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Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2013, Volume 63, pp. 333 - 339
Cryptolepis sanguinolenta and its bioactive alkaloid, cryptolepine have shown anti-inflammatory activity. However, the underlying mechanism of... 
NF-κB | Neuroinflammation | Cryptolepine | Cyclooxygenase-2 | Cryptolepis sanguinolenta | p38 MAPK | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | VIVO | ALZHEIMERS-DISEASE | TRANSCRIPTION | IN-VITRO | NF-kappa B | MICROGLIA | EXPRESSION | PROSTAGLANDIN E-2 | Gene Expression Regulation, Enzymologic - drug effects | Plant Extracts - chemistry | Interleukin-1beta - pharmacology | Plant Extracts - pharmacology | Humans | Immunoblotting | Quinolines - pharmacology | Dose-Response Relationship, Drug | Indole Alkaloids - chemical synthesis | Cyclooxygenase 2 - genetics | Molecular Structure | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Indole Alkaloids - chemistry | Intramolecular Oxidoreductases - metabolism | Neuroblastoma - pathology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Neuroblastoma - genetics | Quinolines - chemistry | Cryptolepis - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Dinoprostone - metabolism | Quinolines - chemical synthesis | Anti-Inflammatory Agents - chemistry | Intramolecular Oxidoreductases - genetics | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Indole Alkaloids - pharmacology | Prostaglandin-E Synthases | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Neuroblastoma - metabolism
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 12/2014, Volume 224, pp. 68 - 77
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 07/2009, Volume 17, Issue 13, pp. 4290 - 4295
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, pp. 2700 - 2705
[Display omitted] Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES... 
Prostaglandin pathway | PGE2 | mPGES-1 | Pain | PTGES | E-2 SYNTHASE-1 | TARGET | WEIGHT-BEARING | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | PGE | Synthetic prostaglandins E | Endometriosis | Sexual disorders | Analysis | Organic acids
Journal Article