprevention | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ACID-BINDING PROTEIN | CYCLOOXYGENASE-2 INHIBITORS | inhibitor design | PHARMACOLOGY & PHARMACY | steroid hormone metabolism | Indomethacin - analogs & derivatives | Oxidation-Reduction | Humans | Enzyme Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Melatonin - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | 3-Hydroxysteroid Dehydrogenases - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Catalysis | Neoplasms, Hormone-Dependent - drug therapy | Melatonin - pharmacology | Phenanthrenes - metabolism | Dihydrotestosterone - metabolism | Enzymes | Care and treatment | Synthetic prostaglandins F | Crystals | Hormones | Organic acids | Heterocyclic compounds | Physiological aspects | Glycols | Hormones, Sex | Indomethacin | Structure | Cancer | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2016, Volume 26, Issue 5, pp. 1411 - 1415
Journal Article
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 12/2018, Volume 59, Issue 15, pp. 5912 - 5923
PURPOSE. We characterize the effect of bimatoprost on orbital adipose tissue in thyroid-associated orbitopathy (TAO) with clinicopathologic correlation.... 
Brown adipose tissue | Prostaglandins | Thyroid eye disease | Adipogenesis | Bimatoprost | thyroid eye disease | CELLS | bimatoprost | ORBITAL FAT | TISSUE | IDENTIFICATION | FP RECEPTOR | IN-VITRO | adipogenesis | brown adipose tissue | DISEASE | GENE-EXPRESSION | OPHTHALMOLOGY | prostaglandins | DIFFERENTIATION | GRAVES OPHTHALMOPATHY | Immunohistochemistry | Antihypertensive Agents - pharmacology | Calcium Signaling - physiology | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Phosphatidylinositol 3-Kinases - metabolism | Stem Cells - metabolism | Bimatoprost - administration & dosage | Cell Movement - physiology | Young Adult | Adipose Tissue - metabolism | Graves Ophthalmopathy - metabolism | Bimatoprost - pharmacology | Female | Retrospective Studies | Graves Ophthalmopathy - drug therapy | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Cell Survival - physiology | Electroretinography | Prostaglandins, Synthetic - administration & dosage | Tomography, Optical Coherence | Prostaglandins, Synthetic - pharmacology | Blotting, Western | Orbit - drug effects | Orbit - metabolism | Animals | Stem Cells - drug effects | Aged | Graves Ophthalmopathy - pathology | Mice | Adipose Tissue - drug effects | Injections, Intraocular | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Biochemistry and Molecular Biology
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2013, Volume 4, Issue 5, pp. 486 - 490
Indomethacin is a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes (COX-1 and COX-2). Deletion of the 2'-methyl group of... 
arachidonic acid | coxib | Cyclooxygenase | inflammation | prostaglandin | nonsteroidal anti-inflammatory drug | nonsteroidal anti-inflammatory drug coxib | SITE | CHEMISTRY, MEDICINAL | ENDOPEROXIDE-H SYNTHASE-1 | TIME-DEPENDENT INHIBITION | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | CYCLOOXYGENASE-2 INHIBITORS | AGENTS | BINDING
Journal Article
Acta Ophthalmologica, ISSN 1755-375X, 09/2017, Volume 95, Issue S259, p. n/a
In a recent large randomized controlled trial (the COMPASS Trial; n = 505, 374 micro-stent, 131 control), the supracilliary micro-stent (MS) used in... 
Glaucoma | Cataract | Prostaglandins | Surgery | Stent (Surgery) | Drugs | Surgical implants | Cornea | Mathematical analysis | Implants | Patients | Intraocular pressure
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 12/2018, Volume 15, Issue 12, pp. e1800334 - n/a
We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL‐37959, which is believed to be a potent nonsteroidal... 
benzofuran | bismuth(III) trifluoromethanesulfonate | NSAID | benzoylation | synthesis design | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | Inhibitors | Benzofuran | Bismuth | Inflammation | Chemical synthesis | Benzoylation | Acylation | Prostaglandin endoperoxide synthase | Index Medicus
Journal Article
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, ISSN 1070-4280, 04/2019, Volume 55, Issue 4, pp. 498 - 501
Acylation of cloprostenol with acetic anhydride in pyridine, followed by treatment of the exhaustive acetylation product with water, gave 9,11,15-triacetoxy... 
synthesis | prostamides | analogs | CHEMISTRY, ORGANIC | prostaglandins | PROSTAGLANDIN | cloprostenol | Bimatoprost | antiglaucoma activity | ETHANOLAMIDE
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e98483 - e98483
Previous studies showed that prostacyclin inhibited fibrosis. However, both receptors of prostacyclin, prostacyclin receptor (IP) and peroxisome... 
ISCHEMIA-REPERFUSION INJURY | PPAR-ALPHA | PROSTAGLANDIN I-2 | MYOCARDIAL FIBROSIS | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | CREB-BINDING-PROTEIN | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | TYROSINE NITRATION | MOLECULAR PATHWAYS | Angiotensin II - pharmacology | Myocytes, Cardiac - cytology | Rats | DNA Primers | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Base Sequence | Myocytes, Cardiac - metabolism | Epoprostenol - pharmacology | Cell Proliferation - drug effects | Receptors, Epoprostenol - drug effects | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Heart | Neonates | Phosphorylation | Smad protein | Collagen (type I) | Immunoprecipitation | Transcription | Collagens | Smooth muscle | Prostacyclin | Nuclei | Proteins | CREB-binding protein | Receptors | Ischemia | Smad2 protein | Rodents | Fibroblasts | Inhibition | Angiotensin II | Heart diseases | Deoxyribonucleic acid--DNA | Analogue | Pulmonary arteries | Protein biosynthesis | Pharmacology | siRNA | Cyclic AMP response element-binding protein | Gene expression | Protein synthesis | Pharmacy | Collagen | Fibrosis | Angiotensin | Peroxisome proliferator-activated receptors | Receptor mechanisms | Laboratory animals | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2016, Volume 24, Issue 8, pp. 1927 - 1935
Journal Article