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Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 09/2007, Volume 34, Issue 9, pp. 938 - 945
SUMMARY • In the present review, we addressed studies in humans and rats to determine the role that oxidative stress may play in mediating cardiovascular... 
kidney | aopcynin | F2-isoprostanes | superoxide | tempol | molsidomine | F2‐isoprostanes | Tempol | Aopcynin | Superoxide | Molsidomine | Kidney | PHYSIOLOGY | DIMORPHISM | SPONTANEOUSLY HYPERTENSIVE-RATS | QUANTIFICATION | PROSTAGLANDIN-F2-ALPHA METABOLITE | F-2-ISOPROSTANES | IN-VIVO | PHARMACOLOGY & PHARMACY | VASODILATOR | POSTMENOPAUSAL WOMEN | PROGRESSION | Cardiovascular Diseases - prevention & control | Humans | Kidney - enzymology | NADPH Oxidases - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Hypertension - drug therapy | Male | Spin Labels | Kidney - metabolism | Cyclic N-Oxides - pharmacology | Acetophenones - pharmacology | Female | Blood Pressure - drug effects | Nitric Oxide Donors - pharmacology | Superoxide Dismutase - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Rats, Inbred SHR | Cardiovascular Diseases - etiology | Glutathione Peroxidase - metabolism | Cardiovascular Diseases - physiopathology | Kidney - drug effects | Cardiovascular Diseases - metabolism | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Antioxidants - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Catalase - metabolism | Antioxidants - therapeutic use | Animals | Ascorbic Acid - pharmacology | Molsidomine - pharmacology | Sex Factors | Hypertension - complications | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Vitamin E - pharmacology | Kidney, drug effects | NG-Nitroarginine Methyl Ester, pharmacology | Nitric Oxide Synthase, antagonists and inhibitors | Oxidative Stress, drug effects | Ascorbic Acid, pharmacology | Hypertension, drug therapy | Cardiovascular Diseases, etiology | Cardiovascular Diseases, prevention and control | Cyclic N-Oxides, pharmacology | Enzyme Inhibitors, pharmacology | Superoxide Dismutase, metabolism | Nitric Oxide Synthase, metabolism | Hypertension, physiopathology | Antioxidants, pharmacology | Kidney, metabolism | NADPH Oxidase, antagonists and inhibitors | Blood Pressure, drug effects | Catalase, metabolism | Cardiovascular Diseases, metabolism | Hypertension, metabolism | Acetophenones, pharmacology | Vitamin E, pharmacology | Antioxidants, therapeutic use | Kidney, enzymology | Nitric Oxide, metabolism | Molsidomine, pharmacology | NADPH Oxidase, metabolism | Hypertension, complications | Nitric Oxide Donors, pharmacology | Glutathione Peroxidase, metabolism | Cardiovascular Diseases, physiopathology | Hypertension | Oxidative stress | Blood pressure
Journal Article
Gastroenterology, ISSN 0016-5085, 2000, Volume 118, Issue 6, pp. 1149 - 1156
Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions,... 
FAT-STORING CELLS | RAT-LIVER | GLOMERULAR MESANGIAL CELLS | DEPENDENT CONTRACTILITY | NITRIC-OXIDE | GROWTH-FACTOR | ITO CELLS | GASTROENTEROLOGY & HEPATOLOGY | SMOOTH-MUSCLE CELLS | PORTAL-HYPERTENSION | ALDOSTERONE SYSTEM | Receptor, Angiotensin, Type 1 | Receptors, Angiotensin - metabolism | Receptor, Angiotensin, Type 2 | Antihypertensive Agents - pharmacology | Iodine Radioisotopes | Liver - enzymology | Humans | Penicillamine - analogs & derivatives | Sodium Nitrite - pharmacology | Liver - drug effects | Thymidine - pharmacology | Nitric Oxide Donors - pharmacology | Radioligand Assay | Thymidine - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Dinoprostone - pharmacology | Angiotensin II - pharmacology | Angiotensin II - metabolism | Cell Size - drug effects | Penicillamine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Rats | Imidazoles - pharmacology | Cell Division - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | Vasoconstrictor Agents - metabolism | Liver - cytology | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Cell research | Liver diseases | Platelet-derived growth factor | Prostaglandins E | Nitric oxide | Angiotensin | Physiological aspects | Bookbinding | DNA synthesis | Peptide hormones | Protein kinases
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2005, Volume 146, Issue 6, pp. 834 - 845
In the spontaneously hypertensive rat (SHR) and aging Wistar–Kyoto rats (WKY), acetylcholine releases an endothelium‐derived contracting factor (EDCF) produced... 
TP receptors | spontaneously hypertensive rat | prostaglandins | Endothelium‐dependent contractions | endoperoxide | prostacyclin | Endoperoxide | Prostaglandins | Prostacyclin | Spontaneously hypertensive rat | Endothelium-dependent contractions | PROSTAGLANDIN-E SYNTHASE | CELLS | CYCLOOXYGENASE-2 | SPONTANEOUSLY HYPERTENSIVE-RATS | PLATELET-AGGREGATION | VASOCONSTRICTOR PROSTANOIDS | H-2 | VASCULAR SMOOTH-MUSCLE | ARTERIES | PHARMACOLOGY & PHARMACY | EXPRESSION | endothelium-dependent contractions | Prostaglandins - pharmacology | Rats, Inbred WKY | Nitrobenzenes - pharmacology | Salicylates - pharmacology | Aorta, Thoracic - drug effects | Prostaglandins I - metabolism | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Acetylcholine - pharmacology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Imidazoles - pharmacology | Aorta, Thoracic - physiopathology | Sulfonamides - pharmacology | Vasoconstriction - drug effects | Hypertension - physiopathology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Prostaglandins I - pharmacology | Prostaglandins - classification | In Vitro Techniques | Thromboxane A2 - secretion | Prostaglandins - metabolism | Papers
Journal Article
Endocrinology, ISSN 0013-7227, 02/2016, Volume 157, Issue 2, pp. 692 - 704
To determine the comprehensive G protein-coupled receptor (GPCR) expression profile in ghrelin-producing cells and to elucidate the role of GPCR-mediated... 
IN-VITRO | PLASMA | ACID | NOREPINEPHRINE | CIRCULATING GHRELIN | RAT STOMACH | SOMATOSTATIN | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | HUMANS | MICE | Immunohistochemistry | Oxytocin - pharmacology | Receptors, G-Protein-Coupled - metabolism | Receptors, Oxytocin - genetics | Muscarinic Agonists - pharmacology | Gene Expression Profiling | Gastric Mucosa - metabolism | RNA, Messenger - metabolism | Somatostatin - pharmacology | Receptors, Somatostatin - genetics | Receptors, Oxytocin - drug effects | Palmitates - pharmacology | Gastric Mucosa - drug effects | Receptors, Adrenergic, beta-1 - drug effects | Receptors, Somatostatin - metabolism | Lactic Acid - pharmacology | Receptors, G-Protein-Coupled - drug effects | Oxytocics - pharmacology | Receptors, Prostaglandin E, EP4 Subtype - agonists | Dinoprostone - pharmacology | Hormones - pharmacology | Colforsin - pharmacology | Ghrelin - drug effects | Adrenergic beta-Agonists - pharmacology | Mice, Transgenic | Receptors, Adrenergic, beta-1 - metabolism | Gastric Mucosa - cytology | Receptor, Muscarinic M4 - agonists | Ghrelin - secretion | Receptors, Oxytocin - metabolism | Animals | Sequence Analysis, RNA | Gastric Mucosa - secretion | Isoproterenol - pharmacology | Receptors, Somatostatin - drug effects | Cell Line, Tumor | Muscarine - pharmacology | Receptors, Adrenergic, beta-1 - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Tryptophan - pharmacology
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 699 - 708
Background and purpose: Studies in isolated preparations of vascular tissue (mainly resistance vessels) provide evidence that anandamide exerts vasorelaxation.... 
vasorelaxation | anandamide | rat aorta | Rat aorta | Vasorelaxation | Anandamide | PHARMACOLOGICAL CHARACTERIZATION | SENSORY NERVES MEDIATE | OXIDATIVE-METABOLISM | PROSTANOID RECEPTORS | CANNABINOID RECEPTOR | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | PROSTAGLANDIN E-2 ETHANOLAMIDE | VANILLOID RECEPTORS | CARDIOVASCULAR FUNCTION | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Bornanes - pharmacology | Endothelium, Vascular - drug effects | Male | Peptide Fragments - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Apamin - pharmacology | Aorta, Abdominal - drug effects | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Piperidines - pharmacology | Charybdotoxin - pharmacology | Benzamides - pharmacology | Vasodilation - physiology | Isoindoles - pharmacology | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Calcitonin Gene-Related Peptide - pharmacology | Nitric Oxide - antagonists & inhibitors | Rats | Capsaicin - analogs & derivatives | Aorta, Abdominal - physiology | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Pyrazoles - administration & dosage | Animals | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2011, Volume 163, Issue 7, pp. 1533 - 1549
BACKGROUND AND PURPOSE Endocannabinoids have both anti‐inflammatory and neuroprotective properties against harmful stimuli. We previously demonstrated that the... 
monoacylglycerol lipase | peroxisome proliferator‐activated receptor‐γ | nuclear factor κ‐B | endocannabinoids | neuroinflammation | cyclooxygenase‐2 | nuclear factor κ-B | peroxisome proliferator-activated receptor-γ | cyclooxygenase-2 | CB1 CANNABINOID RECEPTORS | 2-ARACHIDONYL GLYCEROL | NUCLEAR RECEPTORS | SYNAPTIC-TRANSMISSION | MICROGLIAL CELLS | KAPPA-B | OXIDATIVE-METABOLISM | peroxisome proliferator-activated receptor-gamma | PROTECTS NEURONS | nuclear factor kappa-B | ACTIVATED-RECEPTOR-GAMMA | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Interleukin-1beta - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | NF-kappa B - metabolism | Hippocampus - drug effects | PPAR gamma - metabolism | Excitatory Postsynaptic Potentials - drug effects | Cyclooxygenase 2 - biosynthesis | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Cyclooxygenase 2 - genetics | Prostaglandin D2 - analogs & derivatives | Synaptic Transmission - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Thiazolidinediones - pharmacology | Endocannabinoids | PPAR gamma - genetics | NF-kappa B - antagonists & inhibitors | Cyclooxygenase 2 Inhibitors - pharmacology | Cells, Cultured | Arachidonic Acids - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Animals | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | PPAR gamma - agonists | Mice | Prostaglandin D2 - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Research Papers
Journal Article